A Multicentered, Double-blind, Randomized Controlled Trials of Gankeshuangqing Capsule in the Treatment of Wind-heat Syndrome (Acute Upper Respiratory Infection or Acute Bronchitis)_Chinese Journal of Evidence-Based Medicine

Authors：

1. Teaching Hospital of Chengdu University of Traditional Chinese Medicine; 2. The First Affiliated Hospital of Anhui University Of Traditional Chinese Medicine;3. Fujian Institude of Traditional Chinese Medicine;4. Teaching Hospital of Hubei college of Traditional Chinese Medicine;5. Post-doctoral Scientific Workstation in Kanghong pharmaceutical Group Limited Company;

Corresponding author：

Keywords：

Gankeshuangqing; Acute upper respiratory infection; Acute bronchitis; Randomize controlled trial; Double blinded; Multi-centre

DOI：

10.7507/1672-2531.20100036

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Objective 　To evaluate the therapeutic effect, safty and tolerance of Gankeshuangqing Capsule in the treatment of patients suffering from wind-heat syndrome (acute upper respiratory infection or acute bronchitis).
Methods 　The clinical trials were designed multicentered, double blind, double dummy, randomized and parallel positive drug controlled. A total of 289 patients participated in the trials. Those who suffered from acute upper respiratory infection were given throat virus-detection to make a definite diagnosis of the origins of disease.
Results 　Among the 40 patients who were diagnosed with virus infection, 81.82% in Gankeshuangqing group were healed, but only 50.00% in control group, and significant differences were observed between the two groups (P lt;0.05). At the end of the third day of treatment, the rates of cure and excellence in patients suffering from acute upper respiratory infection were 80.00% in Gankeshuangqing group, and 68.57% in control group, and both groups showed good therapeutic effect，but there was no significant difference between the two groups (P gt;0.05). At the end of the seventh day of treatment, the rates of cure and excellence in patients suffering from acute bronchitis were 82.35% in Gankeshuangqing group, and 63.77% in control group, and both groups showed good therapeutic effect, and there were significant differences between the two groups (P lt;0.05)；only one patient in Gankeshuangqing group had constipation during the treatment, but there was no evidence showing that it is caused by Gankeshuangqing.
Conclusion 　The results show that Gankeshuangqing Capsule has a definite effect on wind-heat syndrome (acute upper respiratory infection or acute bronchitis) with good safety.

Citation： DING Hong,YANG Mingjun,LV Bin,DONG Yan,LI Xijin,LUO Wenjing,JI Hongyan,ZHANG Zongming,ZHANG Nianzhi,WANG Sheng,LI Guolin,LI Xueling,ZHU Dayong,CHEN Shuangping,LIN Binghui,CHEN Zhibin,et al. A Multicentered, Double-blind, Randomized Controlled Trials of Gankeshuangqing Capsule in the Treatment of Wind-heat Syndrome (Acute Upper Respiratory Infection or Acute Bronchitis). Chinese Journal of Evidence-Based Medicine, 2010, 10(1): 14-22. doi: 10.7507/1672-2531.20100036 Copy

1.	Ono K, Nakane H, Fukushima M, et al. Inhibition of reverse transcriptase activity by a flanvonoid compound 5, 6, 7-trihydroxyflanvone. Biochemical and biophysical research communications, 1989, 160(3): 982-987.
2.	Nagai T, Miyaichi Y, tomimon T, et al. Inhibition of influenza virus sialidase and anti-influenza virus activity by plant flavonoids. chem. pharm. bull, 1990, 38(5): 1329-1332.
3.	Xia YF, Ye BQ, Li YD, et al. Andrographolide attenuates inflam mation by inhibition of NF-κB activation through covalent modification of reduced cysteine 62 of p50. J Immunol, 2004, 173(6): 4207-4217.
4.	包旭, 邱练芬, 胡开华. 黄心胶囊的体外抗病毒作用. 中药药理与临床, 2002, 18(4): 30-31.
5.	李强, 郝晓锋, 郭礼新, 等. 感咳双清胶囊抗病毒作用的实验研究. 中国药房, 2005, 16(24): 1859-1860.
6.	Chen F, Chan KH, Jiang Y, et al. In vitro susceptibility of 10 clinical isolates of SARS coronavirus toselected antiviral compounds. Journal of Clinical Virology, 2004, 31(1): 69-75 .

1. Ono K, Nakane H, Fukushima M, et al. Inhibition of reverse transcriptase activity by a flanvonoid compound 5, 6, 7-trihydroxyflanvone. Biochemical and biophysical research communications, 1989, 160(3): 982-987.
2. Nagai T, Miyaichi Y, tomimon T, et al. Inhibition of influenza virus sialidase and anti-influenza virus activity by plant flavonoids. chem. pharm. bull, 1990, 38(5): 1329-1332.
3. Xia YF, Ye BQ, Li YD, et al. Andrographolide attenuates inflam mation by inhibition of NF-κB activation through covalent modification of reduced cysteine 62 of p50. J Immunol, 2004, 173(6): 4207-4217.
4. 包旭, 邱练芬, 胡开华. 黄心胶囊的体外抗病毒作用. 中药药理与临床, 2002, 18(4): 30-31.
5. 李强, 郝晓锋, 郭礼新, 等. 感咳双清胶囊抗病毒作用的实验研究. 中国药房, 2005, 16(24): 1859-1860.
6. Chen F, Chan KH, Jiang Y, et al. In vitro susceptibility of 10 clinical isolates of SARS coronavirus toselected antiviral compounds. Journal of Clinical Virology, 2004, 31(1): 69-75 .

Chinese Journal of Evidence-Based Medicine

A Multicentered, Double-blind, Randomized Controlled Trials of Gankeshuangqing Capsule in the Treatment of Wind-heat Syndrome (Acute Upper Respiratory Infection or Acute Bronchitis)

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