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GRADE要求明确说明相关的背景、人群、干预措施和对照,同时要求不论研究结果能否形成证据,均需详述所有重要结果。对某一特定管理问题,人群、干预措施及结果应在不同研究间足够类似,才能认为得到相似的效应量合乎情理。指南制定者在收集证据前应先详细说明各结局的相对重要性,同样地,证据总结完成时也需要详细说明这一点。考虑到替代结局的重要性,对采用替代指标描述且对患者很重要的结局,作者应评估其重要性,并进而降低这种间接结果的证据质量等级。

Citation: Gordon H. Guyatt,Andrew D. Oxman,Regina Kunz,David Atkins,Jan Brozek,Gunn Vist,Philip Alderson,Paul Glasziou,Yngve FalckYtter,Holger J. Schnemann,代表GRADE工作组. GRADE Guidelines: 2. Framing the Question and Deciding on Important Outcomes△. Chinese Journal of Evidence-Based Medicine, 2011, 11(4): 446-450. doi: 10.7507/1672-2531.20110077 Copy

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