How to Conduct Dose-response Meta-analysis by Using Linear relation and Piecewise Linear Regression Model_Chinese Journal of Evidence-Based Medicine

Authors：

 YUYun-xiang ¹ , ZHANGChao ² , WENGHong ³ , KuangXin-ying ⁴ , GONGTai-fang ¹ , LUYun ¹ ,  XUChang ⁵

1. Department of Orthopaedics I, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China;
2. Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China;
3. Center for Evidence-Based and Translational Medicine, Zhongnan Hospital, Wuhan University, Wuhan 430071, China;
4. Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China;
5. Department of Urology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China;

Corresponding author：

XUChang, Email: xuchang1222@126.com

Keywords：

Dose-response relationship; Linear prediction; Piecewise linear regression; Meta-analysis

DOI：

10.7507/1672-2531.20160020

Video：

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When investing the relationship between independent and dependent variables in dose-response meta-analysis, the common method is to fit a regression function. A well-established model should take both linear and non-linear relationship into consideration. Traditional linear dose-response meta-analysis model showed poor applicability since it was based on simple linear function. We introduced a piecewise linear function into dose-response meta-analysis model which overcame this problem. In this paper, we will give a detailed discussion on traditional linear and piecewise linear regression model in dose-response meta-analysis.

Citation： YUYun-xiang, ZHANGChao, WENGHong, KuangXin-ying, GONGTai-fang, LUYun, XUChang. How to Conduct Dose-response Meta-analysis by Using Linear relation and Piecewise Linear Regression Model. Chinese Journal of Evidence-Based Medicine, 2016, 16(1): 111-114. doi: 10.7507/1672-2531.20160020 Copy

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1. 谢宇, 主编. 回归分析. 第1版. 北京: 社会科学文献出版社, 2010: 49-77.
2. 徐畅, 曾宪涛, 张超, 等. 应用R软件dosresmeta程序包和mvmeta程序包实现剂量-反应关系Meta分析. 中国循证医学杂志, 2015, 15(4): 479-483.
3. 徐畅, 张永刚, 韩芳芳, 等. 剂量-反应关系Meta分析的方法学简介. 中国循证医学杂志, 2015, 15(10): 1236-1240.
4. Greenland S, Longnecker MP. Methods for trend estimation from summarized dose-response data, with applications to meta-analysis. Am J Epidemiol, 1992, 135(11): 1301-1309.
5. 黄静宇, 张超, 李胜, 等. 剂量-反应Meta分析之限制性立方样条函数的应用. 中国循证医学杂志, 2015, 15(12): 1471-1474.
6. 曾宪涛, 主编. 应用STATA做Meta分析. 第1版. 北京: 军事医学科学出版社, 2014: 92-100.
7. Gould W. Linear splines and piecewise linear functions. Stata Technical Bulletin, 1993, 15: 13-17.

Chinese Journal of Evidence-Based Medicine

How to Conduct Dose-response Meta-analysis by Using Linear relation and Piecewise Linear Regression Model

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