Trends in the disease burden of esophageal cancer attributable to alcohol consumption in China from 1990 to 2019 and a gender comparison analysis_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

HU Shoucai ^1,2,3 , YANG Chenglong ^1,2,3 , MA Haotian ^1,2,3 , TAO Yancheng ^1,2,3 ,  HU Gawei ^1,2 ,  LI Qingxin ^1,2

1. Department of Thoracic Surgery, The 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, Lanzhou, 730000, P. R. China;
2. Highland Medicine Department, The 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, Lanzhou, 730050, P. R. China;
3. The First Clinical Department of Gansu University of Traditional Chinese Medicine, Lanzhou, 730000, P. R. China;

Corresponding author：

HU Gawei, Email: 371694464@qq.com; LI Qingxin, Email: liqxchest@163.com

Keywords：

Alcohol consumption; esophageal cancer; disease burden; change trend; Joinpoint model

DOI：

10.7507/1007-4848.202405053

Video：

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Objective To integrate and analyze the disease burden of esophageal cancer caused by alcohol consumption in China from 1990 to 2019, along with the differences between genders, and predict the trends in disease burden changes from 2020 to 2029 to improve prevention and treatment strategies. Methods The disease burden of esophageal cancer caused by alcohol consumption in China from 1990 to 2019 was extracted and integrated from the 2019 Global Burden of Disease (GBD) database, and the corresponding trend was analyzed using the Joinpoint regression model with Joinpoint 4.9.1.0 software. The gray prediction model [GM (1, 1) ] was used to forecast the disease burden of alcohol-related esophageal cancer in China from 2020 to 2029. Results In 2019, the leading causes of esophageal cancer in China were tobacco, alcohol, high body mass index, and insufficient fruit and vegetable intake, accounting for the first to fifth positions in esophageal cancer deaths. From a gender perspective, in 2019, the death number and standardized mortality rate for males were 18.97 times and 20.00 times higher than for females, respectively. The disability-adjusted life years (DALYs) and standardized DALYs rate for males were 33.08 times and 24.78 times higher than those for females, respectively, indicating a heavier disease burden of alcohol-related esophageal cancer among Chinese males. From 1990 to 2019, the average annual percentage change (AAPC) in deaths and DALYs due to alcohol-related esophageal cancer in China was 2.08% and 1.63%, respectively, showing a continuous upward trend with statistical significance (P<0.05). The AAPC values for standardized mortality rate and standardized DALYs rate from 1990 to 2019 were –0.92% and –1.23%, respectively, showing a continuous downward trend with statistical significance (P<0.05). The population aged ≥55 years was the main group bearing the disease burden among all age groups from 1990 to 2019. The gray prediction model predicted that by 2029, the overall standardized mortality rate and standardized DALYs rate would decrease to 2.94/100 000and 67.94/100 000, with a greater decline in females than in males. Conclusion Over the past 30 years, the disease burden of alcohol-related esophageal cancer in China has slightly decreased. However, the reduction in disease burden is still lower compared to the overall decline in esophageal cancer burden, and the disease burden for males is significantly higher than for females. Focusing on prevention and treatment for males and the elderly population remains a major issue in addressing alcohol-related esophageal cancer in China.

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9.	张敏, 徐杰茹, 陈磊, 等. 基于GBD数据分析1990—2019年中国胰腺癌发病趋势. 现代预防医学, 2022, 49(7): 1159-1164.Zhang M, Xu JR, Chen L, et al. Analysis of the incidence trend of pancreatic cancer in China from 1990 to 2019 based on GBD data. Mod Prev Med, 2022, 49(7): 1159-1164.
10.	Rehman S, Rehman E, Ikram M, et al. Cardiovascular disease (CVD): Assessment, prediction and policy implications. BMC Public Health, 2021, 21(1): 1299.
11.	刘爱玲, 周静静, 李成程, 等. 1990—2019年中国归因于烟草的食管癌疾病负担趋势和死亡预测分析. 中国全科医学, 2023, 26(36): 4587-4594, 4601.Liu AL, Zhou JJ, Li CC, et al. Analysis of the disease burden trends and death projections for esophageal cancer attributable to tobacco in China from 1990 to 2019. Chin Gen Pract, 2023, 26(36): 4587-4594, 4601.
12.	王红心, 樊文龙, 杨晓雨, 等. 1990—2019年中国蛋白质能量营养不良发病趋势及预测研究. 中国全科医学, 2023, 26(5): 591-597.Wang HX, Fan WL, Yang XY, et al. Protein-energy malnutrition incidence in China: Trend in 1990-2019 and future trend in 2020-2029. Chin Gen Pract, 2023, 26(5): 591-597.
13.	胡守财, 陶堰成, 马浩天, 等. 1990~2019年中国非风湿性瓣膜性心脏病疾病负担及变化趋势分析. 中国循环杂志, 2024, 39(8): 806-812.Hu SC, Tao YC, Ma HT, et al. Disease burden and changing trend of non-rheumatic valvular heart disease from 1990 to 2019 in China. Chin Circ J, 2024, 39(8): 806-812.
14.	陈飞, 王悠清. 1990—2019年中国食管癌疾病负担及其变化趋势分析. 中国肿瘤, 2021, 30(6): 401-407.Chen F, Wang YQ. Disease burden and trends of esophageal cancer in China during 1990-2019. China Cancer, 2021, 30(6): 401-407.
15.	Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2024, 74(3): 229-263.
16.	Frick C, Rumgay H, Vignat J, et al. Quantitative estimates of preventable and treatable deaths from 36 cancers worldwide: A population-based study. Lancet Glob Health, 2023, 11(11): e1700-e1712.
17.	Catelan D, Biggeri A, Bucchi L, et al. Epidemiologic transition of lung cancer mortality in Italy by sex, province of residence and birth cohort (1920-1929 to 1960-1969). Int J Cancer, 2023, 153(10): 1746-1757.
18.	Ran X, Zeng H, Zheng R, et al. Geographic, sex and socioeconomic disparities in esophageal cancer incidence in China: A population-based study. Int J Cancer, 2024, 154(3): 477-487.
19.	DesJardin JT, Chikwe J, Hahn RT, et al. Sex differences and similarities in valvular heart disease. Circ Res, 2022, 130(4): 455-473.
20.	Jin EH, Han K, Shin CM, et al. Sex and tumor-site differences in the association of alcohol intake with the risk of early-onset colorectal cancer. J Clin Oncol, 2023, 41(22): 3816-3825.
21.	Li S, Chen H, Man J, et al. Changing trends in the disease burden of esophageal cancer in China from 1990 to 2017 and its predicted level in 25 years. Cancer Med, 2021, 10(5): 1889-1899.
22.	Song F, Liu FZ, Liang YF, et al. Clinical, sonographic characteristics and long-term prognosis of valvular heart disease in elderly patients. J Geriatr Cardiol, 2019, 16(1): 33-41.
23.	Yu G, Gong X, Xu Y, et al. The global burden and trends of four major types of heart disease, 1990-2019: A systematic analysis for the Global Burden of Disease Study 2019. Public Health, 2023, 220: 1-9.
24.	Zheng X, Guan Q, Lin X. Changing trends of the disease burden of non-rheumatic valvular heart disease in China from 1990 to 2019 and its predictions: Findings from global burden of disease study. Front Cardiovasc Med, 2023, 9: 912661.

1. 张嘉诚, 高雅, 孔德九, 等. 循环microRNAs作为潜在食管癌标志物诊断价值的Meta分析. 食管疾病, 2023, 5(4): 255-259.Zhang JC, Gao Y, Kong DJ, et al. Meta analysis of diagnostic value of circulating microRNAs as potential biomarkers for esophageal cancer. J Esophageal Dis, 2023, 5(4): 255-259.
2. Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2021, 71(3): 209-249.
3. 刘宗超, 李哲轩, 张阳, 等. 2020全球癌症统计报告解读. 肿瘤综合治疗电子杂志, 2021, 7(2): 1-14.Liu ZC, Li ZX, Zhang Y, et al. Interpretation on the report of Global Cancer Statistics 2020. J Multidiscip Cancer Manag (Electron Ed), 2021, 7(2): 1-14.
4. GBD 2017 Oesophageal Cancer Collaborators. The global, regional, and national burden of oesophageal cancer and its attributable risk factors in 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017. Lancet Gastroenterol Hepatol, 2020, 5(6): 582-597.
5. GBD 2016 Alcohol Collaborators. Alcohol use and burden for 195 countries and territories, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet, 2018, 392(10152): 1015-35.
6. GBD 2017 Risk Factor Collaborators. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017. Lancet, 2018, 392(10159): 1923-94.
7. Millwood IY, Im PK, Bennett D, et al. Alcohol intake and cause-specific mortality: Conventional and genetic evidence in a prospective cohort study of 512 000 adults in China. Lancet Public Health, 2023, 8(12): e956-e967.
8. GBD 2019 Diseases and Injuries Collaborators. Global burden of 369 diseases and injuries in 204 countries and territories, 1990—2019: A systematic analysis for the Global Burden of Disease Study 2019. Lancet, 2020, 396(10258): 1204-1222.
9. 张敏, 徐杰茹, 陈磊, 等. 基于GBD数据分析1990—2019年中国胰腺癌发病趋势. 现代预防医学, 2022, 49(7): 1159-1164.Zhang M, Xu JR, Chen L, et al. Analysis of the incidence trend of pancreatic cancer in China from 1990 to 2019 based on GBD data. Mod Prev Med, 2022, 49(7): 1159-1164.
10. Rehman S, Rehman E, Ikram M, et al. Cardiovascular disease (CVD): Assessment, prediction and policy implications. BMC Public Health, 2021, 21(1): 1299.
11. 刘爱玲, 周静静, 李成程, 等. 1990—2019年中国归因于烟草的食管癌疾病负担趋势和死亡预测分析. 中国全科医学, 2023, 26(36): 4587-4594, 4601.Liu AL, Zhou JJ, Li CC, et al. Analysis of the disease burden trends and death projections for esophageal cancer attributable to tobacco in China from 1990 to 2019. Chin Gen Pract, 2023, 26(36): 4587-4594, 4601.
12. 王红心, 樊文龙, 杨晓雨, 等. 1990—2019年中国蛋白质能量营养不良发病趋势及预测研究. 中国全科医学, 2023, 26(5): 591-597.Wang HX, Fan WL, Yang XY, et al. Protein-energy malnutrition incidence in China: Trend in 1990-2019 and future trend in 2020-2029. Chin Gen Pract, 2023, 26(5): 591-597.
13. 胡守财, 陶堰成, 马浩天, 等. 1990~2019年中国非风湿性瓣膜性心脏病疾病负担及变化趋势分析. 中国循环杂志, 2024, 39(8): 806-812.Hu SC, Tao YC, Ma HT, et al. Disease burden and changing trend of non-rheumatic valvular heart disease from 1990 to 2019 in China. Chin Circ J, 2024, 39(8): 806-812.
14. 陈飞, 王悠清. 1990—2019年中国食管癌疾病负担及其变化趋势分析. 中国肿瘤, 2021, 30(6): 401-407.Chen F, Wang YQ. Disease burden and trends of esophageal cancer in China during 1990-2019. China Cancer, 2021, 30(6): 401-407.
15. Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2024, 74(3): 229-263.
16. Frick C, Rumgay H, Vignat J, et al. Quantitative estimates of preventable and treatable deaths from 36 cancers worldwide: A population-based study. Lancet Glob Health, 2023, 11(11): e1700-e1712.
17. Catelan D, Biggeri A, Bucchi L, et al. Epidemiologic transition of lung cancer mortality in Italy by sex, province of residence and birth cohort (1920-1929 to 1960-1969). Int J Cancer, 2023, 153(10): 1746-1757.
18. Ran X, Zeng H, Zheng R, et al. Geographic, sex and socioeconomic disparities in esophageal cancer incidence in China: A population-based study. Int J Cancer, 2024, 154(3): 477-487.
19. DesJardin JT, Chikwe J, Hahn RT, et al. Sex differences and similarities in valvular heart disease. Circ Res, 2022, 130(4): 455-473.
20. Jin EH, Han K, Shin CM, et al. Sex and tumor-site differences in the association of alcohol intake with the risk of early-onset colorectal cancer. J Clin Oncol, 2023, 41(22): 3816-3825.
21. Li S, Chen H, Man J, et al. Changing trends in the disease burden of esophageal cancer in China from 1990 to 2017 and its predicted level in 25 years. Cancer Med, 2021, 10(5): 1889-1899.
22. Song F, Liu FZ, Liang YF, et al. Clinical, sonographic characteristics and long-term prognosis of valvular heart disease in elderly patients. J Geriatr Cardiol, 2019, 16(1): 33-41.
23. Yu G, Gong X, Xu Y, et al. The global burden and trends of four major types of heart disease, 1990-2019: A systematic analysis for the Global Burden of Disease Study 2019. Public Health, 2023, 220: 1-9.
24. Zheng X, Guan Q, Lin X. Changing trends of the disease burden of non-rheumatic valvular heart disease in China from 1990 to 2019 and its predictions: Findings from global burden of disease study. Front Cardiovasc Med, 2023, 9: 912661.

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Latest ArticlesTrends in the disease burden of esophageal cancer attributable to alcohol consumption in China from 1990 to 2019 and a gender comparison analysis

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