胃癌术后吻合口漏的预防与处理_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

张鹏 ,  陶凯雄

华中科技大学同济医学院附属协和医院胃肠外科（武汉 430022）;

Corresponding author：

陶凯雄, Email: kaixiongtao@hust.edu.cn

Keywords：

DOI：

10.7507/1007-9424.202104078

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Citation： 张鹏, 陶凯雄. 胃癌术后吻合口漏的预防与处理. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2021, 28(6): 717-720. doi: 10.7507/1007-9424.202104078 Copy

1.	中华医学会外科学分会胃肠外科学组, 中国抗癌协会胃癌专业委员会. 胃癌手术消化道重建机械吻合专家共识. 中国实用外科杂志, 2015, 35(6): 584-592.
2.	中国胃肠肿瘤外科联盟, 中国抗癌协会胃癌专业委员会. 中国胃肠肿瘤外科术后并发症诊断登记规范专家共识(2018 版). 中国实用外科杂志, 2018, 38(6): 589-595.
3.	Luo H, Wu L, Huang M, et al. Postoperative morbidity and mortality in patients receiving neoadjuvant chemotherapy for locally advanced gastric cancers: A systematic review and meta-analysis. Medicine (Baltimore), 2018, 97(43): e12932.
4.	Wu L, Ge L, Qin Y, et al. Postoperative morbidity and mortality after neoadjuvant chemotherapy versus upfront surgery for locally advanced gastric cancer: a propensity score matching analysis. Cancer Manag Res, 2019, 11: 6011-6018.
5.	Tonouchi H, Mohri Y, Tanaka K, et al. Diagnostic sensitivity of contrast swallow for leakage after gastric resection. World J Surg, 2007, 31(1): 128-131.
6.	Strauss C, Mal F, Perniceni T, et al. Computed tomography versus water-soluble contrast swallow in the detection of intrathoracic anastomotic leak complicating esophagogastrectomy (Ivor Lewis): a prospective study in 97 patients. Ann Surg, 2010, 251(4): 647-651.
7.	Nederlof N, de Jonge J, de Vringer T, et al. Does routine endoscopy or contrast swallow study after esophagectomy and gastric tube reconstruction change patient management? J Gastrointest Surg, 2017, 21(2): 251-258.
8.	Watanabe M, Miyata H, Gotoh M, et al. Total gastrectomy risk model: data from 20 011 Japanese patients in a nationwide internet-based database. Ann Surg, 2014, 260(6): 1034-1039.
9.	Kurita N, Miyata H, Gotoh M, et al. Risk Model for distal gastrectomy when treating gastric cancer on the basis of data from 33 917 Japanese patients collected using a nationwide web-based data entry system. Ann Surg, 2015, 262(2): 295-303.
10.	王家镔, 郑朝辉, 李平, 等. 术前伴发疾病对腹腔镜辅助全胃切除术后腹部并发症的影响. 中华消化外科杂志, 2017, 16(3): 275-280.
11.	Lang H, Piso P, Stukenborg C, et al. Management and results of proximal anastomotic leaks in a series of 1 114 total gastrectomies for gastric carcinoma. Eur J Surg Oncol, 2000, 26(2): 168-171.
12.	Rutegård M, Lagergren P, Rouvelas I, et al. Intrathoracic anastomotic leakage and mortality after esophageal cancer resection: a population-based study. Ann Surg Oncol, 2012, 19(1): 99-103.
13.	Kim SH, Son SY, Park YS, et al. Risk factors for anastomotic leakage: a retrospective cohort study in a single gastric surgical unit. J Gastric Cancer, 2015, 15(3): 167-175.
14.	Bickenbach KA, Denton B, Gonen M, et al. Impact of obesity on perioperative complications and long-term survival of patients with gastric cancer. Ann Surg Oncol, 2013, 20(3): 780-787.
15.	Wang JB, Zheng CH, Li P, et al. Effect of comorbidities on postoperative complications in patients with gastric cancer after laparoscopy-assisted total gastrectomy: results from an 8-year experience at a large-scale single center. Surg Endosc, 2017, 31(6): 2651-2660.
16.	Deguchi Y, Fukagawa T, Morita S, et al. Identification of risk factors for esophagojejunal anastomotic leakage after gastric surgery. World J Surg, 2012, 36(7): 1617-1622.
17.	Wang Y, Liu Z, Shan F, et al. Optimal timing to surgery after neoadjuvant chemotherapy for locally advanced gastric cancer. Front Oncol, 2020, 10: 613988.
18.	Sah BK, Chen MM, Yan M, et al. Gastric cancer surgery: Billroth Ⅰ or Billroth Ⅱfor distal gastrectomy? BMC Cancer, 2009, 9: 428.
19.	Jiang L, Yang KH, Chen Y, et al. Systematic review and meta-analysis of the effectiveness and safety of extended lymphadenectomy in patients with resectable gastric cancer. Br J Surg, 2014, 101(6): 595-604.
20.	Sasako M, Sano T, Yamamoto S, et al. D2 lymphadenectomy alone or with para-aortic nodal dissection for gastric cancer. N Engl J Med, 2008, 359(5): 453-462.
21.	Nomura S, Sasako M, Katai H, et al. Decreasing complication rates with stapled esophagojejunostomy following a learning curve. Gastric Cancer, 2000, 3(2): 97-101.
22.	Oh SJ, Hong JJ, Oh CA, et al. Stapling technique for performing Billroth Ⅱanastomosis after distal gastrectomy. J Gastrointest Surg, 2011, 15(7): 1244-1246.
23.	尤承忠, 陈卫东, 范新, 等. 管状吻合器使用不当致吻合口梗阻35例临床分析. 中国实用外科杂志, 2016, 36(2): 214-217.
24.	龚磊, 喻晶, 吕真冰, 等. 腹腔镜胃癌 D2 根治术后吻合口漏的个体化治疗. 中国普外基础与临床杂志, 2020, 27(7): 831-835.
25.	崔亚平, 赵锐, 王勇, 等. 早期含 ω-3 多不饱和脂肪酸肠内营养联合静脉补充丙氨酰谷氨酰胺对胃癌根治术后患者炎症反应及免疫功能的作用. 中国普外基础与临床杂志, 2019, 26(7): 785-791.
26.	Kobayashi D, Ishigure K, Mochizuki Y, et al. Multi-institutional prospective feasibility study to explore tolerability and efficacy of oral nutritional supplements for patients with gastric cancer undergoing gastrectomy (CCOG1301). Gastric Cancer, 2017, 20(4): 718-727.
27.	Boerlage TC, van Hees CL, Huitema AD, et al. Proton pump inhibitor prophylaxis after gastric bypass does not cause hypomagnesemia. Obes Surg, 2016, 26(3): 688-690.
28.	Song W, Chen JH, Zhang XH, et al. Effect of somatostatin in advanced gastric cancer after D2 radical gastrectomy. World J Gastroenterol, 2014, 20(40): 14927-14933.
29.	Kim YJ, Shin SK, Lee HJ, et al. Endoscopic management of anastomotic leakage after gastrectomy for gastric cancer: how efficacious is it? Scand J Gastroenterol, 2013, 48(1): 111-118.
30.	Shim CN, Kim HI, Hyung WJ, et al. Self-expanding metal stents or nonstent endoscopic therapy: which is better for anastomotic leaks after total gastrectomy? Surg Endosc, 2014, 28(3): 833-840.
31.	Pross M, Manger T, Reinheckel T, et al. Endoscopic treatment of clinically symptomatic leaks of thoracic esophageal anastomoses. Gastrointest Endosc, 2000, 51(1): 73-76.
32.	Cipolletta L, Bianco MA, Rotondano G, et al. Endoscopic clipping of perforation following pneumatic dilation of esophagojejunal anastomotic strictures. Endoscopy, 2000, 32(9): 720-722.
33.	Choi SI, Park JC, Jung DH, et al. Efficacy of endoscopic vacuum-assisted closure treatment for postoperative anastomotic leak in gastric cancer. Gut Liver, 2020, 14(6): 746-754.
34.	Hwang JJ, Jeong YS, Park YS, et al. Comparison of endoscopic vacuum therapy and endoscopic stent implantation with self-expandable metal stent in treating postsurgical gastroesophageal leakage. Medicine (Baltimore), 2016, 95(16): e3416.
35.	徐麟, 石鑫, 李盖天, 等. 损伤控制理论在腹腔脓毒症中的应用进展. 中国普外基础与临床杂志, 2019, 26(2): 253-256.
36.	Wiggins T, Markar SR, Arya S, et al. Anastomotic reinforcement with omentoplasty following gastrointestinal anastomosis: A systematic review and meta-analysis. Surg Oncol, 2015, 24(3): 181-186.
37.	中国抗癌协会胃癌专业委员会, 中华医学会外科学分会胃肠外科学组. 胃癌围手术期营养治疗中国专家共识(2019 版). 中国实用外科杂志, 2020, 40(2): 145-151.
38.	Blumenthaler AN, Ikoma N, Blum M, et al. Relationship between initial management strategy and survival in patients with gastric outlet obstruction due to gastric cancer. J Surg Oncol, 2020, 122(7): 1373-1382.
39.	Yang W, Chen X, Zhang P, et al. Procalcitonin as an early predictor of intra-abdominal infections following gastric cancer resection. J Surg Res, 2021, 258: 352-361.
40.	Wang J, Yang M, Wang Q, et al. Comparison of early oral feeding with traditional oral feeding after total gastrectomy for gastric cancer: a propensity score matching analysis. Front Oncol, 2019, 9: 1194.
41.	Xu LB, Huang ZX, Zhang HH, et al. Impact of preoperative short-term parenteral nutrition support on the clinical outcome of gastric cancer patients: A propensity score matching analysis. JPEN J Parenter Enteral Nutr, 2020 Jun 17. Online ahead of print.

1. 中华医学会外科学分会胃肠外科学组, 中国抗癌协会胃癌专业委员会. 胃癌手术消化道重建机械吻合专家共识. 中国实用外科杂志, 2015, 35(6): 584-592.
2. 中国胃肠肿瘤外科联盟, 中国抗癌协会胃癌专业委员会. 中国胃肠肿瘤外科术后并发症诊断登记规范专家共识(2018 版). 中国实用外科杂志, 2018, 38(6): 589-595.
3. Luo H, Wu L, Huang M, et al. Postoperative morbidity and mortality in patients receiving neoadjuvant chemotherapy for locally advanced gastric cancers: A systematic review and meta-analysis. Medicine (Baltimore), 2018, 97(43): e12932.
4. Wu L, Ge L, Qin Y, et al. Postoperative morbidity and mortality after neoadjuvant chemotherapy versus upfront surgery for locally advanced gastric cancer: a propensity score matching analysis. Cancer Manag Res, 2019, 11: 6011-6018.
5. Tonouchi H, Mohri Y, Tanaka K, et al. Diagnostic sensitivity of contrast swallow for leakage after gastric resection. World J Surg, 2007, 31(1): 128-131.
6. Strauss C, Mal F, Perniceni T, et al. Computed tomography versus water-soluble contrast swallow in the detection of intrathoracic anastomotic leak complicating esophagogastrectomy (Ivor Lewis): a prospective study in 97 patients. Ann Surg, 2010, 251(4): 647-651.
7. Nederlof N, de Jonge J, de Vringer T, et al. Does routine endoscopy or contrast swallow study after esophagectomy and gastric tube reconstruction change patient management? J Gastrointest Surg, 2017, 21(2): 251-258.
8. Watanabe M, Miyata H, Gotoh M, et al. Total gastrectomy risk model: data from 20 011 Japanese patients in a nationwide internet-based database. Ann Surg, 2014, 260(6): 1034-1039.
9. Kurita N, Miyata H, Gotoh M, et al. Risk Model for distal gastrectomy when treating gastric cancer on the basis of data from 33 917 Japanese patients collected using a nationwide web-based data entry system. Ann Surg, 2015, 262(2): 295-303.
10. 王家镔, 郑朝辉, 李平, 等. 术前伴发疾病对腹腔镜辅助全胃切除术后腹部并发症的影响. 中华消化外科杂志, 2017, 16(3): 275-280.
11. Lang H, Piso P, Stukenborg C, et al. Management and results of proximal anastomotic leaks in a series of 1 114 total gastrectomies for gastric carcinoma. Eur J Surg Oncol, 2000, 26(2): 168-171.
12. Rutegård M, Lagergren P, Rouvelas I, et al. Intrathoracic anastomotic leakage and mortality after esophageal cancer resection: a population-based study. Ann Surg Oncol, 2012, 19(1): 99-103.
13. Kim SH, Son SY, Park YS, et al. Risk factors for anastomotic leakage: a retrospective cohort study in a single gastric surgical unit. J Gastric Cancer, 2015, 15(3): 167-175.
14. Bickenbach KA, Denton B, Gonen M, et al. Impact of obesity on perioperative complications and long-term survival of patients with gastric cancer. Ann Surg Oncol, 2013, 20(3): 780-787.
15. Wang JB, Zheng CH, Li P, et al. Effect of comorbidities on postoperative complications in patients with gastric cancer after laparoscopy-assisted total gastrectomy: results from an 8-year experience at a large-scale single center. Surg Endosc, 2017, 31(6): 2651-2660.
16. Deguchi Y, Fukagawa T, Morita S, et al. Identification of risk factors for esophagojejunal anastomotic leakage after gastric surgery. World J Surg, 2012, 36(7): 1617-1622.
17. Wang Y, Liu Z, Shan F, et al. Optimal timing to surgery after neoadjuvant chemotherapy for locally advanced gastric cancer. Front Oncol, 2020, 10: 613988.
18. Sah BK, Chen MM, Yan M, et al. Gastric cancer surgery: Billroth Ⅰ or Billroth Ⅱfor distal gastrectomy? BMC Cancer, 2009, 9: 428.
19. Jiang L, Yang KH, Chen Y, et al. Systematic review and meta-analysis of the effectiveness and safety of extended lymphadenectomy in patients with resectable gastric cancer. Br J Surg, 2014, 101(6): 595-604.
20. Sasako M, Sano T, Yamamoto S, et al. D2 lymphadenectomy alone or with para-aortic nodal dissection for gastric cancer. N Engl J Med, 2008, 359(5): 453-462.
21. Nomura S, Sasako M, Katai H, et al. Decreasing complication rates with stapled esophagojejunostomy following a learning curve. Gastric Cancer, 2000, 3(2): 97-101.
22. Oh SJ, Hong JJ, Oh CA, et al. Stapling technique for performing Billroth Ⅱanastomosis after distal gastrectomy. J Gastrointest Surg, 2011, 15(7): 1244-1246.
23. 尤承忠, 陈卫东, 范新, 等. 管状吻合器使用不当致吻合口梗阻35例临床分析. 中国实用外科杂志, 2016, 36(2): 214-217.
24. 龚磊, 喻晶, 吕真冰, 等. 腹腔镜胃癌 D2 根治术后吻合口漏的个体化治疗. 中国普外基础与临床杂志, 2020, 27(7): 831-835.
25. 崔亚平, 赵锐, 王勇, 等. 早期含 ω-3 多不饱和脂肪酸肠内营养联合静脉补充丙氨酰谷氨酰胺对胃癌根治术后患者炎症反应及免疫功能的作用. 中国普外基础与临床杂志, 2019, 26(7): 785-791.
26. Kobayashi D, Ishigure K, Mochizuki Y, et al. Multi-institutional prospective feasibility study to explore tolerability and efficacy of oral nutritional supplements for patients with gastric cancer undergoing gastrectomy (CCOG1301). Gastric Cancer, 2017, 20(4): 718-727.
27. Boerlage TC, van Hees CL, Huitema AD, et al. Proton pump inhibitor prophylaxis after gastric bypass does not cause hypomagnesemia. Obes Surg, 2016, 26(3): 688-690.
28. Song W, Chen JH, Zhang XH, et al. Effect of somatostatin in advanced gastric cancer after D2 radical gastrectomy. World J Gastroenterol, 2014, 20(40): 14927-14933.
29. Kim YJ, Shin SK, Lee HJ, et al. Endoscopic management of anastomotic leakage after gastrectomy for gastric cancer: how efficacious is it? Scand J Gastroenterol, 2013, 48(1): 111-118.
30. Shim CN, Kim HI, Hyung WJ, et al. Self-expanding metal stents or nonstent endoscopic therapy: which is better for anastomotic leaks after total gastrectomy? Surg Endosc, 2014, 28(3): 833-840.
31. Pross M, Manger T, Reinheckel T, et al. Endoscopic treatment of clinically symptomatic leaks of thoracic esophageal anastomoses. Gastrointest Endosc, 2000, 51(1): 73-76.
32. Cipolletta L, Bianco MA, Rotondano G, et al. Endoscopic clipping of perforation following pneumatic dilation of esophagojejunal anastomotic strictures. Endoscopy, 2000, 32(9): 720-722.
33. Choi SI, Park JC, Jung DH, et al. Efficacy of endoscopic vacuum-assisted closure treatment for postoperative anastomotic leak in gastric cancer. Gut Liver, 2020, 14(6): 746-754.
34. Hwang JJ, Jeong YS, Park YS, et al. Comparison of endoscopic vacuum therapy and endoscopic stent implantation with self-expandable metal stent in treating postsurgical gastroesophageal leakage. Medicine (Baltimore), 2016, 95(16): e3416.
35. 徐麟, 石鑫, 李盖天, 等. 损伤控制理论在腹腔脓毒症中的应用进展. 中国普外基础与临床杂志, 2019, 26(2): 253-256.
36. Wiggins T, Markar SR, Arya S, et al. Anastomotic reinforcement with omentoplasty following gastrointestinal anastomosis: A systematic review and meta-analysis. Surg Oncol, 2015, 24(3): 181-186.
37. 中国抗癌协会胃癌专业委员会, 中华医学会外科学分会胃肠外科学组. 胃癌围手术期营养治疗中国专家共识(2019 版). 中国实用外科杂志, 2020, 40(2): 145-151.
38. Blumenthaler AN, Ikoma N, Blum M, et al. Relationship between initial management strategy and survival in patients with gastric outlet obstruction due to gastric cancer. J Surg Oncol, 2020, 122(7): 1373-1382.
39. Yang W, Chen X, Zhang P, et al. Procalcitonin as an early predictor of intra-abdominal infections following gastric cancer resection. J Surg Res, 2021, 258: 352-361.
40. Wang J, Yang M, Wang Q, et al. Comparison of early oral feeding with traditional oral feeding after total gastrectomy for gastric cancer: a propensity score matching analysis. Front Oncol, 2019, 9: 1194.
41. Xu LB, Huang ZX, Zhang HH, et al. Impact of preoperative short-term parenteral nutrition support on the clinical outcome of gastric cancer patients: A propensity score matching analysis. JPEN J Parenter Enteral Nutr, 2020 Jun 17. Online ahead of print.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

胃癌术后吻合口漏的预防与处理

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content