Analysis of the correlation between UBE2Q1 expression and clinicopathological features and prognosis of lung adenocarcinoma_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

JIANG Wei ^1,2 , WANG Yuchao ^1,2 , XU Chunhua ^1,2 , ZOU Jue ³ ,  ZHANG Qian ^1,2

1. Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, Jiangsu 210029, P.R. China;
2. Respiratory Medicine Department of Thoracic Hospital, the Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R.China;
3. Department of Pathology, the Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R.China;

Corresponding author：

ZHANG Qian, Email: zqzlhys@163.com

Keywords：

UBE2Q1; lung adenocarcinoma; clinicopathological features; prognosis

DOI：

10.7507/1671-6205.202311014

Video：

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Objective To investigate the correlation between UBE2Q1 expression and clinicopathologic features and prognosis of lung adenocarcinoma. Methods This study retrospectively chose the cancer tissue and para-carcinoma tissue samples of 74 patients with stage I to III lung adenocarcinoma who received radical resection in Nanjing Chest Hospital from January 2013 to December 2016. Immunohistochemistry staining was used to detect the expression level of UBE2Q1, and patients were divided into high-expression group and low-expression group according to the Immunohistochemistry staining score. The correlation of UBE2Q1 expression level and clinicopathological characteristics was analyzed by Chi-square test. Kaplan-Meier survival curve analyzed the correlation between UBE2Q1 and prognosis of lung adenocarcinoma patients. The risk factors affecting the survival of lung adenocarcinoma patients were analyzed by univariate and multivariate Cox proportional risk models. Results UBE2Q1 was highly expressed in lung adenocarcinoma tissues, and the expression level was correlated with tumor diameter, lymph node metastasis, and TNM stage (P<0.05), and did not correlate with patients’ gender, age, smoking history, and tumor differentiation (P>0.05). The results of the Kaplan-Meier survival analysis showed that patients with low expression of UBE2Q1 compared with those with high expression of UBE2Q1 had longer DFS and OS (both P<0.05). Cox proportional risk model showed that tumor diameter, lymph node metastasis, TNM stage, and high UBE2Q1 expression were the risk factors for DFS and OS, among which TNM stage was an independent risk factor. Conclusion UBE2Q1 was highly expressed in lung adenocarcinoma tissues and correlated with large tumor diameter, lymph node metastasis, late TNM stage and poorer prognosis in lung adenocarcinoma, and UBE2Q1 was a risk factor for lung adenocarcinoma.

Citation： JIANG Wei, WANG Yuchao, XU Chunhua, ZOU Jue, ZHANG Qian. Analysis of the correlation between UBE2Q1 expression and clinicopathological features and prognosis of lung adenocarcinoma. Chinese Journal of Respiratory and Critical Care Medicine, 2024, 23(4): 237-241. doi: 10.7507/1671-6205.202311014 Copy

1.	罗汶鑫, 胡丹婧, 李为民. 年轻非小细胞肺癌的临床病理特征及预后研究. 中国呼吸与危重监护杂志, 2020, 19(5): 483-488.
2.	Chen P, Liu Y, Wen Y, et al. Non‐small cell lung cancer in China. Cancer Communications, 2022, 42(10): 937-970.
3.	Wei X, Li X, Hu S, et al. Regulation of Ferroptosis in Lung Adenocarcinoma. International Journal of Molecular Sciences, 2023, 24(19): 14614.
4.	Lu D, Yang J, Liu X, et al. Clinicopathological features, survival outcomes, and appropriate surgical approaches for stage I acinar and papillary predominant lung adenocarcinoma. Cancer Medicine, 2020, 9(10): 3455-3462.
5.	Herbst RS, Morgensztern D, Boshoff C. The biology and management of non-small cell lung cancer. NATURE, 2018, 553(7689): 446-454.
6.	Liu W, Tang X, Qi X, et al. The Ubiquitin Conjugating Enzyme: An Important Ubiquitin Transfer Platform in Ubiquitin-Proteasome System. Int J Mol Sci, 2020, 21(8): 2894.
7.	Bui QT, Hong JH, Kwak M, et al. Ubiquitin-Conjugating Enzymes in Cancer. Cells, 2021, 10(6): 1383.
8.	Hosseini SM, Okoye I, Chaleshtari MG, et al. E2 ubiquitin-conjugating enzymes in cancer: Implications for immunotherapeutic interventions. Clin Chim Acta, 2019, 498: 126-134.
9.	Grzmil P, Altmann ME, Adham IM, et al. Embryo implantation failure and other reproductive defects in Ube2q1-deficient female mice. Reproduction, 2013, 145(1): 45-56.
10.	Seghatoleslam A, Nikseresht M, Shafiee SM, et al. Expression of the novel human gene, UBE2Q1, in breast tumors. Mol Biol Rep, 2012, 39(5): 5135-5141.
11.	Shafiee SM, Seghatoleslam A, Nikseresht M, et al. UBE2Q1 expression in human colorectal tumors and cell lines. Mol Biol Rep, 2013, 40(12): 7045-7051.
12.	Chang R, Wei L, Lu Y, et al. Upregulated expression of ubiquitin-conjugating enzyme E2Q1 (UBE2Q1) is associated with enhanced cell proliferation and poor prognosis in human hapatocellular carcinoma. Journal of Molecular Histology, 2014, 46(1): 45-56.
13.	Zhang B, Deng C, Wang L, et al. Upregulation of UBE2Q1 via gene copy number gain in hepatocellular carcinoma promotes cancer progression through β-catenin-EGFR-PI3K-Akt-mTOR signaling pathway. Molecular Carcinogenesis, 2018, 57(2): 201-215.
14.	Zhan P, Xi G, Zhang B, et al. NCAPG2 promotes tumour proliferation by regulating G2/M phase and associates with poor prognosis in lung adenocarcinoma. Journal of Cellular and Molecular Medicine, 2016, 21(4): 665-676.
15.	Xia C, Dong X, Li H, et al. Cancer statistics in China and United States, 2022: profiles, trends, and determinants. Chinese Medical Journal, 2022, 135(5): 584-590.
16.	Dastsooz H, Cereda M, Donna D, et al. A Comprehensive Bioinformatics Analysis of UBE2C in Cancers. International Journal of Molecular Sciences, 2019, 20(9): 2228.
17.	Hou L, Li Y, Wang Y, et al. UBE2D1 RNA Expression Was an Independent Unfavorable Prognostic Indicator in Lung Adenocarcinoma, but Not in Lung Squamous Cell Carcinoma. Disease Markers, 2018, 2018: 1-8.
18.	Li H, Niu H, Peng Y, et al. Ubc9 promotes invasion and metastasis of lung cancer cells. Oncology Reports, 2013, 29(4): 1588-1594.
19.	Ma X, Qi W, Yang F, et al. UBE2L3 promotes lung adenocarcinoma invasion and metastasis through the GSK-3β/Snail signaling pathway. Am J Transl Res, 2022, 14(7): 4549-4561.
20.	Qin Y, Du J, Fan C. Ube2S regulates Wnt/β-catenin signaling and promotes the progression of non-small cell lung cancer. International Journal of Medical Sciences, 2020, 17(2): 274-279.
21.	Zhou W, Xu J, Li H, et al. Neddylation E2 UBE2F Promotes the Survival of Lung Cancer Cells by Activating CRL5 to Degrade NOXA via the K11 Linkage. Clinical Cancer Research, 2017, 23(4): 1104-1116.
22.	Zhu J, Ao H, Liu M, et al. UBE2T promotes autophagy via the p53/AMPK/mTOR signaling pathway in lung adenocarcinoma. Journal of Translational Medicine, 2021, 19(1): 374.
23.	Topno R, Singh I, Kumar M, et al. Integrated bioinformatic analysis identifies UBE2Q1 as a potential prognostic marker for high grade serous ovarian cancer. BMC Cancer, 2021, 21(1): 220.
24.	Fahmidehkar MA, Shafiee SM, Eftekhar E, et al. Induction of cell proliferation, clonogenicity and cell accumulation in S phase as a consequence of human UBE2Q1 overexpression. Oncol Lett, 2016, 12(3): 2169-2174.
25.	Shafiee SM, Rasti M, Seghatoleslam A, et al. UBE2Q1 in a Human Breast Carcinoma Cell Line: Overexpression and Interaction with p53. Asian Pacific Journal of Cancer Prevention, 2015, 16(9): 3723-3727.

1. 罗汶鑫, 胡丹婧, 李为民. 年轻非小细胞肺癌的临床病理特征及预后研究. 中国呼吸与危重监护杂志, 2020, 19(5): 483-488.
2. Chen P, Liu Y, Wen Y, et al. Non‐small cell lung cancer in China. Cancer Communications, 2022, 42(10): 937-970.
3. Wei X, Li X, Hu S, et al. Regulation of Ferroptosis in Lung Adenocarcinoma. International Journal of Molecular Sciences, 2023, 24(19): 14614.
4. Lu D, Yang J, Liu X, et al. Clinicopathological features, survival outcomes, and appropriate surgical approaches for stage I acinar and papillary predominant lung adenocarcinoma. Cancer Medicine, 2020, 9(10): 3455-3462.
5. Herbst RS, Morgensztern D, Boshoff C. The biology and management of non-small cell lung cancer. NATURE, 2018, 553(7689): 446-454.
6. Liu W, Tang X, Qi X, et al. The Ubiquitin Conjugating Enzyme: An Important Ubiquitin Transfer Platform in Ubiquitin-Proteasome System. Int J Mol Sci, 2020, 21(8): 2894.
7. Bui QT, Hong JH, Kwak M, et al. Ubiquitin-Conjugating Enzymes in Cancer. Cells, 2021, 10(6): 1383.
8. Hosseini SM, Okoye I, Chaleshtari MG, et al. E2 ubiquitin-conjugating enzymes in cancer: Implications for immunotherapeutic interventions. Clin Chim Acta, 2019, 498: 126-134.
9. Grzmil P, Altmann ME, Adham IM, et al. Embryo implantation failure and other reproductive defects in Ube2q1-deficient female mice. Reproduction, 2013, 145(1): 45-56.
10. Seghatoleslam A, Nikseresht M, Shafiee SM, et al. Expression of the novel human gene, UBE2Q1, in breast tumors. Mol Biol Rep, 2012, 39(5): 5135-5141.
11. Shafiee SM, Seghatoleslam A, Nikseresht M, et al. UBE2Q1 expression in human colorectal tumors and cell lines. Mol Biol Rep, 2013, 40(12): 7045-7051.
12. Chang R, Wei L, Lu Y, et al. Upregulated expression of ubiquitin-conjugating enzyme E2Q1 (UBE2Q1) is associated with enhanced cell proliferation and poor prognosis in human hapatocellular carcinoma. Journal of Molecular Histology, 2014, 46(1): 45-56.
13. Zhang B, Deng C, Wang L, et al. Upregulation of UBE2Q1 via gene copy number gain in hepatocellular carcinoma promotes cancer progression through β-catenin-EGFR-PI3K-Akt-mTOR signaling pathway. Molecular Carcinogenesis, 2018, 57(2): 201-215.
14. Zhan P, Xi G, Zhang B, et al. NCAPG2 promotes tumour proliferation by regulating G2/M phase and associates with poor prognosis in lung adenocarcinoma. Journal of Cellular and Molecular Medicine, 2016, 21(4): 665-676.
15. Xia C, Dong X, Li H, et al. Cancer statistics in China and United States, 2022: profiles, trends, and determinants. Chinese Medical Journal, 2022, 135(5): 584-590.
16. Dastsooz H, Cereda M, Donna D, et al. A Comprehensive Bioinformatics Analysis of UBE2C in Cancers. International Journal of Molecular Sciences, 2019, 20(9): 2228.
17. Hou L, Li Y, Wang Y, et al. UBE2D1 RNA Expression Was an Independent Unfavorable Prognostic Indicator in Lung Adenocarcinoma, but Not in Lung Squamous Cell Carcinoma. Disease Markers, 2018, 2018: 1-8.
18. Li H, Niu H, Peng Y, et al. Ubc9 promotes invasion and metastasis of lung cancer cells. Oncology Reports, 2013, 29(4): 1588-1594.
19. Ma X, Qi W, Yang F, et al. UBE2L3 promotes lung adenocarcinoma invasion and metastasis through the GSK-3β/Snail signaling pathway. Am J Transl Res, 2022, 14(7): 4549-4561.
20. Qin Y, Du J, Fan C. Ube2S regulates Wnt/β-catenin signaling and promotes the progression of non-small cell lung cancer. International Journal of Medical Sciences, 2020, 17(2): 274-279.
21. Zhou W, Xu J, Li H, et al. Neddylation E2 UBE2F Promotes the Survival of Lung Cancer Cells by Activating CRL5 to Degrade NOXA via the K11 Linkage. Clinical Cancer Research, 2017, 23(4): 1104-1116.
22. Zhu J, Ao H, Liu M, et al. UBE2T promotes autophagy via the p53/AMPK/mTOR signaling pathway in lung adenocarcinoma. Journal of Translational Medicine, 2021, 19(1): 374.
23. Topno R, Singh I, Kumar M, et al. Integrated bioinformatic analysis identifies UBE2Q1 as a potential prognostic marker for high grade serous ovarian cancer. BMC Cancer, 2021, 21(1): 220.
24. Fahmidehkar MA, Shafiee SM, Eftekhar E, et al. Induction of cell proliferation, clonogenicity and cell accumulation in S phase as a consequence of human UBE2Q1 overexpression. Oncol Lett, 2016, 12(3): 2169-2174.
25. Shafiee SM, Rasti M, Seghatoleslam A, et al. UBE2Q1 in a Human Breast Carcinoma Cell Line: Overexpression and Interaction with p53. Asian Pacific Journal of Cancer Prevention, 2015, 16(9): 3723-3727.

Chinese Journal of Respiratory and Critical Care Medicine

Analysis of the correlation between UBE2Q1 expression and clinicopathological features and prognosis of lung adenocarcinoma

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