Clinical features and progress of catamenial epilepsy-with 20 cases reported_Journal of Epilepsy

Authors：

 CHENYanyan , LVXiaomin , SUNLichao , CHENYu , YANGDan ,  LINWeihong

Departerment of Neurology, the First Hospital of JilinUniversity, Changchun, 130000, China;

Corresponding author：

LINWeihong, Email: linweihong321@163.com

Keywords：

Catamenial; Epilepsy; Clinical features

DOI：

10.7507/2096-0247.20160085

Video：

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Objective To investigate clinical features and progress in women with catamenial epilepsy. Methods The data obtained from retrospective study in 20 patients with catamenial epilepsy and reviewing published study of catamenial epilepsy. Results Seizures of all cases were relatived with the menstrual cycle. Seizures that only occured perimenstrually in 7 cases, 13 cases experienced exacerbation during this time. Only 2 of the 20 cases pointed to generalized sizures.12 of 18 cases which were partial seizures identified with complex partial seizures. Of 17 patients who had EEG results, 1 showed mild abnormal waves, 1 showed slow waves, 1 showed sharp waves, 1 showed spike and slow wave complex, 2 showed generalized polyspike and slow wave complex, 11 showed focal sharp waves,spike waves and spike and slow wave complex. All patients accepted 1 or more AEDs treatment.1 patient seizure free for 2 years after menopause, 2 cases of treatment were unclear, 5 cases had positive outcomes(4 cases seizure free for 1 and more years,1 case for 6 months), 12 cases were poorly controlled, especially 9 cases were refractory epilepsy. Conclusion It is found that catamenial epilepsy more commonly in facal and the rate of refractory epilepsy is higher. Treatment of catamenial epilepsy power with more samples, multi-center clinical trials.

Citation： CHENYanyan, LVXiaomin, SUNLichao, CHENYu, YANGDan, LINWeihong. Clinical features and progress of catamenial epilepsy-with 20 cases reported. Journal of Epilepsy, 2016, 2(6): 484-487. doi: 10.7507/2096-0247.20160085 Copy

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1. Locock C. Discussion. In:Sieveking EH (ed) Analysis of fifty-two cases of epilepsy observed by the author. Med Times Gaz, 1857, 14:524-526.
2. Gowers WR.Epilepsy and other chronic convulsive disorders.1st ed.London:J&A Churchill,1881.
3. Duncan S,Read CL,Brodie MJ.How common is catamenial epilepsy?.Epilepsia, 1993, 34(7):827-831.
4. Herzog AG,Klein P,Ransil BJ.Three patterns of catamenial epilepsy. Epilepsia,1997, 38(11):1082-1088.
5. Herzog AG.Catamenial epilepsy:definition,prevalence,pathophysiology and treatment.Seizure, 2008, 17(2):151-159.
6. Ansell B,Clarke E, RosciszewskaD, et al. Ovarian hormones, anticonvulsant drugs and seizures during the menstrual cycle in women with epilepsy.J Neurol Neurosurg Psychiatry, 1986, 49(10):47-51.
7. Tauboll E, Lundervold A, Gjerstad L. Temporal distribution of seizures in epilepsy. Epilepsy Res, 1991, 8(3):153-165.
8. Herzog AG.Catamenial epilepsy:update on prevalence,pathophysiology and treatment from the findings of the NIH progesterone treatment trial. Seizure Eur J Epilepsy, 2015, 24(2):102-104.
9. Quigg M,Fowler KM,Herzog AG,et al.Circalunar and ultralunar periodicities in women with partial seizures. Epilepsia, 2008, 49(6):1081-1085.
10. Mattson R,CramerJ,Caldwell B,et al.Treatment of seizures with medroxyprogesteroneacetate:preliminary report.Neurology,1984, 34(7):1255-1258.
11. Reddy DS, Gould J,Gangisetty O. A mouse kindling model of perimenstrual catamenial epilepsy.J Pharm ExpTherap,2012, 341(3):784-793.
12. Feely M,Calvert R, J Gibson.Clobazem in catamenial epilepsy:a model for evaluating anticonvulsants.The Lancet,1982, 112(8):71-73.
13. Navis A, HardenC. A treatment approach to catamenial epilepsy. Curr Treat Options Neurol,2016,Jul;18(7):30.
14. 吴江, 贾建平.神经病学.第3版.北京:人民卫生出版社,2015. 323.
15. 张鲁, 迟兆富.难治性癫痫临床特点及疗效分析[硕士学位论文].济南:山东大学, 2009:1-19.

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Clinical features and progress of catamenial epilepsy-with 20 cases reported

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