Clinical diagnosis strategy of epilepsy based on biorhythm perspective_Journal of Epilepsy

Authors：

WANG Yanan ,  WU Zhijun

Department of Neurosurgery, the Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou 510100, China;

Corresponding author：

WU Zhijun, Email: 739012708@qq.com

Keywords：

Biological rhythm; Epilepsy; Circadian rhythms; Electroencephalography; Chronopharmacology

DOI：

10.7507/2096-0247.202412009

Video：

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Epilepsy is a prevalent neurological disorder characterized by recurrent, transient episodes of central nervous system dysfunction resulting from abnormal neuronal discharges in the brain. Diagnosis of epilepsy integrates clinical manifestations, electroencephalogram (EEG) findings, and imaging studies. Clinical presentations are diverse and variable, with abnormal EEG serving as a critical diagnostic indicator; however, some patients exhibit normal EEG results. Moreover, there are still many patients who were underdiagnosed because of atypical epilepsy symptoms. With advancements in EEG and multimodal imaging technologies, diagnostic strategies based on biorhythm theory have emerged. This paper reviewed the diagnostic approaches for epilepsy grounded in biorhythm theory, in order to provide more effective support for the clinical management of epilepsy.

Citation： WANG Yanan, WU Zhijun. Clinical diagnosis strategy of epilepsy based on biorhythm perspective. Journal of Epilepsy, 2025, 11(2): 149-157. doi: 10.7507/2096-0247.202412009 Copy

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31.	许蓓, 周洋, 贾晓彧, 等. 癫痫儿童生活质量的影响因素及家庭干预的疗效分析. 河北医科大学学报, 2018, 39(4): 420-424.
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1. Wang Y, Guo Y, Li Y, et al. Epilepsy in China: major progress in the past two decades. The Lancet Neurology, 2021, 20(4): 316-326.
2. Habte HF, Shafi M, Kassie A. Availability, price and affordability of anti-seizure medicines in Addis Ababa, Ethiopia. Epilepsia Open, 2023, 8(3): e12792.
3. 李静波, 王玉, 刘红权. 癫痫的诊断、命名及分类. 中国临床医生杂志, 2019, 47(10): 1140-1142.
4. 陈爱玲, 刁丽梅. miRNA在癫痫发病机制中的研究进展. 中国实验诊断学, 201, 22(10): 1851-1853.
5. 李蓉, 汪雨萱, 黎玉丹, 等. 抗癫痫药物临床评价指标研究进展. 卒中与神经疾病, 2020, 27(4): 552-556.
6. 张力辉, 韩东岳, 孙树敏, 等. 癫痫患者脑电图异常与血液miR-130b-3p和miR-7及FGL2表达特征的关系. 贵州医科大学学报, 2024, 49(6): 846-851.
7. 敖薪, 余凤英, 罗晓华, 等. 护理人员对生物节律认知程度的现况调查. 中华护理杂志, 2004, 39(8): 45-47.
8. 王赞, 张亚男, 孙晴晴, 等. 癫痫与昼夜节律. 中国睡眠研究会. 中国睡眠研究会第十一届全国学术年会论文汇编, 2019: 1.
9. Karoly PJ, Freestone DR, Cook MJ, et al. Seizure prediction in epilepsy: a critical review. Neurology, 2017, 89(1): 1-12.
10. Baud MO, Wagner O, Batteau A, et al. Multi-day rhythms modulate seizure risk in epilepsy. Nature Communications, 2018, 9(1): 1-10.
11. Li J, Zhang Y, Wang Q, et al. CLOCK gene deletion induces focal epilepsy by disrupting neural circuit function. Journal of Neuroscience, 2017, 37(23): 5678-5689.
12. Gachon F, Olela FF, Langlois F, et al. The loss of PAR bZip transcription factors results in epilepsy due to massive neurodegeneration. Nature Neuroscience, 2004, 7(11): 1184-1193.
13. Sun S, Wang H. Reprogramming of epilepsy genes in a mouse model of temporal lobe epilepsy reveals circadian dynamics. International Journal of Molecular Sciences, 2023, 24(7): 6400.
14. Nsgaard JAR, Gjerstad L, Heuser K, et al. Biological rhythms and epilepsy treatment. Frontiers in Neurology, 2023(14): 1153975.
15. 汪文杰, 姚旭峰. 基于人工智能的癫痫发作预测研究综述. 软件工程, 2024, 27(4): 1-5.
16. 翟文骥, 吴杰, 郑体花, 等. 常见实验动物疾病模型造模方法——癫痫模型Ⅱ. 中国实验动物学报, 2024, 32(6): 786-792.
17. Löscher W. Epileptic seizures and epilepsy: animal models in the discovery of antiepileptic drugs—past, present, and future. Neurochemical Research, 2017, 42(7): 1873-1888.
18. Pease M, Gupta K, Moshé SL, et al. Insights into epileptogenesis from post-traumatic epilepsy. Nature Reviews Neurology, 2024, 20(5): 298-312.
19. 姚庆河, 张华, 高国栋, 等. 脑皮质电刺激对癫痫大鼠脑皮质兴奋性的影响. 中国神经外科杂志, 2010, 26(10): 949-952.
20. 于云莉, 闫勇利, 冯占辉, 等. 颞叶癫痫患者发作间期放电昼夜节律与纺锤波变化的研究. 第五届CAAE脑电图与神经电生理大会, 2024.
21. 许杰, 刘智胜. 癫痫和睡眠. 国际儿科学杂志, 2007, 34(6): 417-417.
22. 谭婉文. 儿童良性癫痫伴中央颞区棘波临床发作生物节律的初步探讨. 南方医科大学, 硕士学位论文, 2022.
23. 吕玉丹. 脑电图技术在癫痫患者睡眠障碍、认知障碍及痫样事件识别中的应用研究. 吉林大学 , 硕士学位论文, 2014.
24. 姚芹. 儿童卒中后早期癫痫发作的临床特征分析. 重庆医科大学, 硕士学位论文, 2020.
25. 卢敏. 褪黑素对谷氨酸钠致痫大鼠海马内5-羟色胺及一氧化氮含量的影响. 华中科技大学, 硕士学位论文, 2006.
26. 李娟. 基于PSG探讨MT对老年慢性失眠及其相关认知障碍的作用. 中南大学, 硕士学位论文, 2022.
27. 周洋凡. 癫痫发作时相特点与治疗和转归的关系研究. 中南大学, 硕士学位论文, 2022.
28. 王从荣. 褪黑素对谷氨酸致痫大鼠海马内谷氨酸GABA及其受体水平的影响. 华中科技大学, 硕士学位论文, 2007.
29. Yu Hongjuan, Li Limin, Liu Chaojie, et al. Factors associated with the quality of life of family caregivers for leukemia patients in China. Health Qual Life Outcomes, 2017, 15(1): 55.
30. 李兴超, 王友芳, 杨淑红, 等. 不同年龄卒中后癫痫发作的相关影响因素分析. 临床医学进展, 2024, 14(2): 4612-4618.
31. 许蓓, 周洋, 贾晓彧, 等. 癫痫儿童生活质量的影响因素及家庭干预的疗效分析. 河北医科大学学报, 2018, 39(4): 420-424.
32. 黄路遥, 丁晶, 汪昕. 癫痫与睡眠障碍共病的研究进展. 中国神经精神疾病杂志, 2024, 50(3): 234-242.
33. 韩飞飞, 雒晨宇, 孙美珍. 癫痫与睡眠障碍相关机制研究进展. 癫痫杂志, 2023, 9(2): 151-155.
34. 侯玉莹, 宋毅军. 癫痫与睡眠障碍. 国际生物医学工程杂志, 2016, 39(6): 5.
35. Parvathy G, Suraj MM, Kabeer KA, et al. Alpha coma: a report. Neurol India, 2017, 65(3): 640-641.
36. 曹兰芳, 徐金苹, 薛海燕. 附着点炎/脊柱关节炎相关幼年特发性关节炎诊治进展. 中国实用儿科杂志, 2021, 36(1): 9-16.
37. Felix C, Judy L. Molecular regulation of brain metabolism underlying circadian epilepsy. Epilepsia, 2021, 62(Suppl): s32-s48.
38. Wu H, Liu Y, Liu L, et al. Decreased expression of the clock gene Bmal1 is involved in the pathogenesis of temporal lobe epilepsy. Molecular Brain, 2021, 14(1): 113.
39. 李荣姬. 局灶性癫痫发作的生物节律. 山西医科大学, 硕士学位论文, 2022.
40. Xu C, Yang J, Rong Y, et al. Decoding circadian rhythm and epileptic activities: clues from animal studies. Frontiers in Neurology, 2020, 11: 751.
41. Srmiy MS, Roni D, Erreis SG, et al. Circadian-like rhythmicity of extracellular brain glutamate in epilepsy. Frontiers in Neurology, 2020, 21: 11398.
42. Sha S, Han W. Clocking epilepsies: a chronomodulated strategy-based therapy for rhythmic seizures. International Journal of Molecular Sciences, 2023, 24(4): 4223-4223.
43. Lin W, XiuYu S, WenRong G, et al. The instigation of the associations between melatonin, circadian genes, and epileptic spasms in infant rats. Frontiers in Neurology, 2020, 11: 497225.
44. Udaya S, Mark C, Wendyl D. Brainwaves beyond diagnosis: wider applications of electroencephalography in idiopathic generalized epilepsy. Epilepsia, 2021, 63(1): 22-41.
45. 何勐, 窦海玲, 周丽娟. 基于血药浓度监测的丙戊酸钠治疗癫痫384例个体化用药分析. 中国药师, 2018, 21(5): 864-866.
46. Brinkmann BH, Karoly PJ, Nurse E S, et al. Seizure diaries and forecasting with wearables: epilepsy monitoring outside the clinic. Frontiers in Neurology, 2021, 12: 690404.
47. 张宇. 生物节律分子Bmal1在颞叶内侧癫痫发病中的作用机制研究. 中国人民解放军空军军医大学, , 硕士学位论文, 2020.
48. Pennell BP. Hormonal aspects of epilepsy. Neurologic Clinics, 2009, 27(4): 941-965.
49. 梁建民. 类固醇激素对雄性大鼠颞叶癫痫脑保护机制的研究. 吉林大学, 博士学位论文, 2004.
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Clinical diagnosis strategy of epilepsy based on biorhythm perspective

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