Tongxinluo Capsule for Vertebrobasilar Artery Insufficiency: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

YANG Le ¹ ,  TANG Yao ² , XU Ting ² , CHENG Kai ¹

1. West China School of Pharmacy; Sichuan University, Chengdu 610041, China;2. Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

TANG Yao, Email: yangle1984_623@126.com

Keywords：

Tongxinluo; Vertebrobasilar artery insufficiency; Randomized controlled trial; Systematic review

DOI：

10.7507/1672-2531.20090043

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Objective 　To assess the effectiveness and safety of Tongxinluo Capsule in the treatment of vertebrobasilar artery insufficiency.
Methods 　The Cochrane Library, MEDLINE, VIP and CNKI were searched. Two authors independently collected data, including randomized controlled trials that met the inclusion criteria. They evaluated the quality of these trials and performed meta-analysis using The Cochrane Collaboration’s RevMan 5.0.
Results 　Eleven studies involving 1157 participants were included. All the included studies were inadequate at reporting randomization, concealment of allocation and blinding. Meta-analysis based on the included studies showed that Tongxinluo Capsule with Danshen was better than Danshen alone in vertebrobasilar artery insufficiency (RR= 1.35, 95%CI 1.24 to 1.48) and blood flow velocity of vertebrobasilar artery (WMD=3.60, 95%CI 2.44 to 4.77 and WMD=3.46, 95%CI 1.89 to 5.04). Tongxinluo Capsule with simple basic therapy was better than simple basic therapy alone in vertebrobasilar artery insufficiency (RR=1.21, 95%CI 1.11 to 1.31) and blood flow velocity of vertebrobasilar artery (WMD=3.85, 95%CI 2.19 to 5.51).
Conclusion 　 Tongxinluo Capsule is an effective and safe drug for vertebrobasilar artery insufficiency. However, due to the limited quantity and quality of the included studies, we can not draw a firm conclusion about the effectiveness of Tongxinluo Capsule compared to the simple basic therapy or Danshen. The results suggest that further and larger-scale trials using Tongxinluo Capsule for vertebrobasilar artery insufficiency are needed.

Citation： YANG Le,TANG Yao,XU Ting,CHENG Kai. Tongxinluo Capsule for Vertebrobasilar Artery Insufficiency: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2009, 09(2): 213-217. doi: 10.7507/1672-2531.20090043 Copy

1.	雷梅, 熊海, 王文志, 等. 通心络胶囊治疗椎基底动脉供血不足50例临床疗效评价. 海南医学院学报, 2007, 13(3): 248-253.
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5.	Stroke--1989. Recommendations on stroke prevention, diagnosis, and therapy. Report of the WHO Task Force on Stroke and other Cerebrovascular Disorders. Stroke, 1989, 20(10): 1407-1431.
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7.	路航, 哈迪拉热马赞. 通心络胶囊在椎-基底动脉供血不足性眩晕的应用. 新疆中医学, 2006, 24(5): 35-37.
8.	黄赛忠, 严立平, 屠明锋. 通心络胶囊联合敏使朗治疗椎-基底动脉供血不足疗效观察. 吉林中医药, 2006, 26(9): 46-49.
9.	陈同明, 陈雅琴, 刘玉娇, 等. 通心络胶囊提升椎-基底动脉系统血液流速42例多普勒观察. 中国医学文献, 内科学, 2006, 27(3): 263-265.
10.	黄文, 周华东, 陈满娥. 通心络胶囊治疗椎-基底动脉供血不足的80例疗效观察. 中国医师杂志, 2002, 增刊: 309-310.
11.	蔡海燕, 王巍, 石志敏. 通心络胶囊治疗椎基底动脉供血不足的疗效观察. 中国实用神经病学杂志, 2006, 10(3): 145-146.
12.	马海生. 通心络治疗椎-基底动脉供血不足临床观察. 中西医结合心脑血管杂志, 2005, 3(6): 557-558.
13.	武红斌. 通心络胶囊治疗椎-基底动脉供血不足60例疗效观察. 长治医学院学报, 2008, 22(4): 266-267.
14.	徐雄鹰, 卢军. 通心络加氟桂利嗪治疗椎基底动脉供血不足102例临床分析. 河南实用神经疾病杂志, 2003, 6(2): 4-6.
15.	李赛春, 邓红霞. 通心络胶囊治疗椎-基底动脉供血不足28例. 湖南中医学院学报, 2003, 23(6): 48-49.
16.	魏国健, 刘和强, 彭从健, 等. 通心络胶囊治疗椎动脉型颈椎病的疗效观察. 现代医院, 2006, 6(5): 75-76.

1. 雷梅, 熊海, 王文志, 等. 通心络胶囊治疗椎基底动脉供血不足50例临床疗效评价. 海南医学院学报, 2007, 13(3): 248-253.
2. 伍新林, 李俊彪, 张瑜, 等. 通心络胶囊对血脂及血粘状态的临床研究. 中国中医基础医学杂志, 2001, 7(5): 32-33.
3. 贾真, 顾复生. 通心络胶囊对血管内皮的影响. 中国医学论坛报, 2002年3月21日.
4. 吴宗贵. 通心络对实验性家兔主动脉粥样斑块内血管内皮因子表达的影响. 中国医学论坛报, 2003-04-17.
5. Stroke--1989. Recommendations on stroke prevention, diagnosis, and therapy. Report of the WHO Task Force on Stroke and other Cerebrovascular Disorders. Stroke, 1989, 20(10): 1407-1431.
6. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.1 [updated September 2008]. The Cochrane Collaboration, 2008. Available from www.cochranehandbook. org.
7. 路航, 哈迪拉热马赞. 通心络胶囊在椎-基底动脉供血不足性眩晕的应用. 新疆中医学, 2006, 24(5): 35-37.
8. 黄赛忠, 严立平, 屠明锋. 通心络胶囊联合敏使朗治疗椎-基底动脉供血不足疗效观察. 吉林中医药, 2006, 26(9): 46-49.
9. 陈同明, 陈雅琴, 刘玉娇, 等. 通心络胶囊提升椎-基底动脉系统血液流速42例多普勒观察. 中国医学文献, 内科学, 2006, 27(3): 263-265.
10. 黄文, 周华东, 陈满娥. 通心络胶囊治疗椎-基底动脉供血不足的80例疗效观察. 中国医师杂志, 2002, 增刊: 309-310.
11. 蔡海燕, 王巍, 石志敏. 通心络胶囊治疗椎基底动脉供血不足的疗效观察. 中国实用神经病学杂志, 2006, 10(3): 145-146.
12. 马海生. 通心络治疗椎-基底动脉供血不足临床观察. 中西医结合心脑血管杂志, 2005, 3(6): 557-558.
13. 武红斌. 通心络胶囊治疗椎-基底动脉供血不足60例疗效观察. 长治医学院学报, 2008, 22(4): 266-267.
14. 徐雄鹰, 卢军. 通心络加氟桂利嗪治疗椎基底动脉供血不足102例临床分析. 河南实用神经疾病杂志, 2003, 6(2): 4-6.
15. 李赛春, 邓红霞. 通心络胶囊治疗椎-基底动脉供血不足28例. 湖南中医学院学报, 2003, 23(6): 48-49.
16. 魏国健, 刘和强, 彭从健, 等. 通心络胶囊治疗椎动脉型颈椎病的疗效观察. 现代医院, 2006, 6(5): 75-76.

Chinese Journal of Evidence-Based Medicine

Tongxinluo Capsule for Vertebrobasilar Artery Insufficiency: A Systematic Review

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