The sample size of a meta-analysis should not be less than a single randomized controlled trial. Trial sequential analysis (TSA) can provide required information size and monitoring boundary to justify the conclusion of meta-analysis. However, the TSA software is only suitable for binary and continuous data, and it cannot analyze the time-to-event data. This paper aimed to introduce how to analyze the time-to-event data using TSA approach.
Citation：
WENGHong, GONGKan, LIUXiaoping, LIXudong, PENGJianping, ZENGXiantao. Application of trial sequential analysis in time-to-event data. Chinese Journal of Evidence-Based Medicine, 2017, 17(2): 239-242. doi: 10.7507/1672-2531.201607062
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Copyright © the editorial department of Chinese Journal of Evidence-Based Medicine of West China Medical Publisher. All rights reserved
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- 1. Pogue J, Yusuf S. Overcoming the limitations of current meta-analysis of randomised controlled trials. Lancet, 1998, 351(9095): 47-52.
- 2. Wetterslev J, Thorlund K, Brok J,et al. Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis. J Clin Epidemiol, 2008, 61(1): 64-75.
- 3. Miladinovic B, Mhaskar R, Hozo I,et al. Optimal information size in trial sequential analysis of time-to-event outcomes reveals potentially inconclusive results because of the risk of random error. J Clin Epidemiol, 2013, 66(6): 654-659.
- 4. 曾宪涛, 冷卫东, 李胜, 等. 如何正确理解及使用 GRADE 系统. 中国循证医学杂志, 2011, 11(9): 985-990.
- 5. 陈耀龙, 杨克虎, 姚亮, 等. GRADE 系统方法学进展. 中国循证儿科杂志, 2013, 8(1): 64-65.
- 6. 陈耀龙, 姚亮, Norris S, 等. GRADE 在系统评价中应用的必要性及注意事项. 中国循证医学杂志, 2013, 13(12): 1401-1404.
- 7. 翁鸿, 李胜, 曾宪涛. 试验序贯分析在 Stata 软件中的实现. 中国循证医学杂志, 2016, 16(12): 1472-1476.
- 8. 曾宪涛, 张超. R 与 Meta 分析. 第 1 版. 北京: 军事医学科学出版社, 2014.
- 9. Meng XY, Liao Y, Liu XP,et al. Concurrent cisplatin-based chemoradiotherapy versus exclusive radiotherapy in high-risk cervical cancer: a meta-analysis. Onco Targets Ther, 2016(9): 1875-1888.
