Relevant Factors Analysis of LevelⅡLymphatic Metastasis in Papillary Thyroid Carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 LÜCheng-zhou , DONGWen-wu , HELiang , ZHANGDa-lin , JIAAi-qing ,  ZHANGHao

Department of General Surgery, The First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning Province, China;

Corresponding author：

ZHANGHao, Email: haozhang@mail.cmu.edu.cn

Keywords：

Papillary thyroid carcinoma; Lymphatic metastasis; Neck dissection

DOI：

10.7507/1007-9424.20150049

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To analyze the relevant factors of levelⅡlymph node metastasis in papillary thyroid carci-noma. Methods The clinicopathologic data of 83 patients from November 2011 to March 2014 were analyzed retrospec-tively. All the primary tumors were papillary thyroid carcinoma located in unilateral lobe with ipsilateral lateral neck lymph node metastasis. The relationship of gender, age, microcarcinoma, superior pole involved by carcinoma, integrated tumor capsule, or extranodal invasion to levelⅡlymph node metastasis was analyzed. The calculated data were analyzed with Chi-Square test and there was significant difference when P < 0.05. Results The rate of lymph node metastasis at levelⅡ, Ⅲ, Ⅳ, Ⅴ, Ⅵwas 51.8% (43/83), 78.3% (65/83), 71.7% (59/83), 4.8% (4/56), and 79.5% (66/83), respectively. There was no significant relationship of gender, age, microcarcinoma, integrated tumor capsule, or extranodal invasion to levelⅡlymph node metastasis (P > 0.05). The rate of lymph node metastasis at levelⅡwas significantly higher when superior pole involved by carcinoma (P < 0.05). Conclusion Among the patients with papillary thyroid carcinoma, when superior pole involved by carcinoma the patient should be underwent selective neck dissection, the proper extent of dissection including levelⅡshould be performed.

Citation： LÜCheng-zhou, DONGWen-wu, HELiang, ZHANGDa-lin, JIAAi-qing, ZHANGHao. Relevant Factors Analysis of LevelⅡLymphatic Metastasis in Papillary Thyroid Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(2): 177-180. doi: 10.7507/1007-9424.20150049 Copy

1.	Mazzaferri EL, Massoll N. Management of papillary and follicular (differentiated) thyroid cancer: new paradigms using recombinant human thyrotropin. Endocr Relat Cancer, 2002, 9(4): 227-247.
2.	Sivanandan R, Soo KC. Pattern of cervical lymph node metastases from papillary carcinoma of the thyroid. Br J Surg, 2001, 88(9): 1241-1244.
3.	Mazzaferri EL, Kloos RT. Clinical review 128: Current approaches to primary therapy for papillary and follicular thyroid cancer. J Clin Endocrinol Metab, 2001, 86(4): 1447-1463.
4.	Moo TA, Mcgill J, Allendorf J, et al. Impact of prophylactic central neck lymph node dissection on early recurrence in papillary thyroid carcinoma. World J Surg, 2010, 34(6): 1187-1191.
5.	鄢丹桂, 张彬, 安常明, 等.甲状腺乳头状癌临床N0患者颈部淋巴结转移规律.中华耳鼻咽喉头颈外科杂志, 2011, 46(11): 887-891.
6.	张强, 张仑, 宋方方, 等.甲状腺乳头状癌颈部淋巴结转移规律临床分析.中国耳鼻咽喉头颈外科, 2010, 17(12): 639-642.
7.	诸林海, 丁向民.甲状腺乳头状癌Ⅵ区阳性淋巴结数与清除方式的选择.中国现代普通外科进展, 2009, 12(7): 576-579.
8.	曾瑞超, 黄慧雅, 李权, 等.甲状腺乳头状微小癌颈侧区淋巴结转移相关因素分析.中华内分泌代谢杂志, 2012, 28(3): 207-210.
9.	张梦萍, 张诠, 郭朱明, 等.乳头状甲状腺癌侧颈淋巴结隐匿性转移相关因素分析.中华临床医师杂志:电子版, 2012, 6(13): 100-102.
10.	张浏阳, 周旋, 姚晓峰, 等.甲状腺乳头状癌Ⅱ区淋巴结隐匿性转移的临床分析.中华耳鼻咽喉头颈外科杂志, 2011, 46(9): 733-737.
11.	Davidson HC, Park BJ, Johnson JT. Papillary thyroid cancer: controversies in the management of neck metastasis. Laryngoscope, 2008, 118(12): 2161-2165.
12.	Mazzaferri EL, Jhiang SM. Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer. Am J Med, 1994, 97(5): 418-428.
13.	Cappiello J, Piazza C, Nicolai P. The spinal accessory nerve in head and neck surgery. Curr Opin Otolaryngol Head Neck Surg, 2007, 15(2): 107-111.
14.	宋军健.甲状腺乳头状腺癌选择性颈清扫术后并发症.中国耳鼻咽喉头颈外科, 2007, 14(6): 331-333.
15.	National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Thyroid carcinoma (Version 1. 2009). http://www.nccn.org/professionals/physician_gls/pdf/thyroid.pdf.
16.	National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Thyroid carcinoma (Version 1. 2010). http://www.nccn.org/professionals/physician_gls/pdf/thyroid.pdf.
17.	National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Thyroid carcinoma (Version 1. 2011). http://www.nccn.org/professionals/physician_gls/pdf/thyroid.pdf.
18.	Caron NR, Tan YY, Ogilvie JB, et al. Selective modified radical neck dissection for papillary thyroid cancer-is levelⅠ, Ⅱand V dissection always necessary? World J Surg, 2006, 30(5): 833-840.
19.	National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Thyroid carcinoma (Version 2. 2012). http://www.nccn.org/professionals/physician_gls/pdf/thyroid.pdf.
20.	Patron V, Bedfert C, Le Clech G, et al. Pattern of lateral neck metastases in N0 papillary thyroid carcinoma. BMC Cancer, 2011, 11: 8.
21.	Palazzo FF, Gosnell J, Savio R, et al. Lymphadenectomy for papillary thyroid cancer: changes in practice over four decades. Eur J Surg Oncol, 2006, 32(3): 340-344.
22.	葛明华, 王可敬, 刘爱华.无区域淋巴结转移甲状腺乳头状癌患者的颈部处理.中国肿瘤临床, 2001, 28(4): 254-256.
23.	中华医学会内分泌学分会, 中华医学会外科学分会, 中国抗癌协会头颈肿瘤专业委员会, 中华医学会核医学分会.甲状腺结节和分化型甲状腺癌诊治指南.中国肿瘤临床, 2012, 39(17): 1249-1272.
24.	朱精强.分化型甲状腺癌颈淋巴结清扫的相关问题.中国普外基础与临床杂志, 2012, 19(8): 809-813.

1. Mazzaferri EL, Massoll N. Management of papillary and follicular (differentiated) thyroid cancer: new paradigms using recombinant human thyrotropin. Endocr Relat Cancer, 2002, 9(4): 227-247.
2. Sivanandan R, Soo KC. Pattern of cervical lymph node metastases from papillary carcinoma of the thyroid. Br J Surg, 2001, 88(9): 1241-1244.
3. Mazzaferri EL, Kloos RT. Clinical review 128: Current approaches to primary therapy for papillary and follicular thyroid cancer. J Clin Endocrinol Metab, 2001, 86(4): 1447-1463.
4. Moo TA, Mcgill J, Allendorf J, et al. Impact of prophylactic central neck lymph node dissection on early recurrence in papillary thyroid carcinoma. World J Surg, 2010, 34(6): 1187-1191.
5. 鄢丹桂, 张彬, 安常明, 等.甲状腺乳头状癌临床N0患者颈部淋巴结转移规律.中华耳鼻咽喉头颈外科杂志, 2011, 46(11): 887-891.
6. 张强, 张仑, 宋方方, 等.甲状腺乳头状癌颈部淋巴结转移规律临床分析.中国耳鼻咽喉头颈外科, 2010, 17(12): 639-642.
7. 诸林海, 丁向民.甲状腺乳头状癌Ⅵ区阳性淋巴结数与清除方式的选择.中国现代普通外科进展, 2009, 12(7): 576-579.
8. 曾瑞超, 黄慧雅, 李权, 等.甲状腺乳头状微小癌颈侧区淋巴结转移相关因素分析.中华内分泌代谢杂志, 2012, 28(3): 207-210.
9. 张梦萍, 张诠, 郭朱明, 等.乳头状甲状腺癌侧颈淋巴结隐匿性转移相关因素分析.中华临床医师杂志:电子版, 2012, 6(13): 100-102.
10. 张浏阳, 周旋, 姚晓峰, 等.甲状腺乳头状癌Ⅱ区淋巴结隐匿性转移的临床分析.中华耳鼻咽喉头颈外科杂志, 2011, 46(9): 733-737.
11. Davidson HC, Park BJ, Johnson JT. Papillary thyroid cancer: controversies in the management of neck metastasis. Laryngoscope, 2008, 118(12): 2161-2165.
12. Mazzaferri EL, Jhiang SM. Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer. Am J Med, 1994, 97(5): 418-428.
13. Cappiello J, Piazza C, Nicolai P. The spinal accessory nerve in head and neck surgery. Curr Opin Otolaryngol Head Neck Surg, 2007, 15(2): 107-111.
14. 宋军健.甲状腺乳头状腺癌选择性颈清扫术后并发症.中国耳鼻咽喉头颈外科, 2007, 14(6): 331-333.
15. National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Thyroid carcinoma (Version 1. 2009). http://www.nccn.org/professionals/physician_gls/pdf/thyroid.pdf.
16. National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Thyroid carcinoma (Version 1. 2010). http://www.nccn.org/professionals/physician_gls/pdf/thyroid.pdf.
17. National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Thyroid carcinoma (Version 1. 2011). http://www.nccn.org/professionals/physician_gls/pdf/thyroid.pdf.
18. Caron NR, Tan YY, Ogilvie JB, et al. Selective modified radical neck dissection for papillary thyroid cancer-is levelⅠ, Ⅱand V dissection always necessary? World J Surg, 2006, 30(5): 833-840.
19. National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Thyroid carcinoma (Version 2. 2012). http://www.nccn.org/professionals/physician_gls/pdf/thyroid.pdf.
20. Patron V, Bedfert C, Le Clech G, et al. Pattern of lateral neck metastases in N0 papillary thyroid carcinoma. BMC Cancer, 2011, 11: 8.
21. Palazzo FF, Gosnell J, Savio R, et al. Lymphadenectomy for papillary thyroid cancer: changes in practice over four decades. Eur J Surg Oncol, 2006, 32(3): 340-344.
22. 葛明华, 王可敬, 刘爱华.无区域淋巴结转移甲状腺乳头状癌患者的颈部处理.中国肿瘤临床, 2001, 28(4): 254-256.
23. 中华医学会内分泌学分会, 中华医学会外科学分会, 中国抗癌协会头颈肿瘤专业委员会, 中华医学会核医学分会.甲状腺结节和分化型甲状腺癌诊治指南.中国肿瘤临床, 2012, 39(17): 1249-1272.
24. 朱精强.分化型甲状腺癌颈淋巴结清扫的相关问题.中国普外基础与临床杂志, 2012, 19(8): 809-813.

Previous Article
应用记忆合金接骨器治疗胸骨骨折
Next Article
心脏瓣膜病合并巨大左心室51例术后近中期疗效观察

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Relevant Factors Analysis of LevelⅡLymphatic Metastasis in Papillary Thyroid Carcinoma

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content