Correlation of Estrogen Receptor α Gene Pvu Ⅱ Site Polymorphisms and Risk of Coronary Heart Disease in Chinese Population: A Meta-Analysis_Chinese Journal of Evidence-Based Medicine

Authors：

WEI Chuandong ^1,2 ,  LI Yan ¹ , SUN Kaisheng ¹ , ZHENG Hongyun ¹ , DAI Wen ¹

1. Department of Laboratory Science, Renmin Hospital, Wuhan University, Wuhan 430060, China;2. Academy of Laboratory Medical Science, You Jiang Medical University for Nationalities, Baise 533000, China;

Corresponding author：

LI Yan, Email: yanlitf@yahoo.com.cn

Keywords：

Estrogen receptor alpha; Coronary heart disease; Polymorphism; Chinese population; Meta-analysis; Systematic review; Case-cpmtrol study

DOI：

10.7507/1672-2531.20110138

Video：

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Objective 　To investigate the correlation of the polymorphism of the estrogen receptor alpha gene Pvu II site and coronary heart disease (CHD) in Chinese population.
Methods 　Such databases as CBM, CNKI, Wangfang database, VIP, MEDLINE, The Cochrane Library, EMbase, Springer, and Ovid were searched from their establishment date to November of 2010 to collect the case-control studies on the correlation of estrogen receptor alpha gene polymorphism Pvu II sites with coronary heart disease of the Chinese. The quality of included studies was evaluated, the available data was extracted, and then the RevMan5.0 software was used for Meta analyses.
Results 　Nine case-control studies were included, involving 1 464 cases with coronary heart disease and 1 203 cases in the control group. The results of Meta-analyses showed that, as to the correlation of the polymorphism of ER alpha gene Pvu II site T/C and CHD, there was no significant difference in the risk of CHD between people with different genotypes, i.e. the C allele versus T allele (OR=0.95, 95%CI 0.77 to 1.17, P=0.63), genotype of (TC + CC) versus TT (OR=0.97, 95%CI 0.73 to 1.28, P=0.81), genotype of TC versus TT (OR = 0.93, 95%CI 0.68 to 1.26, P=0.64), genotype of CC versus TT (OR=0.86, 95%CI 0.57 to 1.31, P=0.49).
Conclusion 　Estrogen receptor alpha gene polymorphism Pvu II site are not associated with the coronary heart disease in Chinese population.

Citation： WEI Chuandong,LI Yan,SUN Kaisheng,ZHENG Hongyun,DAI Wen. Correlation of Estrogen Receptor α Gene Pvu Ⅱ Site Polymorphisms and Risk of Coronary Heart Disease in Chinese Population: A Meta-Analysis. Chinese Journal of Evidence-Based Medicine, 2011, 11(7): 805-810. doi: 10.7507/1672-2531.20110138 Copy

1.	1 Hanke H, Hanke S, Bruck B, et al . Inhibition of the protective effect of estrogen by progesterone in experimental atherosclerosis. Atherosclerosis , 1996, 121(1): 129-138.
2.	2 Ushiyama T, Ueyama H, Inoue K, et al . Estrogen receptor gene polymorphism and generalized osteoarthritis. J Rheumatol , 1998, 25(1): 134-137.
3.	10 Xu H, Hou X, Wang N, et al . Gender-specific effect of estrogen receptor-1 gene polymorphisms in coronary artery disease and its angiographic severity in chinese population. Clin Chim Acta , 2008, 395(1-2): 130-133.
4.	13 Deng G, Zhou G, Zhai Y, et al . Association of estrogen receptor α polymorphisms with susceptibility to chronic hepatitis B virus infection. Hepatology , 2004, 40(2): 318-326.
5.	14 Gold B, Kalush F, Bergeron J, et al . Estrogen receptor genotypes and haplotypes associated with breast cancer risk. Cancer Res , 2004, 64(24): 8891-8900.
6.	15 Kobayashi N, Fujino T, Shirogane T, et al . Estrogen receptor alpha polymorphism as a genetic marker for bone loss, vertebral fractures and susceptibility to estrogen. Maturitas , 2002, 4(3): 193-201.
7.	16 Mansur AP, Nogueira CC, Strunz CM, et al . Genetic polymorphisms of estrogen receptors in patients with premature coronary artery disease. Arch Med Res , 2005, 36(5): 511-517.
8.	17 Kunnas TA, Laippala P, Penttilä A, et al . Association of polymorphism of human alpha oestrogen receptor gene with coronary artery disease in men:a necropsy study. BMJ , 2000, 321(7256): 273-274.
9.	18 Karadağ B, Güven M, Hacioğlu Y, et al . Relationship between two estrogen receptor-alpha gene polymorphisms and angiographic coronary artery disease. Anadolu Kardiyol Derg , 2009, 9(4): 267-272.
10.	19 Boroumand M, Ghaedi M, Mohammadtaghvaei N, et al . Association of estrogen receptor alpha gene polymorphism with the presence of coronary artery disease documented by coronary angiography. Clin Biochem , 2009, 42(9): 835-839.
11.	龙丽, 单可人, 任锡麟. 雌激素受体(ESR) 基因多态性与疾病相关性的研究进展. 国际遗传学杂志, 2008, 31(2): 124-128.
12.	郭志刚, 郑华, 吴赛珠, 等. 雌激素受体基因多态性与冠心病的关系. 中华老年心脑血管病杂志, 2002, 4(6): 374-377.
13.	黄宪章, 张平安, 李艳, 等. 雌激素受体基因多态性与冠心病关系的研究. 中华心血管病杂志, 2002, 30(2): 78-81.
14.	郑红梅. 雌激素受体基因多态性与女性冠状动脉粥样硬化及脂质代谢的关系. 石家庄: 河北医科大学, 2002.
15.	张燕, 谢汝萍, 王荫华, 等. 雌激素受体基因多态性与脑梗死的相关性研究. 中华医学杂志, 2002, 82(21): 1443-1446.
16.	程爱娟, 付乃宽, 许静. 雌激素受体基因多态性与冠心病及血脂关系的研究. 河北医药, 2006, 28(7): 568-570.
17.	李丽华, 赵福梅, 李国庆, 等. 雌激素受体α基因多态性与冠心病及其发病危险因素的相关性研究. 中国分子心脏病学杂志, 2006, 6(2): 90-94.
18.	唐忠志, 李小平, 杨剑虹, 等. 雌激素受体α多态性与心血管疾病危险性的关系研究. 华南国防医学杂志, 2008, 22(2): 35-37.
19.	金莉子, 陈筱潮, 马英东, 等. 雌激素受体α基因PvuⅡ和Xba I酶切多态性与冠心病相关性. 中华生物医学工程杂志, 2010, 16(2): 136-139.

1. 1 Hanke H, Hanke S, Bruck B, et al . Inhibition of the protective effect of estrogen by progesterone in experimental atherosclerosis. Atherosclerosis , 1996, 121(1): 129-138.
2. 2 Ushiyama T, Ueyama H, Inoue K, et al . Estrogen receptor gene polymorphism and generalized osteoarthritis. J Rheumatol , 1998, 25(1): 134-137.
3. 10 Xu H, Hou X, Wang N, et al . Gender-specific effect of estrogen receptor-1 gene polymorphisms in coronary artery disease and its angiographic severity in chinese population. Clin Chim Acta , 2008, 395(1-2): 130-133.
4. 13 Deng G, Zhou G, Zhai Y, et al . Association of estrogen receptor α polymorphisms with susceptibility to chronic hepatitis B virus infection. Hepatology , 2004, 40(2): 318-326.
5. 14 Gold B, Kalush F, Bergeron J, et al . Estrogen receptor genotypes and haplotypes associated with breast cancer risk. Cancer Res , 2004, 64(24): 8891-8900.
6. 15 Kobayashi N, Fujino T, Shirogane T, et al . Estrogen receptor alpha polymorphism as a genetic marker for bone loss, vertebral fractures and susceptibility to estrogen. Maturitas , 2002, 4(3): 193-201.
7. 16 Mansur AP, Nogueira CC, Strunz CM, et al . Genetic polymorphisms of estrogen receptors in patients with premature coronary artery disease. Arch Med Res , 2005, 36(5): 511-517.
8. 17 Kunnas TA, Laippala P, Penttilä A, et al . Association of polymorphism of human alpha oestrogen receptor gene with coronary artery disease in men:a necropsy study. BMJ , 2000, 321(7256): 273-274.
9. 18 Karadağ B, Güven M, Hacioğlu Y, et al . Relationship between two estrogen receptor-alpha gene polymorphisms and angiographic coronary artery disease. Anadolu Kardiyol Derg , 2009, 9(4): 267-272.
10. 19 Boroumand M, Ghaedi M, Mohammadtaghvaei N, et al . Association of estrogen receptor alpha gene polymorphism with the presence of coronary artery disease documented by coronary angiography. Clin Biochem , 2009, 42(9): 835-839.
11. 龙丽, 单可人, 任锡麟. 雌激素受体(ESR) 基因多态性与疾病相关性的研究进展. 国际遗传学杂志, 2008, 31(2): 124-128.
12. 郭志刚, 郑华, 吴赛珠, 等. 雌激素受体基因多态性与冠心病的关系. 中华老年心脑血管病杂志, 2002, 4(6): 374-377.
13. 黄宪章, 张平安, 李艳, 等. 雌激素受体基因多态性与冠心病关系的研究. 中华心血管病杂志, 2002, 30(2): 78-81.
14. 郑红梅. 雌激素受体基因多态性与女性冠状动脉粥样硬化及脂质代谢的关系. 石家庄: 河北医科大学, 2002.
15. 张燕, 谢汝萍, 王荫华, 等. 雌激素受体基因多态性与脑梗死的相关性研究. 中华医学杂志, 2002, 82(21): 1443-1446.
16. 程爱娟, 付乃宽, 许静. 雌激素受体基因多态性与冠心病及血脂关系的研究. 河北医药, 2006, 28(7): 568-570.
17. 李丽华, 赵福梅, 李国庆, 等. 雌激素受体α基因多态性与冠心病及其发病危险因素的相关性研究. 中国分子心脏病学杂志, 2006, 6(2): 90-94.
18. 唐忠志, 李小平, 杨剑虹, 等. 雌激素受体α多态性与心血管疾病危险性的关系研究. 华南国防医学杂志, 2008, 22(2): 35-37.
19. 金莉子, 陈筱潮, 马英东, 等. 雌激素受体α基因PvuⅡ和Xba I酶切多态性与冠心病相关性. 中华生物医学工程杂志, 2010, 16(2): 136-139.

Chinese Journal of Evidence-Based Medicine

Correlation of Estrogen Receptor α Gene Pvu Ⅱ Site Polymorphisms and Risk of Coronary Heart Disease in Chinese Population: A Meta-Analysis

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