Objective To summarize results of the correlation of tumor necrosis factor-α (TNF-α) promoter –308A/G polymorphism with systemic lupus erythematosus (SLE) susceptibility in Chinese populations.
Methods We collected all the publications about the correlation between TNF-α promoter –308A/G polymorphism and SLE in Chinese populations by searching PubMed, EBSCO, CBM, CNKI and Wanfang Data before the date of March 20, 2010. Meta-analysis was performed for checking the difference between two groups about genotypes such as AA versus GG, GA versus GG, AA versus GG+GA, GA+AA versus GG, and A allele versus G allele.
Results A total of 8 studies involving 731 SLE patients and 901 healthy people were included. The meta-analysis of total populations showed that, there was no significant correlation between A allele and increased SLE risk (OR=1.42, 95%CI 0.97 to 2.09, P=0.07); the meta-analyses of populations in different regions showed there was no significant correlation of A allele and increased SLE risk in Chinese Taiwan populations (OR=1.04, 95%CI 0.77 to 1.40, P=0.82). Moreover, there was no significant difference between SLE group and control group in the genotypes of AA versus GG, GA versus GG, AA versus GG+GA, and GA+AA versus GG.
Conclusion This meta-analysis dosen’t demonstrate the correlation between TNF-α promoter–308A/G polymorphism and SLE in Chinese populations.
Citation: GAO Xiang,LV Ling,WANG Xiaoqin. Correlation between TNF-α Promoter–308A/G Polymorphism and Systemic Lupus Erythematosus in Chinese Populations: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2010, 10(9): 1053-1057. doi: 10.7507/1672-2531.20100544 Copy
Copyright © the editorial department of Chinese Journal of Evidence-Based Medicine of West China Medical Publisher. All rights reserved
-
Previous Article
The Furazolidone-based First-line Therapy for Helicobacter Pylori Infection: A Meta-analysis HUANGXuan, LV bin, MENG Lina -
Next Article
Anesthetic Efficacy of Articaine Versus Lidocaine for Irreversible Pulpitis: A Meta-analysis XIAOJiaoling, LI Yali, MA Bin, PENG Hui, SHI Qiongling, YU Zhanhai