Association between polymorphism of long non-coding RNA maternally expressed gene 3and risk of gastric cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 ZHANG Qi , AI Liang , DAI Youguo

Department of Abdominal Surgery, Yunnan Cancer Hospital, Kunming 650118, P. R. China;

Corresponding author：

ZHANG Qi, Email: 576515981@qq.com

Keywords：

long non-coding RNA; maternally expressed gene 3; single nucleotide polymorphism; gastric cancer

DOI：

10.7507/1007-9424.201805074

Video：

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Objective To explore relationship between long non-coding RNA maternally expressed gene 3 (MEG3) polymorphisms and risk of gastric cancer. Methods One hundred and seventy-two Han patients with gastric cancer (gastric cancer group) and 224 Han individuals for physical examination (control group) in the Yunnan Cancer Hospital from March 2013 to October 2017 were selected as subjects. The rs7158663 and rs4081134 polymorphisms of the MEG3 were genotyped by using a TaqMan technique. The associations between the 2 polymorphisms and the risk of the gastric cancer and its clinical features were analyzed using the SPSS software. Results The frequencies of the AG+AA genotype and the A allele of the MEG3 rs7158663 in the gastric cancer group were significantly higher than those in the control group using the GG genotype and G allele as a reference respectively ［adjusted OR=1.71, 95%CI (1.14, 2.56), P=0.010; adjusted OR=1.58, 95%CI (1.15, 2.19), P=0.005］ after the Chi-square test and the adjustment of age and gender. The frequencies of the AG+AA genotype and the A allele of the MEG3 rs4081134 had no significant differences between the gastric cancer group and the control group (P>0.017). Moreover, the polymorphisms of the MEG3 rs7158663 and rs4081134 were not associated with the clinical features of the gastric cancer (P>0.017). Conclusion MEG3 rs7158663 AG+AA genotype might be one of susceptibility gene of gastric cancer in Chinese Han population.

Citation： ZHANG Qi, AI Liang, DAI Youguo. Association between polymorphism of long non-coding RNA maternally expressed gene 3and risk of gastric cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2018, 25(11): 1323-1326. doi: 10.7507/1007-9424.201805074 Copy

1.	郑斌, 王宇. 长链非编码 RNA UCA1 在消化系统肿瘤中的研究进展. 中国肿瘤, 2018, 27(3): 209-213.
2.	张川, 张新晨. 长链非编码 RNA MEG3 在消化道肿瘤中的研究进展. 胃肠病学和肝病学杂志, 2017, 26(9): 1057-1060.
3.	朱栋良, 尹小平, 王芳元. 长链非编码 RNA-MALAT1 对结直肠癌细胞介导的血管形成的影响. 中国普外基础与临床杂志, 2015, 22(1): 60-63.
4.	唐龙, 唐世磊, 刘古月, 等. 长链非编码 RNA 在常见消化系统肿瘤中的研究进展. 中国普外基础与临床杂志, 2015, 22(8): 1014-1018.
5.	杨自国, 郭晓波, 石玉龙, 等. 胃癌转移相关长链非编码 RNA 的研究进展. 中国普外基础与临床杂志, 2015, 22(4): 513-516.
6.	王艺超, 李志辉, 陈文杰, 等. 甲状腺乳头状癌相关长链非编码 RNA 的研究进展. 中国普外基础与临床杂志, 2017, 24(8): 1030-1034.
7.	Li C, Liang G, Yao W, et al. Differential expression profiles of long non-coding RNAs reveal potential biomarkers for identification of human gastric cancer. Oncol Rep, 2016, 35(3): 1529-1540.
8.	Dan J, Wang J, Wang Y, et al. LncRNA-MEG3 inhibits proliferation and metastasis by regulating miRNA-21 in gastric cancer. Biomed Pharmacother, 2018, 99: 931-938.
9.	Wei GH, Wang X. LncRNA MEG3 inhibit proliferation and metastasis of gastric cancer via p53 signaling pathway. Eur Rev Med Pharmacol Sci, 2017, 21(17): 3850-3856.
10.	Peng W, Si S, Zhang Q, et al. Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate gastric cancer progression. J Exp Clin Cancer Res, 2015, 34: 79.
11.	孙倩, 刘博巽, 林梦洁, 等. 长链非编码 RNAMEG3 对胃癌细胞增殖的影响. 南京医科大学学报 (自然科学版), 2014, 34(1): 1-6.
12.	韩韬, 何晓璞, 刘静, 等. 长链非编码 RNA MEG3 抑制人胃癌 SGC-7901 细胞增殖的研究. 现代肿瘤医学, 2015, 23(11): 1504-1508.
13.	孟菲菲, 司君利, 解祥军, 等. 长链非编码 RNAs MEG3 和 GAS5 在胃癌组织中的表达及其与预后的关系. 中国临床研究, 2016, 29(11): 1449-1452, 1457.
14.	Xu G, Meng L, Yuan D, et al. MEG3/miR21 axis affects cell mobility by suppressing epithelial mesenchymal transition in gastric cancer. Oncol Rep, 2018, 40(1): 39-48.
15.	Sun R, Liang Y, Yuan F, et al. Functional polymorphisms in the promoter region of miR-17-92 cluster are associated with a decreased risk of colorectal cancer. Oncotarget, 2017, 8(47): 82531-82540.
16.	Yuan F, Sun R, Li L, et al. A functional variant rs353292 in the flanking region of miR-143/145 contributes to the risk of colorectal cancer. Sci Rep, 2016, 6: 30195.
17.	Cao X, Zhuang S, Hu Y, et al. Associations between polymorphisms of long non-coding RNA MEG3 and risk of colorectal cancer in Chinese. Oncotarget, 2016, 7(14): 19054-19059.
18.	Zhuo ZJ, Zhang R, Zhang J, et al. Associations between lncRNA MEG3 polymorphisms and neuroblastoma risk in Chinese children. Aging (Albany NY), 2018, 10(3): 481-491.
19.	Piccoli MT, Gupta SK, Viereck J, et al. Inhibition of the cardiac fibroblast-enriched lncRNA Meg3 prevents cardiac fibrosis and diastolic dysfunction. Circ Res, 2017, 121(5): 575-583.
20.	Gong WJ, Peng JB, Yin JY, et al. Association between well-characterized lung cancer lncRNA polymorphisms and platinum-based chemotherapy toxicity in Chinese patients with lung cancer. Acta Pharmacol Sin, 2017, 38(4): 581-590.
21.	Zhang Z, Liu T, Wang K, et al. Down-regulation of long non-coding RNA MEG3 indicates an unfavorable prognosis in non-small cell lung cancer: Evidence from the GEO database. Gene, 2017, 630: 49-58.
22.	Wang P, Chen D, Ma H, et al. LncRNA MEG3 enhances cisplatin sensitivity in non-small cell lung cancer by regulating miR-21-5p/SOX7 axis. Onco Targets Ther, 2017, 10: 5137-5149.
23.	Li R, Fang L, Pu Q, et al. MEG3-4 is a miRNA decoy that regulates IL-1β abundance to initiate and then limit inflammation to prevent sepsis during lung infection. Sci Signal, 2018, 11(536): pii: eaao2387.
24.	Wang Q, Li M, Shen Z, et al. The long non-coding RNA MEG3/miR-let-7c-5p axis regulates ethanol-induced hepatic steatosis and apoptosis by targeting NLRC5. Front Pharmacol, 2018, 9: 302.
25.	He JH, Han ZP, Liu JM, et al. Overexpression of long non-coding RNA MEG3 inhibits proliferation of hepatocellular carcinoma Huh7 cells via negative modulation of miRNA-664. J Cell Biochem, 2017, 118(11): 3713-3721.
26.	Wang M, Huang T, Luo G, et al. Long non-coding RNA MEG3 induces renal cell carcinoma cells apoptosis by activating the mitochondrial pathway. J Huazhong Univ Sci Technolog Med Sci, 2015, 35(4): 541-545.
27.	He H, Dai J, Zhuo R, et al. Study on the mechanism behind lncRNA MEG3 affecting clear cell renal cell carcinoma by regulating miR-7/RASL11B signaling. J Cell Physiol, 2018 Jul 3.

1. 郑斌, 王宇. 长链非编码 RNA UCA1 在消化系统肿瘤中的研究进展. 中国肿瘤, 2018, 27(3): 209-213.
2. 张川, 张新晨. 长链非编码 RNA MEG3 在消化道肿瘤中的研究进展. 胃肠病学和肝病学杂志, 2017, 26(9): 1057-1060.
3. 朱栋良, 尹小平, 王芳元. 长链非编码 RNA-MALAT1 对结直肠癌细胞介导的血管形成的影响. 中国普外基础与临床杂志, 2015, 22(1): 60-63.
4. 唐龙, 唐世磊, 刘古月, 等. 长链非编码 RNA 在常见消化系统肿瘤中的研究进展. 中国普外基础与临床杂志, 2015, 22(8): 1014-1018.
5. 杨自国, 郭晓波, 石玉龙, 等. 胃癌转移相关长链非编码 RNA 的研究进展. 中国普外基础与临床杂志, 2015, 22(4): 513-516.
6. 王艺超, 李志辉, 陈文杰, 等. 甲状腺乳头状癌相关长链非编码 RNA 的研究进展. 中国普外基础与临床杂志, 2017, 24(8): 1030-1034.
7. Li C, Liang G, Yao W, et al. Differential expression profiles of long non-coding RNAs reveal potential biomarkers for identification of human gastric cancer. Oncol Rep, 2016, 35(3): 1529-1540.
8. Dan J, Wang J, Wang Y, et al. LncRNA-MEG3 inhibits proliferation and metastasis by regulating miRNA-21 in gastric cancer. Biomed Pharmacother, 2018, 99: 931-938.
9. Wei GH, Wang X. LncRNA MEG3 inhibit proliferation and metastasis of gastric cancer via p53 signaling pathway. Eur Rev Med Pharmacol Sci, 2017, 21(17): 3850-3856.
10. Peng W, Si S, Zhang Q, et al. Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate gastric cancer progression. J Exp Clin Cancer Res, 2015, 34: 79.
11. 孙倩, 刘博巽, 林梦洁, 等. 长链非编码 RNAMEG3 对胃癌细胞增殖的影响. 南京医科大学学报 (自然科学版), 2014, 34(1): 1-6.
12. 韩韬, 何晓璞, 刘静, 等. 长链非编码 RNA MEG3 抑制人胃癌 SGC-7901 细胞增殖的研究. 现代肿瘤医学, 2015, 23(11): 1504-1508.
13. 孟菲菲, 司君利, 解祥军, 等. 长链非编码 RNAs MEG3 和 GAS5 在胃癌组织中的表达及其与预后的关系. 中国临床研究, 2016, 29(11): 1449-1452, 1457.
14. Xu G, Meng L, Yuan D, et al. MEG3/miR21 axis affects cell mobility by suppressing epithelial mesenchymal transition in gastric cancer. Oncol Rep, 2018, 40(1): 39-48.
15. Sun R, Liang Y, Yuan F, et al. Functional polymorphisms in the promoter region of miR-17-92 cluster are associated with a decreased risk of colorectal cancer. Oncotarget, 2017, 8(47): 82531-82540.
16. Yuan F, Sun R, Li L, et al. A functional variant rs353292 in the flanking region of miR-143/145 contributes to the risk of colorectal cancer. Sci Rep, 2016, 6: 30195.
17. Cao X, Zhuang S, Hu Y, et al. Associations between polymorphisms of long non-coding RNA MEG3 and risk of colorectal cancer in Chinese. Oncotarget, 2016, 7(14): 19054-19059.
18. Zhuo ZJ, Zhang R, Zhang J, et al. Associations between lncRNA MEG3 polymorphisms and neuroblastoma risk in Chinese children. Aging (Albany NY), 2018, 10(3): 481-491.
19. Piccoli MT, Gupta SK, Viereck J, et al. Inhibition of the cardiac fibroblast-enriched lncRNA Meg3 prevents cardiac fibrosis and diastolic dysfunction. Circ Res, 2017, 121(5): 575-583.
20. Gong WJ, Peng JB, Yin JY, et al. Association between well-characterized lung cancer lncRNA polymorphisms and platinum-based chemotherapy toxicity in Chinese patients with lung cancer. Acta Pharmacol Sin, 2017, 38(4): 581-590.
21. Zhang Z, Liu T, Wang K, et al. Down-regulation of long non-coding RNA MEG3 indicates an unfavorable prognosis in non-small cell lung cancer: Evidence from the GEO database. Gene, 2017, 630: 49-58.
22. Wang P, Chen D, Ma H, et al. LncRNA MEG3 enhances cisplatin sensitivity in non-small cell lung cancer by regulating miR-21-5p/SOX7 axis. Onco Targets Ther, 2017, 10: 5137-5149.
23. Li R, Fang L, Pu Q, et al. MEG3-4 is a miRNA decoy that regulates IL-1β abundance to initiate and then limit inflammation to prevent sepsis during lung infection. Sci Signal, 2018, 11(536): pii: eaao2387.
24. Wang Q, Li M, Shen Z, et al. The long non-coding RNA MEG3/miR-let-7c-5p axis regulates ethanol-induced hepatic steatosis and apoptosis by targeting NLRC5. Front Pharmacol, 2018, 9: 302.
25. He JH, Han ZP, Liu JM, et al. Overexpression of long non-coding RNA MEG3 inhibits proliferation of hepatocellular carcinoma Huh7 cells via negative modulation of miRNA-664. J Cell Biochem, 2017, 118(11): 3713-3721.
26. Wang M, Huang T, Luo G, et al. Long non-coding RNA MEG3 induces renal cell carcinoma cells apoptosis by activating the mitochondrial pathway. J Huazhong Univ Sci Technolog Med Sci, 2015, 35(4): 541-545.
27. He H, Dai J, Zhuo R, et al. Study on the mechanism behind lncRNA MEG3 affecting clear cell renal cell carcinoma by regulating miR-7/RASL11B signaling. J Cell Physiol, 2018 Jul 3.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Association between polymorphism of long non-coding RNA maternally expressed gene 3and risk of gastric cancer

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