Correlation between Polymorphism in Tumor Necrosis Factor <i>α</i> Gene-308 G/A and Ankylosing Spondylitis in Chinese Population: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 RUANXiao-lan ^1,2 , LISheng ² , AOXu-bin ¹ , HUANGJing-yu ² ,  WENGHong ²

1. Department of Hematology, Renmin Hospital of Wuhan University, Wuhan 430000, China;
2. Center for Evidence-Based and Translational Medicine, Wuhan University, Wuhan 430000, China;

Corresponding author：

WENGHong, Email: wengh92@163.com

Keywords：

Tumor necrosis factor; Gene polymorphism; Ankylosing spondylitis; Chinese population; Meta-analysis

DOI：

10.7507/1672-2531.20160140

Video：

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Objective To evaluate the relationship between tumor necrosis factor-α (TNF-α) gene promoter-308 G/A polymorphism and ankylosing spondylitis (AS) in Chinese population by meta-analysis. Methods The casecontrol studies about the correlation between TNF-α gene polymorphism and AS in Chinese population were retrieved from PubMed, EMbase, CNKI, CBM, WanFang Data and VIP database by two researchers. The retrieval time was from their establishment to December, 2015. After the paper screening, data extraction, and assessment of bias risk, the metaanalysis was conducted by Stata 12.0 software. Results A total of 11 case-control studies involving 1 154 AS patients and 1 458 controls were included. The results of meta-analysis showed that, for Chinese population, there was no significant association between TNF-α-308 G/A polymorphism and AS susceptibility (A vs. G: OR=0.96, 95% CI 0.63 to 1.47, P=0.86; AA vs. AG: OR=0.97, 95% CI 0.51 to 1.84, P=0.93; AA vs. GG: OR=0.92, 95% CI 0.32 to 2.61, P=0.87; AA+AG vs. GG; OR=1.04, 95% CI 0.60 to 1.80, P=0.89; AA vs. AG+GG: OR=1.03, 95% CI 0.58 to 1.82, P=0.92). Conclusion To date, it has not found the relationship between TNF-α gene promoter-308 G/A polymorphism and AS in Chinese population. For the quantity and quality limitation of the included studies, the conclusion has to be verified by more large-scale highquality studies.

Citation： RUANXiao-lan, LISheng, AOXu-bin, HUANGJing-yu, WENGHong. Correlation between Polymorphism in Tumor Necrosis Factor α Gene-308 G/A and Ankylosing Spondylitis in Chinese Population: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2016, 16(8): 906-912. doi: 10.7507/1672-2531.20160140 Copy

1.	冯方, 孙永强.强直性脊柱炎的研究进展.风湿病与关节炎, 2015, 4(5):77-80.
2.	Brown MA, Kenna T, Wordsworth BP. Genetics of ankylosing spondylitis--insights into pathogenesis. Nat Rev Rheumatol, 2016, 12(2):81-91.
3.	Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology:a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA, 2000, 283(15):2008-2012.
4.	曾宪涛, 刘慧, 陈曦, 等. Meta分析系列之四:观察性研究的质量评价工具.中国循证心血管医学杂志, 2012, 4(4):297-299.
5.	Zeng X, Zhang Y, Kwong JS, et al. The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta-analysis, and clinical practice guideline:a systematic review. J Evid Based Med, 2015, 8(1):2-10.
6.	贺艺, 何子奇, 刘菊芳, 等.血管内皮生长因子基因936C/T多态性与子痫前期相关性的Meta分析.中国循证医学杂志, 2015, 15(6): 639-645.
7.	翁鸿, 鄢金柱, 田国祥, 等.牙周病与高血压发病相关性:一项基于观察性研究的Meta分析.中国循证心血管医学杂志, 2015, 7(1): 16-19.
8.	曾宪涛, Joey S. W. Kwong, 田国祥, 等. Meta分析系列之二:Meta分析的软件.中国循证心血管医学杂志, 2012, 4(2):89-91.
9.	Higgins J, Thompson S. Quantifying heterogeneity in a metaanalysis. Stat Med, 2002, 21(11):1539-1559.
10.	林经安, 叶德富, 陈君敏, 等.肿瘤坏死因子-α-308基因多态性与强直性脊柱炎相关性研究.中华风湿病学杂志, 2003, 7(7):420-422.
11.	刘巧红, 吴清敏, 滕云, 等.强直性脊柱炎与肿瘤坏死因子基因启动子-308位点多态性相关的假设验证(英文).中国临床康复, 2004, 8(27):5974-5976.
12.	陈蕊雯.中国汉族人群强直性脊柱炎候选基因的研究.上海:第二军医大学, 2005.
13.	韩星海, 陈蕊雯, 段世伟, 等.肿瘤坏死因子α基因多态性对强直性脊柱炎发病易感性和临床病变程度的影响(英文).中国临床康复, 2005, 9(22):252-254.
14.	Shiau MY, Lo MK, Chang CP, et al. Association of tumour necrosis factor alpha promoter polymorphisms with ankylosing spondylitis in Taiwan. Ann Rheum Dis, 2007, 66(4):562-563.
15.	蔡庆, 刘成刚, 王雅静, 等.强直性脊柱炎患者肿瘤坏死因子α启动子308位点基因多态性分析.军医进修学院学报, 2007, 28(4):279-281.
16.	Lu MC, Yang KL, Tung CH, et al. Higher LPS-stimulated TNF-alpha mRNA levels in peripheral blood mononuclear cells from Chinese ankylosing spondylitis patients with-308G/A polymorphism in promoter region of tumor necrosis factor:association with distinct A33/B58/Cw10 haplotypes. Rheumatol Int, 2008, 29(2):189-195.
17.	梅永君, 李志军, 陈琳洁, 等. TNF-α启动子基因多态性与强直性脊柱炎的易感性.中华临床免疫和变态反应杂志, 2009, 3(3):173-177.
18.	陈进伟, 彭文锋, 毛妮, 等.强直性脊柱炎患者TNF-α-308位点基因多态性对依那西普疗效的影响.新医学, 2011, 42(3):157-159.
19.	Ji Y, Yang X, Yang L, et al. Studies on correlation between singlenucleotide polymorphisms of tumor necrosis factor gene and different stages of ankylosing spondylitis. Cell Biochem Biophys, 2013, 67(3):915-922.
20.	Sun R, Huang Y, Zhang H, et al. MMP-2, TNF-alpha and NLRP1 polymorphisms in Chinese patients with ankylosing spondylitis and rheumatoid arthritis. Mol Biol Rep, 2013, 40(11):6303-6308.
21.	Hohler T, Schaper T, Schneider PM, et al. Association of different tumor necrosis factor alpha promoter allele frequencies with ankylosing spondylitis in HLA-B27 positive individuals. Arthritis Rheum, 1998, 41(8):1489-1492.
22.	Braun J, Bollow M, Neure L, et al. Use of immunohistologic and in situ hybridization techniques in the examination of sacroiliac joint biopsy specimens from patients with ankylosing spondylitis. Arthritis Rheum, 1995, 38(4):499-505.
23.	任昌菊, 张超, 鄢金柱, 等.载脂蛋白E基因多态性与中国人群散发型阿尔茨海默病相关性的Meta分析.中国循证医学杂志, 2014, 14(7):813-820.
24.	Yan Y, Weng H, Shen ZH, et al. Association between interleukin-4 gene-590 c/t, -33 c/t, and 70-base-pair polymorphisms and periodontitis susceptibility:a meta-analysis. J Periodontol, 2014, 85(11):e354-e362.
25.	Weng H, Zhang C, Hu YY, et al. Association between Estrogen Receptor-alpha Gene XbaI and PvuII Polymorphisms and Periodontitis Susceptibility:A Meta-Analysis. Dis Markers, 2015, 2015:741972.

1. 冯方, 孙永强.强直性脊柱炎的研究进展.风湿病与关节炎, 2015, 4(5):77-80.
2. Brown MA, Kenna T, Wordsworth BP. Genetics of ankylosing spondylitis--insights into pathogenesis. Nat Rev Rheumatol, 2016, 12(2):81-91.
3. Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology:a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA, 2000, 283(15):2008-2012.
4. 曾宪涛, 刘慧, 陈曦, 等. Meta分析系列之四:观察性研究的质量评价工具.中国循证心血管医学杂志, 2012, 4(4):297-299.
5. Zeng X, Zhang Y, Kwong JS, et al. The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta-analysis, and clinical practice guideline:a systematic review. J Evid Based Med, 2015, 8(1):2-10.
6. 贺艺, 何子奇, 刘菊芳, 等.血管内皮生长因子基因936C/T多态性与子痫前期相关性的Meta分析.中国循证医学杂志, 2015, 15(6): 639-645.
7. 翁鸿, 鄢金柱, 田国祥, 等.牙周病与高血压发病相关性:一项基于观察性研究的Meta分析.中国循证心血管医学杂志, 2015, 7(1): 16-19.
8. 曾宪涛, Joey S. W. Kwong, 田国祥, 等. Meta分析系列之二:Meta分析的软件.中国循证心血管医学杂志, 2012, 4(2):89-91.
9. Higgins J, Thompson S. Quantifying heterogeneity in a metaanalysis. Stat Med, 2002, 21(11):1539-1559.
10. 林经安, 叶德富, 陈君敏, 等.肿瘤坏死因子-α-308基因多态性与强直性脊柱炎相关性研究.中华风湿病学杂志, 2003, 7(7):420-422.
11. 刘巧红, 吴清敏, 滕云, 等.强直性脊柱炎与肿瘤坏死因子基因启动子-308位点多态性相关的假设验证(英文).中国临床康复, 2004, 8(27):5974-5976.
12. 陈蕊雯.中国汉族人群强直性脊柱炎候选基因的研究.上海:第二军医大学, 2005.
13. 韩星海, 陈蕊雯, 段世伟, 等.肿瘤坏死因子α基因多态性对强直性脊柱炎发病易感性和临床病变程度的影响(英文).中国临床康复, 2005, 9(22):252-254.
14. Shiau MY, Lo MK, Chang CP, et al. Association of tumour necrosis factor alpha promoter polymorphisms with ankylosing spondylitis in Taiwan. Ann Rheum Dis, 2007, 66(4):562-563.
15. 蔡庆, 刘成刚, 王雅静, 等.强直性脊柱炎患者肿瘤坏死因子α启动子308位点基因多态性分析.军医进修学院学报, 2007, 28(4):279-281.
16. Lu MC, Yang KL, Tung CH, et al. Higher LPS-stimulated TNF-alpha mRNA levels in peripheral blood mononuclear cells from Chinese ankylosing spondylitis patients with-308G/A polymorphism in promoter region of tumor necrosis factor:association with distinct A33/B58/Cw10 haplotypes. Rheumatol Int, 2008, 29(2):189-195.
17. 梅永君, 李志军, 陈琳洁, 等. TNF-α启动子基因多态性与强直性脊柱炎的易感性.中华临床免疫和变态反应杂志, 2009, 3(3):173-177.
18. 陈进伟, 彭文锋, 毛妮, 等.强直性脊柱炎患者TNF-α-308位点基因多态性对依那西普疗效的影响.新医学, 2011, 42(3):157-159.
19. Ji Y, Yang X, Yang L, et al. Studies on correlation between singlenucleotide polymorphisms of tumor necrosis factor gene and different stages of ankylosing spondylitis. Cell Biochem Biophys, 2013, 67(3):915-922.
20. Sun R, Huang Y, Zhang H, et al. MMP-2, TNF-alpha and NLRP1 polymorphisms in Chinese patients with ankylosing spondylitis and rheumatoid arthritis. Mol Biol Rep, 2013, 40(11):6303-6308.
21. Hohler T, Schaper T, Schneider PM, et al. Association of different tumor necrosis factor alpha promoter allele frequencies with ankylosing spondylitis in HLA-B27 positive individuals. Arthritis Rheum, 1998, 41(8):1489-1492.
22. Braun J, Bollow M, Neure L, et al. Use of immunohistologic and in situ hybridization techniques in the examination of sacroiliac joint biopsy specimens from patients with ankylosing spondylitis. Arthritis Rheum, 1995, 38(4):499-505.
23. 任昌菊, 张超, 鄢金柱, 等.载脂蛋白E基因多态性与中国人群散发型阿尔茨海默病相关性的Meta分析.中国循证医学杂志, 2014, 14(7):813-820.
24. Yan Y, Weng H, Shen ZH, et al. Association between interleukin-4 gene-590 c/t, -33 c/t, and 70-base-pair polymorphisms and periodontitis susceptibility:a meta-analysis. J Periodontol, 2014, 85(11):e354-e362.
25. Weng H, Zhang C, Hu YY, et al. Association between Estrogen Receptor-alpha Gene XbaI and PvuII Polymorphisms and Periodontitis Susceptibility:A Meta-Analysis. Dis Markers, 2015, 2015:741972.

Chinese Journal of Evidence-Based Medicine

Correlation between Polymorphism in Tumor Necrosis Factor α Gene-308 G/A and Ankylosing Spondylitis in Chinese Population: A Meta-analysis

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