LIN Jinyi 1,2 , LIU Jing 1,3 , PANG Jiyun 2 , WANG Xiaodong 1,2 , LI Li 4
  • 1. Division of Gastrointestinal Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
  • 2. West China School of Medicine in Sichuan University, Chengdu 610041, P. R. China;
  • 3. West China School of Nursing, Sichuan University, Chengdu 610041, P. R. China;
  • 4. Colorectal Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
WANG Xiaodong, Email: wangxiaodong@wchscu.cn
colorectal cancer; marital status; overall survival; disease specific survival
10.7507/1007-9424.202303081
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Objective To analyze the relation between marital status and prognosis of patients with colorectal cancer (CRC) in the Database from Colorectal Cancer (DACCA). Methods The DACCA version selected for this data analysis was updated on January 13, 2023. The data items analysis included the age, gender, marital status, tumor location, tumor property, pathological TNM (pTNM) stage, survival status, and survival time. According to the marital status, the patients were assigned into five marital statuses: the first marriage, unmarried, divorced, remarriage, and widowed groups. The overall survival (OS) and disease specific survival (DSS) of the 5 marital statuses were analyzed, and then the risk factors affecting OS and DSS were analyzed by the Cox proportional hazards regression model. Results A total of 7 373 data were obtained from the DACCA according to the screening conditions, of which 6 696 (90.8%) were first marriage, 108 (1.5%) were unmarried, 198 (2.7%) were divorced, 22 (0.3%) were remarriage, and 349 (4.7%) were widowed. The OS and DSS curves had no statistical differences among the CRC patients with 5 marital statuses (χ2=2.692, P=0.611; χ2=2.927, P=0.570). The 3-year cumulative overall survival rate and disease specific survival rate among the 5 marital status patients had statistical differences among the patients with five marital statuses (χ2=24.65, P<0.001; χ2=18.63, P=0.001), further pairwise comparison showed that the 3-year cumulative overall survival rate and disease specific survival rate in the CRC patients with first marriage were higher than those in the widowed patients (Z=3.36, P<0.01; Z=3.02, P<0.01). The multivariate analysis results by the Cox proportional hazards regression model did not find the marital status was associated with the OS and DSS (P>0.05). Conclusions From the real-world analysis results of this study, it is found that 3-year cumulative overall survival rate and disease specific survival rate in patients with first marriage are higher as compared with widowed patients. It is necessary to pay more attention to the long-term follow-up of CRC patients in unmarried or widowed status.

Citation： LIN Jinyi, LIU Jing, PANG Jiyun, WANG Xiaodong, LI Li. Effect of marital status on long-term survival of patients with colorectal cancer: a real-world study based on DACCA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2023, 30(6): 660-665. doi: 10.7507/1007-9424.202303081 Copy

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