Intrathyroid thymic carcinoma and literature review: Two cases reports_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

LIU Haijun ^1,2 , CHENG yumeng ² ,  ZHANG Yajie ² ,  LI Hecheng ²

1. Department of Thoracic and Cardiac Surgery, The Fifth People's Hospital, Datong, 037000, Shanxi, P. R. China;
2. Department of Thoracic Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, P. R. China;

Corresponding author：

ZHANG Yajie, Email: zhangyajieryan@163.com; LI Hecheng, Email: lihecheng2000@hotmail.com

Keywords：

Intrathyroid thymic carcinoma; surgical treatment; case report

DOI：

10.7507/1007-4848.202501056

Video：

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Intrathyroid thymic carcinoma (ITTC) is a rare type of malignent tumor. Two cases of ITTC were reported. Both patients underwent surgical treatment and recovered well after surgery, with no surgery-related complications and no recurrence during follow-up. In order to discuss the clinical features, diagnosis and treatment of ITTC, the literature review was conducted.

1.	Miyauchi A, Kuma K, Matsuzuka F, et al. Intrathyroidal epithelial thymoma: an entity distinct from squamous cell carcinoma of the thyroid. World J Surg, 1985, 9(1): 128-135.
2.	Miyauchi A, Kuma K, Matsuzuka F, et al. Intrathyroidal epithelial thymoma: An entity distinct from squamous cell carcinoma of the thyroid. World J Surg, 1985, 9(1): 128-135.
3.	Lloyd RV, Osamura RY, Klöppel G, et al in WHO Classification of Tumours Editorial. Editor in Chief. WHO Classification of Tumours of Endocrine Organs. Verlag: World Health Organization. 2017. 10.
4.	Gurizzan C, Zamparini M, Volante M, et al. Outcome of patients with intrathyroidal thymic carcinoma: a pooled analysis. Endocrine-Related Cancer, 2021, 28(8): 593-604.
5.	Huang C, Wang L, Wang Y, et al. Carcinoma showing thymus-like differentiation of the thyroid (CASTLE). Pathology, Research and Practice, 2013, 209(10): 662-665.
6.	Cui A, Du Y, Hou C, et al. Case Reports: A role of postoperative radiation therapy in completely resected early stage intrathyroid thymic carcinoma: A case report and literature review of the diagnosis and treatment. Front Oncol, 2023, 13: 1234961.
7.	Ge W, Yao YZ, Chen G, et al. Clinical analysis of 82 cases of carcinoma showing thymus-like differentiation of the thyroid. Oncol Letters, 2016, 11(2): 1321-1326.
8.	邵硕, 郑宁, 程景风, 等. 腮腺异位胸腺组织发生的胸腺癌一例. 中国临床案例成果数据库, 2022, 4(1): E00908-E00908.Shao S, Zheng L, Chen JF, et al. Carcinoma exists in ectopic thymic tissue of parotid gland: A case report. China Clinical Case Outcomes Database, 2022, 4(1): E00908-E00908.
9.	冯一星, 张晟. 甲状腺内胸腺癌声像图特征及临床病理特点分析. 中华超声影像学杂志, 2019, 28(3): 241-245.Feng YX, Zhang M. Ultrasonographic and clinical pathological features of intrathyroid thymic carcinoma). Chin J Ultrasonog, 2019, 28(3): 241-245.
10.	Wu B, Sun T, Gu Y, et al. CT and MR imaging of thyroid carcinoma showing thymus-like differentiation (CASTLE): a report of ten cases. Br J Radiol, 2016, 89(1060): 20150726.
11.	Wu B, Sun T, Gu Y, et al. CT and MR imaging of thyroid carcinoma showing thymus-like differentiation (CASTLE): a report of ten cases. Br J Radiol, 2016, 89(1060): 20150726.
12.	Ito Y, Miyauchi A, Nakamura Y, et al. Clinicopathologic significance of intrathyroidal epithelial thymoma/carcinoma showing thymus-like differentiation: A collaborative study with Member Institutes of The Japanese Society of Thyroid Surgery. Am J Clin Pathol, 2007, 127(2): 230-236.
13.	Owen D, Chu B, Lehman AM, et al. Expression patterns, prognostic value, and intratumoral heterogeneity of PD-L1 and PD-1 in thymoma and thymic carcinoma. J Thorac Oncol, 2018, 13(8): 1204-1212.
14.	Giaccone G, Kim C, Thompson J, et al. Pembrolizumab in patients with thymic carcinoma: A single-arm, single-centre, phase 2 study. Lancet Oncol, 2018, 19(3): 347-355.
15.	Giaccone G, Kim C. Durable response in patients with thymic carcinoma treated with pembrolizumab after prolonged follow-up. J Thorac Oncol, 2021, 16(3): 483-485.

1. Miyauchi A, Kuma K, Matsuzuka F, et al. Intrathyroidal epithelial thymoma: an entity distinct from squamous cell carcinoma of the thyroid. World J Surg, 1985, 9(1): 128-135.
2. Miyauchi A, Kuma K, Matsuzuka F, et al. Intrathyroidal epithelial thymoma: An entity distinct from squamous cell carcinoma of the thyroid. World J Surg, 1985, 9(1): 128-135.
3. Lloyd RV, Osamura RY, Klöppel G, et al in WHO Classification of Tumours Editorial. Editor in Chief. WHO Classification of Tumours of Endocrine Organs. Verlag: World Health Organization. 2017. 10.
4. Gurizzan C, Zamparini M, Volante M, et al. Outcome of patients with intrathyroidal thymic carcinoma: a pooled analysis. Endocrine-Related Cancer, 2021, 28(8): 593-604.
5. Huang C, Wang L, Wang Y, et al. Carcinoma showing thymus-like differentiation of the thyroid (CASTLE). Pathology, Research and Practice, 2013, 209(10): 662-665.
6. Cui A, Du Y, Hou C, et al. Case Reports: A role of postoperative radiation therapy in completely resected early stage intrathyroid thymic carcinoma: A case report and literature review of the diagnosis and treatment. Front Oncol, 2023, 13: 1234961.
7. Ge W, Yao YZ, Chen G, et al. Clinical analysis of 82 cases of carcinoma showing thymus-like differentiation of the thyroid. Oncol Letters, 2016, 11(2): 1321-1326.
8. 邵硕, 郑宁, 程景风, 等. 腮腺异位胸腺组织发生的胸腺癌一例. 中国临床案例成果数据库, 2022, 4(1): E00908-E00908.Shao S, Zheng L, Chen JF, et al. Carcinoma exists in ectopic thymic tissue of parotid gland: A case report. China Clinical Case Outcomes Database, 2022, 4(1): E00908-E00908.
9. 冯一星, 张晟. 甲状腺内胸腺癌声像图特征及临床病理特点分析. 中华超声影像学杂志, 2019, 28(3): 241-245.Feng YX, Zhang M. Ultrasonographic and clinical pathological features of intrathyroid thymic carcinoma). Chin J Ultrasonog, 2019, 28(3): 241-245.
10. Wu B, Sun T, Gu Y, et al. CT and MR imaging of thyroid carcinoma showing thymus-like differentiation (CASTLE): a report of ten cases. Br J Radiol, 2016, 89(1060): 20150726.
11. Wu B, Sun T, Gu Y, et al. CT and MR imaging of thyroid carcinoma showing thymus-like differentiation (CASTLE): a report of ten cases. Br J Radiol, 2016, 89(1060): 20150726.
12. Ito Y, Miyauchi A, Nakamura Y, et al. Clinicopathologic significance of intrathyroidal epithelial thymoma/carcinoma showing thymus-like differentiation: A collaborative study with Member Institutes of The Japanese Society of Thyroid Surgery. Am J Clin Pathol, 2007, 127(2): 230-236.
13. Owen D, Chu B, Lehman AM, et al. Expression patterns, prognostic value, and intratumoral heterogeneity of PD-L1 and PD-1 in thymoma and thymic carcinoma. J Thorac Oncol, 2018, 13(8): 1204-1212.
14. Giaccone G, Kim C, Thompson J, et al. Pembrolizumab in patients with thymic carcinoma: A single-arm, single-centre, phase 2 study. Lancet Oncol, 2018, 19(3): 347-355.
15. Giaccone G, Kim C. Durable response in patients with thymic carcinoma treated with pembrolizumab after prolonged follow-up. J Thorac Oncol, 2021, 16(3): 483-485.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

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