Diagnostic Value of MRI versus Bone Scan for Osseous Metastasis in Breast Cancer: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

LI Yunzhi ^1,2 , MA Bin ¹ , YANG Kehu ^1,2 ,  ZHOU Huaiqi ^1,2,3

1. Evidence-Based Medicine Center of Lanzhou University, Basic Science School of Lanzhou University, LanZhou 730000, China;2. The First Clinical College of Lanzhou University, Lanzhou 730000, China;3. The First Hospital of Lanzhou University, Lanzhou 730000, China;

Corresponding author：

ZHOU Huaiqi, Email: zhouhuaiqi@163.com

Keywords：

Breast cancer; Osseous metastases; Magnetic resonance imaging; Bone scan; Meta-analysis

DOI：

10.7507/1672-2531.20100563

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective 　To assess the diagnostic value of MRI and Bone Scan (BS) for osseous metastases in patients with breast cancer.
Methods 　The trials were searched from PubMed, EMBASE, Cochrane Library, CBM, CNKI and VIP; the Criteria for inclusion and exclusion were based on the standard for diagnosis tests. Meta-Disc software (Version 1.4) was used for data analysis; and the area under curve (AUC) of SROC was calculated.
Results 　A total of 5 researches involving 329 patients were included. The sensitivity of MRI and BS were 0.99 (0.97, 1.00) and 0.93 (0.88, 0.97) respectively; the specificity for MRI and BS were 0.99 (0.95, 1.00) and 0.86 (0.79, 0.92) respectively; and the AUC of SROC curve for MRI and BS were 0.993 6 and 0.967 5 respectively.
Conclusion 　MRI can be regarded as an effective and feasible method for osseous metastases in breast cancer.

Citation： LI Yunzhi,MA Bin,YANG Kehu,ZHOU Huaiqi. Diagnostic Value of MRI versus Bone Scan for Osseous Metastasis in Breast Cancer: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2010, 10(10): 1159-1163. doi: 10.7507/1672-2531.20100563 Copy

1.	Parkin DM, Bray F, Ferlay J, et al. Global cancer statistics, 2002. CA Cancer J Clin, 2005, 55(2): 74-108.
2.	Chen HH, Su WC, Guo HR, et al. Clinical significance and outcome of one or two rib lesions on bone scans in breast cancer patients without known metastases. Nucl Med Commun, 2003, 24(11): 1167-1174.
3.	Boxer DI, Todd CE, Coleman R, et al. Bone secodaries in breast cancer: the solitary metastasis. NuclMed, 1989, 30(8): 1318-1320.
4.	Jacoboson AF, Stomper PC, Jochelson MS, et al. Association between number and sites of new bone scan abnormalities and presence of skeletal metastases in patients with breast cancer. J Nucl Med, 1990, 31(4): 387-392.
5.	Nakanishi K, Kobayashi M, Takahashi S, et al. Whole body MRI for detecting metastatic bone tumor: comparison with bone scintigrams. Magn Reson Med Sci, 2005, 4(1): 11-17.
6.	Daldrup-Link HE, Franzius C, Link TM, et al. Whole-body MR imaging for detection of bone metastasis in children andyoung adults: comparison with skeletal scintigraphy and FDG PET. Am J Roentgenol, 2001, 177(1): 229-236.
7.	Mentzel HJ, Kentouche K, Sauner D, et al. Comparison of whole-body STIR-MRI and 99mTc-methylenediphosphonate scintigraphy in children with suspected multifocal bone lesions. Eur Radiol, 2004, 14(12): 2297-2302.
8.	Sackett DL, St raus SE, Richardson WS, et al. Evidence-based medicine: How to practice and teach EBM[M] 2nded. London: Churchill Livingstone, 2000. 235-2237, 241-244.
9.	Liehtinghagen R, Bahr M. Noninvasive diagnosis of fibrosis in chronic liver disease. Expert Re Mol Diagn, 2004, 4(5): 715-726.
10.	Whiting P, Rutjes AW, Reitsma JB, et al. The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol, 2003, 3: 25-38.
11.	张天嵩, 钟文昭. Meta -DiSc软件在诊断试验Meta分析中的应用. 循证医学, 2008, 8(2): 97-100,108.
12.	Zamora J, Abraira V, Muriel A, et al. Meta-DiSc:a software for meta-analysis of test accuracy data. BMC Medical Research Methodology, 2006, 12: 6-31.
13.	Kim DS, Hong SH, Choi JY, et al. Magnetic resonance imaging diagnoses of bone scan abnormalities in breast cancer patients. NuclMedCommun, 2009, 30(9): 736-741.
14.	Yilmaz MH, Ozguroglu M, Mert D, et al. Diagnostic value of magnetic resonance imaging and scintigraphy in patients with metastatic breast cancer of the axial skeleton: a comparative study. Med Oncol, 2008, 25(3): 257-263.
15.	Engelhard K, Hollenbach HP, Wohlfart K, et al. Comparison of whole-body MRI with automatic moving table technique and bonescintigraphy for screening for bone metastases in patients with breast cancer. Eur Radiol, 2004, 14(1): 99-105.
16.	Altehoefer C, Ghanem N, Högerle S, et al. Comparative detectability of bone metastases and impact on therapy of magnetic resonance imaging and bone scintigraphy in patients with breast cancer. Eur J Radiol, 2001, 40(1): 16-23.
17.	Layer G, Steudel A, Schüller H, et al. Magnetic resonance imaging to detect bone marrow metastases in the initial staging of small cell lung carcinoma and breast carcinoma. Cancer, 1999, 85(4): 1004-1009.
18.	Jones AL, Williams MP, Powles TJ, et al. Magnetic resonance imaging in the detection of skeletal metastases in patients with breast cancer. Br J Cancer, 1990, 62(2): 296-298.
19.	Ahmed A, Glynne-Jones R, Ell PJ. Skeletal scintigraphy in carcinoma of the breast-a ten year retrospective study of 389 patients. Nucl Med Commun, 1990, 11(6): 421-426.

1. Parkin DM, Bray F, Ferlay J, et al. Global cancer statistics, 2002. CA Cancer J Clin, 2005, 55(2): 74-108.
2. Chen HH, Su WC, Guo HR, et al. Clinical significance and outcome of one or two rib lesions on bone scans in breast cancer patients without known metastases. Nucl Med Commun, 2003, 24(11): 1167-1174.
3. Boxer DI, Todd CE, Coleman R, et al. Bone secodaries in breast cancer: the solitary metastasis. NuclMed, 1989, 30(8): 1318-1320.
4. Jacoboson AF, Stomper PC, Jochelson MS, et al. Association between number and sites of new bone scan abnormalities and presence of skeletal metastases in patients with breast cancer. J Nucl Med, 1990, 31(4): 387-392.
5. Nakanishi K, Kobayashi M, Takahashi S, et al. Whole body MRI for detecting metastatic bone tumor: comparison with bone scintigrams. Magn Reson Med Sci, 2005, 4(1): 11-17.
6. Daldrup-Link HE, Franzius C, Link TM, et al. Whole-body MR imaging for detection of bone metastasis in children andyoung adults: comparison with skeletal scintigraphy and FDG PET. Am J Roentgenol, 2001, 177(1): 229-236.
7. Mentzel HJ, Kentouche K, Sauner D, et al. Comparison of whole-body STIR-MRI and 99mTc-methylenediphosphonate scintigraphy in children with suspected multifocal bone lesions. Eur Radiol, 2004, 14(12): 2297-2302.
8. Sackett DL, St raus SE, Richardson WS, et al. Evidence-based medicine: How to practice and teach EBM[M] 2nded. London: Churchill Livingstone, 2000. 235-2237, 241-244.
9. Liehtinghagen R, Bahr M. Noninvasive diagnosis of fibrosis in chronic liver disease. Expert Re Mol Diagn, 2004, 4(5): 715-726.
10. Whiting P, Rutjes AW, Reitsma JB, et al. The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol, 2003, 3: 25-38.
11. 张天嵩, 钟文昭. Meta -DiSc软件在诊断试验Meta分析中的应用. 循证医学, 2008, 8(2): 97-100,108.
12. Zamora J, Abraira V, Muriel A, et al. Meta-DiSc:a software for meta-analysis of test accuracy data. BMC Medical Research Methodology, 2006, 12: 6-31.
13. Kim DS, Hong SH, Choi JY, et al. Magnetic resonance imaging diagnoses of bone scan abnormalities in breast cancer patients. NuclMedCommun, 2009, 30(9): 736-741.
14. Yilmaz MH, Ozguroglu M, Mert D, et al. Diagnostic value of magnetic resonance imaging and scintigraphy in patients with metastatic breast cancer of the axial skeleton: a comparative study. Med Oncol, 2008, 25(3): 257-263.
15. Engelhard K, Hollenbach HP, Wohlfart K, et al. Comparison of whole-body MRI with automatic moving table technique and bonescintigraphy for screening for bone metastases in patients with breast cancer. Eur Radiol, 2004, 14(1): 99-105.
16. Altehoefer C, Ghanem N, Högerle S, et al. Comparative detectability of bone metastases and impact on therapy of magnetic resonance imaging and bone scintigraphy in patients with breast cancer. Eur J Radiol, 2001, 40(1): 16-23.
17. Layer G, Steudel A, Schüller H, et al. Magnetic resonance imaging to detect bone marrow metastases in the initial staging of small cell lung carcinoma and breast carcinoma. Cancer, 1999, 85(4): 1004-1009.
18. Jones AL, Williams MP, Powles TJ, et al. Magnetic resonance imaging in the detection of skeletal metastases in patients with breast cancer. Br J Cancer, 1990, 62(2): 296-298.
19. Ahmed A, Glynne-Jones R, Ell PJ. Skeletal scintigraphy in carcinoma of the breast-a ten year retrospective study of 389 patients. Nucl Med Commun, 1990, 11(6): 421-426.

Chinese Journal of Evidence-Based Medicine

Diagnostic Value of MRI versus Bone Scan for Osseous Metastasis in Breast Cancer: A Meta-analysis

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