Clinical analysis of 109 cases of epilepsy secondary to cerebral infarction_Journal of Epilepsy

Authors：

YANG Yang ,  WANG Guangxin , LIU Peng ,  SU Guohai

Research Institute of Translational Medicine, Central Hospital Affiliated to Shandong First Medical University, Jinan 250013, China;

Corresponding author：

WANG Guangxin, Email: 2280887385@qq.com; SU Guohai, Email: suguohai65@163.com

Keywords：

Cerebral infarction; Secondary epilepsy; Diagnosis; Treatment

DOI：

10.7507/2096-0247.20210050

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To analyze the clinical characteristics, risk factors, treatment and prognosis of epilepsy secondary to cerebral infarction.Methods The clinical data of 109 patients with epilepsy secondary to cerebral infarction admitted to the Affiliated Central Hospital of Shandong First Medical University from October 2018 to February 2021 were retrospectively analyzed, including the location of cerebral infarction, seizure type, seizure time and antiepileptic treatment.Results 3 426 patients with cerebral infarction were treated in the same period, and the incidence of epilepsy secondary to cerebral infarction was 3.18%. Among 109 patients with epilepsy secondary to cerebral infarction, 71 were male and 38 were female, the average age was (67.42 ± 28.58) years. Time of seizure after cerebral infarction: 67 cases (61.47%) were early onset epilepsy and 42 cases (42.47%) were late onset epilepsy. The infarct site: 63.30% (69 /109) in cortex, 11.93% (13/109) in subcortical area, and 24.77% (27/109) in lacunar infarction secondary epilepsy. 5 cases died, the fatality rate was 1.59%, of which 4 patients died of early onset epilepsy, status epilepticus, and 1 patient died of late onset epilepsy due to acute cerebral infarction.Conclusions In patients with epilepsy secondary to cerebral infarction, the cortex is the most common site of infarction; focal seizures are more than comprehensive seizures; status epilepticus often indicates poor prognosis, so timely antiepileptic treatment should be given to improve the prognosis.

Citation： YANG Yang, WANG Guangxin, LIU Peng, SU Guohai. Clinical analysis of 109 cases of epilepsy secondary to cerebral infarction. Journal of Epilepsy, 2021, 7(4): 314-317. doi: 10.7507/2096-0247.20210050 Copy

1.	Bektas G, Kipoglu O, Pembegul Yildiz E, et al. Epileptic spasm and other forms of epilepsy in presumed perinatal arterial ischemic stroke in Turkey after more than 10 years follow-up: A single centre study. Brain Dev, 2019, 41(8): 699-705.
2.	Bamford J, Sandercock P, Dennis M, et al. Classification and natural history of clinically identifiable subtypes of cerebral infarction. Lancet, 1991, 337(8756): 1521-1526.
3.	Thijs RD, Surges R, O'Brien TJ, et al. Epilepsy in adults. Lancet, 2019, 393(10172): 689-701.
4.	Winkler AS, Leonardi M, Michael BD, et al. A WHO resolution on epilepsy and other neurological disorders. Lancet Neurol, 2021, 20(3): 171-172.
5.	Benninger F, Holtkamp M. Epileptic seizures and epilepsy after a stroke: Incidence, prevention and treatment. Nervenarzt, 2017, 88(10): 1197-1207.
6.	Rosenow F, Klein KM, Hamer HM. Non-invasive EEG evaluation in epilepsy diagnosis. Expert Rev Neurother, 2015, 15(4): 425-44.
7.	Ding D, Zhou D, Sander JW, et al. Epilepsy in China: major progress in the past two decades. Lancet Neurol, 2021, 20(4): 316-326.
8.	Scheffer IE, Berkovic S, Capovilla G, et al. ILAE classification of the epilepsies: position paper of the ILAE Commission for Classification and Terminology. Epilepsia, 2017, 58(4): 512-521.
9.	Shorvon SD. The etiologic classification of epilepsy. Epilepsia, 2011, 52(6): 1052-1057.
10.	Hanin A, Demeret S, Nguyen-Michel VH, et al. Continuous EEG monitoring in the follow-up of convulsive status epilepticus patients: A proposal and preliminary validation of an EEG-based seizure build-up score (EaSiBUSSEs). Neurophysiol Clin, 2021, 51(2): 101-110.
11.	Menon B, Shorvon SD. Ischaemic stroke in adults and epilepsy. Epilepsy Res, 2009, 87(1): 1-11.
12.	Rady A, Elfatatry A, Molokhia T, et al. Psychiatric comorbidities in patients with psychogenic nonepileptic seizures. Epilepsy Behav, 2021, 118: 107918.
13.	Zamecnik J. Neuropathology of refractory epilepsy: the structural basis and mechanisms of epileptogenesis. Cesk Patol, 2012, 48(2): 76-82.
14.	Prasad Hrishi A, Ruby Lionel K, Prathapadas U. Head rules over the heart: cardiac manifestations of cerebral disorders. Indian J Crit Care Med, 2019, 23(7): 329-335.
15.	Fallah MS, Neupane B, Al Nassar M, et al. Interpreting the tests of focal cortical dysplasia for epilepsy surgery referral. Can J Neurol Sci, 2019, 46(5): 559-565.
16.	李伟. 托吡酯治疗脑梗死后继发癫痫的效果及其对认知功能的影响. 国际精神病学杂志, 2019, 46(6): 1049-1051.
17.	Holtkamp M, Beghi E, Benninger F, et al. European Stroke Organisation guidelines for the management of post-stroke seizures and epilepsy. Eur Stroke J, 2017, 2(2): 103-115.
18.	Vivekananda U. Redefining the role of magnetoencephalography in refractory epilepsy. Seizure, 2020, 83: 70-75.
19.	Hasan TF, Tatum W. Ambulatory EEG usefulness in epilepsy management. J Clin Neurophysiol, 2021, 38(2): 101-111.
20.	Pyrzowski J, Le Douget J E, Fouad A, et al. Zero-crossing patterns reveal subtle epileptiform discharges in the scalp EEG. Sci Rep, 2021, 11(1): 4128.

1. Bektas G, Kipoglu O, Pembegul Yildiz E, et al. Epileptic spasm and other forms of epilepsy in presumed perinatal arterial ischemic stroke in Turkey after more than 10 years follow-up: A single centre study. Brain Dev, 2019, 41(8): 699-705.
2. Bamford J, Sandercock P, Dennis M, et al. Classification and natural history of clinically identifiable subtypes of cerebral infarction. Lancet, 1991, 337(8756): 1521-1526.
3. Thijs RD, Surges R, O'Brien TJ, et al. Epilepsy in adults. Lancet, 2019, 393(10172): 689-701.
4. Winkler AS, Leonardi M, Michael BD, et al. A WHO resolution on epilepsy and other neurological disorders. Lancet Neurol, 2021, 20(3): 171-172.
5. Benninger F, Holtkamp M. Epileptic seizures and epilepsy after a stroke: Incidence, prevention and treatment. Nervenarzt, 2017, 88(10): 1197-1207.
6. Rosenow F, Klein KM, Hamer HM. Non-invasive EEG evaluation in epilepsy diagnosis. Expert Rev Neurother, 2015, 15(4): 425-44.
7. Ding D, Zhou D, Sander JW, et al. Epilepsy in China: major progress in the past two decades. Lancet Neurol, 2021, 20(4): 316-326.
8. Scheffer IE, Berkovic S, Capovilla G, et al. ILAE classification of the epilepsies: position paper of the ILAE Commission for Classification and Terminology. Epilepsia, 2017, 58(4): 512-521.
9. Shorvon SD. The etiologic classification of epilepsy. Epilepsia, 2011, 52(6): 1052-1057.
10. Hanin A, Demeret S, Nguyen-Michel VH, et al. Continuous EEG monitoring in the follow-up of convulsive status epilepticus patients: A proposal and preliminary validation of an EEG-based seizure build-up score (EaSiBUSSEs). Neurophysiol Clin, 2021, 51(2): 101-110.
11. Menon B, Shorvon SD. Ischaemic stroke in adults and epilepsy. Epilepsy Res, 2009, 87(1): 1-11.
12. Rady A, Elfatatry A, Molokhia T, et al. Psychiatric comorbidities in patients with psychogenic nonepileptic seizures. Epilepsy Behav, 2021, 118: 107918.
13. Zamecnik J. Neuropathology of refractory epilepsy: the structural basis and mechanisms of epileptogenesis. Cesk Patol, 2012, 48(2): 76-82.
14. Prasad Hrishi A, Ruby Lionel K, Prathapadas U. Head rules over the heart: cardiac manifestations of cerebral disorders. Indian J Crit Care Med, 2019, 23(7): 329-335.
15. Fallah MS, Neupane B, Al Nassar M, et al. Interpreting the tests of focal cortical dysplasia for epilepsy surgery referral. Can J Neurol Sci, 2019, 46(5): 559-565.
16. 李伟. 托吡酯治疗脑梗死后继发癫痫的效果及其对认知功能的影响. 国际精神病学杂志, 2019, 46(6): 1049-1051.
17. Holtkamp M, Beghi E, Benninger F, et al. European Stroke Organisation guidelines for the management of post-stroke seizures and epilepsy. Eur Stroke J, 2017, 2(2): 103-115.
18. Vivekananda U. Redefining the role of magnetoencephalography in refractory epilepsy. Seizure, 2020, 83: 70-75.
19. Hasan TF, Tatum W. Ambulatory EEG usefulness in epilepsy management. J Clin Neurophysiol, 2021, 38(2): 101-111.
20. Pyrzowski J, Le Douget J E, Fouad A, et al. Zero-crossing patterns reveal subtle epileptiform discharges in the scalp EEG. Sci Rep, 2021, 11(1): 4128.

Journal of Epilepsy

Clinical analysis of 109 cases of epilepsy secondary to cerebral infarction

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content