The association between polymorphisms in <i>scavenger receptor class B1</i> (<i>SCARB1</i>) gene and risk of cardiovascular diseases: a meta-analysis _Chinese Journal of Evidence-Based Medicine

Authors：

HE Pan ¹ , FAN Siyu ¹ , ZHI Hong ² ,  WANG Lina ¹

1. Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing 210009, P.R.China;
2. Department of Cardiology, Zhongda Hospital, Southeast University, Nanjing 210009, P.R.China;

Corresponding author：

WANG Lina, Email: lnwang@seu.edu.cn

Keywords：

Scavenger receptor class B1; SCARB1; Cardiovascular disease; Polymorphism; Meta-analysis

DOI：

10.7507/1672-2531.201803061

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Objectives To evaluate the relationships between the Scavenger Receptor Class B1 (SCARB1) polymorphisms and susceptibility of cardiovascular diseases (CVDs). Methods Databases including PubMed, Web of Science, CNKI, WanFang Data and VIP were searched from inception to December 31^st 2017 to collect case-control studies on relationships between Scavenger Receptor Class B1 (SCARB1) polymorphisms and susceptibility of CVDs. Paper screening, data extraction and assessment of risk of bias were carried out. Meta-analysis was then conducted by Stata 12.0 software. Results In total, 12 studies relevant to SCARB1 rs5888C/T, rs4238001 G/A and rs10846744 G/C polymorphisms were included. Meta-analysis showed that there was no significant association between the rs5888 C/T polymorphism and susceptibility of CVDs (C vs. T: OR=0.97, 95%CI 0.86 to 1.09, P=0.627), neither for the rs4238001 G/A (G vs. A: OR=0.87, 95%CI 0.64 to 1.17, P=0.344). However, the rs10846744 G/C polymorphism was significantly associated with CVDs risk (G vs. C: OR=1.30, 95%CI 1.11 to 1.52, P=0.001). Subgroup analysis showed that, for non-Asian subjects, there was a significant association between the rs5888 C/T polymorphism and susceptibility of CVDs (C vs. T: OR=0.82, 95% CI 0.68 to 0.99, P=0.040). Conclusions SCARB1 rs10864744 G/C polymorphism could be associated with risk of CVDs. Considering the quantity and quality limitation of the included studies, the conclusion has to be verified by more large-scale high quality studies.

Citation： HE Pan, FAN Siyu, ZHI Hong, WANG Lina. The association between polymorphisms in scavenger receptor class B1 (SCARB1) gene and risk of cardiovascular diseases: a meta-analysis . Chinese Journal of Evidence-Based Medicine, 2018, 18(10): 1053-1061. doi: 10.7507/1672-2531.201803061 Copy

1.	GBD 2016 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet, 2017, 390(10100): 1211-1259.
2.	陈伟伟, 高润霖, 刘力生, 等. 《中国心血管病报告 2017》概要. 中国循环杂志, 2018, 33(1): 1-8.
3.	Van EM, Pennings M, Hoekstra M, et al. Scavenger receptor BI and ATP-binding cassette transporter A1 in reverse cholesterol transport and atherosclerosis. Curr Opin Lipidol, 2005, 16(3): 307-315.
4.	Ohgami N, Miyazaki A, Sakai M, et al. Advanced glycation end products (AGE) inhibit scavenger receptor class B type I-mediated reverse cholesterol transport: a new crossroad of AGE to cholesterol metabolism. J Atheroscler Thromb, 2003, 10(1): 1-6.
5.	Chen L, Zhang J, Deng X, et al. Lysophosphatidic acid directly induces macrophage-derived foam cell formation by blocking the expression of SRBI. Biochem Biophys Res Commun, 2017, 491(3): 587-594.
6.	Constantineau J, Greason E, West M, et al. A synonymous variant in scavenger receptor, class B, type I gene is associated with lower SR-BI protein expression and function. Atherosclerosis, 2010, 210(1): 177-182.
7.	Yang XP, Sethi A, Yanek LR, et al. SCARB1 gene variants are associated with the phenotype of combined high high-density lipoprotein cholesterol and high lipoprotein (a). Circ-Cardiovasc Gene, 2016, 9(5): 408-418.
8.	Liao J, Guo X, Wang M, et al. Scavenger receptor class b type 1 deletion led to coronary atherosclerosis and ischemic heart disease in low-density lipoprotein receptor knockout mice on modified western-type diet. J Atheroscler Thromb, 2017, 24(2): 133-146.
9.	Yoon Y, Song J, Hong SH, et al. Analysis of multiple single nucleotide polymorphisms of candidate genes related to coronary heart disease susceptibility by using support vector machines. Clin Chem Lab Med, 2003, 41(4): 529-534.
10.	Zeng TT, Tang DJ, Ye YX, et al. Influence of SCARB1 gene SNPs on serum lipid levels and susceptibility to coronary heart disease and cerebral infarction in a Chinese population. Gene, 2017, 626: 319-325.
11.	Wu DF, Yin RX, Cao XL, et al. Scavenger receptor class B type 1 gene rs5888 single nucleotide polymorphism and the risk of coronary artery disease and ischemic stroke: a case-control study. Int J Med Sci, 2013, 10(12): 1771-1777.
12.	Ritsch A, Sonderegger G, Sandhofer A, et al. Scavenger receptor class B type I polymorphisms and peripheral arterial disease. Metabolism, 2007, 56(8): 1135-1141.
13.	Goodarzynejad H, Boroumand M, Behmanesh M, et al. The rs5888 single nucleotide polymorphism in scavenger receptor class B type 1(SCARB1) gene and the risk of premature coronary artery disease: a case-control study. Lipids Health Dis, 2016, 15: 7.
14.	Yin RX, Wu JZ, Liu WY, et al. Association of several lipid-related gene polymorphisms and blood pressure variation in the Bai Ku Yao population. Am J Hypertens, 2012, 25(8): 927-936.
15.	Rejeb J, Omezzine A, Boumaiza I, et al. Association of three polymorphisms of scavenger receptor class BI gene (exon8, exon1, intron5) with coronary stenosis in a coronary Tunisian population. Gene, 2012, 511(2): 383-388.
16.	Ayhan H, Gormus U, Isbir S, et al. SCARB1 gene polymorphisms and HDL subfractions in coronary artery disease. In Vivo, 2017, 31(5): 873-876.
17.	ArulJothi KN, Abinaya M, Abirami BS, et al. SCARB1 rs5888 c.1050C>T polymorphism and the risk of hypercholesterolemia and myocardial infarction in Indian Tamil population. Pak J Zool, 2017, 49(3): 1019-1024.
18.	Stanislovaitiene D, Lesauskaite V, Zaliuniene D, et al. SCARB1 single nucleotide polymorphism (rs5888) is associated with serum lipid profile and myocardial infarction in an age- and gender-dependent manner. Lipids Health Dis, 2013, 12: 24.
19.	莫丹衡. SR-BI 基因 G4A 多态性与脑卒中的关联性研究. 长沙: 中南大学, 2007.
20.	畅晓燕. B 族 I 型清道夫受体基因多态性与血脂代谢及冠心病关系的研究. 天津: 天津医科大学, 2012.
21.	Brodeur MR, Luangrath V, Bourret G, et al. Physiological importance of SR-BI in the in vivo metabolism of human HDL and LDL in male and female mice. J Lipid Res, 2005, 46(4): 687-696.
22.	Van Eck M, Hoekstra M, Out R, et al. Scavenger receptor BI facilitates the metabolism of VLDL lipoproteins in vivo. J Lipid Res, 2008, 49(1): 136-146.
23.	Ueda Y, Gong E, Royer L, et al. Relationship between expression levels and atherogenesis in scavenger receptor class B, type I transgenics. J Biol Chem, 2000, 275(27): 20368-20373.
24.	Zerbib J, Seddon JM, Richard F, et al. rs5888 variant of SCARB1 gene is a possible susceptibility factor for age-related macular degeneration. PLoS One, 2009, 4(10): e 7341.
25.	Rodriguez-Esparragon F, Rodriguez-Perez JC, Hernandez-Trujillo Y, et al. Allelic variants of the human scavenger receptor class B type 1 and paraoxonase 1 on coronary heart disease: genotype-phenotype correlations. Arterioscl Throm Vas, 2005, 25(4): 854-860.
26.	Yin RX, Wu DF, Aung LHH, et al. Several lipid-related gene polymorphisms interact with overweight/obesity to modulate blood pressure levels. Int J Mol Sci, 2012, 13(9): 12062-12081.
27.	Yates M, Kolmakova A, Zhao Y, et al. Clinical impact of scavenger receptor class B type I gene polymorphisms on human female fertility. Hum Reprod, 2011, 26(7): 1910-1916.
28.	West M, Greason E, Kolmakova A, et al. Scavenger receptor class B type I protein as an independent predictor of high-density lipoprotein cholesterol levels in subjects with hyperalphalipoproteinemia. J Clin Endocrinol Metab, 2009, 94(4): 1451-1457.
29.	Acton SL, Kozarsky KF, Rigotti A. The HDL receptor SR-BI: a new therapeutic target for atherosclerosis? Mol Med Today, 1999, 5(12): 518-524.
30.	Manichaikul A, Wang XQ, Musani SK, et al. Association of the lipoprotein receptor SCARB1 common missense variant rs4238001 with incident coronary heart disease. PLoS One, 2015, 10(5): e0125497.
31.	Velasco M, Alexander C, King J, et al. Association of lower plasma estradiol levels and low expression of scavenger receptor class B, type I in infertile women. Fertil Steril, 2006, 85(5): 1391-1397.
32.	莫丹衡, 许宏伟, 邓景贵, 等. SR-BI 基因 G4A 多态性与脑出血的关联性研究. 中风与神经疾病杂志, 2008, 25(2): 227-228.
33.	Suchindran S, Rivedal D, Guyton JR, et al. Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study. PLoS Genet, 2010, 6(4): e1000928.
34.	Naj AC, West M, Rich SS, et al. Association of scavenger receptor class B type I polymorphisms with subclinical atherosclerosis: the multi-ethnic study of atherosclerosis. Circ Cardiovasc Genet, 2010, 3(1): 47-52.
35.	Golden D, Kolmakova A, Sura S, et al. Lymphocyte activation gene 3 and coronary artery disease. JCI Insight, 2016, 1(17): e88628.

1. GBD 2016 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet, 2017, 390(10100): 1211-1259.
2. 陈伟伟, 高润霖, 刘力生, 等. 《中国心血管病报告 2017》概要. 中国循环杂志, 2018, 33(1): 1-8.
3. Van EM, Pennings M, Hoekstra M, et al. Scavenger receptor BI and ATP-binding cassette transporter A1 in reverse cholesterol transport and atherosclerosis. Curr Opin Lipidol, 2005, 16(3): 307-315.
4. Ohgami N, Miyazaki A, Sakai M, et al. Advanced glycation end products (AGE) inhibit scavenger receptor class B type I-mediated reverse cholesterol transport: a new crossroad of AGE to cholesterol metabolism. J Atheroscler Thromb, 2003, 10(1): 1-6.
5. Chen L, Zhang J, Deng X, et al. Lysophosphatidic acid directly induces macrophage-derived foam cell formation by blocking the expression of SRBI. Biochem Biophys Res Commun, 2017, 491(3): 587-594.
6. Constantineau J, Greason E, West M, et al. A synonymous variant in scavenger receptor, class B, type I gene is associated with lower SR-BI protein expression and function. Atherosclerosis, 2010, 210(1): 177-182.
7. Yang XP, Sethi A, Yanek LR, et al. SCARB1 gene variants are associated with the phenotype of combined high high-density lipoprotein cholesterol and high lipoprotein (a). Circ-Cardiovasc Gene, 2016, 9(5): 408-418.
8. Liao J, Guo X, Wang M, et al. Scavenger receptor class b type 1 deletion led to coronary atherosclerosis and ischemic heart disease in low-density lipoprotein receptor knockout mice on modified western-type diet. J Atheroscler Thromb, 2017, 24(2): 133-146.
9. Yoon Y, Song J, Hong SH, et al. Analysis of multiple single nucleotide polymorphisms of candidate genes related to coronary heart disease susceptibility by using support vector machines. Clin Chem Lab Med, 2003, 41(4): 529-534.
10. Zeng TT, Tang DJ, Ye YX, et al. Influence of SCARB1 gene SNPs on serum lipid levels and susceptibility to coronary heart disease and cerebral infarction in a Chinese population. Gene, 2017, 626: 319-325.
11. Wu DF, Yin RX, Cao XL, et al. Scavenger receptor class B type 1 gene rs5888 single nucleotide polymorphism and the risk of coronary artery disease and ischemic stroke: a case-control study. Int J Med Sci, 2013, 10(12): 1771-1777.
12. Ritsch A, Sonderegger G, Sandhofer A, et al. Scavenger receptor class B type I polymorphisms and peripheral arterial disease. Metabolism, 2007, 56(8): 1135-1141.
13. Goodarzynejad H, Boroumand M, Behmanesh M, et al. The rs5888 single nucleotide polymorphism in scavenger receptor class B type 1(SCARB1) gene and the risk of premature coronary artery disease: a case-control study. Lipids Health Dis, 2016, 15: 7.
14. Yin RX, Wu JZ, Liu WY, et al. Association of several lipid-related gene polymorphisms and blood pressure variation in the Bai Ku Yao population. Am J Hypertens, 2012, 25(8): 927-936.
15. Rejeb J, Omezzine A, Boumaiza I, et al. Association of three polymorphisms of scavenger receptor class BI gene (exon8, exon1, intron5) with coronary stenosis in a coronary Tunisian population. Gene, 2012, 511(2): 383-388.
16. Ayhan H, Gormus U, Isbir S, et al. SCARB1 gene polymorphisms and HDL subfractions in coronary artery disease. In Vivo, 2017, 31(5): 873-876.
17. ArulJothi KN, Abinaya M, Abirami BS, et al. SCARB1 rs5888 c.1050C>T polymorphism and the risk of hypercholesterolemia and myocardial infarction in Indian Tamil population. Pak J Zool, 2017, 49(3): 1019-1024.
18. Stanislovaitiene D, Lesauskaite V, Zaliuniene D, et al. SCARB1 single nucleotide polymorphism (rs5888) is associated with serum lipid profile and myocardial infarction in an age- and gender-dependent manner. Lipids Health Dis, 2013, 12: 24.
19. 莫丹衡. SR-BI 基因 G4A 多态性与脑卒中的关联性研究. 长沙: 中南大学, 2007.
20. 畅晓燕. B 族 I 型清道夫受体基因多态性与血脂代谢及冠心病关系的研究. 天津: 天津医科大学, 2012.
21. Brodeur MR, Luangrath V, Bourret G, et al. Physiological importance of SR-BI in the in vivo metabolism of human HDL and LDL in male and female mice. J Lipid Res, 2005, 46(4): 687-696.
22. Van Eck M, Hoekstra M, Out R, et al. Scavenger receptor BI facilitates the metabolism of VLDL lipoproteins in vivo. J Lipid Res, 2008, 49(1): 136-146.
23. Ueda Y, Gong E, Royer L, et al. Relationship between expression levels and atherogenesis in scavenger receptor class B, type I transgenics. J Biol Chem, 2000, 275(27): 20368-20373.
24. Zerbib J, Seddon JM, Richard F, et al. rs5888 variant of SCARB1 gene is a possible susceptibility factor for age-related macular degeneration. PLoS One, 2009, 4(10): e 7341.
25. Rodriguez-Esparragon F, Rodriguez-Perez JC, Hernandez-Trujillo Y, et al. Allelic variants of the human scavenger receptor class B type 1 and paraoxonase 1 on coronary heart disease: genotype-phenotype correlations. Arterioscl Throm Vas, 2005, 25(4): 854-860.
26. Yin RX, Wu DF, Aung LHH, et al. Several lipid-related gene polymorphisms interact with overweight/obesity to modulate blood pressure levels. Int J Mol Sci, 2012, 13(9): 12062-12081.
27. Yates M, Kolmakova A, Zhao Y, et al. Clinical impact of scavenger receptor class B type I gene polymorphisms on human female fertility. Hum Reprod, 2011, 26(7): 1910-1916.
28. West M, Greason E, Kolmakova A, et al. Scavenger receptor class B type I protein as an independent predictor of high-density lipoprotein cholesterol levels in subjects with hyperalphalipoproteinemia. J Clin Endocrinol Metab, 2009, 94(4): 1451-1457.
29. Acton SL, Kozarsky KF, Rigotti A. The HDL receptor SR-BI: a new therapeutic target for atherosclerosis? Mol Med Today, 1999, 5(12): 518-524.
30. Manichaikul A, Wang XQ, Musani SK, et al. Association of the lipoprotein receptor SCARB1 common missense variant rs4238001 with incident coronary heart disease. PLoS One, 2015, 10(5): e0125497.
31. Velasco M, Alexander C, King J, et al. Association of lower plasma estradiol levels and low expression of scavenger receptor class B, type I in infertile women. Fertil Steril, 2006, 85(5): 1391-1397.
32. 莫丹衡, 许宏伟, 邓景贵, 等. SR-BI 基因 G4A 多态性与脑出血的关联性研究. 中风与神经疾病杂志, 2008, 25(2): 227-228.
33. Suchindran S, Rivedal D, Guyton JR, et al. Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study. PLoS Genet, 2010, 6(4): e1000928.
34. Naj AC, West M, Rich SS, et al. Association of scavenger receptor class B type I polymorphisms with subclinical atherosclerosis: the multi-ethnic study of atherosclerosis. Circ Cardiovasc Genet, 2010, 3(1): 47-52.
35. Golden D, Kolmakova A, Sura S, et al. Lymphocyte activation gene 3 and coronary artery disease. JCI Insight, 2016, 1(17): e88628.

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The association between polymorphisms in scavenger receptor class B1 (SCARB1) gene and risk of cardiovascular diseases: a meta-analysis

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