Analysis of clinical symptoms of digestive system in patients with COVID-19_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LIANG Tao ,  MAI Gang , WANG Qiaoli , SONG Xiongfeng , WU Zhixuan , WANG Zhicong

COVID-19 Treatment Team, Peoples’ Hospital of Deyang City, Deyang, Sichuan 618000, R. P. China;

Corresponding author：

MAI Gang, Email: maigang68@hotmail.com

Keywords：

COVID-19; SARS-Cov-2 nucleic acid; digestive tract symptom; liver function; feces

DOI：

10.7507/1007-9424.202002061

Video：

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Objective To investigate whether novel coronavirus pneumonia (COVID-19) patients complicated with digestive tract symptoms and its influence on digestive system related biochemical indexes.Methods Sixteen novel coronavirus pneumonia patients in our hospital were observed, and their epidemiological data, clinical manifestations and clinical laboratory indicators were analyzed statistically.Results The age of the patients ranged from 5 to 75 years old, and the median age was 46.0 years old. Most of them were male (9 cases, 56.25%), the occurrence of COVID-19 appeared in family aggregation (12 cases, 75.00%). Sixt patients (37.50%) were complicated with basic diseases. The initial symptom involving digestive system accounting for 18.75% (3 cases) of all participants. The main manifestation of a diarrhea in 2 (12.5%) and melena in 1 (6.25%) patients, respectively. Five patients (31.25%) had symptoms of digestive system during the course of the disease, the main symptoms were diarrhea in 3 (18.75%), melena in 1 (6.25%) and loss of appetitein in 5 (31.25%) patients, respectively. The SARS-Cov-2 nucleic acid in the feces of the patients were negative in all patients. In 50.00% of the patients, the SARS-Cov-2 nucleic acid in the feces were negative, but the throat swab/sputum nucleic acid were still positive at the same time or later. Two patients (12.50%) had elevated ALT and 1 patient (6.25%) had elevated AST at the time of admission.Conclusions Patients with COVID-19 will show symptoms of digestive tract.

Citation： LIANG Tao, MAI Gang, WANG Qiaoli, SONG Xiongfeng, WU Zhixuan, WANG Zhicong. Analysis of clinical symptoms of digestive system in patients with COVID-19. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2020, 27(7): 785-789. doi: 10.7507/1007-9424.202002061 Copy

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1. 杨小玲, 万娟, 任秋平, 等. 新型冠状病毒感染肺炎疫情下肝移植受者住院及居家防控策略. 中国普外基础与临床杂志, 2020, 27(4): 393-395.
2. 吕涛, 杨家印, 严律南, 等. 新型冠状病毒性肺炎疫情时期器官移植调整策略及体会. 中国普外基础与临床杂志, 2020, 27(3): 261-264.
3. 国家卫生健康委办公厅, 国家中医药管理局办公室. 新型冠状病毒感染的肺炎诊疗方案(试行第五版). 国卫办医涵[2020] 103号. 2020-02-04. http://www.nhc.gov.cn/yzygj/s7653p/202002/3b09b894ac9b4204a79db5b8912d4440.shtml.
4. Yeo C, Kaushal S, Yeo D, et al. Enteric involvement of coronaviruses: is faecal-oral transmission of SARS-CoV-2 possible? Lancet Gastroenterol Hepatol, 2020, 5(4): 335-337.
5. 王文辰, 夏彦明, 朱建飞, 等. 血管紧张素转换酶 2 在人类高致病性冠状病毒肺炎中作用的研究进展. 中国胸心血管外科临床杂杂, 2020, 27(5): 588-596.
6. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet, 2020, 395(10223): 497-506.
7. Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet, 2020, 395(10223): 507-513.
8. Hashimoto T, Perlot T, Rehman A, et al. ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature, 2012, 487(7408): 477-481.
9. 刘川, 江自成, 邵初晓, 等. 新型冠状病毒肺炎与肝功能损伤的关系初探: 一项多中心研究. 中华肝脏病杂志, 2020, 28(2): 148-152.
10. Qi F, Qian S, Zhang S, et al. Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses. Biochem Biophys Res Commun, 2020, 526(1): 135-140.
11. 李萍, 赵四林, 陈煜枫, 等. 2 例新型冠状病毒肺炎粪便 SARS-CoV-2 核酸阳性临床启示. 国际检验医学杂志, 2020, 41(4): 385-388.
12. Gao QY, Chen YX, Fang JY, et al. 2019 novel coronavirus infection and gastrointestinal tract. J Dig Dis, 2020, 21(3): 125-126.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Analysis of clinical symptoms of digestive system in patients with COVID-19

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