Case analysis: CT manifestations of hepatoid adenocarcinoma of gallbladder with liver involvement_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LIU Senhao , ZHU Fei , LÜ Su ,  CHEN Weixia

Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

CHEN Weixia, Email: wxchen25@126.com

Keywords：

gallbladder; hepatoid adenocarcinoma; alpha fetoprotein; imaging manifestations

DOI：

10.7507/1007-9424.202501004

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

The authors presented CT manifestations of a patient with hepatoid adenocarcinoma of gallbladder with liver involvement and briefly described the clinical features, imaging manifestations, and differential diagnosis of the disease in order to enhance the readers’ better awareness of the imaging manifestations, thus to reduce the misdiagnosis of the disease.

Citation： LIU Senhao, ZHU Fei, LÜ Su, CHEN Weixia. Case analysis: CT manifestations of hepatoid adenocarcinoma of gallbladder with liver involvement. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2025, 32(7): 839-842. doi: 10.7507/1007-9424.202501004 Copy

1.	Metzgeroth G, Ströbel P, Baumbusch T, et al. Hepatoid adenocarcinoma—Review of the literature illustrated by a rare case originating in the peritoneal cavity. Onkologie, 2010, 33(5): 263-269.
2.	Su JS, Chen YT, Wang RC, et al. Clinicopathological characteristics in the differential diagnosis of hepatoid adenocarcinoma: A literature review. World J Gastroenterol, 2013, 19(3): 321-327.
3.	王鹤霖, 戴朝六. 胆囊肝样腺癌的诊断与治疗现状. 中华消化外科杂志, 2017, 16(11): 1163-1166.
4.	方会娟, 徐小艳. 胆囊肝样腺癌的镜下特征: 相互交织移行的肝样分化区和腺癌区. 中国普外基础与临床杂志, 2024, 31(4): 474-478.
5.	李巧转, 周志华, 王倩, 等. 胆囊肝样腺癌4例临床病理分析. 武警医学, 2023, 34(1): 54-57.
6.	Devi NR, Sathyalakshmi R, Devi J, et al. Hepatoid adenocarcinoma of the gall bladder—A rare variant. J Clin Diagn Res, 2015, 9(8): ED09-ED10. doi: 10.7860/JCDR/2015/10799.6324.
7.	Li Z, Jiang Q, Chen X, et al. Primary hepatoid adenocarcinoma of gallbladder with MB21D2/GALNT12/ARID2 mutations: A case report. Front Endocrinol (Lausanne), 2022, 12: 791153. doi: 10.3389/fendo.2021.791153.
8.	van den Bos IC, Hussain SM, Dwarkasing RS, et al. Hepatoid adenocarcinoma of the gallbladder: A mimicker of hepatocellular carcinoma. Br J Radiol, 2007, 80(960): e317-e320. doi: 10.1259/bjr/97773297.
9.	舒适, 黄燕涛, 冷媛媛, 等. 胆囊原发性肝样腺癌影像学特征分析及文献复习. 中国CT和MRI杂志, 2024, 22(3): 182-183.
10.	张帅, 郭茜, 李琦, 等. 肝样腺癌CT及MRI表现. 中国医学影像技术, 2023, 39(4): 555-559.
11.	Dixit N, Trivedi S, Bansal VK. Clear-cell adenocarcinoma of the gallbladder with alpha-fetoprotein production: A case report and review of the literature. Gastrointest Tumors, 2021, 8(2): 52-57.
12.	Fujii H, Yamaguchi K, Ohnishi N, et al. Adenoendocrine cell carcinoma of the gallbladder producing a high level of alpha-fetoprotein. Clin J Gastroenterol, 2012, 5(4): 261-267.
13.	Mita J, Tada K, Kuboyama Y, et al. Poorly differentiated adenocarcinoma with signet ring cells of the gallbladder producing a high level of alpha-fetoprotein: A case report. Int J Surg Case Rep, 2022, 101: 107780. doi: 10.1016/j.ijscr.2022.107780.
14.	Lee JH, Lee KG, Paik SS, et al. Hepatoid adenocarcinoma of the gallbladder with production of alpha-fetoprotein. J Korean Surg Soc, 2011, 80(6): 440-444.
15.	Qian X, Zhou D, Gao B, et al. An alpha-fetoprotein-negative hepatoid adenocarcinoma of the gallbladder with squamous differentiation. Hepatobiliary Surg Nutr, 2020, 9(1): 116-118.
16.	Iwasaki S, Hidaka H, Uojima H, et al. A case of successful treatment with lenvatinib in primary hepatoid adenocarcinoma of the gallbladder that was difficult to distinguish from hepatocellular carcinoma. Clin J Gastroenterol, 2022, 15(6): 1108-1114.
17.	Zhou J, Sun H, Wang Z, et al. Guidelines for the diagnosis and treatment of primary liver cancer (2022 Edition). Liver Cancer, 2023, 12(5): 405-444.

1. Metzgeroth G, Ströbel P, Baumbusch T, et al. Hepatoid adenocarcinoma—Review of the literature illustrated by a rare case originating in the peritoneal cavity. Onkologie, 2010, 33(5): 263-269.
2. Su JS, Chen YT, Wang RC, et al. Clinicopathological characteristics in the differential diagnosis of hepatoid adenocarcinoma: A literature review. World J Gastroenterol, 2013, 19(3): 321-327.
3. 王鹤霖, 戴朝六. 胆囊肝样腺癌的诊断与治疗现状. 中华消化外科杂志, 2017, 16(11): 1163-1166.
4. 方会娟, 徐小艳. 胆囊肝样腺癌的镜下特征: 相互交织移行的肝样分化区和腺癌区. 中国普外基础与临床杂志, 2024, 31(4): 474-478.
5. 李巧转, 周志华, 王倩, 等. 胆囊肝样腺癌4例临床病理分析. 武警医学, 2023, 34(1): 54-57.
6. Devi NR, Sathyalakshmi R, Devi J, et al. Hepatoid adenocarcinoma of the gall bladder—A rare variant. J Clin Diagn Res, 2015, 9(8): ED09-ED10. doi: 10.7860/JCDR/2015/10799.6324.
7. Li Z, Jiang Q, Chen X, et al. Primary hepatoid adenocarcinoma of gallbladder with MB21D2/GALNT12/ARID2 mutations: A case report. Front Endocrinol (Lausanne), 2022, 12: 791153. doi: 10.3389/fendo.2021.791153.
8. van den Bos IC, Hussain SM, Dwarkasing RS, et al. Hepatoid adenocarcinoma of the gallbladder: A mimicker of hepatocellular carcinoma. Br J Radiol, 2007, 80(960): e317-e320. doi: 10.1259/bjr/97773297.
9. 舒适, 黄燕涛, 冷媛媛, 等. 胆囊原发性肝样腺癌影像学特征分析及文献复习. 中国CT和MRI杂志, 2024, 22(3): 182-183.
10. 张帅, 郭茜, 李琦, 等. 肝样腺癌CT及MRI表现. 中国医学影像技术, 2023, 39(4): 555-559.
11. Dixit N, Trivedi S, Bansal VK. Clear-cell adenocarcinoma of the gallbladder with alpha-fetoprotein production: A case report and review of the literature. Gastrointest Tumors, 2021, 8(2): 52-57.
12. Fujii H, Yamaguchi K, Ohnishi N, et al. Adenoendocrine cell carcinoma of the gallbladder producing a high level of alpha-fetoprotein. Clin J Gastroenterol, 2012, 5(4): 261-267.
13. Mita J, Tada K, Kuboyama Y, et al. Poorly differentiated adenocarcinoma with signet ring cells of the gallbladder producing a high level of alpha-fetoprotein: A case report. Int J Surg Case Rep, 2022, 101: 107780. doi: 10.1016/j.ijscr.2022.107780.
14. Lee JH, Lee KG, Paik SS, et al. Hepatoid adenocarcinoma of the gallbladder with production of alpha-fetoprotein. J Korean Surg Soc, 2011, 80(6): 440-444.
15. Qian X, Zhou D, Gao B, et al. An alpha-fetoprotein-negative hepatoid adenocarcinoma of the gallbladder with squamous differentiation. Hepatobiliary Surg Nutr, 2020, 9(1): 116-118.
16. Iwasaki S, Hidaka H, Uojima H, et al. A case of successful treatment with lenvatinib in primary hepatoid adenocarcinoma of the gallbladder that was difficult to distinguish from hepatocellular carcinoma. Clin J Gastroenterol, 2022, 15(6): 1108-1114.
17. Zhou J, Sun H, Wang Z, et al. Guidelines for the diagnosis and treatment of primary liver cancer (2022 Edition). Liver Cancer, 2023, 12(5): 405-444.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Case analysis: CT manifestations of hepatoid adenocarcinoma of gallbladder with liver involvement

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content