Effect of Ozone for Chest Infection Patients after Thoracotomy_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

谭雄 ,  赖应龙 , 李金洁 , 赵永生 , 何光杰 , 费俊杰 , 谭何易 , 杨绍福

南充市川北医学院附属医院胸心外科（四川南充 637000）;

Corresponding author：

赖应龙, Email: laiyinglong2000@163.com

Keywords：

臭氧治疗; 食管胸腔瘘; 开胸手术

DOI：

10.7507/1007-4848.20160222

Video：

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目的探索食管癌、贲门癌、贲门失弛缓症术后胸腔感染的有效处理方法。方法选取我院胸外科2012年1月至2014年6月间因食管癌、贲门癌、贲门失弛缓症手术并发食管胸腔瘘的患者42例，分为常规+臭氧治疗组和常规治疗组。常规治疗组28例，男22例、女6例，年龄54～78（63.5±6.8）岁，行胸腔闭式引流、抗感染、营养支持治疗；常规+臭氧治疗组14例，男11例、女3例，年龄39～74（64.7±9.1）岁，行常规治疗+臭氧胸腔保留灌注治疗。结果两组年龄、性别、体重差异均无统计学意义（P＞0.05），常规+臭氧治疗组疗效明显优于常规治疗组：住院时间更短（P=0.017），住院费用更低（P=0.016），死亡率[0.00%（0/14）vs. 10.71%（3/28）]更低。结论臭氧具有便捷、杀菌、消毒、不良反应以及促进脓腔吸收的作用，可以提高治疗效果，缩短住院时间，减少住院费用，值得临床推广和运用。

Citation： 谭雄, 赖应龙, 李金洁, 赵永生, 何光杰, 费俊杰, 谭何易, 杨绍福. Effect of Ozone for Chest Infection Patients after Thoracotomy. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2016, 23(9): 931-933. doi: 10.7507/1007-4848.20160222 Copy

1.	龚太乾, 蒋耀光, 王如文, 等.食管癌术后早期并发症及死亡原因分析.中国胸心血管外科临床杂志, 2005, 12(3):173-176.
2.	刘奎, 杨秀芝, 王明钊, 等.胸内食管吻合口隐匿瘘的诊断与治疗.中国胸心血管外科临床杂志, 2012, 19(4):399-401.
3.	沃琤, 高素香, 周丽君, 等.臭氧套袋治疗感染创面的疗效观察.临床和实验医学杂志, 2010, 9(16):1266.
4.	杨光煜, 何苡, 胡为才, 等. 53例食管癌贲门癌术后吻合口瘘及相关并发症的处理.中华胸心血管外科杂志, 2014, 30(1):11-13.
5.	Murthy SC, Law S, Whooley BP, et al. Atrial fibrillation after esophagectomy is a marker postoperative morbidity and mortality. J Thorac Cardiovasc Surg, 2003, 126:1162-1167.
6.	平育敏, 何明, 孟宪利, 等.食管癌和贲门癌术后并发症的防治.中华医学杂志, 2009, 89(5):296-300.
7.	Larini A, Bocci V. Effects of ozone on isolated peripheral blood mononuclear cells. Toxicology in Vitro, 2005, 19:55-61.
8.	Larini A, Bianchi L, Bocci V. The ozone tolerance:I) Enhancement of antioxidant enzymes is ozone dose-dependent in Jurkat cells. Free Radic Res, 2003, 37(11):1163-1168.
9.	Arakawa S. Basic characteristics and clinical application of ozone nano-bubble water. Kokubyo Gakkai Zasshi, 2013, 80(1):1-7.
10.	Ito K, Inoue S, Hiraku Y, et al. Mechanism of site-specific DNA damage induced by ozone. Mutat Res, 2005, (1-2):60-70.
11.	Tamai M, Matsushita S, Miyanohara H, et al. Antimicrobial effect of an ultrasonic levitation washer disinfector with silver electrolysis and ozone oxidation on methicillin-resistant Staphylococcus aureus. J Dermatol, 2013, 40(12):1020-1026.
12.	Gulmen S, Kurtoglu T, Meteoglu I, et al. Ozone therapy as an adjunct to vancomycin enhances bacterial elimination in methicillin resistant Staphylococcus aureus mediastinitis. J Surg Res, 2013, 185(1):64-69.
13.	李宗玉.臭氧水在创面治疗中应用的实验研究.第二军医大学, 2010.博士学位论文.
14.	张威, 王雪山, 徐业凯, 等.臭氧对感染创面治疗的探讨.医学信息(中旬刊), 2011, 24(5):2013.
15.	段芙红, 姜建威.医用臭氧气浴治疗糖尿病足的作用机制探讨.中国误诊学杂志, 2010, 10(28):6909.
16.	Zanardi I, Burgassi S, Paccagnini E, et al. What is the best strategy for enhancing the effects of topically applied ozonated oils in cutaneous infections? Biomed Res Int, 2013, 2013:702949.
17.	李受南, 白春高, 雷敬富, 等.食管癌术后并发症和死亡原因分析.中国现代医生, 2013, 51(36):142-143, 146.
18.	陈唯真, 杨腊虎. 2011年版《英国药典》概览.中国药事, 2011(9):943-947, 950.
19.	黄伟钊, 吴颖猛, 叶红雨, 等.食管癌术后消化道瘘的个体化治疗.中国胸心血管外科临床杂志, 2011, 18(5):469-471.
20.	魏洁.合理应用抗菌药物减少院内细菌感染.中国医药科学, 2012, 2(18):178, 180.

1. 龚太乾, 蒋耀光, 王如文, 等.食管癌术后早期并发症及死亡原因分析.中国胸心血管外科临床杂志, 2005, 12(3):173-176.
2. 刘奎, 杨秀芝, 王明钊, 等.胸内食管吻合口隐匿瘘的诊断与治疗.中国胸心血管外科临床杂志, 2012, 19(4):399-401.
3. 沃琤, 高素香, 周丽君, 等.臭氧套袋治疗感染创面的疗效观察.临床和实验医学杂志, 2010, 9(16):1266.
4. 杨光煜, 何苡, 胡为才, 等. 53例食管癌贲门癌术后吻合口瘘及相关并发症的处理.中华胸心血管外科杂志, 2014, 30(1):11-13.
5. Murthy SC, Law S, Whooley BP, et al. Atrial fibrillation after esophagectomy is a marker postoperative morbidity and mortality. J Thorac Cardiovasc Surg, 2003, 126:1162-1167.
6. 平育敏, 何明, 孟宪利, 等.食管癌和贲门癌术后并发症的防治.中华医学杂志, 2009, 89(5):296-300.
7. Larini A, Bocci V. Effects of ozone on isolated peripheral blood mononuclear cells. Toxicology in Vitro, 2005, 19:55-61.
8. Larini A, Bianchi L, Bocci V. The ozone tolerance:I) Enhancement of antioxidant enzymes is ozone dose-dependent in Jurkat cells. Free Radic Res, 2003, 37(11):1163-1168.
9. Arakawa S. Basic characteristics and clinical application of ozone nano-bubble water. Kokubyo Gakkai Zasshi, 2013, 80(1):1-7.
10. Ito K, Inoue S, Hiraku Y, et al. Mechanism of site-specific DNA damage induced by ozone. Mutat Res, 2005, (1-2):60-70.
11. Tamai M, Matsushita S, Miyanohara H, et al. Antimicrobial effect of an ultrasonic levitation washer disinfector with silver electrolysis and ozone oxidation on methicillin-resistant Staphylococcus aureus. J Dermatol, 2013, 40(12):1020-1026.
12. Gulmen S, Kurtoglu T, Meteoglu I, et al. Ozone therapy as an adjunct to vancomycin enhances bacterial elimination in methicillin resistant Staphylococcus aureus mediastinitis. J Surg Res, 2013, 185(1):64-69.
13. 李宗玉.臭氧水在创面治疗中应用的实验研究.第二军医大学, 2010.博士学位论文.
14. 张威, 王雪山, 徐业凯, 等.臭氧对感染创面治疗的探讨.医学信息(中旬刊), 2011, 24(5):2013.
15. 段芙红, 姜建威.医用臭氧气浴治疗糖尿病足的作用机制探讨.中国误诊学杂志, 2010, 10(28):6909.
16. Zanardi I, Burgassi S, Paccagnini E, et al. What is the best strategy for enhancing the effects of topically applied ozonated oils in cutaneous infections? Biomed Res Int, 2013, 2013:702949.
17. 李受南, 白春高, 雷敬富, 等.食管癌术后并发症和死亡原因分析.中国现代医生, 2013, 51(36):142-143, 146.
18. 陈唯真, 杨腊虎. 2011年版《英国药典》概览.中国药事, 2011(9):943-947, 950.
19. 黄伟钊, 吴颖猛, 叶红雨, 等.食管癌术后消化道瘘的个体化治疗.中国胸心血管外科临床杂志, 2011, 18(5):469-471.
20. 魏洁.合理应用抗菌药物减少院内细菌感染.中国医药科学, 2012, 2(18):178, 180.

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