Research progress on the diagnosis, treatment, and prognosis of status epilepticus_Journal of Epilepsy

Authors：

LI Yuanyuan ,  ZHANG Hong

Department of Neurology, Shengjing Hospital of China Medical University, Shenyang 110022, China;

Corresponding author：

ZHANG Hong, Email: zhangh.7211@163.com

Keywords：

Status epilepticus; Diagnosis; Treatment; Prognosis

DOI：

10.7507/2096-0247.202501006

Video：

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Abstract Full text Figures/Tables Video References Cited by

Status epilepticus (SE) is one of the most common neurological emergencies. Prolonged seizures can cause permanent neuronal death in the central nervous system, necessitating early recognition and timely intervention. Although there is some consensus on the diagnosis and treatment of SE, the high heterogeneity of SE patients presents a significant challenge for standardized management and prognosis prediction. This review summarizes the current research progress on the diagnosis, treatment, and prognosis of SE, aiming to provide references for early diagnosis, early treatment, and early prediction of prognosis.

Citation： LI Yuanyuan, ZHANG Hong. Research progress on the diagnosis, treatment, and prognosis of status epilepticus. Journal of Epilepsy, 2025, 11(3): 250-255. doi: 10.7507/2096-0247.202501006 Copy

1.
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48.	Rossetti AO, Logroscino G, Bromfield EB. A clinical score for prognosis of status epilepticus in adults Neurology, 2006, 66(11): 1736-1738.
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51.	牛杰朝, 张瑜, 王建东, 等. 儿童癫痫持续状态严重程度评分量表与PEDSS评分量表对癫痫持续状态患儿近期预后评估的应用价值中华实用儿科临床杂志, 2024, 39(1): 54-58.
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1.
2.
3. Giovannini G, Monti G, Polisi MM, et al. A one-year prospective study of refractory status epilepticus in Modena, Italy Epilepsy & Behavior, 2015, 49: 141-145.
4.
5. Guidelines for Epidemiologic Studies on Epilepsy - 1993 - Epilepsia - Wiley Online Library[EB/OL]. [2024-09-20]. https://onlinelibrary.wiley.com/doi/10.1111/j.1528-1157.1993.tb00433.x.
6. Lowenstein D H, Bleck T, Macdonald RL. It’s Time to Revise the Definition of Status Epilepticus Epilepsia, 1999, 40(1): 120-122.
7. Shorvon S, Sen A. What is status epilepticus and what do we know about its epidemiology? Seizure, 2020, 75: 131-136.
8. Trinka E, Cock H, Hesdorffer D, et al. A definition and classification of status epilepticus--Report of the ILAE Task Force on Classification of Status Epilepticus. Epilepsia, 2015, 56(10): 1515-1523.
9.
10.
11. Gaddamanugu S, Shafaat O, Sotoudeh H, et al. Clinical applications of diffusion-weighted sequence in brain imaging: beyond stroke Neuroradiology, 2022, 64(1): 15-30.
12.
13. Privitera MD, Strawsburg RH. Electroencephalographic monitoring in the emergency department Emergency Medicine Clinics of North America, 1994, 12(4): 1089-1100.
14. Neurocritical Care Society Status Epilepticus Guideline Writing Committee, Brophy GM, Bell R, et al. Guidelines for the Evaluation and Management of Status Epilepticus Neurocritical Care, 2012, 17(1): 3-23.
15. Beniczky S, Hirsch L J, Kaplan P W, et al. Unified EEG terminology and criteria for nonconvulsive status epilepticus Epilepsia, 2013, 54(s6): 28-29.
16.
17.
18.
19.
20.
21.
22.
23. Glauser T, Shinnar S, Gloss D, et al. Evidence-based guideline: treatment of convulsive status epilepticus in children and adults: report of the Guideline Committee of the American Epilepsy Society Epilepsy Currents, 2016, 16(1): 48-61.
24.
25.
26.
27.
28.
29. Khoujah D, Abraham MK. Status epilepticus: what’s new? Emergency Medicine Clinics of North America, 2016, 34(4): 759-776.
30.
31.
32.
33. Sutter R, Kaplan PW. Can anesthetic treatment worsen outcome in status epilepticus? Epilepsy & Behavior, 2015, 49: 294-297.
34. Gettings JV, Chafjiri FMA, Patel AA, et al. Diagnosis and management of status epilepticus: improving the status quo The Lancet Neurology, 2025, 24(1): 65-76.
35.
36.
37.
38.
39.
40.
41.
42.
43. Pinto LF, Oliveira JPS de, Midon AM. Status epilepticus: review on diagnosis, monitoring and treatment. Arquivos De Neuro-Psiquiatria, 2022, 80(5 Suppl 1): 193-203.
44.
45.
46.
47.
48. Rossetti AO, Logroscino G, Bromfield EB. A clinical score for prognosis of status epilepticus in adults Neurology, 2006, 66(11): 1736-1738.
49.
50.
51. 牛杰朝, 张瑜, 王建东, 等. 儿童癫痫持续状态严重程度评分量表与PEDSS评分量表对癫痫持续状态患儿近期预后评估的应用价值中华实用儿科临床杂志, 2024, 39(1): 54-58.
52.
53.
54.
55.
56.

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