Maternal alcoholic consumption during pregnancy and the risk of childhood cancer in offspring: a systematic review and meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

HUANG Danqi ¹ , LIU Jingyi ¹ , XIONG Wei ² , WANG Huilin ¹ , YANG Min ³ , WANG Quan ⁴ , ZHENG Bobo ⁵ , TIAN Jinhui ^6,7 ,  YUAN Jinqiu ⁸ ,  LI Jiang ¹ ,  ZHAI Jingbo ⁹

1. Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P. R. China;
2. Department of Gynecology Endocrine&Reproductive Center, National Clinical Research Center for Obstetric&Gynecologic Diseases Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College/Chinese Academy of Medical Sciences, Beijing 100730, P. R. China;
3. Comprehensive Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital. Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P. R. China;
4. Ambulatory Surgery Center of Xijing Hospital, Fourth Military Medical University, Xi’an 710068, P. R. China;
5. Department of General Surgery, Shaanxi Provincial People’ s Hospital, Xi'an 710068, P. R. China;
6. Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, P. R. China;
7. Key Laboratory of Evidence-Based Medicine and Knowledge Translation of Gansu Province, Lanzhou University, Lanzhou 730000, P. R. China;
8. Clinical Research Center, the Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, P. R. China;
9. School of Public Health, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, P. R. China;

Corresponding author：

YUAN Jinqiu, Email: yuanjq5@mail.sysu.edu.cn; LI Jiang, Email: lij@cicams.ac.cn; ZHAI Jingbo, Email: zhaijingbo@foxmail.com

Keywords：

Pregnancy; Alcohol drinking; Childhood tumors; Meta-analysis

DOI：

10.7507/1672-2531.202412165

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To systematically review the relationship between maternal alcoholic consumption during pregnancy and the occurrence of childhood cancer in offspring. Methods The PubMed, Embase, Web of Science, Cochrane library, CNKI, WanFang Data, VIP, and CBM databases were electronically searched to obtain related case-control and cohort studies from inception to December 2024. Two reviewers independently screened articles, extracted data and assessed the risk of bias of the included articles. Meta-analysis was performed by using the RevMan 5.4 software. Results A total of 18 articles involving 9 childhood tumors' outcome were included. The results of meta-analysis showed that compared with women who never drink alcohol during pregnancy, alcoholic consumption during pregnancy increased the incidence risk of childhood cancer (OR=1.13, 95%CI 1.01 to 1.26, P=0.04). Subgroup analysis showed that alcoholic consumption during pregnancy significantly increased the incidence risk of acute leukemia (OR=1.17, 95%CI 1.06 to 1.30, P=0.002) and acute lymphocytic leukemia (OR=1.23, 95%CI 1.02 to 1.48, P=0.03). Conclusion The current evidence suggests that alcoholic consumption during pregnancy significantly increases the incidence risk of childhood cancer in offspring, particularly acute leukemia and acute lymphocytic leukemia. Due to the limited quantity and quality of the included articles, more high-quality birth cohort studies are needed to verify the above conclusion.

Citation： HUANG Danqi, LIU Jingyi, XIONG Wei, WANG Huilin, YANG Min, WANG Quan, ZHENG Bobo, TIAN Jinhui, YUAN Jinqiu, LI Jiang, ZHAI Jingbo. Maternal alcoholic consumption during pregnancy and the risk of childhood cancer in offspring: a systematic review and meta-analysis. Chinese Journal of Evidence-Based Medicine, 2025, 25(8): 895-901. doi: 10.7507/1672-2531.202412165 Copy

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Chinese Journal of Evidence-Based Medicine

Maternal alcoholic consumption during pregnancy and the risk of childhood cancer in offspring: a systematic review and meta-analysis

Abstract Full text Figures/Tables Video References Cited by

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