Correlation between Adenoviral Infection and Encephalitis in Children: A Meta-Analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 LIYa-min ,  TANWen-jie

Biotech Center for Viral Disease Emergency, National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China;

Corresponding author：

TANWen-jie, Email: tanwj28@hotmail.com

Keywords：

Adenoviral infection; Encephalitis; Correlation; Meta-analysis

DOI：

10.7507/1672-2531.20140139

Video：

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Objective To systematically review the correlation between adenoviral infection and encephalitis in children. Methods Studies on the correlation between adenoviral infection and encephalitis among children were retrieved in the databases of CHKD, CNKI, WanFang Data, CMCC, PubMed, Ovid, EBSCO, and Science New during 1978-2013. According to our inclusion and exclusion criteria, literature was screened. After data extraction, meta-analysis was conducted using Comprehensive Meta Analysis 2.0. Results A total of 18 studies were enrolled. The results of meta-analysis indicated that:the prevalence of infection of human adenovirus in children with encephalitis was p₁=10.8% (95%CI 6.5% to 15.2%, P < 0.000 01). The incidence of encephalitis in children with adenoviral infection was p₂=31.4% (95%CI 14.1% to 48.6%, P < 0.000 01). The results of two studies showed that, the correlation coefficients between adenoviral infection and encephalitis were OR₁=2.22 (95%CI 0.32 to 14.79, P > 0.05), and OR₂=1.12 (95%CI 0.14 to 9.10, P > 0.05), respectively, both with no significant difference. In addition, the subgenus B adenoviruses, including type 3 and type 7 were more associated with encephalitis, followed by type 1 and type 2 in subgenus C and type 8 in subgenus D. Conclusion Current evidence shows that no correlation exists between adenoviral infection and encephalitis in children. However, the above conclusion needs to be verified by conducting more rationally-designed studies so as to clarify the correlation.

Citation： LIYa-min, TANWen-jie. Correlation between Adenoviral Infection and Encephalitis in Children: A Meta-Analysis. Chinese Journal of Evidence-Based Medicine, 2014, 14(7): 835-840. doi: 10.7507/1672-2531.20140139 Copy

1.	Jones MS, Harrach B, Ganac RD, et al. New adenovirus species found in a patient presenting with gastroenteritis. J Virol, 2007, 81(11):5978-5984.
2.	Lenaerts L, Clercq E, Naesens L, et al. Clinical features and treatment of adenovirus infections. Rev Med Virol, 2008, 18(6):357-374.
3.	Monath TP. Japanese encephalitis-a plague of the Orient. N Engl J Med, 1988, 319(10):641-643.
4.	Sawyer MH. Enterovirus infections:diagnosis and treatment. Pediatr Infect Dis, 1999, 18:1033-1040.
5.	符贻峰, 黄兹宝, 黄壮福, 等.病毒性脑炎126例的临床及病原学分析.中国美容医学杂志, 2012, 21(8):71-73.
6.	李静, 李幼平.不断完善与发展的Cochrane系统评价.中国循证医学杂志, 2008, 8(9):742-743.
7.	李盈, 顾怀婷. 《中国循证医学杂志》发表系统评价/Meta分析的文献计量分析.中国循证医学杂志, 2012, 12(10):1279-1282.
8.	Chalmers I, Hedges L, Cooper H, et al. A brief history of research synthesis. Evaluation & the Health Professions, 2002, 25(1):12-37.
9.	Solomon T, Thao TT, Lewthwaite P, et al. A cohort study to assess the new WHO Japanese encephalitis surveillance standards. Bull World Health Organ, 2008, 86(3):178-186.
10.	许梅骊.小儿腺病毒脑炎24例报道.蚌埠医学院学报, 1981, 6(1):42-45.
11.	白汉玉, 沐桂藩, 孙月英, 等.病毒性脑炎、脑膜炎的病原学探讨.北京医学杂志, 1982, 4(4):193-194.
12.	杨善存, 王一力, 黄丽春, 等.小儿散发性脑炎病原学和临床的探讨.中国神经精神疾病杂志, 1986, 12(1):4-7.
13.	郭植材, 涂地勤, 姜德昭, 等.小儿散发性脑炎70例临床分析及病毒学检测.广西医学院学报, 1987, 4(1), 6-8.
14.	谢若男, 费选文, 曾嫦, 等.潮汕地区散发性病毒性脑膜炎的病毒病原学分析.中华传染病杂志, 2005, 23(4):260-262.
15.	金玉, 余唯琪, 薛君莉, 等.儿童病毒性脑炎脑膜炎98例临床分析.中国实用儿科杂志, 2003, 18(4):212-214.
16.	邵新华, 吴洁, 汪梅先.小儿病毒性脑炎与抗病毒抗体IgM的临床意义.海南医学, 2004, 15(9):50-52.
17.	费选文, 谢若男, 曾嫦, 等.潮汕地区散发性病毒性脑膜炎的病毒病原学分析.中华传染病杂志, 2005, 23(4):260-262.
18.	冯同豹, 汤政, 刘凌, 等.病毒性脑炎的早期诊断及更昔洛韦疗效评价.实用儿科临床杂志. 2007, 22(9):696-697.
19.	曹青.儿童病毒性脑炎、脑膜炎92例临床及病毒病原学分析.医学理论与实践. 2007, 20(3):259-260.
20.	Belsy A, Odalys V, Luis S, et al. Molecular characterization of adenoviral infections in Cuba:report of an unusual association of species D adenoviruses with different clinical syndromes. Arch Virol, 2009, 154(4):619-627.
21.	陈焕辉, 陈翊, 林涛, 等.广州地区儿童病毒性脑炎病原构成和流行特点.广州医药, 2012, 43(1):18-21.
22.	Simila S, Joupila R, Salmi A, et al. Encephalomeningitis in children associated with an adenovirus type 7 epidemic. Acta Pediatr Scand, 1970, 59(4):310-316.
23.	楼方岑.腺病毒感染.四川医学, 1983, 2(5):300.
24.	傅文永, 刘为民, 许忠, 等.腺病毒与小儿中枢神经系感染:附31例临床分析.临床儿科杂志, 1991, 9(2):111-112.
25.	Hon KL, Leung E, Tang J, et al. Premorbid factors and outcome associated with respiratory virus infection in a pediatric intensive care unit. Pediatr Pulmonol, 2008, 43(4):275-280.
26.	Lai CY, Lee CJ, Lee PL, et al. Adenovirus serotype 3 and 7 infection with acute respiratory failure in children in Taiwan, 2010-2011. PLoS ONE, 8(1):e53614.
27.	朱汝南, 邓洁, 王芳, 等. 2000年秋冬至2002年夏北京地区急性呼吸道感染病毒病原学研究.临床儿科杂志, 2003, 21(1):25-28.
28.	Carballal G, Videla CM, Espinosa MA, et al. Multi-centered study of viral acute lower respiratory infections in children from four cities of Argentina. J Med Virol, 2001, 64(2):167-174.
29.	Fujimoto T, Chikahira M, Kase T, et al. Single-tube multiplex PCR for rapid and sensitive diagnosis of subgenus B and other subgenera adenoviruses in clinical samples. Microbiol Immunol, 2000, 44(10):821-826.
30.	Dubberke ER, Tu B, Rivet DJ, et al. Acute meningoencephalitis caused by adenovirus serotype 26. J Neurovirol, 2006, 12(3):235-240.
31.	The Cochrane Collaboration. 9.1.4 When not to use Meta-analysis in a review. Cochrane Handbook for Systematic Reviews of Interventions. 5.1.0. March 2011. Available at:http://www.cochrane-handbook.org.
32.	Kelsey DS, Adenovirus meningoencephalitis. Pediatrics, 1978, 61(3):291-293.
33.	Chou SM, Roos R, Burnell R, et al. Subacute focal adenovirus encephalitis. J Neuropathol Exp Neurol, 1973, 32(1):34-50.
34.	Straussberg R, Harel L, Levy Y, et al. A syndrome of transient encephalopathy associated with adenovirus infection. Pediatrics, 2001, 107(5):E69.
35.	Munoz-Almagro C, Gonzalez-Cuevas A, Cambra FJ, et al. Rapid diagnosis of therapeutic meningoencephalitis by PCR. Enferm Infet Microbiol Clin, 2002, 20(3):110-121.

1. Jones MS, Harrach B, Ganac RD, et al. New adenovirus species found in a patient presenting with gastroenteritis. J Virol, 2007, 81(11):5978-5984.
2. Lenaerts L, Clercq E, Naesens L, et al. Clinical features and treatment of adenovirus infections. Rev Med Virol, 2008, 18(6):357-374.
3. Monath TP. Japanese encephalitis-a plague of the Orient. N Engl J Med, 1988, 319(10):641-643.
4. Sawyer MH. Enterovirus infections:diagnosis and treatment. Pediatr Infect Dis, 1999, 18:1033-1040.
5. 符贻峰, 黄兹宝, 黄壮福, 等.病毒性脑炎126例的临床及病原学分析.中国美容医学杂志, 2012, 21(8):71-73.
6. 李静, 李幼平.不断完善与发展的Cochrane系统评价.中国循证医学杂志, 2008, 8(9):742-743.
7. 李盈, 顾怀婷. 《中国循证医学杂志》发表系统评价/Meta分析的文献计量分析.中国循证医学杂志, 2012, 12(10):1279-1282.
8. Chalmers I, Hedges L, Cooper H, et al. A brief history of research synthesis. Evaluation & the Health Professions, 2002, 25(1):12-37.
9. Solomon T, Thao TT, Lewthwaite P, et al. A cohort study to assess the new WHO Japanese encephalitis surveillance standards. Bull World Health Organ, 2008, 86(3):178-186.
10. 许梅骊.小儿腺病毒脑炎24例报道.蚌埠医学院学报, 1981, 6(1):42-45.
11. 白汉玉, 沐桂藩, 孙月英, 等.病毒性脑炎、脑膜炎的病原学探讨.北京医学杂志, 1982, 4(4):193-194.
12. 杨善存, 王一力, 黄丽春, 等.小儿散发性脑炎病原学和临床的探讨.中国神经精神疾病杂志, 1986, 12(1):4-7.
13. 郭植材, 涂地勤, 姜德昭, 等.小儿散发性脑炎70例临床分析及病毒学检测.广西医学院学报, 1987, 4(1), 6-8.
14. 谢若男, 费选文, 曾嫦, 等.潮汕地区散发性病毒性脑膜炎的病毒病原学分析.中华传染病杂志, 2005, 23(4):260-262.
15. 金玉, 余唯琪, 薛君莉, 等.儿童病毒性脑炎脑膜炎98例临床分析.中国实用儿科杂志, 2003, 18(4):212-214.
16. 邵新华, 吴洁, 汪梅先.小儿病毒性脑炎与抗病毒抗体IgM的临床意义.海南医学, 2004, 15(9):50-52.
17. 费选文, 谢若男, 曾嫦, 等.潮汕地区散发性病毒性脑膜炎的病毒病原学分析.中华传染病杂志, 2005, 23(4):260-262.
18. 冯同豹, 汤政, 刘凌, 等.病毒性脑炎的早期诊断及更昔洛韦疗效评价.实用儿科临床杂志. 2007, 22(9):696-697.
19. 曹青.儿童病毒性脑炎、脑膜炎92例临床及病毒病原学分析.医学理论与实践. 2007, 20(3):259-260.
20. Belsy A, Odalys V, Luis S, et al. Molecular characterization of adenoviral infections in Cuba:report of an unusual association of species D adenoviruses with different clinical syndromes. Arch Virol, 2009, 154(4):619-627.
21. 陈焕辉, 陈翊, 林涛, 等.广州地区儿童病毒性脑炎病原构成和流行特点.广州医药, 2012, 43(1):18-21.
22. Simila S, Joupila R, Salmi A, et al. Encephalomeningitis in children associated with an adenovirus type 7 epidemic. Acta Pediatr Scand, 1970, 59(4):310-316.
23. 楼方岑.腺病毒感染.四川医学, 1983, 2(5):300.
24. 傅文永, 刘为民, 许忠, 等.腺病毒与小儿中枢神经系感染:附31例临床分析.临床儿科杂志, 1991, 9(2):111-112.
25. Hon KL, Leung E, Tang J, et al. Premorbid factors and outcome associated with respiratory virus infection in a pediatric intensive care unit. Pediatr Pulmonol, 2008, 43(4):275-280.
26. Lai CY, Lee CJ, Lee PL, et al. Adenovirus serotype 3 and 7 infection with acute respiratory failure in children in Taiwan, 2010-2011. PLoS ONE, 8(1):e53614.
27. 朱汝南, 邓洁, 王芳, 等. 2000年秋冬至2002年夏北京地区急性呼吸道感染病毒病原学研究.临床儿科杂志, 2003, 21(1):25-28.
28. Carballal G, Videla CM, Espinosa MA, et al. Multi-centered study of viral acute lower respiratory infections in children from four cities of Argentina. J Med Virol, 2001, 64(2):167-174.
29. Fujimoto T, Chikahira M, Kase T, et al. Single-tube multiplex PCR for rapid and sensitive diagnosis of subgenus B and other subgenera adenoviruses in clinical samples. Microbiol Immunol, 2000, 44(10):821-826.
30. Dubberke ER, Tu B, Rivet DJ, et al. Acute meningoencephalitis caused by adenovirus serotype 26. J Neurovirol, 2006, 12(3):235-240.
31. The Cochrane Collaboration. 9.1.4 When not to use Meta-analysis in a review. Cochrane Handbook for Systematic Reviews of Interventions. 5.1.0. March 2011. Available at:http://www.cochrane-handbook.org.
32. Kelsey DS, Adenovirus meningoencephalitis. Pediatrics, 1978, 61(3):291-293.
33. Chou SM, Roos R, Burnell R, et al. Subacute focal adenovirus encephalitis. J Neuropathol Exp Neurol, 1973, 32(1):34-50.
34. Straussberg R, Harel L, Levy Y, et al. A syndrome of transient encephalopathy associated with adenovirus infection. Pediatrics, 2001, 107(5):E69.
35. Munoz-Almagro C, Gonzalez-Cuevas A, Cambra FJ, et al. Rapid diagnosis of therapeutic meningoencephalitis by PCR. Enferm Infet Microbiol Clin, 2002, 20(3):110-121.

Chinese Journal of Evidence-Based Medicine

Correlation between Adenoviral Infection and Encephalitis in Children: A Meta-Analysis

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