Comparison of results of two kinds of blood ketone instrument in children epilepsy patients with ketogenic diet_Journal of Epilepsy

Authors：

WANG Juan ,  GUO Yi , CHENG Min , JIANG Li

Department of Neurology, Children's Hospital, Chongqing Medical University, Chongqing 400014, China;

Corresponding author：

GUO Yi, Email: 1274912965@qq.com

Keywords：

Blood ketone instruments; β-hydroxybutyrate; Ketogenic diet; Epilepsy; Children

DOI：

10.7507/2096-0247.20180002

Video：

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Objective Compare and analyze the value of β-hydroxybutyrate from two kinds of blood ketone instruments (Optium Xceed blood ketone body instrument from American Abbott laboratories and TBS-1 blood ketone body instrument from Beijing Yicheng company), and provide instructions for clinical applications. Methods Select 7 children patients with epilepsy which have a response to ketogenic diet. The two kinds of blood ketone instruments were used to test blood ketone value of whole blood synchronously in five different periods, and compare the 70 results. Results The measuring results obtained from these two kinds of blood ketone body instruments have statistical difference significantly. The value acquired from TBS-1 blood ketone body instrument is lower than that from Optium Xceed blood ketone body instrument. Measurements using a paired t test, the value of t=12.14, P<0.01. The results from two kinds of blood ketone body instruments are statistically significant. Conclusion The values from 2 kinds of blood ketone instruments are different, which would influence the clinical judgment. At present, the key problem is that there is lack of special blood ketone measure technology for patients with ketogenic diet. How to improve the measure accuracy of high-level blood ketone value remains the future work.

Citation： WANG Juan, GUO Yi, CHENG Min, JIANG Li. Comparison of results of two kinds of blood ketone instrument in children epilepsy patients with ketogenic diet. Journal of Epilepsy, 2018, 4(1): 6-9. doi: 10.7507/2096-0247.20180002 Copy

1.	Achanta LB, Rae CD. β-Hydroxybutyrate in the brain: one molecule, multiple mechanisms. Neurochem Res, 2017, 42(1): 35-49.
2.	熊立凡. 临床检验基础. 第 3 版. 北京: 人民卫生出版社, 2003: 134-135.
3.	Walta AM, Keltanen T, Lindroos K, et al. The usefulness of point-of-care (POC) tests in screening elevated glucose and ketone body levels postmortem. Forensic Sci Int, 2016, 266(10): 299-303.
4.	Chong SK, Reineke EL. Point-of-Care Glucose and Ketone Monitoring. Topics in Compan An Med, 2016, 31(4): 18-26.
5.	Ruskin DN, Murphy MI, Slade SL, et al. Ketogenic diet improves behaviors in a maternal immune activation model of autism spectrum disorder. PLoS One, 2017, 12(2): e0171643.
6.	White H, Venkatesh B, Jones M, et al. Serial changes in plasma ketone concentrations in patients with acute brain injury. Neuro Res, 2017, 39(1): 1-6.
7.	Sacks DB, Bruns DE, Goldstein DE, et al. Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Clin Chem, 2002, 48(3): 436-472.
8.	卢妙莲, 王建兵, 曹永坚, 等. 两种 POCT 血酮体仪与生化分析仪对 β－羟丁酸检测结果的比对分析. 国际检验医学杂志, 2013, 34(11): 1434-1435.
9.	van der Louw E, van den Hurk D, Neal E, et al. Ketogenic diet guidelines for infants with refractory epilepsy. Eur J Paediatr Neurol, 2016, 20(6): 1-12.
10.	Kinsella JM, Barker G, King J, et al. Implementing point of care blood ketone testing in the emergency department. Australas Emerg Nurs J, 2012, 15(2): 63-67.
11.	Wlaz P, Soca1a K, Nieoczym D, et al. Anticonvulsant profile of caprylic acid, a main constituent of the medium-chain triglyceride (MCT) ketogenic diet in mice. Neuropharmacology, 2012, 62(1): 1882-1889.

1. Achanta LB, Rae CD. β-Hydroxybutyrate in the brain: one molecule, multiple mechanisms. Neurochem Res, 2017, 42(1): 35-49.
2. 熊立凡. 临床检验基础. 第 3 版. 北京: 人民卫生出版社, 2003: 134-135.
3. Walta AM, Keltanen T, Lindroos K, et al. The usefulness of point-of-care (POC) tests in screening elevated glucose and ketone body levels postmortem. Forensic Sci Int, 2016, 266(10): 299-303.
4. Chong SK, Reineke EL. Point-of-Care Glucose and Ketone Monitoring. Topics in Compan An Med, 2016, 31(4): 18-26.
5. Ruskin DN, Murphy MI, Slade SL, et al. Ketogenic diet improves behaviors in a maternal immune activation model of autism spectrum disorder. PLoS One, 2017, 12(2): e0171643.
6. White H, Venkatesh B, Jones M, et al. Serial changes in plasma ketone concentrations in patients with acute brain injury. Neuro Res, 2017, 39(1): 1-6.
7. Sacks DB, Bruns DE, Goldstein DE, et al. Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Clin Chem, 2002, 48(3): 436-472.
8. 卢妙莲, 王建兵, 曹永坚, 等. 两种 POCT 血酮体仪与生化分析仪对 β－羟丁酸检测结果的比对分析. 国际检验医学杂志, 2013, 34(11): 1434-1435.
9. van der Louw E, van den Hurk D, Neal E, et al. Ketogenic diet guidelines for infants with refractory epilepsy. Eur J Paediatr Neurol, 2016, 20(6): 1-12.
10. Kinsella JM, Barker G, King J, et al. Implementing point of care blood ketone testing in the emergency department. Australas Emerg Nurs J, 2012, 15(2): 63-67.
11. Wlaz P, Soca1a K, Nieoczym D, et al. Anticonvulsant profile of caprylic acid, a main constituent of the medium-chain triglyceride (MCT) ketogenic diet in mice. Neuropharmacology, 2012, 62(1): 1882-1889.

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