Clinical characteristics of autoimmune encephalitis in common antibody types and epileptic seizures_Journal of Epilepsy

Authors：

LI Xuebin ¹ , YANG Can ¹ , GAO Mingkang ¹ ,  LI Qiubo ²

1. Clinical Medical College of Jining Medical University, Jining 272000, China;
2. Department of Paediatrics, Affiliated Hospital of Jining Medical University, Jining 272000, China;

Corresponding author：

LI Qiubo, Email: lqb0072@126.com

Keywords：

Autoimmune encephalitis; Sleep disorders; Seizures; Psychiatric symptoms; Cognitive impairment

DOI：

10.7507/2096-0247.202309006

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Patients with autoimmune encephalitis are mainly characterized by behavioral, mental and motor abnormalities, neurological dysfunction, memory deficits and seizures. Different antibody types of autoimmune encephalitis its pathogenesis, clinical characteristics are different, in recent years found immune related epilepsy is closely related to autoimmune encephalitis, based on autoimmune encephalitis type is more, we choose more common autoimmune encephalitis, expounds its characteristics, to help clinical diagnosis.

Citation： LI Xuebin, YANG Can, GAO Mingkang, LI Qiubo. Clinical characteristics of autoimmune encephalitis in common antibody types and epileptic seizures. Journal of Epilepsy, 2023, 9(6): 513-516. doi: 10.7507/2096-0247.202309006 Copy

1.	Alexopoulos H, Dalakas MC. The immunobiology of autoimmune encephalitides. J Autoimmun, 2019, 104: 102339.
2.	Co DO, Kwon JM. Autoimmune encephalitis: distinguishing features and specific therapies. Crit Care Clin, 2022, 38(2): 393-412.
3.	Schieveld J, Strik J, van Kraaij S, et al. Psychiatric manifestations and psychopharmacology of autoimmune encephalitis: a multidisciplinary approach. Handb Clin Neurol, 2019, 165: 285-307.
4.	Chen L, Zhu L, Lu D, et al. Association between autoimmune encephalitis and epilepsy: systematic review and meta-analysis. Seizure, 2021, 91: 346-359.
5.	Cucuzza ME, Pavone P, D'Ambra A, et al. Autoimmune encephalitis and CSF anti-AMPA GluR3 antibodies in childhood: a case report and literature review. Neurol Sci, 2022, 43(9): 5237-5241.
6.	Ford H, Griffith S, Warren N, et al. Psychiatric manifestations of autoimmune encephalitis. Autoimmun Rev, 2022, 21(9): 103145.
7.	Dutra LA, Abrantes F, Toso FF, et al. Autoimmune encephalitis: a review of diagnosis and treatment. Arq Neuropsiquiatr, 2018, 76(1): 41-49.
8.	Esposito S, Principi N, Calabresi P, et al. An evolving redefinition of autoimmune encephalitis. Autoimmun Rev, 2019, 18(2): 155-163.
9.	Pruss H. Pathophysiology and prognostic factors of autoimmune encephalitis. Fortschr Neurol Psychiatr, 2016, 84(5): 264-270.
10.	Jafarpour S, Santoro JD. Autoimmune encephalitis. Pediatr Rev, 2022, 43(4): 198-211.
11.	Blattner MS, Day GS. Sleep disturbances in patients with autoimmune encephalitis. Curr Neurol Neurosci Rep, 2020, 20(7): 28.
12.	Ciano-Petersen NL, Muniz-Castrillo S, Vogrig A, et al. Immunomodulation in the acute phase of autoimmune encephalitis. Rev Neurol (Paris), 2022, 178(1-2): 34-47.
13.	Uy CE, Binks S, Irani SR. Autoimmune encephalitis: clinical spectrum and management. Pract Neurol, 2021, 21(5): 412-423.
14.	Hebert J, Muccilli A, Wennberg RA, et al. Autoimmune encephalitis and autoantibodies: a review of clinical implications. J Appl Lab Med, 2022, 7(1): 81-98.
15.	Broadley J, Seneviratne U, Beech P, et al. Prognosticating autoimmune encephalitis: a systematic review. J Autoimmun, 2019, 96: 24-34.
16.	Zhu S, Yu J, Wu Y, et al. Pathophysiology and clinical management of autoimmune encephalitis-associated seizures. Neuroimmunomodulation, 2022, 20: 1-14.
17.	李学斌, 杨灿, 李秋波. 抗N-甲基-D-天门冬氨酸受体脑炎病理机制的研究进展. 中风与神经疾病杂志, 2023, 40(4): 382-384.
18.	Boesen MS, Born AP, Lydolph MC, et al. Pediatric autoimmune encephalitis in Denmark during 2011-17: a nationwide multicenter population-based cohort study. Eur J Paediatr Neurol, 2019, 23(4): 639-652.
19.	Endres D, Leypoldt F, Bechter K, et al. Autoimmune encephalitis as a differential diagnosis of schizophreniform psychosis: clinical symptomatology, pathophysiology, diagnostic approach, and therapeutic considerations. Eur Arch Psychiatry Clin Neurosci, 2020, 270(7): 803-818.
20.	Ellul M A, Wood G, Tooren H, et al. Update on the diagnosis and management of autoimmune encephalitis. Clin Med (Lond), 2020, 20(4): 389-392.
21.	Pruss H. Postviral autoimmune encephalitis: manifestations in children and adults. Curr Opin Neurol, 2017, 30(3): 327-333.
22.	Chen B, Lopez C A, Sirven J I, et al. Autoimmune encephalitis-related seizures and epilepsy: diagnostic and therapeutic approaches. Mayo Clin Proc, 2021, 96(8): 2029-2039.
23.	Trewin BP, Freeman I, Ramanathan S, et al. Immunotherapy in autoimmune encephalitis. Curr Opin Neurol, 2022, 35(3): 399-414.
24.	Kunchok A, McKeon A, Zekeridou A, et al. Autoimmune/paraneoplastic encephalitis antibody biomarkers: frequency, age, and sex associations. Mayo Clin Proc, 2022, 97(3): 547-559.
25.	Seery N, Butzkueven H, O'Brien TJ, et al. Rare antibody-mediated and seronegative autoimmune encephalitis: an update. Autoimmun Rev, 2022, 21(7): 103118.
26.	Liang C, Chu E, Kuoy E, et al. Autoimmune-mediated encephalitis and mimics: a neuroimaging review. J Neuroimaging, 2022, 15: 256-261.
27.	Hara M, Arino H, Petit-Pedrol M, et al. DPPX antibody-associated encephalitis: main syndrome and antibody effects. Neurology, 2017, 88(14): 1340-1348.
28.	Spatola M, Sabater L, Planaguma J, et al. Encephalitis with mGluR5 antibodies: symptoms and antibody effects. Neurology, 2018, 90(22): e1964-e1972.
29.	Dade M, Berzero G, Izquierdo C, et al. Neurological syndromes associated with anti-GAD antibodies. Int J Mol Sci, 2020, 21(10): 361-365.

1. Alexopoulos H, Dalakas MC. The immunobiology of autoimmune encephalitides. J Autoimmun, 2019, 104: 102339.
2. Co DO, Kwon JM. Autoimmune encephalitis: distinguishing features and specific therapies. Crit Care Clin, 2022, 38(2): 393-412.
3. Schieveld J, Strik J, van Kraaij S, et al. Psychiatric manifestations and psychopharmacology of autoimmune encephalitis: a multidisciplinary approach. Handb Clin Neurol, 2019, 165: 285-307.
4. Chen L, Zhu L, Lu D, et al. Association between autoimmune encephalitis and epilepsy: systematic review and meta-analysis. Seizure, 2021, 91: 346-359.
5. Cucuzza ME, Pavone P, D'Ambra A, et al. Autoimmune encephalitis and CSF anti-AMPA GluR3 antibodies in childhood: a case report and literature review. Neurol Sci, 2022, 43(9): 5237-5241.
6. Ford H, Griffith S, Warren N, et al. Psychiatric manifestations of autoimmune encephalitis. Autoimmun Rev, 2022, 21(9): 103145.
7. Dutra LA, Abrantes F, Toso FF, et al. Autoimmune encephalitis: a review of diagnosis and treatment. Arq Neuropsiquiatr, 2018, 76(1): 41-49.
8. Esposito S, Principi N, Calabresi P, et al. An evolving redefinition of autoimmune encephalitis. Autoimmun Rev, 2019, 18(2): 155-163.
9. Pruss H. Pathophysiology and prognostic factors of autoimmune encephalitis. Fortschr Neurol Psychiatr, 2016, 84(5): 264-270.
10. Jafarpour S, Santoro JD. Autoimmune encephalitis. Pediatr Rev, 2022, 43(4): 198-211.
11. Blattner MS, Day GS. Sleep disturbances in patients with autoimmune encephalitis. Curr Neurol Neurosci Rep, 2020, 20(7): 28.
12. Ciano-Petersen NL, Muniz-Castrillo S, Vogrig A, et al. Immunomodulation in the acute phase of autoimmune encephalitis. Rev Neurol (Paris), 2022, 178(1-2): 34-47.
13. Uy CE, Binks S, Irani SR. Autoimmune encephalitis: clinical spectrum and management. Pract Neurol, 2021, 21(5): 412-423.
14. Hebert J, Muccilli A, Wennberg RA, et al. Autoimmune encephalitis and autoantibodies: a review of clinical implications. J Appl Lab Med, 2022, 7(1): 81-98.
15. Broadley J, Seneviratne U, Beech P, et al. Prognosticating autoimmune encephalitis: a systematic review. J Autoimmun, 2019, 96: 24-34.
16. Zhu S, Yu J, Wu Y, et al. Pathophysiology and clinical management of autoimmune encephalitis-associated seizures. Neuroimmunomodulation, 2022, 20: 1-14.
17. 李学斌, 杨灿, 李秋波. 抗N-甲基-D-天门冬氨酸受体脑炎病理机制的研究进展. 中风与神经疾病杂志, 2023, 40(4): 382-384.
18. Boesen MS, Born AP, Lydolph MC, et al. Pediatric autoimmune encephalitis in Denmark during 2011-17: a nationwide multicenter population-based cohort study. Eur J Paediatr Neurol, 2019, 23(4): 639-652.
19. Endres D, Leypoldt F, Bechter K, et al. Autoimmune encephalitis as a differential diagnosis of schizophreniform psychosis: clinical symptomatology, pathophysiology, diagnostic approach, and therapeutic considerations. Eur Arch Psychiatry Clin Neurosci, 2020, 270(7): 803-818.
20. Ellul M A, Wood G, Tooren H, et al. Update on the diagnosis and management of autoimmune encephalitis. Clin Med (Lond), 2020, 20(4): 389-392.
21. Pruss H. Postviral autoimmune encephalitis: manifestations in children and adults. Curr Opin Neurol, 2017, 30(3): 327-333.
22. Chen B, Lopez C A, Sirven J I, et al. Autoimmune encephalitis-related seizures and epilepsy: diagnostic and therapeutic approaches. Mayo Clin Proc, 2021, 96(8): 2029-2039.
23. Trewin BP, Freeman I, Ramanathan S, et al. Immunotherapy in autoimmune encephalitis. Curr Opin Neurol, 2022, 35(3): 399-414.
24. Kunchok A, McKeon A, Zekeridou A, et al. Autoimmune/paraneoplastic encephalitis antibody biomarkers: frequency, age, and sex associations. Mayo Clin Proc, 2022, 97(3): 547-559.
25. Seery N, Butzkueven H, O'Brien TJ, et al. Rare antibody-mediated and seronegative autoimmune encephalitis: an update. Autoimmun Rev, 2022, 21(7): 103118.
26. Liang C, Chu E, Kuoy E, et al. Autoimmune-mediated encephalitis and mimics: a neuroimaging review. J Neuroimaging, 2022, 15: 256-261.
27. Hara M, Arino H, Petit-Pedrol M, et al. DPPX antibody-associated encephalitis: main syndrome and antibody effects. Neurology, 2017, 88(14): 1340-1348.
28. Spatola M, Sabater L, Planaguma J, et al. Encephalitis with mGluR5 antibodies: symptoms and antibody effects. Neurology, 2018, 90(22): e1964-e1972.
29. Dade M, Berzero G, Izquierdo C, et al. Neurological syndromes associated with anti-GAD antibodies. Int J Mol Sci, 2020, 21(10): 361-365.

Previous Article
Responsive neurostimulation: a new treatment option for refractory epilepsy
Next Article
基于AI实时翻译技术的融合课堂在癫痫临床教学实践中的应用

Journal of Epilepsy

Clinical characteristics of autoimmune encephalitis in common antibody types and epileptic seizures

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content