Correlation between TNF-α Promoter–308A/G Polymorphism and Systemic Lupus Erythematosus in Chinese Populations: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

GAO Xiang ¹ ,  LV Ling ¹ , WANG Xiaoqin ²

1. Department of Rheumatology, Huashan Hospital Affiliated with Fudan University, Shanghai 200040, China;2. Department of Hemotology, Huashan Hospital Affiliated with Fudan University, Shanghai 200040, China;

Corresponding author：

LV Ling, Email: huashanlvling@sina.com

Keywords：

Meta-analysis; TNF-α; Systemic lupus erythematosus; Genetic polymorphisms; Chinese populations

DOI：

10.7507/1672-2531.20100544

Video：

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Objective 　To summarize results of the correlation of tumor necrosis factor-α (TNF-α) promoter –308A/G polymorphism with systemic lupus erythematosus (SLE) susceptibility in Chinese populations.
Methods 　We collected all the publications about the correlation between TNF-α promoter –308A/G polymorphism and SLE in Chinese populations by searching PubMed, EBSCO, CBM, CNKI and Wanfang Data before the date of March 20, 2010. Meta-analysis was performed for checking the difference between two groups about genotypes such as AA versus GG, GA versus GG, AA versus GG+GA, GA+AA versus GG, and A allele versus G allele.
Results 　A total of 8 studies involving 731 SLE patients and 901 healthy people were included. The meta-analysis of total populations showed that, there was no significant correlation between A allele and increased SLE risk (OR=1.42, 95%CI 0.97 to 2.09, P=0.07); the meta-analyses of populations in different regions showed there was no significant correlation of A allele and increased SLE risk in Chinese Taiwan populations (OR=1.04, 95%CI 0.77 to 1.40, P=0.82). Moreover, there was no significant difference between SLE group and control group in the genotypes of AA versus GG, GA versus GG, AA versus GG+GA, and GA+AA versus GG.
Conclusion 　This meta-analysis dosen’t demonstrate the correlation between TNF-α promoter–308A/G polymorphism and SLE in Chinese populations.

Citation： GAO Xiang,LV Ling,WANG Xiaoqin. Correlation between TNF-α Promoter–308A/G Polymorphism and Systemic Lupus Erythematosus in Chinese Populations: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2010, 10(9): 1053-1057. doi: 10.7507/1672-2531.20100544 Copy

1.	Harley JB, Moser KL, Gaffney PM, et al. The genetics of human systemic lupus erythematosus. Curr Opin Immunol, 1998, 10(6): 690-696.
2.	Vyse TJ, Kotzin BL. Genetic basis of systemic lupus erythematosus. Curr Opin Immunol, 1996, 8(6): 843-851.
3.	Wilson AG, de Vries N, Pociot F, et al. An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles. J Exp Med, 1993, 177(2): 557-560.
4.	Fedczyna TO, Lutz J, Pachman LM. Expression of TNF alpha by muscle fibers in biopsies from children with untreated juvenile dermatomyositis: association with the TNFalpha-308A allele. Clin Immunol, 2001, 100(2): 236-239.
5.	Studnicka-Benke A, Steiner G, Petera P, et al. Tumour necrosis factor alpha and its soluble receptors parallel clinical disease and autoimmune activity in systemic lupus erythematosus. Br J Rheumatol, 1996, 35(11): 1067-1074.
6.	Rood MJ, van Krugten MV, Zanelli E, et al. TNF-308A and HLA-DR3 alleles contribute independently to susceptibility to systemic lupus erythematosus. Arthritis Rheum, 2000, 43(1): 129-134.
7.	van der Linden MW, van der Slik AR, Zanelli E, et al. Six microsatellite markers on the short arm of chromosome in relation to HLA-DR3 and TNF-308A in systemic lupus erythematosus. Genes Immun, 2001, 2(7): 373-380.
8.	May LA, Huang Q, Morris D, et al. Relationship of tumour necrosis factor alpha gene polymorphisms and neuropsychiatric lupus. Lupus, 2002, 11(2): 114-118.
9.	Parks CG, Pandey JP, Dooley MA, et al. Genetic polymorphisms in tumor necrosis factor (TNF)-alpha and TNF-beta in a populationbased study of systemic lupus erythematosus: associations and interaction with the interleukin-1alpha-889 C/T polymorphism. Hum Immunol, 2004, 65(6): 622-631.
10.	Bayley JP, de Rooij H, van den Elsen PJ, et al. Functional analysis of linker-scan mutants spanning the -376, -308, -244, and -238 polymorphic sites of the TNF-alpha promoter. Cytokine, 2001, 14(6): 316-323.
11.	吴晓梅, 时玥, 时景璞, 等. 中国汉族人群脑出血患者血管紧张素转换酶基因插入/缺失多态性的Meta分析. 中国循证医学杂志, 2009, 9(12): 1323-1327.
12.	李静, 康德英. 系统评价与meta分析. 见: 王家良, 主编. 临床流行病学: 临床科研设计、测量与评价. 上海: 上海科学技术出版社, 2009. 264-268.
13.	Lin YJ, Chen RH, Wan L, et al. Association of TNF-alpha gene polymorphisms with systemic lupus erythematosus in Taiwanese patients. Lupus, 2009, 18(11): 974-979.
14.	Tsai LJ, Hsiao SH, Tsai LM, et al. The sodium-dependent glucose cotransporter SLC5A11 as an autoimmune modiWer gene in SLE. Tissue Antigens, 2008, 71(2): 114-126.
15.	Lu LY, Cheng HH, Sung PK, et al. Tumor necrosis factor-beta +252A polymorphism is associated with systemic lupus erythematosus in Taiwan. J Formos Med Assoc, 2005, 104(8): 563-570.
16.	付朝伟, 沈福民, 江峰, 等. 肿瘤坏死因子A基因多态性与系统性红斑狼疮的相关研究. 中华医学遗传学杂志, 2002, 19(6): 532-533.
17.	刘稚然, 唐坤, 施为, 等. 系统性红斑狼疮患者肿瘤坏死因子α基因多态性研究. 中华皮肤科杂志, 2001, 34(1): 56.
18.	王敏, 董怡, 黄尚志, 等. 肿瘤坏死因子α基因多态性及其与系统性红斑狼疮的相关性. 中华内科杂志, 1999, 38(6): 393-396.
19.	王育新, 章友康, 朱世乐, 等. 肿瘤坏死因子的基因多态性与系统性红斑狼疮的相关性分析. 中华医学杂志, 1998, 78(2): 111-114.
20.	Chen CJ, Yen JH, Tsai WC, et al. The TNF2 allele does not contribute towards susceptibility to systemic lupus erythematosus. Immunol Lett, 1997, 55(1): 1-3.
21.	Huizinga TW, Westendorp RG, Bollen EL, et al. TNF-alpha promoter polymorphisms, production and susceptibility to multiple sclerosis in different groups of patients. J Neuroimmunol, 1997, 72(2): 149-153.
22.	Lee YH, Harley JB, Nath SK. Meta-analysis of TNF-alpha promoter –308A/G polymorphism and SLE susceptibility. Eur J Hum Genet, 2006, 14(3): 364-371.
23.	Zou YF, Feng XL, Tao JH, et al. Meta-analysis of TNF-alpha promoter -308A/G polymorphism and SLE susceptibility in Asian populations. Rheumatol Int, 2010 Mar 24. [Epub ahead of print]:.
24.	Fong KY, Howe HS, Tin SK, et al. Polymorphism of the regulatory region of tumour necrosis factor alpha gene in patients with systemic lupus erythematosus. Ann Acad Med Singapore, 1996, 25(1): 90-93.
25.	Azizah MR, Kuak SH, Ainol SS, et al. Association of the tumor necrosis factor alpha gene polymorphism with susceptibility and clinical-immunological Wndings of systemic lupus erythematosus. Asian Pac J Allergy Immunol, 2004, 22(2-3): 159-163.
26.	沈洪兵. 循证医学. 见: 姜庆五, 主编. 临床流行病学. 北京: 高等教育出版社, 2007, 240-250.

1. Harley JB, Moser KL, Gaffney PM, et al. The genetics of human systemic lupus erythematosus. Curr Opin Immunol, 1998, 10(6): 690-696.
2. Vyse TJ, Kotzin BL. Genetic basis of systemic lupus erythematosus. Curr Opin Immunol, 1996, 8(6): 843-851.
3. Wilson AG, de Vries N, Pociot F, et al. An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles. J Exp Med, 1993, 177(2): 557-560.
4. Fedczyna TO, Lutz J, Pachman LM. Expression of TNF alpha by muscle fibers in biopsies from children with untreated juvenile dermatomyositis: association with the TNFalpha-308A allele. Clin Immunol, 2001, 100(2): 236-239.
5. Studnicka-Benke A, Steiner G, Petera P, et al. Tumour necrosis factor alpha and its soluble receptors parallel clinical disease and autoimmune activity in systemic lupus erythematosus. Br J Rheumatol, 1996, 35(11): 1067-1074.
6. Rood MJ, van Krugten MV, Zanelli E, et al. TNF-308A and HLA-DR3 alleles contribute independently to susceptibility to systemic lupus erythematosus. Arthritis Rheum, 2000, 43(1): 129-134.
7. van der Linden MW, van der Slik AR, Zanelli E, et al. Six microsatellite markers on the short arm of chromosome in relation to HLA-DR3 and TNF-308A in systemic lupus erythematosus. Genes Immun, 2001, 2(7): 373-380.
8. May LA, Huang Q, Morris D, et al. Relationship of tumour necrosis factor alpha gene polymorphisms and neuropsychiatric lupus. Lupus, 2002, 11(2): 114-118.
9. Parks CG, Pandey JP, Dooley MA, et al. Genetic polymorphisms in tumor necrosis factor (TNF)-alpha and TNF-beta in a populationbased study of systemic lupus erythematosus: associations and interaction with the interleukin-1alpha-889 C/T polymorphism. Hum Immunol, 2004, 65(6): 622-631.
10. Bayley JP, de Rooij H, van den Elsen PJ, et al. Functional analysis of linker-scan mutants spanning the -376, -308, -244, and -238 polymorphic sites of the TNF-alpha promoter. Cytokine, 2001, 14(6): 316-323.
11. 吴晓梅, 时玥, 时景璞, 等. 中国汉族人群脑出血患者血管紧张素转换酶基因插入/缺失多态性的Meta分析. 中国循证医学杂志, 2009, 9(12): 1323-1327.
12. 李静, 康德英. 系统评价与meta分析. 见: 王家良, 主编. 临床流行病学: 临床科研设计、测量与评价. 上海: 上海科学技术出版社, 2009. 264-268.
13. Lin YJ, Chen RH, Wan L, et al. Association of TNF-alpha gene polymorphisms with systemic lupus erythematosus in Taiwanese patients. Lupus, 2009, 18(11): 974-979.
14. Tsai LJ, Hsiao SH, Tsai LM, et al. The sodium-dependent glucose cotransporter SLC5A11 as an autoimmune modiWer gene in SLE. Tissue Antigens, 2008, 71(2): 114-126.
15. Lu LY, Cheng HH, Sung PK, et al. Tumor necrosis factor-beta +252A polymorphism is associated with systemic lupus erythematosus in Taiwan. J Formos Med Assoc, 2005, 104(8): 563-570.
16. 付朝伟, 沈福民, 江峰, 等. 肿瘤坏死因子A基因多态性与系统性红斑狼疮的相关研究. 中华医学遗传学杂志, 2002, 19(6): 532-533.
17. 刘稚然, 唐坤, 施为, 等. 系统性红斑狼疮患者肿瘤坏死因子α基因多态性研究. 中华皮肤科杂志, 2001, 34(1): 56.
18. 王敏, 董怡, 黄尚志, 等. 肿瘤坏死因子α基因多态性及其与系统性红斑狼疮的相关性. 中华内科杂志, 1999, 38(6): 393-396.
19. 王育新, 章友康, 朱世乐, 等. 肿瘤坏死因子的基因多态性与系统性红斑狼疮的相关性分析. 中华医学杂志, 1998, 78(2): 111-114.
20. Chen CJ, Yen JH, Tsai WC, et al. The TNF2 allele does not contribute towards susceptibility to systemic lupus erythematosus. Immunol Lett, 1997, 55(1): 1-3.
21. Huizinga TW, Westendorp RG, Bollen EL, et al. TNF-alpha promoter polymorphisms, production and susceptibility to multiple sclerosis in different groups of patients. J Neuroimmunol, 1997, 72(2): 149-153.
22. Lee YH, Harley JB, Nath SK. Meta-analysis of TNF-alpha promoter –308A/G polymorphism and SLE susceptibility. Eur J Hum Genet, 2006, 14(3): 364-371.
23. Zou YF, Feng XL, Tao JH, et al. Meta-analysis of TNF-alpha promoter -308A/G polymorphism and SLE susceptibility in Asian populations. Rheumatol Int, 2010 Mar 24. [Epub ahead of print]:.
24. Fong KY, Howe HS, Tin SK, et al. Polymorphism of the regulatory region of tumour necrosis factor alpha gene in patients with systemic lupus erythematosus. Ann Acad Med Singapore, 1996, 25(1): 90-93.
25. Azizah MR, Kuak SH, Ainol SS, et al. Association of the tumor necrosis factor alpha gene polymorphism with susceptibility and clinical-immunological Wndings of systemic lupus erythematosus. Asian Pac J Allergy Immunol, 2004, 22(2-3): 159-163.
26. 沈洪兵. 循证医学. 见: 姜庆五, 主编. 临床流行病学. 北京: 高等教育出版社, 2007, 240-250.

Chinese Journal of Evidence-Based Medicine

Correlation between TNF-α Promoter–308A/G Polymorphism and Systemic Lupus Erythematosus in Chinese Populations: A Meta-analysis

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