LI Pei 1 , CHEN Defeng 2 , Dong Xuhui 1 , HE Mengxin 1 , LI Jiabao 1 , YANG Yang 3 , PENG Wanlin 4
  • 1. School of Nursing, Guangxi University of Traditional Chinese Medicine, Nanning 530200, P. R. China;
  • 2. Department of Gastrointestinal, Hernia and Intestinal Fistula Surgery, Guangxi Zhuang Autonomous Region People's Hospital, Nanning 530016, P. R. China;
  • 3. School of Nursing, Youjiang Medical College for Nationalities, Baise 533000, P. R. China;
  • 4. Chengdu Seventh People's Hospital, Chengdu 610213, P. R. China;
CHEN Defeng, Email: de_feng_chen@163.com
Overweight; Obesity; Time-restricted eating; Network meta-analysis
10.7507/1672-2531.202410162
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Objective  To systematically review the efficacy of eight time-restricted eating strategies on overweight/obese adults using network meta-analysis. Methods The Scopus, MEDLINE, Embase, PubMed, Web of Science, and Cochrane Library databases were electronically searched to collect studies on randomized controlled trials (RCTs) on the intervention effects of eight time-restricted eating strategies on overweight/obese adults from inception to September 18, 2024. Two researchers independently screened the literature, extracted data, and assessed the risk of bias of the included studies. Network meta-analysis was performed using ADDIS 1.16.8 and Stata 18.0 software. Results A total of 23 RCTs involving 1 306 overweight/obese adults were included. The network meta-analysis revealed that compared with standard diets, the 8-hour time-restricted eating combined with a low-carbohydrate diet (MD=−4.01, 95%CI −5.95 to −2.08, P<0.05) showed better weight reduction effects. Compared with standard diets, the 8-hour time-restricted eating combined with a low-carbohydrate diet (MD=−3.54, 95%CI −5.44 to −1.63, P<0.05) and the 8-hour time-restricted eating combined with a low-sugar diet (MD=−4.19, 95%CI −8.33 to −0.05, P<0.05) significantly improved overall fat mass. Compared with standard diets, the 8-hour time-restricted eating combined with a low-sugar diet (MD=−15.42, 95%CI −29.12 to −1.72, P<0.05) had a better effect on fasting blood glucose control. The 8-hour time-restricted eating combined with high-intensity interval training (MD=−3.68, 95%CI −6.57 to −0.79, P<0.05) showed better results in reducing waist circumference. No statistical significance was found in direct comparisons regarding bone mineral content. The efficacy ranking showed that the 8-hour time-restricted eating combined with a low-carbohydrate diet was most effective for weight reduction; the 8-hour time-restricted eating combined with a low-sugar diet was more effective in reducing overall fat mass and controlling fasting blood glucose; the 8-hour time-restricted eating combined with calorie restriction had significant effects on waist circumference improvement; and the 8-hour time-restricted eating combined with high-intensity interval training was more effective for increasing bone mineral content. Conclusion Based on the results of the network meta-analysis and ranking, different time-restricted eating strategies have specific advantages for the intervention of overweight or obese individuals. The choice of the appropriate strategy should consider individual dietary habits and health conditions. Due to the limited quantity and quality of the included studies, more high-quality studies are needed to verify the above conclusion.

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