Analysis of real world studies on traditional Chinese medicine in China_Chinese Journal of Evidence-Based Medicine

Authors：

CHEN Ji ^1,2 , SUN Yue ^1,2 , BU Youxiang ^1,2 ,  TIAN Jinhui ^1,2,3

1. Evidence-based Nursing Center, School of Nursing, Lanzhou University, Lanzhou, 730000, P.R.China;
2. Evidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, P.R.China;
3. Key Laboratory of Evidence-based Medicine and Knowledge Translation of Gansu Province, Lanzhou, 730000, P.R.China;

Corresponding author：

TIAN Jinhui, Email: tjh996@163.com

Keywords：

Traditional Chinese medicine; Real world study; Hospital information system

DOI：

10.7507/1672-2531.201807103

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ObjectivesTo analyze the active areas of real world studies on traditional Chinese medicine in China.MethodsCBM, CNKI, WanFang Data, PubMed and EMbase databases were electronically searched to collect real world studies on traditional Chinese medicine in China from inception to 26^th April, 2018. The main research contents (research direction, data sources, and research methods) by Excel were extracted, together with the primary information by BICOMS-2 software and production of the network figures by NetDraw 2.084 software.ResultsEventually, 373 real world studies in traditional Chinese medicine were included, in which the initial one was punished in 2008. The top three ranking of authors involved in real world studies on traditional Chinese were Xie Yanming, Zhuang Yan, Yang Wei, and the top three ranking of institutions were Institute of Basic Research in Clinical Medicine of China Academy of Chinese Medical Sciences, School of Statistics of Renmin University of China, and the PLA Navy General Hospital. The amount of related studies in Beijing accounted for 74.26%. It was found that the active areas involve real world, hospital information system, real world study, drug combination, and propensity score method. In terms of the main studied contents on the use of traditional Chinese medicine in the real world, in which the top three were Fufang Kushen injection, Dengzhanxixin injection, and Shuxuetong injection. Digestive system disease, nervous system disease and cardiovascular disease received the highest attention rate, specifically stroke, coronary heart disease, virus hepatitis and hypertension. 58.18% studies were retrospective studies, 49.60% of the information were from the hospital information system, and 56.30% studies used data mining to carry out statistical analysis.ConclusionsMost real world studies on traditional Chinese medicine are based on HIS, and use data mining to study Chinese medicine preparations. The research attention on Chinese medicine is higher than that of the method of diagnosis and treatment, similarly the Chinese medicine preparations is higher than traditional Chinese medicine. In future, attention should be paid to traditional Chinese medicine, prescription and traditional methods of diagnosis and treatment, such as moxibustion and scraping.

Citation： CHEN Ji, SUN Yue, BU Youxiang, TIAN Jinhui. Analysis of real world studies on traditional Chinese medicine in China. Chinese Journal of Evidence-Based Medicine, 2018, 18(11): 1216-1223. doi: 10.7507/1672-2531.201807103 Copy

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1. 国务院. 中医药健康服务发展规划(2016-2030年). 北京, 2016.
2. 陈静锋, 郭崇慧, 魏伟. " 互联网+中医药”: 重构中医药全产业链发展模式. 中国软科学, 2016, 21(6): 26-38.
3. 胡本祥. 关于中医药研究方法地思考. 陕西中医学院学报, 2015, 38(6): 1-4.
4. Grapow MT, von Wattenwyl R, Guller U, et al. Randomized controlled trials do not reflect reality: real-world analyses are critical for treatment guidelines! J Thorac Cardiovasc Surg, 2006, 132(1): 5-7.
5. Price D, Brusselle G, Roche N, et al. Real-world research and its importance in respiratory medicine. Breathe (Sheff), 2015, 11(1): 26-38.
6. 田金徽, 马文娟, 高亚, 等. 国外TBL教学研究主题分析. 中国医药导刊, 2018, 20(1): 59-64.
7. 康德英. 浅议真实世界研究. 中国癌症防治杂志, 2017, 9(2): 100-103.
8. 孙鑫, 谭婧, 唐立, 等. 重新认识真实世界研究. 中国循证医学杂志, 2017, 17(2): 126-130.
9. Wang S, Liu B, Xiong N, et al. Discussion of solutions to ethical issues in real-world study. Front Med, 2014, 8(3): 316-320.
10. 吴嘉瑞, 唐仕欢, 郭位先, 等. 基于数据挖掘的名老中医经验传承研究述评. 中国中药杂志, 2014, 39(4): 614-617.
11. 刘志华, 孙晓波. 网络药理学: 中医药现代化的新机遇. 药学学报, 2012, 47(6): 696-703.
12. Jiang M, Yang J, Zhang C, et al. Clinical studies with traditional Chinese medicine in the past decade and future research and development. Planta Med, 2010, 76(17): 2048-2064.
13. Tang JL, Liu BY, Ma KW. Traditional Chinese Medicine. Lancet, 2008, 372(9654): 1938-1940.

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