Neoadjuvant Intraarterial Chemotherapy in the Treatment of Advanced Cervical Cancer: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

SHI Wentao ¹ , FENG Ying ¹ , JIANG Yushu ¹ , HE Qianwen ¹ ,  WEI Lei ^1,2

1. Department of Pathophysiology, Medical College, Wuhan University, Wuhan, Hubei 430071; 2. Research Center of Structural Biology, Wuhan University, Wuhan, Hubei 430071;

Corresponding author：

WEI Lei, Email: leiweifr@hotmail.com

Keywords：

Uterine cervical neoplasms; Neoadjuvant intraarterial chemotherapy; Systematic Review; Meta-analysis

DOI：

10.7507/1672-2531.20100429

Video：

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Objective 　To assess the efficacy and safety of neoadjuvant intraarterial chemotherapy in the treatment of advanced cervical cancer.
Methods 　We searched databases including PubMed, EMbase, The Cochrane Library, VIP, CNKI, CBMdisc, conference articles, and Ongoing Controlled Trial for Random Controlled Trials and quasi-Random Controlled Trials up to October 2009. For homogeneous studies, we performed meta-analysis.
Results 　Fifteen studies involving 1 331 participants with advanced cervical cancer were included. Twelve studies showed that the efficacy of the NIC group was 6.72 times than that of the traditional group. Several studies showed that the survival rate of the NIC group was better than that of the traditional group. Meanwhile, the adverse events of the NIC group were fewer than those of the traditional group.
Conclusions 　The results of this system review show that, NIC which is more effective than conventional treatments with less adverse reactions provides a new adjunct for clinical treatment of advanced cervical cancer . However, due to the current clinical treatment for the disease is the coexistence of multiple chemotherapy program status, the higher quality and more focused clinical research which will compare NIC with a variety of conventional chemotherapy are needed in the further.

Citation： SHI Wentao,FENG Ying,JIANG Yushu,HE Qianwen,WEI Lei. Neoadjuvant Intraarterial Chemotherapy in the Treatment of Advanced Cervical Cancer: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2010, 10(4): 463-470. doi: 10.7507/1672-2531.20100429 Copy

1.	史妍嫣, 王丰莲. 贝伐单抗联合PB方案治疗中晚期宫颈癌的临床观察. 中国医疗前沿, 2009, 4(7): 104-105.
2.	王登凤, 胡丽娜. 宫颈癌的预防研究进展. 肿瘤预防与治疗, 2008, 21(4): 349-352．.
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13.	王焱, 贾海宁, 李莉莉, 等. 超选择动脉插管持续灌注化疗治疗晚期宫颈癌临床疗效观察. 河南诊断与治疗杂志, 1998, 12(3): 190-191.
14.	林华强, 郭兴杰. 诺维本联合顺铂、阿霉素用于中晚期宫颈癌术前介入治疗的临床研究. 中国伤残医学, 2007, 15(1): 23-25.
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19.	张志安, 易红艳, 江燕丽. 先期髂内动脉灌注化疗加栓塞治疗巨块型宫颈癌疗效观察. 中华临床医学研究杂志, 2005, 11(15): 2133-2134.
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21.	谢榕, 林肖玉. 125例宫颈鳞癌化疗合并放疗与单纯放疗的疗效分析. 浙江肿瘤, 1996, 2(2): 69-69.
22.	候金峰, 霍志军, 王世江. 介入栓塞化疗联合放疗应用于中晚期子宫颈癌治疗的疗效观察. 安徽医药, 2009, 13(1): 69-71.
23.	牛长庚. 中晚期宫颈癌放疗联合介入化疗临床观察. 中国误诊学杂志, 2007, 7(1): 72-73.
24.	陈春林, 谭道彩, 梁立志. 动静脉灌注化疗子宫颈癌组织药物浓度的比较. 中华妇产科杂志, 1995, 30(5): 298.

1. 史妍嫣, 王丰莲. 贝伐单抗联合PB方案治疗中晚期宫颈癌的临床观察. 中国医疗前沿, 2009, 4(7): 104-105.
2. 王登凤, 胡丽娜. 宫颈癌的预防研究进展. 肿瘤预防与治疗, 2008, 21(4): 349-352．.
3. Fischer U, Raptis G, Gessner W, et al. Epidemiologie und formale pathogenese des zervixkarzinoms (epidemiology and pathogenesis of cervical cancer). Zentralblatt fur Gynakologie, 2001, 123(4): 198-205.
4. Parkin DM, Bray F, Ferlay J, et al. Estimating the world cancer burden: globocan 2000. International journal of cancer Journal International du Cancer, 2001, 94(2): 153-156．.
5. 郭述真. 子宫颈癌ABC. 人人健康, 2001, 2: 24-26.
6. 包影, 李楷滨. 宫颈癌的新辅助动脉化疗. 实用妇产科杂志, 2003, 19(4): 208-209.
7. 林仲秋. FIGO/IGCS 妇科恶性肿瘤分期及临床实践指南之三：宫颈癌. 国际妇产科学杂志, 2008, 35(3): 226-228.
8. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.1 [updated September 2008]. The Cochrane Collaboration, 2008. Available from www.cochranehandbook. org.
9. 金华, 杨建梅, 古丽娜•库尔班. 宫颈癌巨块型介入治疗的近期临床疗效观察. 新疆医学, 2006, 36: 17-19.
10. 耿进朝, 张勇, 李明山, 等. 超选择性TACE和静脉化疗治疗宫颈癌的临床应用. 中国临床医学影像杂志, 2004, 15(3): 155-157.
11. 夏风云, 高峰, 蒋春林. 腹壁下动脉插管化疗在中晚期宫颈癌治疗中的价值. 新乡医学院学报, 1998, 15(3): 278-279.
12. 谢晓英, 罗红凤. 介入治疗联合放疗在中晚期宫颈癌的近期疗效观察. 赣南医学院学报, 2005, 25(4): 445-446.
13. 王焱, 贾海宁, 李莉莉, 等. 超选择动脉插管持续灌注化疗治疗晚期宫颈癌临床疗效观察. 河南诊断与治疗杂志, 1998, 12(3): 190-191.
14. 林华强, 郭兴杰. 诺维本联合顺铂、阿霉素用于中晚期宫颈癌术前介入治疗的临床研究. 中国伤残医学, 2007, 15(1): 23-25.
15. 牛书怀, 吕俊玲, 房朝晖. 晚期宫颈癌两种治疗方法的临床分析. 实用癌症杂志, 1997, 12(3): 224-224.
16. 解国清, 敖国昆, 乔丽亚, 等. 中晚期宫颈癌术前介入治疗的临床研究. 中国肿瘤临床与康复, 2009, 16(2): 165-166.
17. 杨运胜, 高国兰, 徐仁根, 等. 介入化疗加后装腔内放疗在Ⅱb期宫颈癌术前治疗中的作用探讨. 江西医药, 2006, 41(5): 249-251.
18. 刘国燕, 许倩, 郜智慧. 介入化疗在中晚期宫颈癌综合治疗中的临床应用. 现代肿瘤医学, 2008, 6(4): 639-641.
19. 张志安, 易红艳, 江燕丽. 先期髂内动脉灌注化疗加栓塞治疗巨块型宫颈癌疗效观察. 中华临床医学研究杂志, 2005, 11(15): 2133-2134.
20. 李玲, 隋丽华, 程丽坤, 等. IIb期子宫颈癌患者术前动脉插管化疗的十年观察. 中华妇产科杂志, 1989, 24(1): 37-39.
21. 谢榕, 林肖玉. 125例宫颈鳞癌化疗合并放疗与单纯放疗的疗效分析. 浙江肿瘤, 1996, 2(2): 69-69.
22. 候金峰, 霍志军, 王世江. 介入栓塞化疗联合放疗应用于中晚期子宫颈癌治疗的疗效观察. 安徽医药, 2009, 13(1): 69-71.
23. 牛长庚. 中晚期宫颈癌放疗联合介入化疗临床观察. 中国误诊学杂志, 2007, 7(1): 72-73.
24. 陈春林, 谭道彩, 梁立志. 动静脉灌注化疗子宫颈癌组织药物浓度的比较. 中华妇产科杂志, 1995, 30(5): 298.

Chinese Journal of Evidence-Based Medicine

Neoadjuvant Intraarterial Chemotherapy in the Treatment of Advanced Cervical Cancer: A Systematic Review

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