Analysis of the prevalence status and trend of gallbladder cancer in Zhejiang Province from 2000 to 2021_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

YANG Xiaojing ¹ , WANG Jiaran ¹ , JIN Ting ¹ , HAN Jiayu ¹ , FAN Jianqiang ¹ , ZHANG Xinxi ¹ , DU Lingbin ^2,3 ,  LI Huizhang ^2,3

1. Center for Disease Control and Prevention of Shangyu District, Shaoxing, Zhejiang 312000, P. R. China;
2. Zhejiang Provincial Office of Cancer Prevention and Control, Hangzhou 310022, P. R. China;
3. Prevention and Treatment Department, Zhejiang Cancer Hospital, Hangzhou 310022, P. R. China;

Corresponding author：

LI Huizhang, Email: huizhang_220@163.com

Keywords：

gallbladder cancer; incidence; mortality; trend analysis; Zhejiang Province

DOI：

10.7507/1007-9424.202506003

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Objective To analyze the epidemiological characteristics and trends of gallbladder cancer incidence and mortality in Zhejiang cancer registration areas from 2000 to 2021, providing a basis for formulating prevention and control strategies for gallbladder cancer. Methods Data on incidence and mortality were collected from 22 cancer registry areas in Zhejiang Province from 2000 to 2021, calculating the crude incidence (mortality), age-standardized incidence / mortality rate by Chinese standard population(ASR China), age-standardized incidence /mortality rate by World standard population (ASR World) and cumulative rate (0–74 years old). The average annual percentage change (AAPC) was calculated by using Joinpoint software. Results In 2021, the crude incidence of gallbladder cancer in Zhejiang cancer registration areas was 6.79 per 100 000. The ASR China and ASR World were 2.99 and 2.96 per 100 000, respectively, ranking 18th of all new cancer cases. The incidence ASR China in female (3.13 per 100 000) was higher than that in male (2.85 per 100 000). The incidence ASR China in rural areas (3.01 per 100 000) was slightly higher than that in urban areas (2.97 per 100 000). The crude mortality of gallbladder cancer was 5.14 per 100 000, with the mortality ASR China and ASR World of 2.09 and 2.10 per 100 000, respectively, ranking 10th of all new cancer deaths. The mortality ASR China in female (2.19 per 100 000) was higher than that in male (1.98 per 100 000). The mortality ASR China in urban areas (2.11 per 100 000) was slightly higher than that in rural areas (2.07 per 100 000). Both the crude incidence and mortality of gallbladder cancer increased with age. The crude incidence and mortality showed an upward trend over time, with AAPC of 2.59% and 3.75%, respectively (P<0.001). The incidence ASR China did not show significant changes over time (AAPC=0.05%, P=0.856). The incidence ASR China in male and rural areas showed increasing trends over time, with AAPCs of 0.89% (P=0.016) and 1.14% (P=0.001), respectively. The incidence ASR China in female and urban areas showed no significant trends over time, with AAPCs of –0.26% (P=0.503) and –0.02% (P=0.967), respectively. The mortality showed a slower upward trend after adjusting the age structure (AAPC=1.01%, P=0.020). Conclusions The elderly population in rural areas, especially elderly women, are the primary targets for the prevention and control of gallbladder cancer. Aging is the main factor contributing to the increase in the incidence and mortality of gallbladder cancer. After adjusting for demographic factors, the overall upward trend of the incidence in the male population and rural areas, as well as mortality, cannot be ignored.

Citation： YANG Xiaojing, WANG Jiaran, JIN Ting, HAN Jiayu, FAN Jianqiang, ZHANG Xinxi, DU Lingbin, LI Huizhang. Analysis of the prevalence status and trend of gallbladder cancer in Zhejiang Province from 2000 to 2021. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2025, 32(6): 714-721. doi: 10.7507/1007-9424.202506003 Copy

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15.	胡霄, 李丽, 欧阳一非, 等. 2000–2018年中国十六省(自治区、直辖市)7~17岁儿童青少年超重与肥胖流行趋势. 卫生研究, 2022, 51(4): 568-573.

1. Stinton LM, Shaffer EA. Epidemiology of gallbladder disease: cholelithiasis and cancer. Gut Liver, 2012, 6(2): 172-187.
2. 单季军, 王添琳, 李相成. 胆囊癌转化治疗的研究现状. 中国普外基础与临床杂志, 2023, 30(4): 385-391.
3. 曾琦惠, 李富宇. 《腹腔镜胆囊癌根治性切除专家共识 (2023)》解读. 中国普外基础与临床杂志, 2025, 32(1): 46-49.
4. Han B, Zheng R, Zeng H, et al. Cancer incidence and mortality in China, 2022. J Natl Cancer Cent, 2024, 4(1): 47-53.
5. Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2024, 74(3): 229-263.
6. Guo H, Zhang D, Li Z, et al. Global burden of gallbladder cancer in 2022 and predictions to 2042. Dig Liver Dis, 2025, 57(6): 1294-1300.
7. 沈欢, 孙中明, 缪丹丹, 等. 2009–2019年江苏省肿瘤登记地区胆囊癌发病趋势及年龄变化分析. 中国肿瘤外科杂志, 2024, 16(3): 215-220.
8. 张克博, 刘玉琴, 丁高恒, 等. 2019年甘肃省肿瘤登记地区胆囊癌流行特征及2010–2019年变化趋势分析. 中国肿瘤, 2024, 33(2): 96-102.
9. 黄瑜, 刘玉琴, 丁高恒, 等. 2009–2015年甘肃省肿瘤登记地区胆囊癌流行特征及变化趋势分析. 实用肿瘤学杂志, 2021, 35(3): 193-199.
10. 国家癌症中心. 中国肿瘤登记工作指导手册-2016. 北京: 人民卫生出版社, 2016: 100-105.
11. Bray F, Parkin DM. Evaluation of data quality in the cancer registry: principles and methods. Part Ⅰ: comparability, validity and timeliness. Eur J Cancer, 2009, 45(5): 747-755.
12. 刘珊山, 李初谊, 郑英, 等. 1990–2019年中国胆囊癌疾病负担研究及未来趋势分析. 中国全科医学, 2024, 27(14): 1742-1749.
13. Iyer P, Barreto SG, Sahoo B, et al. Non-typhoidal Salmonella DNA traces in gallbladder cancer. Infect Agent Cancer, 2016, 11: 12. doi: 10.1186/s13027-016-0057-x.
14. Chan TF, Wu CH, Chiu HF, et al. Parity and risk of death from gallbladder cancer among a cohort of premenopausal parous women in Taiwan. Int J Environ Res Public Health, 2015, 12(2): 1864-1873.
15. 胡霄, 李丽, 欧阳一非, 等. 2000–2018年中国十六省(自治区、直辖市)7~17岁儿童青少年超重与肥胖流行趋势. 卫生研究, 2022, 51(4): 568-573.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Analysis of the prevalence status and trend of gallbladder cancer in Zhejiang Province from 2000 to 2021

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