炎症、癫痫发作和癫痫发生：对人类疾病的探索_Journal of Epilepsy

Authors：

 TanTH , PeruccaP , O'BrienTJ , 高凡凯　李硕　译 , 薛国芳　审

Corresponding author：

TanTH, Email: mastura.monif@monash.edu

Keywords：

神经系统自身免疫性疾病、细胞因子、癫痫、癫痫发作

DOI：

10.7507/2096-0247.202204010

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癫痫在历史上被认为是一种神经元信号异常传导的疾病，表现为癫痫发作。随着大量自身抗体的发现和对自身免疫性脑炎认识的不断加深，人们越来越重视先天性和适应性免疫系统在癫痫发作和癫痫发生中的作用。在不同的癫痫发作相关的神经炎症和自身免疫疾病中，不同程度观察到了致病性抗体、补体激活、CD8⁺细胞毒性T细胞和小胶质细胞激活。这些异常的免疫反应被认为会导致神经元信号传导破坏，产生急性症状性癫痫发作，并且在某些情况下，还会发展为长期的自身免疫性癫痫。虽然早期使用免疫调节疗法可以改善自身免疫性脑炎和自身免疫性癫痫的预后，但患者的识别和治疗方法的选择并不总是明确。本篇综述讨论了免疫系统的不同成分在各种形式的癫痫发作中的作用，包括自身免疫性脑炎、自身免疫性癫痫、Rasmussen脑炎、热性感染相关性癫痫综合征和新发难治性癫痫持续状态。尤其是讨论了在这些疾病中观察到的病理生理学和独特的细胞因子谱，及其与诊断、预后和治疗决策的联系。

Citation： TanTH, PeruccaP, O'BrienTJ, 高凡凯　李硕　译, 薛国芳　审. 炎症、癫痫发作和癫痫发生：对人类疾病的探索. Journal of Epilepsy, 2022, 8(4): 348-365. doi: 10.7507/2096-0247.202204010 Copy

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