Levels of Plasma Fibrinogen, Serum Bilirubin, Uric Acid and Mild Stenosis of Coronary Artery: A Relationship Analysis_Chinese Journal of Evidence-Based Medicine

Authors：

WANG Su ¹ , HUANG Ji ¹ , WANG Yan ² , ZHANG Jingmei ¹ , Tao Ying ¹ , YIN Chengqian ¹ , SUN Tao ¹ , QUE Bin ¹ ,  LI Zhizhong ¹

1. Emergency Center, Beijing Anzhen Hospital, Capital University of Medical Sciences, Beijing 100029, China;2. Laboratory Department, Beijing Anzhen Hospital, Capital University of Medical Sciences, Beijing 100029, China;

Corresponding author：

LI Zhizhong, Email: lzzeagle2@sina.com

Keywords：

Fibrinogen; Bilirubin; Uric acid; Mild stenosis of coronary artery

DOI：

10.7507/1672-2531.20100448

Video：

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Objective 　To study the relationship between the levels of plasma fibrinogen, serum bilirubin, uric acid and mild stenosis of coronary artery.
Methods 　Patients with suspected myocardial ischemia who underwent coronary angiography in our hospital were divided into the coronary artery mild stenosis group and the normal control group according to the result of coronary arteriongraphy between April 2007 to May 2009. Logistic regression was used to identify the risk factor of mild stenosis of coronary artery.
Results 　Two-hundred and seventy-nine patients involving 191 patients with mild stenosis of coronary artery and 88 patients with normal coronary artery were included. The factors of gender, age, history of hypertension or diabetes mellitus, smoking history, systolic blood pressure, levels of plasma fibrinogen and serum creatinin were significantly different between the two groups. Multivariate logistic regression models found that the factors of age (OR=1.084, 95%CI 1.040 to 1.129, P lt;0.001), hypertension (OR=3.025, 95%CI 1.462 to 6.261, P=0.003), diabetes mellitus (OR=2.519, 95%CI 1.066 to 5.951, P=0.035), smoking history (OR=5.412, 95%CI 2.186 to 13.401, P lt;0.001), plasma fibrinogen (OR=1.748, 95%CI 1.059 to 2.885, P=0.029), serum bilirubin (OR=0.599, 95%CI 0.418 to 0.858, P=0.005), and high-density lipoprotein (HDL) cholesterol (OR=0.219, 95%CI 0.049 to 0.985, P=0.048) were independently associated with mild stenosis of coronary artery. By contrast, the level of serum uric acid was not associated with mild stenosis of coronary artery.
Conclusion 　Except for traditional risk factors, levels of fibrinogen and bilirubin are independent risk factors of mild stenosis of coronary artery.

Citation： WANG Su,HUANG Ji,WANG Yan,ZHANG Jingmei,Tao Ying,YIN Chengqian,SUN Tao,QUE Bin,LI Zhizhong. Levels of Plasma Fibrinogen, Serum Bilirubin, Uric Acid and Mild Stenosis of Coronary Artery: A Relationship Analysis. Chinese Journal of Evidence-Based Medicine, 2010, 10(5): 555-557. doi: 10.7507/1672-2531.20100448 Copy

1.	刘梅颜, 胡大一, 严俊儒, 等. 冠心病患者血浆纤维蛋白原改变的临床意义探讨. 中华心血管病杂志, 2005, 33(9): 815-816.
2.	姚友杰, 杨敏华, 许炳灿, 等. 血清尿酸、胆红素和超敏C反应蛋白与冠状动脉病变程度关系研究. 中国介入心脏病学杂志, 2008, 16(6): 323-327.
3.	岳晓春. 血清胆红素与冠心病关系的临床研究. 第四军医大学学报, 2008, 29(23): 2130.
4.	刘梅颜, 胡大一. 尿酸水平对冠脉病变的预测. 西安交通大学学报 (医学版), 2006, 27(1): 36-38.
5.	彭永权, 周锡平. 108例冠心病患者血浆纤维蛋白原与冠状动脉狭窄程度的临床研究. 中国循环杂志, 2008, 23(4): 313.
6.	Tanaka M, Fukui M, Tomiyasuc K, et al. Low serum bilirubin concentration is associated with coronary artery calcification (CAC). Atherosclerosis, 2009, 206(1): 287-291.
7.	Coutinho TA, Turner ST, Peyser PA, et al. Associations of Serum Uric Acid With Markers of Inflammation, Metabolic Syndrome, and Subclinical Coronary Atherosclerosis. Am J Hypertension, 2007, 20(1): 83-89.
8.	Santos RD, Nasir K, Orakzai R, et al. Relation of Uric Acid Levels to Presence of Coronary Artery Calcium Detected by Electron Beam Tomography in Men Free of Symptomatic Myocardial Ischemia With Versus Without the Metabolic Syndrome. Am J Cardiol, 2007, 99(1): 42-45.

1. 刘梅颜, 胡大一, 严俊儒, 等. 冠心病患者血浆纤维蛋白原改变的临床意义探讨. 中华心血管病杂志, 2005, 33(9): 815-816.
2. 姚友杰, 杨敏华, 许炳灿, 等. 血清尿酸、胆红素和超敏C反应蛋白与冠状动脉病变程度关系研究. 中国介入心脏病学杂志, 2008, 16(6): 323-327.
3. 岳晓春. 血清胆红素与冠心病关系的临床研究. 第四军医大学学报, 2008, 29(23): 2130.
4. 刘梅颜, 胡大一. 尿酸水平对冠脉病变的预测. 西安交通大学学报 (医学版), 2006, 27(1): 36-38.
5. 彭永权, 周锡平. 108例冠心病患者血浆纤维蛋白原与冠状动脉狭窄程度的临床研究. 中国循环杂志, 2008, 23(4): 313.
6. Tanaka M, Fukui M, Tomiyasuc K, et al. Low serum bilirubin concentration is associated with coronary artery calcification (CAC). Atherosclerosis, 2009, 206(1): 287-291.
7. Coutinho TA, Turner ST, Peyser PA, et al. Associations of Serum Uric Acid With Markers of Inflammation, Metabolic Syndrome, and Subclinical Coronary Atherosclerosis. Am J Hypertension, 2007, 20(1): 83-89.
8. Santos RD, Nasir K, Orakzai R, et al. Relation of Uric Acid Levels to Presence of Coronary Artery Calcium Detected by Electron Beam Tomography in Men Free of Symptomatic Myocardial Ischemia With Versus Without the Metabolic Syndrome. Am J Cardiol, 2007, 99(1): 42-45.

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Levels of Plasma Fibrinogen, Serum Bilirubin, Uric Acid and Mild Stenosis of Coronary Artery: A Relationship Analysis

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