Association between rs1799971 Polymorphism in OPRM1 Gene on Opioid Requirements after Surgery in Asians: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 YANGJing , ZHENGbin , ZENGXiao-fang , LINa ,  LIUMao-bai

Department of Pharmacy, the Union Hospital of Fujian Medical University, FuZhou 350001, China;

Corresponding author：

LIUMao-bai, Email: liumb0591@sina.com

Keywords：

Polymorphism; rs1799971; Opioids; Meta-analysis; Case-control study

DOI：

10.7507/1672-2531.20160210

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To evaluate the relationship between OPRM1 gene rs1799971 polymorphism and opioid analgesics requirement after surgery in Asians. Methods We electronically searched databases including CNKI, CBM, VIP, WanFang Data, EMbase and MEDLINE to collect studies about the correlation between OPRM1 gene rs1799971 polymorphism and opioid analgesics requirement after surgery in Asia. The retrieval time was from the establishment to March 1st, 2015. Two reviewers independently screened literature, extracted data and assessed the risk bias of including studies, and then meta-analysis was performed by using RevMan 5.2 software. Results A total of 10 case-control studies involving 1 612 patients were included. The results of meta-analysis showed that the requirement of opioid analgesics after surgery for GG genotype carriers was more than AG carriers (SMD=-0.44, 95%CI -0.61 to -0.28, P<0.000 01), AA genotype carriers (SMD=-0.55, 95%CI -0.71 to -0.38, P<0.000 01), and AA+AG genotype carriers (SMD=-0.50, 95%CI -0.66 to -0.35, P<0.000 01). Conclusion The current evidence showed that the requirement of opioid analgesics after surgery for GG genotype of rs1799971 polymorphism in OPRM1 gene is higher in Asians. Due to the limited quality and quantity of included studies, the above results are needed to be further validated by more studies.

Citation： YANGJing, ZHENGbin, ZENGXiao-fang, LINa, LIUMao-bai. Association between rs1799971 Polymorphism in OPRM1 Gene on Opioid Requirements after Surgery in Asians: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2016, 16(12): 1388-1393. doi: 10.7507/1672-2531.20160210 Copy

1.	中华医学会麻醉学分会. 成人术后疼痛处理专家共识. 临床麻醉学杂志, 2010, 26(3):190-196.
2.	Macintyre PE, Jarvis DA. Age is the best predictor of postoperative morphine requirements. Pain, 1996, 64(2):357-364.
3.	Aubrun F, Salvi N, Coriat P, et al. Sex- and age-related differences in morphine requirements for postoperative pain relief. Anesthesiology, 2005, 103(1):156-160.
4.	Lloret LC, Decleves X, Oppert JM, et al. Pharmacology of morphine in obese patients:clinical implications. Clin Pharmacokinet, 2009, 48(10):635-651.
5.	周晨. 术后阿片类药物代谢与μ-阿片受体基因OPRM1A118G位点多态性之间关系的Meta 分析. 杭州:浙江大学, 2010.
6.	Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 2010, 25(9):603-605.
7.	郑明华, 主编. Meta分析软件的应用与实例解析. 第一版. 北京:人民卫生出版社, 2013:5.
8.	陈杰. u阿片受体A118G基因多态性对舒芬太尼术后病人自控镇痛的影响. 沈阳:中国医科大学, 2008.
9.	诸光峰, 上官王宁, 张高娇. 浙南地区女性人群OPRM1基因多态性(rs1799971)与舒芬太尼自控镇痛效果的研究. 浙江医学杂志, 2014, 36(24):1997-1999.
10.	梁惠霞, 徐漾漾, 包金荣. OPRM1, CYP3A 基因多态性对芬太尼腹式子宫全切术镇痛效果的影响. 中国基层医药, 2014, 21(20):3078-3080.
11.	张卫. OPRM1和CYP3A基因多态性对芬太尼镇痛效应的影响. 郑州:郑州大学, 2009.
12.	张双全, 李少英, 谭秀华. μ受体基因118A→G突变对芬太尼椎管内镇痛作用的影响. 南方医科大学学报, 2013, 33(2):309-311.
13.	Zhang W, Zhang YZ, Kan QC, et al. Association of human l-opioid receptor gene polymorphism A118G with fentanyl analgesia consumption in Chinese gynaecological patients. Anaesthesia, 2010, 65:130-135.
14.	Zhang J, Yuan J, Kan QC, et al. Study of the OPRM1 A118G genetic polymorphism associated with postoperative nausea and vomiting induced by fentanyl intravenous analgesia. Minerva Anestesiologica, 2011, 77(1):33-39.
15.	Haysshida M, Nagashima M, Satoh Y, et al. Analgesic requirements after major abdominal surgery are associated with OPRM1 gene polymorphism genotype and halotype. Pharmacogenomics, 2008, 9(11):1605-1616.
16.	Liu J, Hu D, Jiang Y, et al. Association between single nucleotide polymorphisms in the OPRM1 Gene and intraoperative remifentanil consumption in northern Chinese women. Pharmacology, 2014, 94(5-6):273-279.
17.	Xu GH, Gao M, Sheng QY, et al. Opioid receptor A118G polymorphism does not affect the consumption of sufentanil and ropivacaine by patient-controlled epidural analgesia after cesarean section. The Drug Monit, 2015, 37(1):53-57.
18.	Klepstad P, Rakvag TT, Kaasa S, et al. The 118A>G polymorphism in the human m-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease. Acta Anaesthesiol Scand, 2004, 48(10):1232-1239.
19.	Tsai FF, Fan SZ, Yang YM, et al. Human opioid m-receptor A118G polymorphism may protect against central pruritus by epidural morphine for post-cesarean analgesia. Acta Anaesthesiol Scand, 2010, 54(10):1265-1269.
20.	Sia AT, Lim Y, Lim EC, et al. A118G single nucleotide polymorphism of human m-opioid receptor gene influences pain perception and patient-controlled intravenous morphine consumption after intrathecal morphine for postcesarean analgesia. Anesthesiology, 2008, 109(3):520-526.

1. 中华医学会麻醉学分会. 成人术后疼痛处理专家共识. 临床麻醉学杂志, 2010, 26(3):190-196.
2. Macintyre PE, Jarvis DA. Age is the best predictor of postoperative morphine requirements. Pain, 1996, 64(2):357-364.
3. Aubrun F, Salvi N, Coriat P, et al. Sex- and age-related differences in morphine requirements for postoperative pain relief. Anesthesiology, 2005, 103(1):156-160.
4. Lloret LC, Decleves X, Oppert JM, et al. Pharmacology of morphine in obese patients:clinical implications. Clin Pharmacokinet, 2009, 48(10):635-651.
5. 周晨. 术后阿片类药物代谢与μ-阿片受体基因OPRM1A118G位点多态性之间关系的Meta 分析. 杭州:浙江大学, 2010.
6. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 2010, 25(9):603-605.
7. 郑明华, 主编. Meta分析软件的应用与实例解析. 第一版. 北京:人民卫生出版社, 2013:5.
8. 陈杰. u阿片受体A118G基因多态性对舒芬太尼术后病人自控镇痛的影响. 沈阳:中国医科大学, 2008.
9. 诸光峰, 上官王宁, 张高娇. 浙南地区女性人群OPRM1基因多态性(rs1799971)与舒芬太尼自控镇痛效果的研究. 浙江医学杂志, 2014, 36(24):1997-1999.
10. 梁惠霞, 徐漾漾, 包金荣. OPRM1, CYP3A 基因多态性对芬太尼腹式子宫全切术镇痛效果的影响. 中国基层医药, 2014, 21(20):3078-3080.
11. 张卫. OPRM1和CYP3A基因多态性对芬太尼镇痛效应的影响. 郑州:郑州大学, 2009.
12. 张双全, 李少英, 谭秀华. μ受体基因118A→G突变对芬太尼椎管内镇痛作用的影响. 南方医科大学学报, 2013, 33(2):309-311.
13. Zhang W, Zhang YZ, Kan QC, et al. Association of human l-opioid receptor gene polymorphism A118G with fentanyl analgesia consumption in Chinese gynaecological patients. Anaesthesia, 2010, 65:130-135.
14. Zhang J, Yuan J, Kan QC, et al. Study of the OPRM1 A118G genetic polymorphism associated with postoperative nausea and vomiting induced by fentanyl intravenous analgesia. Minerva Anestesiologica, 2011, 77(1):33-39.
15. Haysshida M, Nagashima M, Satoh Y, et al. Analgesic requirements after major abdominal surgery are associated with OPRM1 gene polymorphism genotype and halotype. Pharmacogenomics, 2008, 9(11):1605-1616.
16. Liu J, Hu D, Jiang Y, et al. Association between single nucleotide polymorphisms in the OPRM1 Gene and intraoperative remifentanil consumption in northern Chinese women. Pharmacology, 2014, 94(5-6):273-279.
17. Xu GH, Gao M, Sheng QY, et al. Opioid receptor A118G polymorphism does not affect the consumption of sufentanil and ropivacaine by patient-controlled epidural analgesia after cesarean section. The Drug Monit, 2015, 37(1):53-57.
18. Klepstad P, Rakvag TT, Kaasa S, et al. The 118A>G polymorphism in the human m-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease. Acta Anaesthesiol Scand, 2004, 48(10):1232-1239.
19. Tsai FF, Fan SZ, Yang YM, et al. Human opioid m-receptor A118G polymorphism may protect against central pruritus by epidural morphine for post-cesarean analgesia. Acta Anaesthesiol Scand, 2010, 54(10):1265-1269.
20. Sia AT, Lim Y, Lim EC, et al. A118G single nucleotide polymorphism of human m-opioid receptor gene influences pain perception and patient-controlled intravenous morphine consumption after intrathecal morphine for postcesarean analgesia. Anesthesiology, 2008, 109(3):520-526.

Chinese Journal of Evidence-Based Medicine

Association between rs1799971 Polymorphism in OPRM1 Gene on Opioid Requirements after Surgery in Asians: A Meta-analysis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content