Effect of Olfactory Ensheathing Cells Transplantation for Motor Function Restitution on Spinal Cord Injury of Rats: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

1. Grade 2006 of Clinical School, Chengdu Medical College, Chengdu 610083, China;2. Experiment Technology Center of Chengdu Medical College, Chengdu 610083, China;

Corresponding author：

Keywords：

Neuroscience; Transplantation; Olfactory ensheathing cells; Spinal cord injury; Meta-analysis; SD rats

DOI：

10.7507/1672-2531.20100569

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Objective 　To review evidences of the relationship between olfactory ensheathing cells (OECs) transplantation and motor functional restitution of spinal cord injury (SCI).
Methods 　We searched the CBM, CNKI, VIP and PubMed databases for collecting relative studies published from January 1989 to December 2009. Randomized controlled experiments of treating rats SCI with OECs transplantation were included. Quality of included experiments was assessed by Jadad scale, and the available data were abstracted and meta-analyzed with RevMan 4.2 software.
Results 　A total of 12 randomized controlled experiments were identified. Meta-analysis showed that, OECs group was higher than control group in both BBB score (WMD=1.67, 95%CI 0.99 to 2.36; WMD=3.61, 95%CI 1.97 to 5.26; WMD=6.50, 95%CI 5.76 to 7.24; WMD=4.23, 95%CI 1.19 to 7.28; WMD=1.90, 95%CI 1.22 to 2.58; WMD=3.30, 95%CI 2.63 to 3.97) and MEP latency period (WMD= – 3.98, 95%CI – 5.71 to – 2.25), but there was no statistical significance in SEP latency period or amplitude period (WMD= – 7.13, 95%CI – 16.49 to 2.23; WMD=3.00, 95%CI – 1.12 to 7.11; WMD=1.95, 95%CI – 0.89 to4.78).
Conclusions 　This meta-analysis based on current experiments suggests that OECs transplantation is superior in motor function restitution after spinal cord injury, but is similar as control group in SEP latency or amplitude.

Citation： CHEN Wei,HE Lina,LI Ang,LIANG Nan. Effect of Olfactory Ensheathing Cells Transplantation for Motor Function Restitution on Spinal Cord Injury of Rats: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2010, 10(10): 1194-1198. doi: 10.7507/1672-2531.20100569 Copy

1.	Runyan SA, Phelps PE. Mouse olfactory ensheathing glia enhance axon outgrowth on a myelin substrate in vitro. Exp Neurol, 2009, 216(1): 95.
2.	Su ZD, Cao L, Zhu YL, et al. Nogo enhances the adhesion of olfactory ensheathing cells and inhibits their migration. Cell Science J, 2007, 120(Pt 11): 1877-1887.
3.	Jadad AR, Moore RA, Carroll D. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials, 1996, 17: 1-12.
4.	Basso DM, Beattie MS, Bresnahan JC. Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp Neurol, 1996, 139(2): 244-256.
5.	陈庆山, 陈欣, 杨磊, 等. 大鼠自体嗅成鞘细胞移植治疗脊髓损伤的实验研究. 解剖学报, 2005, 36(5): 477-480.
6.	吴卫江, 惠国桢, 吕然博, 等. 人胚嗅鞘细胞与胚胎脊髓组织联合移植对大鼠脊髓损伤的治疗作用. 江苏医药, 2006, 32(10): 948-950.
7.	李绍波, 章为, 丁艳, 等. 嗅鞘细胞移植对脊髓半横断损伤大鼠后肢运动功能的影响. 四川解剖学杂志, 2007, 15(1): 14-17.
8.	闫慧博, 鲁凯伍, 江建明, 等. OECs移植联合IN-1抗体修复急性脊髓损伤的实验研究. 中国临床解剖学杂志, 2008, 26(2): 158-162.
9.	朱文标, 邓宇斌, 毕小彬, 等. 骨髓间质干细胞与胚胎嗅鞘细胞联合移植治疗大鼠脊髓损伤的实验研究. 中国脊柱脊髓杂志, 2006, 16(l2): 932-936.
10.	杨金伟, 杨慧娟, 殷露玮, 等. 神经干细胞与嗅鞘细胞移植对脊髓全横断大鼠后肢运动功能的影响. 昆明医学院学报, 2007, (6): 19-23.
11.	袁普卫, 贺西京, 王国毓, 等. 嗅鞘细胞移植对脊髓损伤后损伤区MAG表达影响的实验研究. 美中国际创伤杂志, 2006, 5(2): 8-10.
12.	王国毓, 贺西京, 袁普卫, 等. 嗅鞘细胞移植对脊髓损伤大鼠诱发电位的影响. 中国组织工程研究与临床康复, 2007, 11(3): 505-508.
13.	贾彬, 李杰, 贺西京, 等. 嗅黏膜嗅鞘细胞与肌基膜管联合移植修复脊髓损伤. 中国组织工程研究与临床康复, 2008, 12(51): 10041-10044.
14.	Jike L, Francois F, Alan MS, et al. olfactory ensheathing cells promote locomotor recovery after delayed transplantation into transected spinal cord. Brain, 2002, 125: 14-21.
15.	Karim F, Lisa S, Mary BB, et al. Combining Schwann Cell Bridges and Olfactory-Ensheathing Glia Grafts with Chondroitinase Promotes Locomotor Recovery after Complete Transection of the Spinal Cord. Neuroscience J, 2005, 25(5): 1169-1178.
16.	Masanori S, Bryan CH, Karen LL, et al. Protection of Corticospinal Tract Neurons After Dorsal Spinal Cord Transection and Engraftment of Olfactory Ensheathing Cells. Glia, 2006, 53(4): 352-359.
17.	麦劲壮, 李河, 方积乾, 等. Meta分析中失安全系数的估计. 循证医学, 2006, 6(5): 297-300, 303.
18.	Blakemore WF, Crang AJ. The use of cultured autologous Schwann cells to remyelinate areas of persistent demyelination in the central nervous system. J Neurol Sci, 1985, 70: 207-223.
19.	Duncan ID, Hammang JP, Gilmore SA. Schwann cell myelination of the myelin deficient rat spinal cord following X-irradiation. Glia, 1988, 1: 233-239.
20.	Keirstead HS, Ben-Hur T, Rogister B, et al. Polysialylated neural cell adhesion molecule-positive CNS precursors generate both oligodendrocytes and Schwann cells to remyelinate the CNS after transplantation. J Neurosci, 1999, 19: 7529-7536.
21.	Brustle O, Jones KN, Learish RD, et al. Embryonic stem cell-derived glial precursors: a source of myelinating transplants. Science, 1999, 285: 754-756.
22.	Christine R, Masanori S, Karen LL, et al. Potential of olfactory ensheathing cells for cell-based therapy in spinal cord injury. JRRD, 2008, 45(1): 141-152.
23.	Masanori S, Joel AB, Karen LL, et al. Molecular reconstruction of nodes of ranvier after remyelination by transplanted olfactory ensheathing cells in the demyelinated spinal cord. J Neurosci, 2006, 26(6): 1803-1812.

1. Runyan SA, Phelps PE. Mouse olfactory ensheathing glia enhance axon outgrowth on a myelin substrate in vitro. Exp Neurol, 2009, 216(1): 95.
2. Su ZD, Cao L, Zhu YL, et al. Nogo enhances the adhesion of olfactory ensheathing cells and inhibits their migration. Cell Science J, 2007, 120(Pt 11): 1877-1887.
3. Jadad AR, Moore RA, Carroll D. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials, 1996, 17: 1-12.
4. Basso DM, Beattie MS, Bresnahan JC. Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp Neurol, 1996, 139(2): 244-256.
5. 陈庆山, 陈欣, 杨磊, 等. 大鼠自体嗅成鞘细胞移植治疗脊髓损伤的实验研究. 解剖学报, 2005, 36(5): 477-480.
6. 吴卫江, 惠国桢, 吕然博, 等. 人胚嗅鞘细胞与胚胎脊髓组织联合移植对大鼠脊髓损伤的治疗作用. 江苏医药, 2006, 32(10): 948-950.
7. 李绍波, 章为, 丁艳, 等. 嗅鞘细胞移植对脊髓半横断损伤大鼠后肢运动功能的影响. 四川解剖学杂志, 2007, 15(1): 14-17.
8. 闫慧博, 鲁凯伍, 江建明, 等. OECs移植联合IN-1抗体修复急性脊髓损伤的实验研究. 中国临床解剖学杂志, 2008, 26(2): 158-162.
9. 朱文标, 邓宇斌, 毕小彬, 等. 骨髓间质干细胞与胚胎嗅鞘细胞联合移植治疗大鼠脊髓损伤的实验研究. 中国脊柱脊髓杂志, 2006, 16(l2): 932-936.
10. 杨金伟, 杨慧娟, 殷露玮, 等. 神经干细胞与嗅鞘细胞移植对脊髓全横断大鼠后肢运动功能的影响. 昆明医学院学报, 2007, (6): 19-23.
11. 袁普卫, 贺西京, 王国毓, 等. 嗅鞘细胞移植对脊髓损伤后损伤区MAG表达影响的实验研究. 美中国际创伤杂志, 2006, 5(2): 8-10.
12. 王国毓, 贺西京, 袁普卫, 等. 嗅鞘细胞移植对脊髓损伤大鼠诱发电位的影响. 中国组织工程研究与临床康复, 2007, 11(3): 505-508.
13. 贾彬, 李杰, 贺西京, 等. 嗅黏膜嗅鞘细胞与肌基膜管联合移植修复脊髓损伤. 中国组织工程研究与临床康复, 2008, 12(51): 10041-10044.
14. Jike L, Francois F, Alan MS, et al. olfactory ensheathing cells promote locomotor recovery after delayed transplantation into transected spinal cord. Brain, 2002, 125: 14-21.
15. Karim F, Lisa S, Mary BB, et al. Combining Schwann Cell Bridges and Olfactory-Ensheathing Glia Grafts with Chondroitinase Promotes Locomotor Recovery after Complete Transection of the Spinal Cord. Neuroscience J, 2005, 25(5): 1169-1178.
16. Masanori S, Bryan CH, Karen LL, et al. Protection of Corticospinal Tract Neurons After Dorsal Spinal Cord Transection and Engraftment of Olfactory Ensheathing Cells. Glia, 2006, 53(4): 352-359.
17. 麦劲壮, 李河, 方积乾, 等. Meta分析中失安全系数的估计. 循证医学, 2006, 6(5): 297-300, 303.
18. Blakemore WF, Crang AJ. The use of cultured autologous Schwann cells to remyelinate areas of persistent demyelination in the central nervous system. J Neurol Sci, 1985, 70: 207-223.
19. Duncan ID, Hammang JP, Gilmore SA. Schwann cell myelination of the myelin deficient rat spinal cord following X-irradiation. Glia, 1988, 1: 233-239.
20. Keirstead HS, Ben-Hur T, Rogister B, et al. Polysialylated neural cell adhesion molecule-positive CNS precursors generate both oligodendrocytes and Schwann cells to remyelinate the CNS after transplantation. J Neurosci, 1999, 19: 7529-7536.
21. Brustle O, Jones KN, Learish RD, et al. Embryonic stem cell-derived glial precursors: a source of myelinating transplants. Science, 1999, 285: 754-756.
22. Christine R, Masanori S, Karen LL, et al. Potential of olfactory ensheathing cells for cell-based therapy in spinal cord injury. JRRD, 2008, 45(1): 141-152.
23. Masanori S, Joel AB, Karen LL, et al. Molecular reconstruction of nodes of ranvier after remyelination by transplanted olfactory ensheathing cells in the demyelinated spinal cord. J Neurosci, 2006, 26(6): 1803-1812.

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Effect of Olfactory Ensheathing Cells Transplantation for Motor Function Restitution on Spinal Cord Injury of Rats: A Systematic Review

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