Efficacy of bronchoscopy-guided <sup>125</sup>I seeds implantation combined with chemotherapy for advanced central type lung cancer _Chinese Journal of Respiratory and Critical Care Medicine

Authors：

 LIN Hui ¹ , SU Xianghua ² ,  XIAO Jianhong ¹

1. Respiratory Department, Mindong Hospital Affiliated to Fujian Medical University, Fu’an, Fujian 355000, P. R. China;
2. Neurosurgery Department, Mindong Hospital Affiliated to Fujian Medical University, Fu’an, Fujian 355000, P. R. China;

Corresponding author：

XIAO Jianhong, Email: xjh1030@sina.com

Keywords：

Electronic bronchoscopy; Lung neoplasms; Radioactive particles ¹²⁵I; Chemotherapy

DOI：

10.7507/1671-6205.201701022

Video：

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Objective To explore the efficacy and safety of bronchoscopy-guided radioactive ¹²⁵I seeds implantation combination with chemotherapy for advanced central type lung cancer. Methods Sixty-six patients with central type lung cancer in stage Ⅲb or Ⅳ were enrolled in this study from May 2014 to July 2016. The patients were randomly divided into two groups, ie. bronchoscopy-guided seeds implantation combined with chemotherapy group (experimental group, n=30) and chemotherapy group (control group, n=36). All patients accepted GP regimen (gemcitabine plus cisplatin) chemotherapy and were followed up by CT and electric bronchoscopy (EB) examination 1, 3, 5 months later. According to WHO unified standard, the efficacy and adverse effects were evaluated . Results In the experimental group and the control group, the response rate (complete response plus partial response) was 80.00% and 50.00%, respectively. There was significant difference between two groups (P<0.05). The incidence rate of hemoptysis in the experimental group was significantly higher than that in the control group (P<0.05), but there was no significant difference between the two groups in the incidence rate of pneumothorax, fever or bone marrow suppression (allP>0.05). All adverse reactions were light and could be controlled. Conclusions The short-term clinical efficacy is better in the bronchoscopy-guided seeds implantation combined with chemotherapy group. The bronchoscopy-guided seeds implantation combined with chemotherapy is a safe and minimally invasive treatment for advanced central type lung cancer.

Citation： LIN Hui, SU Xianghua, XIAO Jianhong. Efficacy of bronchoscopy-guided ¹²⁵I seeds implantation combined with chemotherapy for advanced central type lung cancer . Chinese Journal of Respiratory and Critical Care Medicine, 2017, 16(6): 567-570. doi: 10.7507/1671-6205.201701022 Copy

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14.	Neg S, Ellis RJ, Merrick GS, et al. American Brachytherapy Society Commendation for reporting morbidity after prostate brachytherapy. In J Radiat Biol Phys, 2002, 54(2): 462-470.
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16.	焦德超, 张福君, 陆郦工, 等. ¹²⁵I 粒子组织间植入治疗肺恶性肿瘤. 介入放射学杂志, 2008, 17(3): 190-193.
17.	胡晓坤, 王明友, 杨国志, 等. CT 导引经皮穿刺组织间植入 ¹²⁵I 放射微粒子治疗中心型肺癌的应用研究. 中华放射学杂志, 2004, 38(9): 910-915.
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19.	余红波, 崔亚利, 郭雨栋. ¹²⁵I 粒子与放疗分别联合化疗治疗Ⅲb 期 NSCLC 的比较. 实用肿瘤学杂志, 2008, 22(1): 23.

1. Zheng R, Zeng H, Zhang S, et al. National estimates of cancer prevalence in China, 2011. Cancer Lett, 2016, 370(1): 33-38.
2. Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012. CA Cancer J Clin, 2015, 65(2): 87-108.
3. Chen W, Zheng R, Baade PD, et al. Cancer statistics in china 2015.CA Cancer J Clin, 2016, 66(2): 115-132.
4. 李真斌, 汤晓梅, 易向军, 等. 电子支气管镜介导冷冻治疗联合放化疗治疗中晚期中央型 NSCLC 的临床研究. 中国医学创新, 2014, 11(36): 27-29.
5. 柯明耀, 吴雪梅, 林玉妹, 等. 经支气管镜置入支架及植入放射性粒子治疗肺癌中心气管狭窄. 中国内镜杂志, 2009, 15(3): 240-245.
6. 柯明耀, 姜燕, 王珠缎, 等. 经支气管镜植入放射性粒子治疗晚期中心型肺癌.临床肺科杂志, 2006, 11(2): 247-248.
7. 张旭, 岳世昌, 赵翌. 手术加 ¹²⁵I 粒子植入治疗肺癌的初步评价. 实用医学杂志, 2005, 21(4): 375.
8. 张福君, 李传行, 吴沛宏, 等. ¹²⁵I 粒子组织间植入治疗局部晚期肺癌的对比研究. 中华医学杂志, 2007, 86(47): 3272-3275.
9. 李力军, 马林, 吕大鹏, 等. 现代高新技术治疗恶性肿瘤. 北京: 人民军医出版社, 2003, 133-155.
10. 蒋美萍, 刘粉霞, 金红艳, 等. 局部中晚期非小细胞肺癌同步与序贯放化疗的疗效对比. 数理医药学杂志, 2010, 23(1): 57-58.
11. 周明, 王远东, 凌国辉, 等. 重组人血管内皮抑素与化疗联合治疗肺癌的时序性研究. 中华实验外科杂志, 2011, 28(10): 1743-1745.
12. 张明川, 梅同华, 厉明, 等. 持续小剂量化疗对 A549 肺癌生长及 VE-Cadherin 的影响. 肿瘤防治研究, 2011, 38(6): 624-627.
13. Furuse K, Fukuoka M, Kawahara M, et al. Phase Ⅲ study of concurrent versus sequential thoracic radiotherapy in combination with mitomycin, vindesine, and cisplatin in unresectable stage Ⅲ non-small-cell lung cancer. J Clin Oncol, 1999, 17(9): 2692.
14. Neg S, Ellis RJ, Merrick GS, et al. American Brachytherapy Society Commendation for reporting morbidity after prostate brachytherapy. In J Radiat Biol Phys, 2002, 54(2): 462-470.
15. 李玉亮, 王永正, 张福君. CT 引导下经皮穿刺植入 ¹²⁵I 粒子治疗老年中心型肺癌近期疗效分析. 中华肿瘤防治杂志, 2007, 14(23): 1818-1820.
16. 焦德超, 张福君, 陆郦工, 等. ¹²⁵I 粒子组织间植入治疗肺恶性肿瘤. 介入放射学杂志, 2008, 17(3): 190-193.
17. 胡晓坤, 王明友, 杨国志, 等. CT 导引经皮穿刺组织间植入 ¹²⁵I 放射微粒子治疗中心型肺癌的应用研究. 中华放射学杂志, 2004, 38(9): 910-915.
18. 马海涛, 吴翼伟, 秦涌, 等. 姑息性切除加术中 ¹²⁵I 种子源植入治疗晚期非小细胞肺癌. 中华核医学杂志, 2003, 23(6): 342-343.
19. 余红波, 崔亚利, 郭雨栋. ¹²⁵I 粒子与放疗分别联合化疗治疗Ⅲb 期 NSCLC 的比较. 实用肿瘤学杂志, 2008, 22(1): 23.

Chinese Journal of Respiratory and Critical Care Medicine

Efficacy of bronchoscopy-guided ¹²⁵I seeds implantation combined with chemotherapy for advanced central type lung cancer

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Efficacy of bronchoscopy-guided 125I seeds implantation combined with chemotherapy for advanced central type lung cancer

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Efficacy of bronchoscopy-guided ¹²⁵I seeds implantation combined with chemotherapy for advanced central type lung cancer