支气管颗粒细胞瘤一例并文献复习_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

田刚 , 葛继文 ,  刘心存

济宁医学院附属医院呼吸内二科（山东济宁 272029）;

Corresponding author：

刘心存, Email: tiangang930@126.com

Keywords：

颗粒细胞瘤; 支气管

DOI：

10.7507/1671-6205.201807001

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目的分析支气管颗粒细胞瘤（BGCT）的临床表现、诊断及治疗，提高医务人员对该病的认识。方法回顾性分析济宁医学院附属医院呼吸科 2017 年 6 月收治的 1 例 BGCT 患者的临床资料并进行相关文献复习。以“支气管，颗粒细胞瘤”、“Granular cell tumor，Bronchus or Bronchial”为关键词检索 2007 年 1 月至 2017 年 7 月中国知网、万方数据库及 PubMed 数据库的相关文献，共获文献 17 篇，选取临床资料齐全的文章共 8 篇，其中中文 4 篇，外文 4 篇。结果患者男性，40 岁，因"反复咯血 2 年，再发 2 d"入院。双源 CT 支气管动脉血管成像示双侧支气管动脉未见明显增粗，右肺中叶部分膨胀不全。电子支气管镜检查示右肺中间段支气管管壁息肉样新生物，表面可见血管。于新生物行钳夹及毛刷检查，病理报告颗粒细胞瘤。确诊为 BGCT 后行氩气刀局部切除及冷冻治疗，2017 年 8 月复查胸部 CT 及支气管镜未见明显异常。文献复习检索到 8 篇“支气管颗粒细胞瘤”相关文献，均为病例报道，共 8 例，包括本病例在内共 9 例，其中男 4 例，女 5 例，年龄 17～62 岁，中位年龄为 55 岁。3 例为查体发现，6 例有临床症状，临床症状以咯血、胸痛、胸闷、呼吸困难为主。8 例行经支气管肺活组织检查，1 例经开胸探查术，均经病理检查确诊，其中 6 例联合免疫组织化学确诊。患者确诊后，其中 5 例行外科手术切除，3 例经电子支气管镜摘除，1 例未行 GCT 的干预治疗。结论 BGCT 罕见，由于临床表现及影像学检查缺乏特异性，组织病理学检查是诊断的金标准。电子支气管镜在诊断与治疗方面均有重要意义。

Citation： 田刚, 葛继文, 刘心存. 支气管颗粒细胞瘤一例并文献复习. Chinese Journal of Respiratory and Critical Care Medicine, 2019, 18(1): 76-80. doi: 10.7507/1671-6205.201807001 Copy

1.	张大发, 唐进, 王宾, 等. 原发性支气管内颗粒细胞瘤一例. 江苏医药, 2007, 3(7): 717.
2.	Joung MK, Lee YJ, Chung CU, et al. A case of granular cell tumor of the trachea. Korean J Intern Med, 2007, 22(2): 101-105.
3.	姚刚, 罗晓琴, 陈永红. 支气管颗粒细胞瘤 1 例. 临床肺科杂志, 2008, 13(3): 294.
4.	Meyer MA, Becker JM, Quinones W. Endobronchial granular cell tumor: a case report. J Radiol Case Rep, 2010, 4(8): 29-35.
5.	王峥, 陈靖, 初建国. 支气管颗粒细胞瘤一例. 中华放射学杂志, 2013, 47(1): 94.
6.	魏建国, 袁晓露, 孙爱静. 原发支气管良性颗粒细胞瘤 1 例. 中国肿瘤临床, 2014, 41(5): 354.
7.	Kim HJ, An S, Kim HR. Primary bronchial granular cell tumor in an adult male. Korean J Thorac Cardiovasc Surg, 2014, 47(2): 193-196.
8.	Venur VA, Zhang G, Farver C, et al. Coexistent pulmonary granular cell tumor and adenocarcinoma of the lung. Transl Lung Cancer Res, 2014, 3(4): 262-264.
9.	Abrikossoff A. Uber Myome, ausgehend von der quergestreiften Willkürlichen muskulatur. Virchows Arch Pathol Anat, 1926, 260(1): 215-233.
10.	Funan HU. Clinical Dermatology. 12^th revision. In: Demis DJ, McGuire J, editors. Vol. 4. London: Harper and Row Publishers. 1982, 1-5.
11.	Guarnieri T, Cardinale L, Macchia G, et al. Multiphasic multidetector computed tomography study of a rare tracheal tumor: granular cell tumor. Case Rep Pulmonol, 2014, 2014: 807430.
12.	Fanburg-Smith JC, Meis-Kindblom JM, Fante R, et al. Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol, 1998, 22(7): 779-794.
13.	Fechner RE, Bentinck BR, Askew JB Jr. Acinic cell tumor of the lung. A histologic and ultrastructural study. Cancer, 1972, 29(2): 501-508.
14.	Gayen T, Das A, Shome K, et al. Granular cell tumor: an uncommon benign neoplasm. Indian J Dermatol, 2015, 60(3): 322.
15.	van der Maten J, Blaauwgeers JL, Sutedja TG, et al. Granular cell tumors of the tracheobronchial tree. J Thorac Cardiovasc Surg, 2003, 126(3): 740-743.
16.	Daniel TM, Smith RH, Faunce HF, et al. Transbronchoscopic versus surgical resection of the tracheobronchial granular cell myoblastoma: suggested approach based on follow-up of all treated cases. J Thorac Cardiovasc Surg, 1980, 80(6): 898-903.

1. 张大发, 唐进, 王宾, 等. 原发性支气管内颗粒细胞瘤一例. 江苏医药, 2007, 3(7): 717.
2. Joung MK, Lee YJ, Chung CU, et al. A case of granular cell tumor of the trachea. Korean J Intern Med, 2007, 22(2): 101-105.
3. 姚刚, 罗晓琴, 陈永红. 支气管颗粒细胞瘤 1 例. 临床肺科杂志, 2008, 13(3): 294.
4. Meyer MA, Becker JM, Quinones W. Endobronchial granular cell tumor: a case report. J Radiol Case Rep, 2010, 4(8): 29-35.
5. 王峥, 陈靖, 初建国. 支气管颗粒细胞瘤一例. 中华放射学杂志, 2013, 47(1): 94.
6. 魏建国, 袁晓露, 孙爱静. 原发支气管良性颗粒细胞瘤 1 例. 中国肿瘤临床, 2014, 41(5): 354.
7. Kim HJ, An S, Kim HR. Primary bronchial granular cell tumor in an adult male. Korean J Thorac Cardiovasc Surg, 2014, 47(2): 193-196.
8. Venur VA, Zhang G, Farver C, et al. Coexistent pulmonary granular cell tumor and adenocarcinoma of the lung. Transl Lung Cancer Res, 2014, 3(4): 262-264.
9. Abrikossoff A. Uber Myome, ausgehend von der quergestreiften Willkürlichen muskulatur. Virchows Arch Pathol Anat, 1926, 260(1): 215-233.
10. Funan HU. Clinical Dermatology. 12^th revision. In: Demis DJ, McGuire J, editors. Vol. 4. London: Harper and Row Publishers. 1982, 1-5.
11. Guarnieri T, Cardinale L, Macchia G, et al. Multiphasic multidetector computed tomography study of a rare tracheal tumor: granular cell tumor. Case Rep Pulmonol, 2014, 2014: 807430.
12. Fanburg-Smith JC, Meis-Kindblom JM, Fante R, et al. Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol, 1998, 22(7): 779-794.
13. Fechner RE, Bentinck BR, Askew JB Jr. Acinic cell tumor of the lung. A histologic and ultrastructural study. Cancer, 1972, 29(2): 501-508.
14. Gayen T, Das A, Shome K, et al. Granular cell tumor: an uncommon benign neoplasm. Indian J Dermatol, 2015, 60(3): 322.
15. van der Maten J, Blaauwgeers JL, Sutedja TG, et al. Granular cell tumors of the tracheobronchial tree. J Thorac Cardiovasc Surg, 2003, 126(3): 740-743.
16. Daniel TM, Smith RH, Faunce HF, et al. Transbronchoscopic versus surgical resection of the tracheobronchial granular cell myoblastoma: suggested approach based on follow-up of all treated cases. J Thorac Cardiovasc Surg, 1980, 80(6): 898-903.

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