Risk Factors on Lung Cancer: A Meta-Analysis_Chinese Journal of Evidence-Based Medicine

Authors：

WANG Dongmei ¹ , CHEN Bojiang ¹ ,  LI Weimin ¹ , LI Jing ² , CHEN Wenbin ¹

1. Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China;2. Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

LI Weimin, Email: weimi003@yahoo.com

Keywords：

Lung cancer; Risk factor; Meta-analysis; Odds ratio

DOI：

10.7507/1672-2531.20100610

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective 　To study the risk factors of lung cancer and provide scientific evidence for preventing and managing such disease.
Methods ?The database of MEDLINE, CNKI, and CBM were searched and literature domestically and internationally from January 1997 to January 2007 was collected. The RevMan 4.2 software was used for meta-analysis.
Results 　A total of 40 studies involving 16 559 cases and 25 119 controls were included. The pooled OR values and population attributable risk percentage (PARP) for smoking, female passive smoking from husband, female passive smoking from colleague, chronic bronchitis, emphysema, pulmonary tuberculosis, family history of cancer, and family history of lung cancer were 5.75 (69.16%), 1.32 (14.52%), 1.21 (5.87%), 1.68 (7.45%), 2.70 (10.18%), 1.58 (1.91%), 1.24 (8.92%), and 1.59 (5.33%), respectively.
Conclusion 　Risk factors related to the incidence of lung cancer are smoking, female passive smoking from husband and colleague, chronic bronchitis, emphysema, pulmonary tuberculosis, family history of cancer, family history of lung cancer and so on. Besides, the results of PARP indicate that smoking is the most important factor, followed by female passive smoking from husband, emphysema, family history of cancer sequentially, which suggest that environmental and genetic factors play important roles in the development of lung cancer.

Citation： WANG Dongmei,CHEN Bojiang,LI Weimin,LI Jing,CHEN Wenbin. Risk Factors on Lung Cancer: A Meta-Analysis. Chinese Journal of Evidence-Based Medicine, 2010, 10(12): 1446-1459. doi: 10.7507/1672-2531.20100610 Copy

1.	Pirozynski M. 100 years of lung cancer. Respir Med, 2006, 100(12): 2073-2084.
2.	Lichtenstein MJ, Mulrow CD, Elwood PC. Guidelines for reading case-control studies. J Chronic Dis, 1987, 40(9): 893-903.
3.	Light RJ, Pillemer DB. Quantitative procedures. In Summing up: The Science of Reviewing Research: Harvard University Press, 1984.
4.	Matos E, Vilensky M, Boffetta P, et al. Lung cancer and smoking: a case-control study in Buenos Aires, Argentina. Lung Cancer, 1998, 21(3): 155-163.
5.	Droste JH, Weyler JJ, Van Meerbeeck JP, et al. Occupational risk factors of lung cancer: a hospital based case-control study. Occup Environ Med, 1999, 56(5): 322-327.
6.	刘双, 刘泽英, 胡尚基. 吸烟与肺癌发生的回顾性分析. 心肺血管病杂志, 1999, 18(3): 222-223.
7.	Agudo A, Ahrens W, Benhamou E, et al. Lung cancer and cigarette smoking in women: a multicenter case-control study in Europe. Int J Cancer, 2000, 88(5): 820-827.
8.	Osann KE, Lowery JT, Schell MJ. Small cell lung cancer in women: risk associated with smoking, prior respiratory disease, and occupation. Lung Cancer, 2000, 28(1): 1-10.
9.	Simonato L, Zambon P, Ardit S, et al. Lung cancer risk in Venice: a population-based case-control study. Eur J Cancer Prev, 2000, 9(1): 35-39.
10.	Seow A, Poh WT, Teh M, et al. Fumes from meat cooking and lung cancer risk in Chinese women. Cancer Epidemiol Biomarkers Prev, 2000, 9(11): 1215-1221.
11.	顾雪松. 吸烟与肺癌危险性的病例对照研究. 江苏预防医学, 2000, 11(1): 18-19.
12.	Stellman SD, Takezaki T, Wang L, et al. Smoking and Lung Cancer Risk in American and Japanese Men: An International Case-Control Study. Cancer Epidemiology Biomarkers & Prevention, 2001, 10(11): 1193-1199.
13.	Rachtan J. Smoking, passive smoking and lung cancer cell types among women in Poland. Lung Cancer, 2002, 35(2): 129-136.
14.	Kubík AK, Zatloukal P, Tomásek L, et al. Lung cancer risk among Czech women: a case-control study. Prev Med, 2002, 34(4): 436-444.
15.	Sasco AJ, Merrill RM, Dari I, et al. A case-control study of lung cancer in Casablanca, Morocco. Cancer Causes Control, 2002, 13(7): 609-616.
16.	Chan-Yeung M, Koo LC, Ho JC, et al. Risk factors associated with lung cancer in Hong Kong. Lung Cancer, 2003, 40(2): 131-140.
17.	张亚旭, 吴树岭, 韩惠丽. 哈尔滨市南岗区103例肺癌患者相关危险因素对照分析. 中国初级卫生保健, 2003, 17(3): 32-33.
18.	De Stefani E, Deneo-Pellegrini H, Boffetta P, et al. Cigarette smoking and risk of large cell carcinoma of the lung: a case-control study in Uruguay. Lung Cancer, 2004, 43(3): 267-274.
19.	卢家强, 陈亚利, 霍敏琴. 顺德容奇地区肺癌危险因素的病例对照研究. 中国自然医学杂志, 2004, 6(1): 13-15.
20.	韩勇, 王云杰, 朱江, 等. 西安地区肺癌危险因素的病例对照分析. 现代肿瘤医学, 2005, 13(2): 267-269.
21.	Franco-Marina F, Villalba-Caloca J, Corcho-Berdugo A. Role of active and passive smoking on lung cancer etiology in Mexico City. Salud Publica Mex, 2006, 48 (suppl 1): S75-S82.
22.	Neuberger JS, Mahnken JD, Mayo MS, et al. Risk factors for lung cancer in Iowa women: implications for prevention. Cancer Detect Prev, 2006, 30(2): 158-167.
23.	靳光付, 胡志斌, 马红霞, 等. 肿瘤家族史和吸烟在肺癌发生中的交互作用研究. 中华流行病学杂志, 2006, 27(12): 1095-1096.
24.	Nyberg F, Agrenius V, Svartengren K, et al. Environmental tobacco smoke and lung cancer in nonsmokers: does time since exposure play a role? Epidemiology, 1998, 9(3): 301-308.
25.	Zaridze D, Maximovitch D, Zemlyanaya G, et al. Exposure to environmental tobacco smoke and risk of lung cancer in non-smoking women from Moscow, Russia. Int J Cancer, 1998, 75(3): 335-338.
26.	Rapiti E, Jindal SK, Gupta D, et al. Passive smoking and lung cancer in Chandigarh, India. Lung Cancer, 1999, 23:183-189.
27.	Zhong L, Goldberg MS, Gao YT, et al. A case-control study of lung cancer and environmental tobacco smoke among nonsmoking women living in Shanghai, China. Cancer Causes and Control, 1999, 10: 607-616.
28.	Lee CH, Ko YC, Goggins W, et al. Lifetime environmental exposure to tobacco smoke and primary lung cancer of non-smoking Taiwanese women. Int J Epidemiol, 2000, 29(2): 224-231.
29.	Kreuzer M, Krauss M, Kreienbrock L, et al. Environmental tobacco smoke and lung cancer: a case-control study in Germany. Am J Epidemiol, 2000, 151(3): 241-250.
30.	Ko YC, Lee CH, Chen MJ, et al. Risk factors for primary lung cancer among non-smoking women in Taiwan. Int J Epidemiol, 1997, 26(1): 24-31.
31.	Mayne ST, Buenconsejo J, Janerich DT. Previous lung disease and risk of lung cancer among men and women nonsmokers. Am J Epidemiol, 1999, 149(1): 13-20.
32.	Brownson RC, Alavanja MC. Previous lung disease and lung cancer risk among women (United States). Cancer Causes Control, 2000, 11(9): 853-858.
33.	Kreuzer M, Heinrich J, Kreienbrock L, et al. Risk factors for lung cancer among nonsmoking women. Int J Cancer, 2002, 100(6): 706-713.
34.	Brenner AV, Wang Z, Kleinerman RA, et al. Previous pulmonary diseases and risk of lung cancer in Gansu Province, China. Int J Epidemiol, 2001, 30(1): 118-124.
35.	Ramanakumar AV, Parent ME, Menzies D, et al. Risk of lung cancer following nonmalignant respiratory conditions: evidence from two case-control studies in Montreal, Canada. Lung Cancer, 2006, 53(1): 5-12.
36.	刘恩菊, 项永兵, 金凡, 等. 上海市区非吸烟女性肺癌病例对照研究的多因素分析. 肿瘤, 2001, 21(6): 421-425.
37.	Gorlova OY, Zhang Y, Schabath MB, et al. Never smokers and lung cancer risk: a case-control study of epidemiological factors. Int J Cancer, 2006, 118(7): 1798-1804.
38.	Wünsch-Filho V, Boffetta P, Colin D, et al. Familial cancer aggregation and the risk of lung cancer. Sao Paulo Med J, 2002, 120(2): 38-44.
39.	De Stefani E, Boffetta P, Brennan P, et al. Occupational exposures and risk of adenocarcinoma of the lung in Uruguay. Cancer Causes Control, 2005, 16(7): 851-856.
40.	Etzel CJ, Amos CI, Spitz MR. Risk for smoking-related cancer among relatives of lung cancer patients. Cancer Res, 2003, 63(23): 8531-8535.
41.	Wu PF, Lee CH, Wang MJ, et al. Cancer aggregation and complex segregation analysis of families with female non-smoking lung cancer probands in Taiwan. Eur J Cancer, 2004, 40(2): 260-266.
42.	Matakidou A, Eisen T, Bridle H, et al. Case-control study of familial lung cancer risks in UK women. Int J Cancer, 2005, 116(3): 445-450.
43.	Cassidy A, Myles JP, Duffy SW, et al. Family history and risk of lung cancer: age-at-diagnosis in cases and first-degree relatives. Br J Cancer, 2006, 95(9): 1288-1290.
44.	Wynder EL, Higgins ITT, Harris RE. The wish bias. J Clin Epidemiol, 1990, 43: 619.

1. Pirozynski M. 100 years of lung cancer. Respir Med, 2006, 100(12): 2073-2084.
2. Lichtenstein MJ, Mulrow CD, Elwood PC. Guidelines for reading case-control studies. J Chronic Dis, 1987, 40(9): 893-903.
3. Light RJ, Pillemer DB. Quantitative procedures. In Summing up: The Science of Reviewing Research: Harvard University Press, 1984.
4. Matos E, Vilensky M, Boffetta P, et al. Lung cancer and smoking: a case-control study in Buenos Aires, Argentina. Lung Cancer, 1998, 21(3): 155-163.
5. Droste JH, Weyler JJ, Van Meerbeeck JP, et al. Occupational risk factors of lung cancer: a hospital based case-control study. Occup Environ Med, 1999, 56(5): 322-327.
6. 刘双, 刘泽英, 胡尚基. 吸烟与肺癌发生的回顾性分析. 心肺血管病杂志, 1999, 18(3): 222-223.
7. Agudo A, Ahrens W, Benhamou E, et al. Lung cancer and cigarette smoking in women: a multicenter case-control study in Europe. Int J Cancer, 2000, 88(5): 820-827.
8. Osann KE, Lowery JT, Schell MJ. Small cell lung cancer in women: risk associated with smoking, prior respiratory disease, and occupation. Lung Cancer, 2000, 28(1): 1-10.
9. Simonato L, Zambon P, Ardit S, et al. Lung cancer risk in Venice: a population-based case-control study. Eur J Cancer Prev, 2000, 9(1): 35-39.
10. Seow A, Poh WT, Teh M, et al. Fumes from meat cooking and lung cancer risk in Chinese women. Cancer Epidemiol Biomarkers Prev, 2000, 9(11): 1215-1221.
11. 顾雪松. 吸烟与肺癌危险性的病例对照研究. 江苏预防医学, 2000, 11(1): 18-19.
12. Stellman SD, Takezaki T, Wang L, et al. Smoking and Lung Cancer Risk in American and Japanese Men: An International Case-Control Study. Cancer Epidemiology Biomarkers & Prevention, 2001, 10(11): 1193-1199.
13. Rachtan J. Smoking, passive smoking and lung cancer cell types among women in Poland. Lung Cancer, 2002, 35(2): 129-136.
14. Kubík AK, Zatloukal P, Tomásek L, et al. Lung cancer risk among Czech women: a case-control study. Prev Med, 2002, 34(4): 436-444.
15. Sasco AJ, Merrill RM, Dari I, et al. A case-control study of lung cancer in Casablanca, Morocco. Cancer Causes Control, 2002, 13(7): 609-616.
16. Chan-Yeung M, Koo LC, Ho JC, et al. Risk factors associated with lung cancer in Hong Kong. Lung Cancer, 2003, 40(2): 131-140.
17. 张亚旭, 吴树岭, 韩惠丽. 哈尔滨市南岗区103例肺癌患者相关危险因素对照分析. 中国初级卫生保健, 2003, 17(3): 32-33.
18. De Stefani E, Deneo-Pellegrini H, Boffetta P, et al. Cigarette smoking and risk of large cell carcinoma of the lung: a case-control study in Uruguay. Lung Cancer, 2004, 43(3): 267-274.
19. 卢家强, 陈亚利, 霍敏琴. 顺德容奇地区肺癌危险因素的病例对照研究. 中国自然医学杂志, 2004, 6(1): 13-15.
20. 韩勇, 王云杰, 朱江, 等. 西安地区肺癌危险因素的病例对照分析. 现代肿瘤医学, 2005, 13(2): 267-269.
21. Franco-Marina F, Villalba-Caloca J, Corcho-Berdugo A. Role of active and passive smoking on lung cancer etiology in Mexico City. Salud Publica Mex, 2006, 48 (suppl 1): S75-S82.
22. Neuberger JS, Mahnken JD, Mayo MS, et al. Risk factors for lung cancer in Iowa women: implications for prevention. Cancer Detect Prev, 2006, 30(2): 158-167.
23. 靳光付, 胡志斌, 马红霞, 等. 肿瘤家族史和吸烟在肺癌发生中的交互作用研究. 中华流行病学杂志, 2006, 27(12): 1095-1096.
24. Nyberg F, Agrenius V, Svartengren K, et al. Environmental tobacco smoke and lung cancer in nonsmokers: does time since exposure play a role? Epidemiology, 1998, 9(3): 301-308.
25. Zaridze D, Maximovitch D, Zemlyanaya G, et al. Exposure to environmental tobacco smoke and risk of lung cancer in non-smoking women from Moscow, Russia. Int J Cancer, 1998, 75(3): 335-338.
26. Rapiti E, Jindal SK, Gupta D, et al. Passive smoking and lung cancer in Chandigarh, India. Lung Cancer, 1999, 23:183-189.
27. Zhong L, Goldberg MS, Gao YT, et al. A case-control study of lung cancer and environmental tobacco smoke among nonsmoking women living in Shanghai, China. Cancer Causes and Control, 1999, 10: 607-616.
28. Lee CH, Ko YC, Goggins W, et al. Lifetime environmental exposure to tobacco smoke and primary lung cancer of non-smoking Taiwanese women. Int J Epidemiol, 2000, 29(2): 224-231.
29. Kreuzer M, Krauss M, Kreienbrock L, et al. Environmental tobacco smoke and lung cancer: a case-control study in Germany. Am J Epidemiol, 2000, 151(3): 241-250.
30. Ko YC, Lee CH, Chen MJ, et al. Risk factors for primary lung cancer among non-smoking women in Taiwan. Int J Epidemiol, 1997, 26(1): 24-31.
31. Mayne ST, Buenconsejo J, Janerich DT. Previous lung disease and risk of lung cancer among men and women nonsmokers. Am J Epidemiol, 1999, 149(1): 13-20.
32. Brownson RC, Alavanja MC. Previous lung disease and lung cancer risk among women (United States). Cancer Causes Control, 2000, 11(9): 853-858.
33. Kreuzer M, Heinrich J, Kreienbrock L, et al. Risk factors for lung cancer among nonsmoking women. Int J Cancer, 2002, 100(6): 706-713.
34. Brenner AV, Wang Z, Kleinerman RA, et al. Previous pulmonary diseases and risk of lung cancer in Gansu Province, China. Int J Epidemiol, 2001, 30(1): 118-124.
35. Ramanakumar AV, Parent ME, Menzies D, et al. Risk of lung cancer following nonmalignant respiratory conditions: evidence from two case-control studies in Montreal, Canada. Lung Cancer, 2006, 53(1): 5-12.
36. 刘恩菊, 项永兵, 金凡, 等. 上海市区非吸烟女性肺癌病例对照研究的多因素分析. 肿瘤, 2001, 21(6): 421-425.
37. Gorlova OY, Zhang Y, Schabath MB, et al. Never smokers and lung cancer risk: a case-control study of epidemiological factors. Int J Cancer, 2006, 118(7): 1798-1804.
38. Wünsch-Filho V, Boffetta P, Colin D, et al. Familial cancer aggregation and the risk of lung cancer. Sao Paulo Med J, 2002, 120(2): 38-44.
39. De Stefani E, Boffetta P, Brennan P, et al. Occupational exposures and risk of adenocarcinoma of the lung in Uruguay. Cancer Causes Control, 2005, 16(7): 851-856.
40. Etzel CJ, Amos CI, Spitz MR. Risk for smoking-related cancer among relatives of lung cancer patients. Cancer Res, 2003, 63(23): 8531-8535.
41. Wu PF, Lee CH, Wang MJ, et al. Cancer aggregation and complex segregation analysis of families with female non-smoking lung cancer probands in Taiwan. Eur J Cancer, 2004, 40(2): 260-266.
42. Matakidou A, Eisen T, Bridle H, et al. Case-control study of familial lung cancer risks in UK women. Int J Cancer, 2005, 116(3): 445-450.
43. Cassidy A, Myles JP, Duffy SW, et al. Family history and risk of lung cancer: age-at-diagnosis in cases and first-degree relatives. Br J Cancer, 2006, 95(9): 1288-1290.
44. Wynder EL, Higgins ITT, Harris RE. The wish bias. J Clin Epidemiol, 1990, 43: 619.

Chinese Journal of Evidence-Based Medicine

Risk Factors on Lung Cancer: A Meta-Analysis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content