Correlative analysis of obstructive sleep apnea hypopnea syndrome and biochemical markers in children_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

 ZHU Peiqiang ¹ , LIU Dezhong ² , PAN Chongping ³

1. Department of Clinical Laboratory, Heze Maternal and Child Health-Care Hospital, Heze, Shandong 274014, P. R. China;
2. Department of Clinical Laboratory, Heze Traditional Chinese Medicine Hospital, Heze, Shandong 274014, P. R. China;
3. Department of Clinical Laboratory, Heze Municipal Hospital, Heze, Shandong 274014, P. R. China;

Corresponding author：

ZHU Peiqiang, Email: wangxue11w@163.com

Keywords：

Obstructive sleep apnea hypopnea syndrome; Children; Biochemical index; Relevance

DOI：

10.7507/1671-6205.201705030

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Objective To investigate the correlation between obstructive sleep apnea hypopnea syndrome (OSAHS) and biochemical indexes in children. Methods Seventy-eight children with OSAHS in our hospital from January 2015 to February 2017 were recruited as an observation group, and 100 normal children who underwent physical examination were selected as a control group in the same period. The mean values and positive rates of biochemical markers were compared between two groups including alanine aminotransferase (ALT), blood urea nitrogen (BUN), total cholesterol (TC), triglyceride (TG), creatine kinase isoenzyme (CK-MB), cardiac troponin I (cTnI), fasting blood glucose (FPG) level. Results The mean values of biochemical indexes showed significant differences between the observation group and the control group except BUN and FPG [ALT, (52.1±26.2) U/L vs. (41.3±18.5) U/L; TC, (4.9±0.9) mmol/L vs. (4.3±0.8) mmol/L; TG, (1.4±0.7) mmol/L vs. (1.0±0.4) mmol/L; CK-MB, (24.3±9.5) U/L vs. (11.2±8.2) U/L; cTnI, (1.4±0.7) μg/L vs. (1.0±0.6) μg/L] (all P<0.05). The positive rates also showed significant differences between the observation group and the control group except BUN and FPG [ALT (48.7%vs. 14.0%), TC (24.4% vs. 8.0%), TG (23.1% vs. 8.0%), CK-MB (41.0% vs. 11.0%), cTnI (34.6% vs. 7.0%) (all P<0.05). Conclusions The cardiac function and liver function are significantly impaired in children with OSAHS, showing the disorder of lipid metabolism to some extent. These abnormal indexes may be the occurrence and development of OSAHS. More attention should be paid to the detection of biochemical indexes in children with OSAHS.

Citation： ZHU Peiqiang, LIU Dezhong, PAN Chongping. Correlative analysis of obstructive sleep apnea hypopnea syndrome and biochemical markers in children. Chinese Journal of Respiratory and Critical Care Medicine, 2018, 17(2): 169-171. doi: 10.7507/1671-6205.201705030 Copy

1.	周艾. 儿童阻塞性睡眠呼吸暂停低通气综合征的腺样体检查. 临床肺科杂志, 2010, 15(11): 1602-1604.
2.	中华医学会耳鼻咽喉科学分会, 中华耳鼻咽喉头颈外科杂志编委会. 儿童阻塞性睡眠呼吸暂停低通气综合征诊疗指南草案 (乌鲁木齐). 中华耳鼻咽喉头颈外科杂志, 2007, 42(2): 83-84.
3.	常丽, 曹玲. 儿童阻塞性睡眠呼吸暂停低通气综合征血氧饱和度变化分析. 中国实用儿科杂志, 2011, 26(2): 131-133.
4.	郭建梅, 曹洁, 崔明亮, 等. OSAHS 患者咽部解剖与呼吸驱动的关系研究. 临床肺科杂志, 2012, 17(1): 18-19.
5.	张焕改, 蔡晓红, 李美丽, 等. 鼾症对儿童睡眠结构及生长发育的影响. 实用儿科临床杂志, 2010, 25(4): 252-254.
6.	穆亚平, 赵方, 马洪刚, 等. 儿童及青少年肥胖症糖脂代谢异常早期诊断和干预的研究. 中国实用儿科杂志, 2011, 26(8):587-591.
7.	许志飞, 安嘉清, 李豫川, 等. 肥胖儿童睡眠呼吸障碍与肥胖相关性调查研究. 中国实用儿科杂志, 2011, 26(4): 260-263.
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9.	Friedman M, Ibrahim H, Bass L. Clinical staging for sleep disordered breathing. Otolaryngol Head Neck Surg, 2012, 137 (1): 13-21.
10.	Kohler M, Bloch KE, Stradling JR. The role of the nose in the pathogenesis of obstructive sleep apnoea and snoring. Eur Respir J, 2014, 37(6): 1208-1215.
11.	Bhat TA, Panzica L, Kalathil SG, et al. Immune dysfunction in patients with chronic obstructive pulmonary disease. Ann Am Thorac soc, 2015, 12(2): S169-S175.
12.	李正功, 张勇, 李涛平, 等. 阻塞性睡眠呼吸暂停低通气综合征患者免疫功能的损伤及相关机制研究. 中华肺部疾病病杂志: 电子版, 2011, 4(4): 276-280.
13.	侯冬青, 王湘富, 杨辉红, 等. 阻塞性睡眠呼吸暂停低通气综合征的临床流行病学调查及相关因素分析. 医学临床研究, 2006, 23(3): 297-299.
14.	尹雪玲, 孟杰, 张伟, 等. CPAP 联合口腔矫治器治疗阻塞型睡眠呼吸暂停低通气综合征伴高血压疗效观察. 山东医药, 2014, 54(16): 45-46.
15.	黄家军, 刘畅, 苏炳泽, 等. 老年阻塞性睡眠呼吸暂停综合征多导睡眠图与认知功能的相关性. 中国老年学杂志, 2014, 34(20): 5700-5701.

1. 周艾. 儿童阻塞性睡眠呼吸暂停低通气综合征的腺样体检查. 临床肺科杂志, 2010, 15(11): 1602-1604.
2. 中华医学会耳鼻咽喉科学分会, 中华耳鼻咽喉头颈外科杂志编委会. 儿童阻塞性睡眠呼吸暂停低通气综合征诊疗指南草案 (乌鲁木齐). 中华耳鼻咽喉头颈外科杂志, 2007, 42(2): 83-84.
3. 常丽, 曹玲. 儿童阻塞性睡眠呼吸暂停低通气综合征血氧饱和度变化分析. 中国实用儿科杂志, 2011, 26(2): 131-133.
4. 郭建梅, 曹洁, 崔明亮, 等. OSAHS 患者咽部解剖与呼吸驱动的关系研究. 临床肺科杂志, 2012, 17(1): 18-19.
5. 张焕改, 蔡晓红, 李美丽, 等. 鼾症对儿童睡眠结构及生长发育的影响. 实用儿科临床杂志, 2010, 25(4): 252-254.
6. 穆亚平, 赵方, 马洪刚, 等. 儿童及青少年肥胖症糖脂代谢异常早期诊断和干预的研究. 中国实用儿科杂志, 2011, 26(8):587-591.
7. 许志飞, 安嘉清, 李豫川, 等. 肥胖儿童睡眠呼吸障碍与肥胖相关性调查研究. 中国实用儿科杂志, 2011, 26(4): 260-263.
8. Hassid S, Afrapoli AH, Decaestecker C, et al. UPPP for snoring: long-term results and patient satisfaction. Acta Otorhinolaryngol Belg, 2012, 66(2): 157-162.
9. Friedman M, Ibrahim H, Bass L. Clinical staging for sleep disordered breathing. Otolaryngol Head Neck Surg, 2012, 137 (1): 13-21.
10. Kohler M, Bloch KE, Stradling JR. The role of the nose in the pathogenesis of obstructive sleep apnoea and snoring. Eur Respir J, 2014, 37(6): 1208-1215.
11. Bhat TA, Panzica L, Kalathil SG, et al. Immune dysfunction in patients with chronic obstructive pulmonary disease. Ann Am Thorac soc, 2015, 12(2): S169-S175.
12. 李正功, 张勇, 李涛平, 等. 阻塞性睡眠呼吸暂停低通气综合征患者免疫功能的损伤及相关机制研究. 中华肺部疾病病杂志: 电子版, 2011, 4(4): 276-280.
13. 侯冬青, 王湘富, 杨辉红, 等. 阻塞性睡眠呼吸暂停低通气综合征的临床流行病学调查及相关因素分析. 医学临床研究, 2006, 23(3): 297-299.
14. 尹雪玲, 孟杰, 张伟, 等. CPAP 联合口腔矫治器治疗阻塞型睡眠呼吸暂停低通气综合征伴高血压疗效观察. 山东医药, 2014, 54(16): 45-46.
15. 黄家军, 刘畅, 苏炳泽, 等. 老年阻塞性睡眠呼吸暂停综合征多导睡眠图与认知功能的相关性. 中国老年学杂志, 2014, 34(20): 5700-5701.

Chinese Journal of Respiratory and Critical Care Medicine

Correlative analysis of obstructive sleep apnea hypopnea syndrome and biochemical markers in children

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