The clinical features and Video-EEG of Eyelid myoclonia-nonconvulsive status epilepticus in children_Journal of Epilepsy

Authors：

GAO Zaifen ¹ , LUO Junxia ¹ , CHEN Yehong ¹ , HU Wandong ¹ , CHEN Chuanmei ¹ , QI Fang ¹ ,  SUN Ruopeng ²

1. Department of Neural endocrinology VEEG room, Qilu Children's Hospital of Shandong University, Jinan 250022, China;
2. Pediatric Medical Centre Qilu Hospital of Shandong University, Jinan 250000, China;

Corresponding author：

SUN Ruopeng, Email: ruopeng4813@sina.com

Keywords：

Eyelid myoclonia; Nonconvulsive status epilepticus; Video electroencephalogram

DOI：

10.7507/2096-0247.20170030

Video：

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ObjectiveTo study the clinical and EEG features, therapeutic response and prognosis of eyelid myoclonia-nonconvulsive status epilepticus (EM-NCSE) in children.MethodsCollected the clinical and EEG data of 3 children with EM-NCSE that were diagnosed in department of neurology in Qilu Children Hospital of Shandong university during the January in 2015 to August in 2016.Analysed the therapeutic response to antiepletic drugs(AEDs).ResultsAmong the three children, there were 2 girls and 1 boy.The age at the onset of the disease was from 6 to 10 years old.The average age of them is 8.67 years old.The clinical manifestations include mental confusion, dysphoria, winking and scrolling up the eyes.The typical vedio electroencephalography (VEEG) in the patients showed 3~6 Hz generalized spike and waves and polyspikes burst, especially in the frontal and the anterior temporal region.In addition, the eye closure and intermittent photic stimulation helped to induce discharges and clinical events as eyelid myoclonia (EM).ConclusionsEM-NCSE is one of the idiopathic and generalized epileptic disease and characterized by EM.Video EEG monitoring plays an important role in the diagnosis of this disease.The drugs of choice for treatment was diazepam.When the event was controlled, AEDs were effective for the following therapy.

Citation： GAO Zaifen, LUO Junxia, CHEN Yehong, HU Wandong, CHEN Chuanmei, QI Fang, SUN Ruopeng. The clinical features and Video-EEG of Eyelid myoclonia-nonconvulsive status epilepticus in children. Journal of Epilepsy, 2017, 3(3): 199-203. doi: 10.7507/2096-0247.20170030 Copy

1.	Sevgi EB, Saygi S, Ciger A, et al. Eye closure sensitivity and epileptic syndromes:a retrospective study of 26 adult cases. Seizure, 2007, 16 (1):1-21.
2.	Mnatsakanyan L, Chung JM, Tsimerinov EI, et al. Intravenous lacosamide in refractory nonconvulsive status epilepticus. Seizure, 2012, 21(3):198-201.
3.	Shorvon SD.What is nonconvulsive status epilepticus, and what are its subtypes.Epilepsia, 2007, 48(11):35-38.
4.	Sutte RR, Kaplan PW.The neurophysiologic types of nonconvulsive status epilepticus:EEG patterns of different phenotypes.Epilepsia, 2013, 54(6):23-27.
5.	卢强, 金丽日, 周祥琴, 等.额叶非惊厥性癫痫持续状态临床和脑电图特征.协和医学杂志, 2012, 3(3):318-322.
6.	Martina F, Alessandra M, Jinane F, et al. Ictal epileptic headache revealing nonconvulsive status epilepticus in a case of eyelid myoclonia with absences.The Journal of Headache and Pain, 2015, 16(3):105-108.
7.	Panayiotopoulos CP. A clinical guide to epileptic syndromes and their treatment.Springer; 2nd ed.2007.2nd revised edition.2010:578.
8.	Maganti R, Gerber P, Drees C, et al. Nonconvulsive status epilepticus.Epilepsy Behav, 2008, 12(4):572-586.
9.	Sevgi DE, Saygi S. Unusual features in eyelid myoclonia with ab-sences:a patient with mild mental retardation and background slowing on electroencephalography.Epilepsy Behav, 2006, 10(8):442-445.

1. Sevgi EB, Saygi S, Ciger A, et al. Eye closure sensitivity and epileptic syndromes:a retrospective study of 26 adult cases. Seizure, 2007, 16 (1):1-21.
2. Mnatsakanyan L, Chung JM, Tsimerinov EI, et al. Intravenous lacosamide in refractory nonconvulsive status epilepticus. Seizure, 2012, 21(3):198-201.
3. Shorvon SD.What is nonconvulsive status epilepticus, and what are its subtypes.Epilepsia, 2007, 48(11):35-38.
4. Sutte RR, Kaplan PW.The neurophysiologic types of nonconvulsive status epilepticus:EEG patterns of different phenotypes.Epilepsia, 2013, 54(6):23-27.
5. 卢强, 金丽日, 周祥琴, 等.额叶非惊厥性癫痫持续状态临床和脑电图特征.协和医学杂志, 2012, 3(3):318-322.
6. Martina F, Alessandra M, Jinane F, et al. Ictal epileptic headache revealing nonconvulsive status epilepticus in a case of eyelid myoclonia with absences.The Journal of Headache and Pain, 2015, 16(3):105-108.
7. Panayiotopoulos CP. A clinical guide to epileptic syndromes and their treatment.Springer; 2nd ed.2007.2nd revised edition.2010:578.
8. Maganti R, Gerber P, Drees C, et al. Nonconvulsive status epilepticus.Epilepsy Behav, 2008, 12(4):572-586.
9. Sevgi DE, Saygi S. Unusual features in eyelid myoclonia with ab-sences:a patient with mild mental retardation and background slowing on electroencephalography.Epilepsy Behav, 2006, 10(8):442-445.

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