Advances in the study of neutrophil extracellular traps and inflammatory diseases_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

DU Jian , DENG Hongyang , SHAO Ziwei , HAN Wenfeng , ZHANG Youcheng ,  XU Xiaodong

The Second Department of General Surgery, The Second Hospital of Lanzhou University, Lanzhou 730030, P. R. China;

Corresponding author：

XU Xiaodong, Email: 13893273850@163.com

Keywords：

neutrophil extracellular traps; sepsis; anti-neutrophil cytoplasmic autoantibody-associated vasculitis; acute pancreatitis; review

DOI：

10.7507/1007-9424.201907056

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To investigate the regulation mechanism of neutrophils extracellular traps (NETs) on inflammatory diseases and to provide guidance for the treatment of related inflammatory diseases.Method The literatures about the relationship between NETs and inflammatory diseases were reviewed.Results NETs played an important role in sepsis, anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis, acute pancreatitis, inflammatory bowel disease, and other inflammatory diseases, which were related to the development or activity of the diseases. By regulating the formation of NETs pathway, reducing the production of NETs, we could ultimately reduce the inflammation of the disease.Conclusion NETs is involved in the course of sepsis, ANCA-associated vasculitis, acute pancreatitis, inflammatory bowel disease, and other inflammatory diseases, but further investigation and clinical inflammatory verification are needed.

Citation： DU Jian, DENG Hongyang, SHAO Ziwei, HAN Wenfeng, ZHANG Youcheng, XU Xiaodong. Advances in the study of neutrophil extracellular traps and inflammatory diseases. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2020, 27(4): 510-514. doi: 10.7507/1007-9424.201907056 Copy

1.	Brinkmann V, Reichard U, Goosmann C, et al. Neutrophil extracellular traps kill bacteria. Science, 2004, 303(5663): 1532-1535.
2.	Bhagirath VC, Dwivedi DJ, Liaw PC. Comparison of the proinflammatory and procoagulant properties of nuclear, mitochondrial, and bacterial DNA. Shock, 2015, 44(3): 265-271.
3.	Abrams ST, Zhang N, Manson J, et al. Circulating histones are mediators of trauma-associated lung injury. Am J Respir Crit Care Med, 2013, 187(2): 160-169.
4.	Abrams ST, Zhang N, Dart C, et al. Human CRP defends against the toxicity of circulating histones. J Immunol, 2013, 191(5): 2495-2502.
5.	Biron BM, Chung CS, O’Brien XM, et al. Cl-amidine prevents histone 3 citrullination and neutrophil extracellular trap formation, and improves survival in a murine sepsis model. J Innate Immun, 2017, 9(1): 22-32.
6.	Yang H, Tracey KJ. Targeting HMGB1 in inflammation. Biochim Biophys Acta, 2010, 1799(1-2): 149-156.
7.	Martinod K, Witsch T, Farley K, et al. Neutrophil elastase-deficient mice form neutrophil extracellular traps in an experimental model of deep vein thrombosis. J Thromb Haemost, 2016, 14(3): 551-558.
8.	Metzler KD, Goosmann C, Lubojemska A, et al. A myeloperoxidase-containing complex regulates neutrophil elastase release and actin dynamics during NETosis. Cell Rep, 2014, 8(3): 883-896.
9.	Majewski P, Majchrzak-Gorecka M, Grygier B, et al. Inhibitors of serine proteases in regulating the production and function of neutrophil extracellular traps. Front Immunol, 2016, 7: 261.
10.	Yuen J, Pluthero FG, Douda DN, et al. NETosing neutrophils activate complement both on their own nets and bacteria via alternative and non-alternative pathways. Front Immunol, 2016, 7: 137.
11.	Döring Y, Soehnlein O, Weber C. Neutrophil extracellular traps in atherosclerosis and atherothrombosis. Circ Res, 2017, 120(4): 736-743.
12.	Muniz VS, Silva JC, Braga YAV, et al. Eosinophils release extracellular DNA traps in response to Aspergillus fumigatus. J Allergy Clin Immunol, 2018, 141(2): 571-585.
13.	von Köckritz-Blickwede M, Goldmann O, Thulin P, et al. Phagocytosis-independent antimicrobial activity of mast cells by means of extracellular trap formation. Blood, 2008, 111(6): 3070-3080.
14.	Hartl D. Macrophages and platelets join forces to release kidney-damaging DNA traps. Nat Med, 2018, 24(2): 128-129.
15.	Ullah I, Ritchie ND, Evans TJ. The interrelationship between phagocytosis, autophagy and formation of neutrophil extracellular traps following infection of human neutrophils by Streptococcus pneumoniae. Innate Immun, 2017, 23(5): 413-423.
16.	Etulain J, Martinod K, Wong SL, et al. P-selectin promotes neutrophil extracellular trap formation in mice. Blood, 2015, 126(2): 242-246.
17.	Behnen M, Leschczyk C, Möller S, et al. Immobilized immune complexes induce neutrophil extracellular trap release by human neutrophil granulocytes via FcγRⅢB and Mac-1. J Immunol, 2014, 193(4): 1954-1965.
18.	Alemán OR, Mora N, Cortes-Vieyra R, et al. Differential use of human neutrophil Fcγ receptors for inducing neutrophil extracellular trap formation. J Immunol Res, 2016, 2016: 2908034.
19.	Chen K, Nishi H, Travers R, et al. Endocytosis of soluble immune complexes leads to their clearance by FcγR Ⅲ B but induces neutrophil extracellular traps via FcγR Ⅱ A in vivo. Blood, 2012, 120(22): 4421-4431.
20.	Vong L, Lorentz RJ, Assa A, et al. Probiotic Lactobacillus rhamnosus inhibits the formation of neutrophil extracellular traps. J Immunol, 2014, 192(4): 1870-1877.
21.	Kamoshida G, Kikuchi-Ueda T, Nishida S, et al. Pathogenic bacterium Acinetobacter baumannii inhibits the formation of neutrophil extracellular traps by suppressing neutrophil adhesion. Front Immunol, 2018, 9: 178.
22.	Hoffmann JHO, Schaekel K, Hartl D, et al. Dimethyl fumarate modulates neutrophil extracellular trap formation in a glutathione- and superoxide-dependent manner. Br J Dermatol, 2018, 178(1): 207-214.
23.	O’Brien XM, Biron BM, Reichner JS. Consequences of extracellular trap formation in sepsis. Curr Opin Hematol, 2017, 24(1): 66-71.
24.	Park SY, Shrestha S, Youn YJ, et al. Autophagy primes neutrophils for neutrophil extracellular trap formation during sepsis. Am J Respir Crit Care Med, 2017, 196(5): 577-589.
25.	Yang S, Qi H, Kan K, et al. Neutrophil extracellular traps promote hypercoagulability in patients with sepsis. Shock, 2017, 47(2): 132-139.
26.	Chen L, Zhao Y, Lai D, et al. Neutrophil extracellular traps promote macrophage pyroptosis in sepsis. Cell Death Dis, 2018, 9(6): 597.
27.	Nakazawa D, Tomaru U, Suzuki A, et al. Abnormal conformation and impaired degradation of propylthiouracil-induced neutrophil extracellular traps: implications of disordered neutrophil extracellular traps in a rat model of myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum, 2012, 64(11): 3779-3787.
28.	Kusunoki Y, Nakazawa D, Shida H, et al. Peptidylarginine deiminase inhibitor suppresses neutrophil extracellular trap formation and MPO-ANCA production. Front Immunol, 2016, 7: 227.
29.	Hasegawa J, Wakai S, Kono M, et al. An autopsy case of myeloperoxidase-anti-neutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis accompanied by cryoglobulinemic vasculitis affecting the kidneys, skin, and gastrointestinal tract. Intern Med, 2018, 57(18): 2739-2745.
30.	Yoshida M, Yamada M, Sudo Y, et al. Myeloperoxidase anti-neutrophil cytoplasmic antibody affinity is associated with the formation of neutrophil extracellular traps in the kidney and vasculitis activity in myeloperoxidase anti-neutrophil cytoplasmic antibody-associated microscopic polyangiitis. Nephrology (Carlton), 2016, 21(7): 624-629.
31.	Takeuchi H, Kawasaki T, Shigematsu K, et al. Neutrophil extracellular traps in neuropathy with anti-neutrophil cytoplasmic autoantibody-associated microscopic polyangiitis. Clin Rheumatol, 2017, 36(4): 913-917.
32.	Banks PA, Bollen TL, Dervenis C, et al. Classification of acute pancreatitis–2012: revision of the Atlanta classification and definitions by international consensus. Gut, 2013, 62(1): 102-111.
33.	Murthy P, Singhi AD, Ross MA, et al. Enhanced neutrophil extracellular trap formation in acute pancreatitis contributes to disease severity and is reduced by chloroquine. Front Immunol, 2019, 10: 28.
34.	Merza M, Hartman H, Rahman M, et al. Neutrophil extracellular traps induce trypsin activation, inflammation, and tissue damage in mice with severe acute pancreatitis. Gastroenterology, 2015, 149(7): 1920-1931.e8.
35.	Szatmary P, Liu T, Abrams ST, et al. Systemic histone release disrupts plasmalemma and contributes to necrosis in acute pancreatitis. Pancreatology, 2017, 17(6): 884-892.
36.	Madhi R, Rahman M, Taha D, et al. Targeting peptidylarginine deiminase reduces neutrophil extracellular trap formation and tissue injury in severe acute pancreatitis. J Cell Physiol, 2019, 234(7): 11850-11860.
37.	Cao M, Yu M, Zhang Y, et al. Neutrophil extracellular traps exacerbate inflammatory responses and thrombotic tendency in both a murine colitis model and patients with inflammatory bowel disease. 2017. http://so.hiqq.com.cn/.
38.	Mohanty T, Fisher J, Bakochi A, et al. Neutrophil extracellular traps in the central nervous system hinder bacterial clearance during pneumococcal meningitis. Nat Commun, 2019, 10(1): 1667.

1. Brinkmann V, Reichard U, Goosmann C, et al. Neutrophil extracellular traps kill bacteria. Science, 2004, 303(5663): 1532-1535.
2. Bhagirath VC, Dwivedi DJ, Liaw PC. Comparison of the proinflammatory and procoagulant properties of nuclear, mitochondrial, and bacterial DNA. Shock, 2015, 44(3): 265-271.
3. Abrams ST, Zhang N, Manson J, et al. Circulating histones are mediators of trauma-associated lung injury. Am J Respir Crit Care Med, 2013, 187(2): 160-169.
4. Abrams ST, Zhang N, Dart C, et al. Human CRP defends against the toxicity of circulating histones. J Immunol, 2013, 191(5): 2495-2502.
5. Biron BM, Chung CS, O’Brien XM, et al. Cl-amidine prevents histone 3 citrullination and neutrophil extracellular trap formation, and improves survival in a murine sepsis model. J Innate Immun, 2017, 9(1): 22-32.
6. Yang H, Tracey KJ. Targeting HMGB1 in inflammation. Biochim Biophys Acta, 2010, 1799(1-2): 149-156.
7. Martinod K, Witsch T, Farley K, et al. Neutrophil elastase-deficient mice form neutrophil extracellular traps in an experimental model of deep vein thrombosis. J Thromb Haemost, 2016, 14(3): 551-558.
8. Metzler KD, Goosmann C, Lubojemska A, et al. A myeloperoxidase-containing complex regulates neutrophil elastase release and actin dynamics during NETosis. Cell Rep, 2014, 8(3): 883-896.
9. Majewski P, Majchrzak-Gorecka M, Grygier B, et al. Inhibitors of serine proteases in regulating the production and function of neutrophil extracellular traps. Front Immunol, 2016, 7: 261.
10. Yuen J, Pluthero FG, Douda DN, et al. NETosing neutrophils activate complement both on their own nets and bacteria via alternative and non-alternative pathways. Front Immunol, 2016, 7: 137.
11. Döring Y, Soehnlein O, Weber C. Neutrophil extracellular traps in atherosclerosis and atherothrombosis. Circ Res, 2017, 120(4): 736-743.
12. Muniz VS, Silva JC, Braga YAV, et al. Eosinophils release extracellular DNA traps in response to Aspergillus fumigatus. J Allergy Clin Immunol, 2018, 141(2): 571-585.
13. von Köckritz-Blickwede M, Goldmann O, Thulin P, et al. Phagocytosis-independent antimicrobial activity of mast cells by means of extracellular trap formation. Blood, 2008, 111(6): 3070-3080.
14. Hartl D. Macrophages and platelets join forces to release kidney-damaging DNA traps. Nat Med, 2018, 24(2): 128-129.
15. Ullah I, Ritchie ND, Evans TJ. The interrelationship between phagocytosis, autophagy and formation of neutrophil extracellular traps following infection of human neutrophils by Streptococcus pneumoniae. Innate Immun, 2017, 23(5): 413-423.
16. Etulain J, Martinod K, Wong SL, et al. P-selectin promotes neutrophil extracellular trap formation in mice. Blood, 2015, 126(2): 242-246.
17. Behnen M, Leschczyk C, Möller S, et al. Immobilized immune complexes induce neutrophil extracellular trap release by human neutrophil granulocytes via FcγRⅢB and Mac-1. J Immunol, 2014, 193(4): 1954-1965.
18. Alemán OR, Mora N, Cortes-Vieyra R, et al. Differential use of human neutrophil Fcγ receptors for inducing neutrophil extracellular trap formation. J Immunol Res, 2016, 2016: 2908034.
19. Chen K, Nishi H, Travers R, et al. Endocytosis of soluble immune complexes leads to their clearance by FcγR Ⅲ B but induces neutrophil extracellular traps via FcγR Ⅱ A in vivo. Blood, 2012, 120(22): 4421-4431.
20. Vong L, Lorentz RJ, Assa A, et al. Probiotic Lactobacillus rhamnosus inhibits the formation of neutrophil extracellular traps. J Immunol, 2014, 192(4): 1870-1877.
21. Kamoshida G, Kikuchi-Ueda T, Nishida S, et al. Pathogenic bacterium Acinetobacter baumannii inhibits the formation of neutrophil extracellular traps by suppressing neutrophil adhesion. Front Immunol, 2018, 9: 178.
22. Hoffmann JHO, Schaekel K, Hartl D, et al. Dimethyl fumarate modulates neutrophil extracellular trap formation in a glutathione- and superoxide-dependent manner. Br J Dermatol, 2018, 178(1): 207-214.
23. O’Brien XM, Biron BM, Reichner JS. Consequences of extracellular trap formation in sepsis. Curr Opin Hematol, 2017, 24(1): 66-71.
24. Park SY, Shrestha S, Youn YJ, et al. Autophagy primes neutrophils for neutrophil extracellular trap formation during sepsis. Am J Respir Crit Care Med, 2017, 196(5): 577-589.
25. Yang S, Qi H, Kan K, et al. Neutrophil extracellular traps promote hypercoagulability in patients with sepsis. Shock, 2017, 47(2): 132-139.
26. Chen L, Zhao Y, Lai D, et al. Neutrophil extracellular traps promote macrophage pyroptosis in sepsis. Cell Death Dis, 2018, 9(6): 597.
27. Nakazawa D, Tomaru U, Suzuki A, et al. Abnormal conformation and impaired degradation of propylthiouracil-induced neutrophil extracellular traps: implications of disordered neutrophil extracellular traps in a rat model of myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum, 2012, 64(11): 3779-3787.
28. Kusunoki Y, Nakazawa D, Shida H, et al. Peptidylarginine deiminase inhibitor suppresses neutrophil extracellular trap formation and MPO-ANCA production. Front Immunol, 2016, 7: 227.
29. Hasegawa J, Wakai S, Kono M, et al. An autopsy case of myeloperoxidase-anti-neutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis accompanied by cryoglobulinemic vasculitis affecting the kidneys, skin, and gastrointestinal tract. Intern Med, 2018, 57(18): 2739-2745.
30. Yoshida M, Yamada M, Sudo Y, et al. Myeloperoxidase anti-neutrophil cytoplasmic antibody affinity is associated with the formation of neutrophil extracellular traps in the kidney and vasculitis activity in myeloperoxidase anti-neutrophil cytoplasmic antibody-associated microscopic polyangiitis. Nephrology (Carlton), 2016, 21(7): 624-629.
31. Takeuchi H, Kawasaki T, Shigematsu K, et al. Neutrophil extracellular traps in neuropathy with anti-neutrophil cytoplasmic autoantibody-associated microscopic polyangiitis. Clin Rheumatol, 2017, 36(4): 913-917.
32. Banks PA, Bollen TL, Dervenis C, et al. Classification of acute pancreatitis–2012: revision of the Atlanta classification and definitions by international consensus. Gut, 2013, 62(1): 102-111.
33. Murthy P, Singhi AD, Ross MA, et al. Enhanced neutrophil extracellular trap formation in acute pancreatitis contributes to disease severity and is reduced by chloroquine. Front Immunol, 2019, 10: 28.
34. Merza M, Hartman H, Rahman M, et al. Neutrophil extracellular traps induce trypsin activation, inflammation, and tissue damage in mice with severe acute pancreatitis. Gastroenterology, 2015, 149(7): 1920-1931.e8.
35. Szatmary P, Liu T, Abrams ST, et al. Systemic histone release disrupts plasmalemma and contributes to necrosis in acute pancreatitis. Pancreatology, 2017, 17(6): 884-892.
36. Madhi R, Rahman M, Taha D, et al. Targeting peptidylarginine deiminase reduces neutrophil extracellular trap formation and tissue injury in severe acute pancreatitis. J Cell Physiol, 2019, 234(7): 11850-11860.
37. Cao M, Yu M, Zhang Y, et al. Neutrophil extracellular traps exacerbate inflammatory responses and thrombotic tendency in both a murine colitis model and patients with inflammatory bowel disease. 2017. http://so.hiqq.com.cn/.
38. Mohanty T, Fisher J, Bakochi A, et al. Neutrophil extracellular traps in the central nervous system hinder bacterial clearance during pneumococcal meningitis. Nat Commun, 2019, 10(1): 1667.

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Advances in the study of neutrophil extracellular traps and inflammatory diseases

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