Predictive value of soluble ST-2 in left ventricular function and structural changes in breast cancer patients receiving doxorubicin chemotherapy_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

DUAN Qi ¹ ,  YANG Yingtao ¹ , YANG Qing ² , LIU Xiaozhe ¹

1. Department of Breast Surgery, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P. R. China;
2. Department of Ultrasound Diagnosis, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P. R. China;

Corresponding author：

YANG Yingtao, Email: yangyingtao001@126.com

Keywords：

breast cancer; anthracycline; soluble carcinogenesis inhibitor 2; cardiac function

DOI：

10.7507/1007-9424.201906089

Video：

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Objective To evaluate whether soluble carcinogenesis inhibitor 2 (ST-2) level can be used as indicators for predicting left ventricular dysfunction by detecting sST-2 and other cardiac function indexes in patients with breast cancer who receiving doxorubicin chemotherapy.Methods A retrospective study of 90 breast cancer patients who received doxorubicin (pyrubicin) chemotherapy in the Department of Breast Surgery, The Fifth Affiliated Hospital of Zhengzhou University from September 2016 to June 2018 was performed. Peripheral venous blood samples were collected before chemotherapy and one year after receiving doxorubicin chemotherapy, to detect sST-2 level and cardiac function indexes, and echocardiography was performed at the same time.Results Compared with pre-chemotherapy, sST-2, left ventricular end-systolic volume (LVESV), left ventricular end diastolic volume (LVEDV), left ventricular systolic diameter (LVESD), left ventricular diastolic internal diameter (LVEDD), and E/e' value increased at one year after chemotherapy, while left ventricular eject fraction (LVEF) decreased, the difference was statistically significant (P<0.05). There was a negative correlation between the level of sST-2 and LVEF (r=–0.618, P<0.05). The receiver operating characteristic curve (ROC) showed that the 11.9 ng/mL of sST-2 concentration was the best threshold to predict left ventricular dysfunction, and the sensitivity and specificity were 90.6% and 69.2%, respectively, the area under the ROC curve was 0.836 (P<0.05).Conclusion sST-2 has a certain diagnostic value for predicting left ventricular function and structural changes in breast cancer patients who receiving doxorubicin chemotherapy.

Citation： DUAN Qi, YANG Yingtao, YANG Qing, LIU Xiaozhe. Predictive value of soluble ST-2 in left ventricular function and structural changes in breast cancer patients receiving doxorubicin chemotherapy. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2020, 27(2): 147-151. doi: 10.7507/1007-9424.201906089 Copy

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2.	World Health Organization. Globocan 2012 v1.0. 2017-03-04. http://globocan.iarc.fr.
3.	Oeffinger KC, Fontham ET, Etzioni R, et al. Breast cancer screening for women at average risk: 2015 guideline update from the American Cancer Society. JAMA, 2015, 314(15): 1599-1614.
4.	Apuri S. Neoadjuvant and adjuvant therapies for breast cancer. South Med J, 2017, 110(10): 638-642.
5.	司徒红林, 张蓉, 陈前军. 蒽环类化疗药物在治疗乳腺癌中的应用. 广东医学, 2006, 27(10): 1579-1581.
6.	Rygiel K. Benefits of antihypertensive medications for anthracycline- and trastuzumab-induced cardiotoxicity in patients with breast cancer: insights from recent clinical trials. Indian J Pharmacol, 2016, 48(5): 490-497.
7.	Cardinale D, Colombo A, Bacchiani G, et al. Early detection of anthracycline cardiotoxicity and improvement with heart failure therapy. Circulation, 2015, 131(22): 1981-1988.
8.	Drafts BC, Twomley KM, D’Agostino R Jr, et al. Low to moderate dose anthracycline-based chemotherapy is associated with early noninvasive imaging evidence of subclinical cardiovascular disease. JACC Cardiovasc Imaging, 2013, 6(8): 877-885.
9.	Von Hoff DD, Layard MW, Basa P, et al. Risk factors for doxorubicin-induced congestive heart failure. Ann Intern Med, 1979, 91(5): 710-717.
10.	Seidman A, Hudis C, Pierri MK, et al. Cardiac dysfunction in the trastuzumab clinical trials experience. J Clin Oncol, 2002, 20(5): 1215-1221.
11.	Bayes-Genis A, Januzzi JL, Gaggin HK, et al. ST2 pathogenetic profile in ambulatory heart failure patients. J Card Fail, 2015, 21(4): 355-361.
12.	Zheng L, Tan W, Zhang J, et al. Combining trastuzumab and cetuximab combats trastuzumab-resistant gastric cancer by effective inhibition of EGFR/ErbB2 heterodimerization and signaling. Cancer Immunol Immunother, 2014, 63(6): 581-586.
13.	Florescu M, Cinteza M, Vinereanu D. Chemotherapy-induced cardiotoxicity. Maedica (Buchar), 2013, 8(1): 59-67.
14.	胡夕春, 张剑, 陈德滇, 等. 中国蒽环类药物治疗乳腺癌专家共识. 中国肿瘤临床, 2018, 45(3): 120-125.
15.	Lukianova NY, Andriiv AV, Chekhun VF. Correlation of iodine symporter expression in highly and low malignant cell lines of human breast cancer differed in their sensitivity to doxorubicin. Exp Oncol, 2016, 38(3): 169-171.
16.	McGowan JV, Chung R, Maulik A, et al. Anthracycline chemotherapy and cardiotoxicity. Cardiovasc Drugs Ther, 2017, 31(1): 63-75.
17.	Sawyer DB. Anthracyclines and heart failure. N Engl J Med, 2013, 368(12): 1154-1156.
18.	Bansal N, Amdani S, Lipshultz ER, et al. Chemotherapy-induced cardiotoxicity in children. Expert Opin Drug Metab Toxicol, 2017, 13(8): 817-832.
19.	Mueller T, Dieplinger B, Gegenhuber A, et al. Increased plasma concentrations of soluble ST2 are predictive for 1-year mortality in patients with acute destabilized heart failure. Clin Chem, 2008, 54(4): 752-756.
20.	孙爱梅, 刘婷, 陈还珍. 可溶性 ST2 对冠心病的危险分层价值及其与心功能的关系. 中国心血管杂志, 2017, 22(1): 19-23.
21.	Ky B, French B, McCloskey K, et al. High-sensitivity ST2 for prediction of adverse outcomes in chronic heart failure. Circ Heart Fail, 2011, 4(2): 180-187.
22.	Broch K, Ueland T, Nymo SH, et al. Soluble ST2 is associated with adverse outcome in patients with heart failure of ischaemic aetiology. Eur J Heart Fail, 2012, 14(3): 268-277.
23.	牛琳, 赵敏, 周芳, 等. 重复测量分析左心房最小容积与最大容积在评价蒽环类药物所致心脏毒性中的应用价值. 温州医科大学学报, 2018, 48(11): 807-812.
24.	Huang DH, Sun H, Shi JP. Diagnostic value of soluble suppression of tumorigenicity-2 for heart failure. Chin Med J (Engl), 2016, 129(5): 570-577.
25.	Januzzi JL Jr, Peacock WF, Maisel AS, et al. Measurement of the interleukin family member ST2 in patients with acute dyspnea: results from the PRIDE (Pro-Brain Natriuretic Peptide Investigation of Dyspnea in the Emergency Department) study. J Am Coll Cardiol, 2007, 50(7): 607-613.
26.	Aimo A, Vergaro G, Passino C, et al. Prognostic value of soluble suppression of tumorigenicity-2 in chronic heart failure: a meta-analysis. JACC Heart Fail, 2017, 5(4): 280-286.
27.	韩荣丽, 张焱, 薛红梅, 等. 老年慢性心力衰竭患者可溶性致癌抑制因子 2 的水平及临床意义. 中国老年学杂志, 2017, 37(1): 97-99.
28.	Huang G, Zhai J, Huang X, et al. Predictive value of soluble ST-2 for changes of cardiac function and structure in breast cancer patients receiving chemotherapy. Medicine (Baltimore), 2018, 97(38): e12447.

1. Stewart B, Wild C. World cancer report 2014. Lyon: WHO Press, 2014: 362-373.
2. World Health Organization. Globocan 2012 v1.0. 2017-03-04. http://globocan.iarc.fr.
3. Oeffinger KC, Fontham ET, Etzioni R, et al. Breast cancer screening for women at average risk: 2015 guideline update from the American Cancer Society. JAMA, 2015, 314(15): 1599-1614.
4. Apuri S. Neoadjuvant and adjuvant therapies for breast cancer. South Med J, 2017, 110(10): 638-642.
5. 司徒红林, 张蓉, 陈前军. 蒽环类化疗药物在治疗乳腺癌中的应用. 广东医学, 2006, 27(10): 1579-1581.
6. Rygiel K. Benefits of antihypertensive medications for anthracycline- and trastuzumab-induced cardiotoxicity in patients with breast cancer: insights from recent clinical trials. Indian J Pharmacol, 2016, 48(5): 490-497.
7. Cardinale D, Colombo A, Bacchiani G, et al. Early detection of anthracycline cardiotoxicity and improvement with heart failure therapy. Circulation, 2015, 131(22): 1981-1988.
8. Drafts BC, Twomley KM, D’Agostino R Jr, et al. Low to moderate dose anthracycline-based chemotherapy is associated with early noninvasive imaging evidence of subclinical cardiovascular disease. JACC Cardiovasc Imaging, 2013, 6(8): 877-885.
9. Von Hoff DD, Layard MW, Basa P, et al. Risk factors for doxorubicin-induced congestive heart failure. Ann Intern Med, 1979, 91(5): 710-717.
10. Seidman A, Hudis C, Pierri MK, et al. Cardiac dysfunction in the trastuzumab clinical trials experience. J Clin Oncol, 2002, 20(5): 1215-1221.
11. Bayes-Genis A, Januzzi JL, Gaggin HK, et al. ST2 pathogenetic profile in ambulatory heart failure patients. J Card Fail, 2015, 21(4): 355-361.
12. Zheng L, Tan W, Zhang J, et al. Combining trastuzumab and cetuximab combats trastuzumab-resistant gastric cancer by effective inhibition of EGFR/ErbB2 heterodimerization and signaling. Cancer Immunol Immunother, 2014, 63(6): 581-586.
13. Florescu M, Cinteza M, Vinereanu D. Chemotherapy-induced cardiotoxicity. Maedica (Buchar), 2013, 8(1): 59-67.
14. 胡夕春, 张剑, 陈德滇, 等. 中国蒽环类药物治疗乳腺癌专家共识. 中国肿瘤临床, 2018, 45(3): 120-125.
15. Lukianova NY, Andriiv AV, Chekhun VF. Correlation of iodine symporter expression in highly and low malignant cell lines of human breast cancer differed in their sensitivity to doxorubicin. Exp Oncol, 2016, 38(3): 169-171.
16. McGowan JV, Chung R, Maulik A, et al. Anthracycline chemotherapy and cardiotoxicity. Cardiovasc Drugs Ther, 2017, 31(1): 63-75.
17. Sawyer DB. Anthracyclines and heart failure. N Engl J Med, 2013, 368(12): 1154-1156.
18. Bansal N, Amdani S, Lipshultz ER, et al. Chemotherapy-induced cardiotoxicity in children. Expert Opin Drug Metab Toxicol, 2017, 13(8): 817-832.
19. Mueller T, Dieplinger B, Gegenhuber A, et al. Increased plasma concentrations of soluble ST2 are predictive for 1-year mortality in patients with acute destabilized heart failure. Clin Chem, 2008, 54(4): 752-756.
20. 孙爱梅, 刘婷, 陈还珍. 可溶性 ST2 对冠心病的危险分层价值及其与心功能的关系. 中国心血管杂志, 2017, 22(1): 19-23.
21. Ky B, French B, McCloskey K, et al. High-sensitivity ST2 for prediction of adverse outcomes in chronic heart failure. Circ Heart Fail, 2011, 4(2): 180-187.
22. Broch K, Ueland T, Nymo SH, et al. Soluble ST2 is associated with adverse outcome in patients with heart failure of ischaemic aetiology. Eur J Heart Fail, 2012, 14(3): 268-277.
23. 牛琳, 赵敏, 周芳, 等. 重复测量分析左心房最小容积与最大容积在评价蒽环类药物所致心脏毒性中的应用价值. 温州医科大学学报, 2018, 48(11): 807-812.
24. Huang DH, Sun H, Shi JP. Diagnostic value of soluble suppression of tumorigenicity-2 for heart failure. Chin Med J (Engl), 2016, 129(5): 570-577.
25. Januzzi JL Jr, Peacock WF, Maisel AS, et al. Measurement of the interleukin family member ST2 in patients with acute dyspnea: results from the PRIDE (Pro-Brain Natriuretic Peptide Investigation of Dyspnea in the Emergency Department) study. J Am Coll Cardiol, 2007, 50(7): 607-613.
26. Aimo A, Vergaro G, Passino C, et al. Prognostic value of soluble suppression of tumorigenicity-2 in chronic heart failure: a meta-analysis. JACC Heart Fail, 2017, 5(4): 280-286.
27. 韩荣丽, 张焱, 薛红梅, 等. 老年慢性心力衰竭患者可溶性致癌抑制因子 2 的水平及临床意义. 中国老年学杂志, 2017, 37(1): 97-99.
28. Huang G, Zhai J, Huang X, et al. Predictive value of soluble ST-2 for changes of cardiac function and structure in breast cancer patients receiving chemotherapy. Medicine (Baltimore), 2018, 97(38): e12447.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Predictive value of soluble ST-2 in left ventricular function and structural changes in breast cancer patients receiving doxorubicin chemotherapy

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