Both Challenges and Opportunities in Evidence-based Stroke Practice— A Review of 2007’s Clinical Trials on Stroke Treatment_Chinese Journal of Evidence-Based Medicine

Authors：

 LIU Ming , LIU Zhiqin

Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

LIU Ming, Email: wyplmh@hotmail.com

Keywords：

Stroke; Randomized Controlled Trials; Evidence Based Medicine

DOI：

10.7507/1672-2531.20080017

Video：

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In 2007, the findings from clinical trials on stroke treatment have been both encouraging and disappointing. In order to interpret the challenges and opportunity in evidence-based stroke practice, we reviewed several major clinical trials in stroke that were published last year. It revealed that we should strengthen the evidence base for acute stroke care by conducting more high-quality randomized controlled trials and by increasing the energy, resources and manpower available for these trials.

Citation： LIU Ming,LIU Zhiqin. Both Challenges and Opportunities in Evidence-based Stroke Practice— A Review of 2007’s Clinical Trials on Stroke Treatment. Chinese Journal of Evidence-Based Medicine, 2008, 08(2): 71-73. doi: 10.7507/1672-2531.20080017 Copy

1.	Vahedi K, Hofmeijer J, Juettler E, et al. Early decompressive surgery in malignant infarction of the middle cerebral artery: a pooled analysis of three randomised controlled trials. Lancet Neurol, 2007, 6(3): 215-222.
2.	Quinn TJ, Lees KR. Advances in Emerging Therapies 2007. Stroke, 2008, 39: 255-257.
3.	Mant J, Hobbs FD, Fletcher K, et al. Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): a randomised controlled trial. Lancet, 2007, 370(9586): 493-503.
4.	Algra A. Medium intensity oral anticoagulants versus aspirin after cerebral ischaemia of arterial origin (ESPRIT): a randomised controlled trial. Lancet Neurol, 2007, 6(2): 115-124.
5.	Lees KR, Zivin JA, Ashwood T, et al. NXY-059 for acute ischemic stroke. N Engl J Med, 2006, 354(6): 588-600.
6.	Shuaib A, Lees KR, Lyden P, et al. NXY-059 for the treatment of acute ischemic stroke. N Engl J Med, 2007, 357(6): 562-571.
7.	Mayer SA, Brun NC, Begtrup K, et al. Recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med, 2005, 352(8): 777-785.
8.	Mayer SA, Brun NC, Begtrup K, et al. Randomized, placebo-controlled,double-blind phase III study to assess rFVIIa efficacy in acute cerebral haemorrhage: the FAST trial. Cerebrovasc Dis, 2007, 23(suppl 2): 10.
9.	Gray CS, Hildreth AJ, Sandercock PA, et al. Glucose-potassium-insulin infusions in the management of post-stroke hyperglycaemia: the UK Glucose Insulin in Stroke Trial (GIST-UK). Lancet Neurol, 2007, 6(5): 397-406.

1. Vahedi K, Hofmeijer J, Juettler E, et al. Early decompressive surgery in malignant infarction of the middle cerebral artery: a pooled analysis of three randomised controlled trials. Lancet Neurol, 2007, 6(3): 215-222.
2. Quinn TJ, Lees KR. Advances in Emerging Therapies 2007. Stroke, 2008, 39: 255-257.
3. Mant J, Hobbs FD, Fletcher K, et al. Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): a randomised controlled trial. Lancet, 2007, 370(9586): 493-503.
4. Algra A. Medium intensity oral anticoagulants versus aspirin after cerebral ischaemia of arterial origin (ESPRIT): a randomised controlled trial. Lancet Neurol, 2007, 6(2): 115-124.
5. Lees KR, Zivin JA, Ashwood T, et al. NXY-059 for acute ischemic stroke. N Engl J Med, 2006, 354(6): 588-600.
6. Shuaib A, Lees KR, Lyden P, et al. NXY-059 for the treatment of acute ischemic stroke. N Engl J Med, 2007, 357(6): 562-571.
7. Mayer SA, Brun NC, Begtrup K, et al. Recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med, 2005, 352(8): 777-785.
8. Mayer SA, Brun NC, Begtrup K, et al. Randomized, placebo-controlled,double-blind phase III study to assess rFVIIa efficacy in acute cerebral haemorrhage: the FAST trial. Cerebrovasc Dis, 2007, 23(suppl 2): 10.
9. Gray CS, Hildreth AJ, Sandercock PA, et al. Glucose-potassium-insulin infusions in the management of post-stroke hyperglycaemia: the UK Glucose Insulin in Stroke Trial (GIST-UK). Lancet Neurol, 2007, 6(5): 397-406.

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Both Challenges and Opportunities in Evidence-based Stroke Practice— A Review of 2007’s Clinical Trials on Stroke Treatment

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