Incidence and Risk Factors of Myocardial Infarction Complicated by Non-Alcoholic Fatty Liver Disease_Chinese Journal of Evidence-Based Medicine

Authors：

LI Qingxiang ¹ ,  ZHANG Ying ² , ZHU Xiaoling ¹ , BAI Shugong ¹

1. The 35th Wards, Anzhen Hospital, Capital Medical University & Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China;2. Beijing Xuanwu TCM Hospital, Beijing 100056, China;

Corresponding author：

ZHANG Ying, Email: alelqx@126.com

Keywords：

Myocardial infarction; Non-alcoholic fatty liver disease (NAFLD); Ultrasound

DOI：

10.7507/1672-2531.20130068

Video：

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Objective 　To investigate the incidence and risk factors of non-alcoholic fatty liver disease (NAFLD) in patients with myocardial infarction.
Methods 　A total of 634 patients with myocardial infarction from Beijing Anzhen Hospital were asked to take liver and gallbladder ultrasonography during hospitalization, and then divided into the NAFLD and non-NAFLD groups. The incidence and risk factors of the two groups were then analyzed.
Results 　The incidence of NAFLD was 52.2% (331/634). Both body mass index (BMI) and serum alanine aminotransferase of the NAFLD group were higher than those of non-NAFLD group, with significant difference (P lt;0.05). The incidence of NAFLD was positively increased following the severity of coronary diseases (χ2=7.275, P=0.03). The result of multivariable logistic regression analysis showed BMI, multi-vessel lesions of coronary disease, and left main coronary artery lesion were the independent risk factors of NAFLD.
Conclusion 　The myocardial infarction patients who are particularly complicated by overweight, multi-vessel lesions and left main coronary artery lesion have a higher incidence of NAFLD.

Citation： LI Qingxiang,ZHANG Ying,ZHU Xiaoling,BAI Shugong. Incidence and Risk Factors of Myocardial Infarction Complicated by Non-Alcoholic Fatty Liver Disease. Chinese Journal of Evidence-Based Medicine, 2013, 13(4): 404-408. doi: 10.7507/1672-2531.20130068 Copy

1.	Mlinar B, Mare J, Janez A, et al. Molecular mechanisms of insulin resistanee and associated diseases. Clin Chim Acta, 2007, 375(1-2): 20-35.
2.	Kessler A, Levy Y, Roth A, et al. Increased prevalence of NAFLD in patients with acute myocardial infarction independent of BMI. Hepatology, 2005, 42(13): 623.
3.	中华医学会肝脏病学分会脂肪肝和酒精性肝病学组. 非酒精性脂肪性肝病的诊疗指南(2010年修订版). 中华肝脏病杂志, 2010, 18(3): 163-166.
4.	李昭, 张京梅, 陶英, 等. 糖化血红蛋白水平与青年男性急性心肌梗死冠状动脉病变程度的相关性研究. 中国循证医学杂志, 2012, 12(12): 1420-1425.
5.	陈尹, 胡世莲, 李幼平, 等. 全球药物干预治疗高血压合并其他疾病指南的系统评价. 中国循证医学杂志, 2012, 12(10): 1180-1194.
6.	中华医学会糖尿病分会. 中国2型糖尿病防治指南(2010年版). 中国糖尿病杂志, 2012, 2(12): S1-S37.
7.	中华医学会心血管病学分会. 推荐在我国采用心肌梗死全球统一定义. 中华心血管病杂志, 2008, 36(10): 867-869.
8.	章蓉, 吴凤芸, 徐贵发. 对非酒精性脂肪肝患者生活方式干预的效果评价. 山东大学学报(医学版), 2010, 48(8): 113-116.
9.	李立, 苏冬梅, 韩海啸, 等. 中医药治疗非酒精性脂肪性肝炎临床研究的系统评价. 中国循证医学杂志, 2011, 11(2): 195-203.
10.	Brunt EM. Nonalcoholic steatohepatits. Sernin Live Dis, 2004, 24(32): 3-20.
11.	姜慧卿. 非酒精性脂肪性肝病的临床表现与病理学特点. 中国全科医学, 2007, 10(24): 2030-2033.
12.	周琦, 范建高. 非酒精性脂肪性肝病与冠心病的关系及相关研究进展. 中国动脉硬化杂志, 2008, 16(8): 669-672.
13.	马杰, 李晓阳, 王宇, 等. 多层螺旋CT分析胰岛素抵抗与非酒精性脂肪肝及代谢综合征的关系. 河北医药, 2012, 34(17): 2611-2612.
14.	刘瑛琪, 费军. 双源CT评价非酒精性脂肪肝与冠心病关系的研究. 中国临床保健杂志, 2010, 13(6): 582-584.
15.	李晓玲, 朱旅云, 胡丽叶, 等. 肥胖人群血管内皮功能与高血压发生的相关因素分析. 中国医药, 2008, 3(11): 672-674.
16.	徐原宁, 林秀芳, 黄德嘉. 老年男性非酒精性脂肪肝与代谢综合征不同诊断标准的相关性研究. 中国循证医学杂志, 2011, 11(11): 1255-1257.
17.	Koehler EM, Schouten JNL, Hansen BE, et al. Prevalence and risk factors of non-alcoholic fatty liver disease in the elderly: Results from the Rotterdam study. J of Hepatology, 2012, 57(6): 1305-1311.
18.	Tendler D, Lin S, Yancy WS Jr, et al. The effect of a low-carbohyd rate, ketogenic diet on non-alcoholic fatty liver disease: a pilot study.Dig Dis Sci, 2007, 52(2): 589-593.
19.	杨枝, 宁光. 非酒精性脂肪性肝病与肥胖的关系. 上海交通大学学报(医学版), 2011, 31(11): 1652-1656.
20.	Pittas AG, Joseph NA, Greenberg AS. Adipocytokines and insulin resistance. J Clin Endocrin & Metab, 2004, 89(2): 447-452.
21.	Orlandi F, Gambino R, Musso G, et al. Nonalcoholic steatohepatitis versus steatosis: Adipose tissue insulin resistance and dysfunctional response to fat ingestion predict liver injury and altered glucose and lipoprotein metabolism. Hepatology, 2012, 56(3): 933-942.

1. Mlinar B, Mare J, Janez A, et al. Molecular mechanisms of insulin resistanee and associated diseases. Clin Chim Acta, 2007, 375(1-2): 20-35.
2. Kessler A, Levy Y, Roth A, et al. Increased prevalence of NAFLD in patients with acute myocardial infarction independent of BMI. Hepatology, 2005, 42(13): 623.
3. 中华医学会肝脏病学分会脂肪肝和酒精性肝病学组. 非酒精性脂肪性肝病的诊疗指南(2010年修订版). 中华肝脏病杂志, 2010, 18(3): 163-166.
4. 李昭, 张京梅, 陶英, 等. 糖化血红蛋白水平与青年男性急性心肌梗死冠状动脉病变程度的相关性研究. 中国循证医学杂志, 2012, 12(12): 1420-1425.
5. 陈尹, 胡世莲, 李幼平, 等. 全球药物干预治疗高血压合并其他疾病指南的系统评价. 中国循证医学杂志, 2012, 12(10): 1180-1194.
6. 中华医学会糖尿病分会. 中国2型糖尿病防治指南(2010年版). 中国糖尿病杂志, 2012, 2(12): S1-S37.
7. 中华医学会心血管病学分会. 推荐在我国采用心肌梗死全球统一定义. 中华心血管病杂志, 2008, 36(10): 867-869.
8. 章蓉, 吴凤芸, 徐贵发. 对非酒精性脂肪肝患者生活方式干预的效果评价. 山东大学学报(医学版), 2010, 48(8): 113-116.
9. 李立, 苏冬梅, 韩海啸, 等. 中医药治疗非酒精性脂肪性肝炎临床研究的系统评价. 中国循证医学杂志, 2011, 11(2): 195-203.
10. Brunt EM. Nonalcoholic steatohepatits. Sernin Live Dis, 2004, 24(32): 3-20.
11. 姜慧卿. 非酒精性脂肪性肝病的临床表现与病理学特点. 中国全科医学, 2007, 10(24): 2030-2033.
12. 周琦, 范建高. 非酒精性脂肪性肝病与冠心病的关系及相关研究进展. 中国动脉硬化杂志, 2008, 16(8): 669-672.
13. 马杰, 李晓阳, 王宇, 等. 多层螺旋CT分析胰岛素抵抗与非酒精性脂肪肝及代谢综合征的关系. 河北医药, 2012, 34(17): 2611-2612.
14. 刘瑛琪, 费军. 双源CT评价非酒精性脂肪肝与冠心病关系的研究. 中国临床保健杂志, 2010, 13(6): 582-584.
15. 李晓玲, 朱旅云, 胡丽叶, 等. 肥胖人群血管内皮功能与高血压发生的相关因素分析. 中国医药, 2008, 3(11): 672-674.
16. 徐原宁, 林秀芳, 黄德嘉. 老年男性非酒精性脂肪肝与代谢综合征不同诊断标准的相关性研究. 中国循证医学杂志, 2011, 11(11): 1255-1257.
17. Koehler EM, Schouten JNL, Hansen BE, et al. Prevalence and risk factors of non-alcoholic fatty liver disease in the elderly: Results from the Rotterdam study. J of Hepatology, 2012, 57(6): 1305-1311.
18. Tendler D, Lin S, Yancy WS Jr, et al. The effect of a low-carbohyd rate, ketogenic diet on non-alcoholic fatty liver disease: a pilot study.Dig Dis Sci, 2007, 52(2): 589-593.
19. 杨枝, 宁光. 非酒精性脂肪性肝病与肥胖的关系. 上海交通大学学报(医学版), 2011, 31(11): 1652-1656.
20. Pittas AG, Joseph NA, Greenberg AS. Adipocytokines and insulin resistance. J Clin Endocrin & Metab, 2004, 89(2): 447-452.
21. Orlandi F, Gambino R, Musso G, et al. Nonalcoholic steatohepatitis versus steatosis: Adipose tissue insulin resistance and dysfunctional response to fat ingestion predict liver injury and altered glucose and lipoprotein metabolism. Hepatology, 2012, 56(3): 933-942.

Chinese Journal of Evidence-Based Medicine

Incidence and Risk Factors of Myocardial Infarction Complicated by Non-Alcoholic Fatty Liver Disease

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