Relationship Between Ratio of Serum Low Density Lipoprotein Cholesterol to High Density Lipoprotein Cholesterol and Pathological Staging of Colorectal Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 LIHao ¹ , YAOMeng-jie ¹ , ZOUBo-yuan ² , XUJian ¹ ,  DUXiao-hui ^1,3

1. Department of General Surgery, PLA General Hospital, Beijing 100853, China;
2. Clinical Medicine College, Medical College of Nankai University, Tianjin 300071, China;
3. Department of General Surgery, Hainan Branch of PLA General Hospital, Sanya 572013, Hainan Province, China;

Corresponding author：

DUXiao-hui, Email: duxiaohui301@sina.com

Keywords：

Low density lipoprotein cholesterol; High density lipoprotein cholesterol; Colorectal cancer; Tumor staging; Lymph node metastasis; Distant metastasis

DOI：

10.7507/1007-9424.20150078

Video：

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Objective To evaluate the relationship between low density lipoprotein cholesterol (LDL-C)/high density lipoprotein cholesterol (HDL-C) of preoperation (L/H value for short) and the pathological staging of colorectal cancer. Methods The clinical data of 187 patients with colorectal cancer who treated in PLA General Hospital from July 2009 to June 2014 were analyzed retrospectively. Results There were statistical significance in L/H value among different TNM stagings, N stagings, and M stagings (P<0.05):L/H value of TNM Ⅳ staging was higher than those of TNM Ⅰ, Ⅱ, and Ⅲ staging, L/H values of N1 staging and N0 staging were lower than that of N2 staging, L/H value of M1 staging was higher than that of M0 staging. However, there was no statistical significance in L/H value among different T stagings of colorectal cancer (P>0.05). Logistic regression results showed that L/H value were positively associated with TNM staging (OR=4.34, 95% CI:2.837-6.644, P<0.000 1), T staging (OR=1.72, 95% CI:1.175-2.512, P=0.005 3), N staging (OR=2.15, 95% CI:1.422-3.254, P=0.000 3), and M staging (OR=3.04, 95% CI:1.733-5.332, P=0.000 1) of colorectal cancer, and patient with higher L/H value took more risk of progression of tumor, lymph node metastases, and distant metastasis. Conclusions Raise of preoperative L/H value is an independent risk factor for the progression of TNM staging, T staging, N staging, and M staging in colorectal cancer.

Citation： LIHao, YAOMeng-jie, ZOUBo-yuan, XUJian, DUXiao-hui. Relationship Between Ratio of Serum Low Density Lipoprotein Cholesterol to High Density Lipoprotein Cholesterol and Pathological Staging of Colorectal Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(3): 289-292. doi: 10.7507/1007-9424.20150078 Copy

1.	全国肿瘤防治研究办公室,全国肿瘤登记中心, 卫生部疾病预防控制局. 中国肿瘤登记年报(2009). 北京:中国协和医科大学出版社, 2012:335-442.
2.	Grosman H, Fabre B, Mesch V, et al. Lipoproteins, sex hormones and inflammatory markers in association with prostate cancer. Aging Male, 2010, 13(2):87-92.
3.	Kuliszkiewicz-Janus M, Małecki R, Mohamed AS. Lipid changes occuring in the course of hematological cancers. Cell Mol Biol Lett, 2008, 13(3):465-474.
4.	Shah FD, Shukla SN, Shah PM, et al. Significance of alterations in plasma lipid profile levels in breast cancer. Integr Cancer Ther, 2008, 7(1):33-41.
5.	刘业六, 钱海鑫, 秦磊, 等. 血脂相与乳腺癌远处转移的关系. 中华肿瘤杂志, 2012, 34(2): 129-131.
6.	Yang MH, Rampal S, Sung J, et al. The association of serum lipids with colorectal adenomas. Am J Gastroenterol, 2013, 108(5):833-841.
7.	詹建民, 赵先文, 刘东博, 等. 结直肠癌患者脂类水平的改变及其临床意义. 中华胃肠外科杂志, 2009, 12(2): 205-206.
8.	van Duijnhoven FJ, Bueno-De-Mesquita HB, Calligaro M, et al. Blood lipid and lipoprotein concentrations and colorectal cancer risk in the European Prospective Investigation into cancer and nutrition. Gut, 2011, 60(8):1094-1102.
9.	Stephen B, April G, David R, et al. The AJCC cancer staging manual and handbook (7th edition). Heidelberg:Springer-verlag, 2010:143-164.
10.	王玉欣, 路国涛, 肖炜明, 等. 血脂水平与结直肠肿瘤关系的研究. 胃肠病学, 2014, 19(4):229-232.
11.	何勇山, 金黑鹰, 章蓓, 等. 脂代谢与结直肠肿瘤关系的研究进展. 世界华人消化杂志, 2012, 20(6):486-490.
12.	杨永涛, 盛华, 李志文, 等. 胆固醇代谢与结直肠癌的关系及其机制. 中华内分泌代谢杂志, 2014, 30(3):254-257.
13.	Notarnicola M, Altomare DF, Correale M, et al. Serum lipid profile in colorectal cancer patients with and without synchronous distant metastases. Oncology, 2005, 68(4-6):371-374.
14.	Liu YL, Qian HX, Qin L, et al. Serum LDL-C and LDL-C/HDL-C ratio are positively correlated to lymph node stages in males with colorectal cancer. Hepatogastroenterology, 2011, 58(106):383-387.
15.	Carreras F, Sarli L, Pietra N, et al. A critical review of the history of the systems for staging colorectal cancer. G Chir, 1992, 13(5):287-292.
16.	Singh H, Mahmud SM, Turner D, et al. Long-term use of statins and risk of colorectal cancer:a population-based study. Am J Gastroenterol, 2009, 104(12):3015-3023.
17.	Méndez Mora JL, Ortega Calvo M, Cayuela Domínguez A, et al. CA 19.9 and HDL-cholesterol behaviour in a sporadic colorectal carcinoma sample. An Med Interna, 2004, 21(5):227-230.
18.	吕炳建, 来茂德. 代谢综合征、胰岛素抵抗与结直肠癌. 中华病理学杂志, 2006, 35(2):110-112.
19.	Vitols S, Norgren S, Juliusson G, et al. Multilevel regulation of low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression in normal and leukemic cells. Blood, 1994, 84(8):2689-2698.
20.	Bigler RD, Khoo M, Lund-Katz S, et al. Identification of low density lipoprotein as a regulator of Fc receptor-mediated phagocytosis. Proc Natl Acad Sci U S A, 1990, 87(13):4981-4985.
21.	Mccarthy BM, Okano Y, Nakayasu T, et al. Plasma lipoproteins and transferrin regulate the proliferation of a continuous T lymphocyte cell line. J Lipid Res, 1987, 28(9):1067-1077.
22.	马爱迪, 王彩莲, 闵捷, 等. 血清脂质水平与结直肠癌远处转移的相关性分析. 东南大学学报:医学版, 2012, 31(4):471-473.
23.	彭心昭, 李健, 叶汉深, 等. 结直肠癌远处转移与血脂变化的关系研究. 临床肿瘤学杂志, 2008, 13(1):64-66.
24.	Su F, Grijalva V, Navab K, et al. HDL mimetics inhibit tumor development in both induced and spontaneous mouse models of colon cancer. Mol Cancer Ther, 2012, 11(6):1311-1319.
25.	李祖国, 赵亮, 刘莉, 等. 结直肠癌转移动物模型血清中几种蛋白变化的观察. 中华病理学杂志, 2007, 36(1):48-52.
26.	梁振涛, 王宪沛, 曾秋棠, 等. 冠心病合并结直肠癌对血脂水平的影响及他汀类药物调脂的意义. 南方医科大学学报, 2008, 28(5):863-865.

1. 全国肿瘤防治研究办公室,全国肿瘤登记中心, 卫生部疾病预防控制局. 中国肿瘤登记年报(2009). 北京:中国协和医科大学出版社, 2012:335-442.
2. Grosman H, Fabre B, Mesch V, et al. Lipoproteins, sex hormones and inflammatory markers in association with prostate cancer. Aging Male, 2010, 13(2):87-92.
3. Kuliszkiewicz-Janus M, Małecki R, Mohamed AS. Lipid changes occuring in the course of hematological cancers. Cell Mol Biol Lett, 2008, 13(3):465-474.
4. Shah FD, Shukla SN, Shah PM, et al. Significance of alterations in plasma lipid profile levels in breast cancer. Integr Cancer Ther, 2008, 7(1):33-41.
5. 刘业六, 钱海鑫, 秦磊, 等. 血脂相与乳腺癌远处转移的关系. 中华肿瘤杂志, 2012, 34(2): 129-131.
6. Yang MH, Rampal S, Sung J, et al. The association of serum lipids with colorectal adenomas. Am J Gastroenterol, 2013, 108(5):833-841.
7. 詹建民, 赵先文, 刘东博, 等. 结直肠癌患者脂类水平的改变及其临床意义. 中华胃肠外科杂志, 2009, 12(2): 205-206.
8. van Duijnhoven FJ, Bueno-De-Mesquita HB, Calligaro M, et al. Blood lipid and lipoprotein concentrations and colorectal cancer risk in the European Prospective Investigation into cancer and nutrition. Gut, 2011, 60(8):1094-1102.
9. Stephen B, April G, David R, et al. The AJCC cancer staging manual and handbook (7th edition). Heidelberg:Springer-verlag, 2010:143-164.
10. 王玉欣, 路国涛, 肖炜明, 等. 血脂水平与结直肠肿瘤关系的研究. 胃肠病学, 2014, 19(4):229-232.
11. 何勇山, 金黑鹰, 章蓓, 等. 脂代谢与结直肠肿瘤关系的研究进展. 世界华人消化杂志, 2012, 20(6):486-490.
12. 杨永涛, 盛华, 李志文, 等. 胆固醇代谢与结直肠癌的关系及其机制. 中华内分泌代谢杂志, 2014, 30(3):254-257.
13. Notarnicola M, Altomare DF, Correale M, et al. Serum lipid profile in colorectal cancer patients with and without synchronous distant metastases. Oncology, 2005, 68(4-6):371-374.
14. Liu YL, Qian HX, Qin L, et al. Serum LDL-C and LDL-C/HDL-C ratio are positively correlated to lymph node stages in males with colorectal cancer. Hepatogastroenterology, 2011, 58(106):383-387.
15. Carreras F, Sarli L, Pietra N, et al. A critical review of the history of the systems for staging colorectal cancer. G Chir, 1992, 13(5):287-292.
16. Singh H, Mahmud SM, Turner D, et al. Long-term use of statins and risk of colorectal cancer:a population-based study. Am J Gastroenterol, 2009, 104(12):3015-3023.
17. Méndez Mora JL, Ortega Calvo M, Cayuela Domínguez A, et al. CA 19.9 and HDL-cholesterol behaviour in a sporadic colorectal carcinoma sample. An Med Interna, 2004, 21(5):227-230.
18. 吕炳建, 来茂德. 代谢综合征、胰岛素抵抗与结直肠癌. 中华病理学杂志, 2006, 35(2):110-112.
19. Vitols S, Norgren S, Juliusson G, et al. Multilevel regulation of low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression in normal and leukemic cells. Blood, 1994, 84(8):2689-2698.
20. Bigler RD, Khoo M, Lund-Katz S, et al. Identification of low density lipoprotein as a regulator of Fc receptor-mediated phagocytosis. Proc Natl Acad Sci U S A, 1990, 87(13):4981-4985.
21. Mccarthy BM, Okano Y, Nakayasu T, et al. Plasma lipoproteins and transferrin regulate the proliferation of a continuous T lymphocyte cell line. J Lipid Res, 1987, 28(9):1067-1077.
22. 马爱迪, 王彩莲, 闵捷, 等. 血清脂质水平与结直肠癌远处转移的相关性分析. 东南大学学报:医学版, 2012, 31(4):471-473.
23. 彭心昭, 李健, 叶汉深, 等. 结直肠癌远处转移与血脂变化的关系研究. 临床肿瘤学杂志, 2008, 13(1):64-66.
24. Su F, Grijalva V, Navab K, et al. HDL mimetics inhibit tumor development in both induced and spontaneous mouse models of colon cancer. Mol Cancer Ther, 2012, 11(6):1311-1319.
25. 李祖国, 赵亮, 刘莉, 等. 结直肠癌转移动物模型血清中几种蛋白变化的观察. 中华病理学杂志, 2007, 36(1):48-52.
26. 梁振涛, 王宪沛, 曾秋棠, 等. 冠心病合并结直肠癌对血脂水平的影响及他汀类药物调脂的意义. 南方医科大学学报, 2008, 28(5):863-865.

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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Relationship Between Ratio of Serum Low Density Lipoprotein Cholesterol to High Density Lipoprotein Cholesterol and Pathological Staging of Colorectal Cancer

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