癫痫女性孕期奥卡西平血药浓度的动态变化：个案报道_Journal of Epilepsy

Authors：

刘希宁 ¹ , 胡湘蜀 ² , 杨茜蒙 ³ , 张阳 ¹ , 马云燕 ¹ , 陈令民 ¹ ,  张勇 ¹ ,  陈蕾 ³

1. ;
2. ;
3. ;

Corresponding author：

张勇, Email: zhangyongsey@163.com; 陈蕾, Email: leilei_25@163.com

Keywords：

癫痫女性; 孕期; 奥卡西平; 血药浓度

DOI：

10.7507/2096-0247.202502011

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Citation： 刘希宁, 胡湘蜀, 杨茜蒙, 张阳, 马云燕, 陈令民, 张勇, 陈蕾. 癫痫女性孕期奥卡西平血药浓度的动态变化：个案报道. Journal of Epilepsy, 2025, 11(4): 357-361. doi: 10.7507/2096-0247.202502011 Copy

1.	郝南亚, 吴梦倩, 周东, 等. 中国西部女性癫痫患者妊娠及用药数据库的建立与实施. 癫痫杂志, 2016, 2(2): 114-117.
2.	Schoretsanitis G, Deligiannidis KM, Kasperk N, et al. The impact of pregnancy on the pharmacokinetics of antiseizure medications: a systematic review and meta-analysis of data from 674 pregnancies. Prog Neuropsychopharmacol Biol Psychiatry, 2024, 13: 111030.
3.	Voinescu PE, Park S, Chen LQ, et al. Antiepileptic drug clearances during pregnancy and clinical implications for women with epilepsy. Neurology, 2018, 91(13): e1228-e1236.
4.	Battino D, Tomson T, Bonizzoni E, et al. Seizure control and treatment changes in pregnancy: observations from the EURAP epilepsy pregnancy registry. Epilepsia, 2013, 54(9): 1621-1627.
5.	Petrenaite V, Sabers A, Hansen-Schwartz J. Seizure deterioration in women treated with oxcarbazepine during pregnancy. Epilepsy Res, 2009, 84(2-3): 245-249.
6.	Myllynen P, Pienimäki P, Jouppila P, et al. Transplacental passage of oxcarbazepine and its metabolites in vivo. Epilepsia, 2001, 42(11): 1482-1485.
7.	Wei LY, Xu ZY, Lai ZZ, et al. Association of oxcarbazepine concentration with seizure frequency in pregnant women with epilepsy. Epilepsy Behav Rep, 2023, 25: 100640.
8.	Watila MM, Beida O, Kwari S, et al. Seizure occurrence, pregnancy outcome among women with active convulsive epilepsy: one year prospective study. Seizure, 2015, 26: 7-11.
9.	Thomas SV, Syam U, Devi JS, et al. Predictors of seizures during pregnancy in women with epilepsy. Epilepsia, 2012, 53(5): e85-88.
10.	Taubøll E, Sveberg L, Svalheim S. Interactions between hormones and epilepsy. Seizure, 2015, 28: 3-11.
11.	Li Q, Zhang Z, Fang J. Hormonal changes in women with epilepsy. Neuropsychiatr Dis Treat, 2024, 26(20): 373-388.
12.	Adab N, Kini U, Vinten J, et al. The longer term outcome of children born to mothers with epilepsy. J Neurol Neurosurg Psychiatry, 2004, 75: 1575-1583.
13.	Wang D, Lu R, Rempala G, et al. Ligand-free estrogen receptor α (ESR1) as master regulator for the expression of CYP3A4 and other cytochrome P450 enzymes in the human liver. Mol Pharmacol, 2019, 96(4): 430-440.
14.	Ding Y, Tan X, Li CY, et al. Pharmacokinetic changes and therapeutic drug monitoring of lamotrigine during pregnancy. Brain Behav, 2019, 9(7): e01315.
15.	Pennell PB, Hovinga CA. Antiepileptic drug therapy in pregnancy I: gestation-induced effects on AED pharmacokinetics. Int Rev Neurobiol, 2008, 83: 227-240.
16.	Pennell PB. Antiepileptic drug pharmacokinetics during pregnancy and lactation. Neurology, 2003, 61(6 Suppl 2): S35-42.

1. 郝南亚, 吴梦倩, 周东, 等. 中国西部女性癫痫患者妊娠及用药数据库的建立与实施. 癫痫杂志, 2016, 2(2): 114-117.
2. Schoretsanitis G, Deligiannidis KM, Kasperk N, et al. The impact of pregnancy on the pharmacokinetics of antiseizure medications: a systematic review and meta-analysis of data from 674 pregnancies. Prog Neuropsychopharmacol Biol Psychiatry, 2024, 13: 111030.
3. Voinescu PE, Park S, Chen LQ, et al. Antiepileptic drug clearances during pregnancy and clinical implications for women with epilepsy. Neurology, 2018, 91(13): e1228-e1236.
4. Battino D, Tomson T, Bonizzoni E, et al. Seizure control and treatment changes in pregnancy: observations from the EURAP epilepsy pregnancy registry. Epilepsia, 2013, 54(9): 1621-1627.
5. Petrenaite V, Sabers A, Hansen-Schwartz J. Seizure deterioration in women treated with oxcarbazepine during pregnancy. Epilepsy Res, 2009, 84(2-3): 245-249.
6. Myllynen P, Pienimäki P, Jouppila P, et al. Transplacental passage of oxcarbazepine and its metabolites in vivo. Epilepsia, 2001, 42(11): 1482-1485.
7. Wei LY, Xu ZY, Lai ZZ, et al. Association of oxcarbazepine concentration with seizure frequency in pregnant women with epilepsy. Epilepsy Behav Rep, 2023, 25: 100640.
8. Watila MM, Beida O, Kwari S, et al. Seizure occurrence, pregnancy outcome among women with active convulsive epilepsy: one year prospective study. Seizure, 2015, 26: 7-11.
9. Thomas SV, Syam U, Devi JS, et al. Predictors of seizures during pregnancy in women with epilepsy. Epilepsia, 2012, 53(5): e85-88.
10. Taubøll E, Sveberg L, Svalheim S. Interactions between hormones and epilepsy. Seizure, 2015, 28: 3-11.
11. Li Q, Zhang Z, Fang J. Hormonal changes in women with epilepsy. Neuropsychiatr Dis Treat, 2024, 26(20): 373-388.
12. Adab N, Kini U, Vinten J, et al. The longer term outcome of children born to mothers with epilepsy. J Neurol Neurosurg Psychiatry, 2004, 75: 1575-1583.
13. Wang D, Lu R, Rempala G, et al. Ligand-free estrogen receptor α (ESR1) as master regulator for the expression of CYP3A4 and other cytochrome P450 enzymes in the human liver. Mol Pharmacol, 2019, 96(4): 430-440.
14. Ding Y, Tan X, Li CY, et al. Pharmacokinetic changes and therapeutic drug monitoring of lamotrigine during pregnancy. Brain Behav, 2019, 9(7): e01315.
15. Pennell PB, Hovinga CA. Antiepileptic drug therapy in pregnancy I: gestation-induced effects on AED pharmacokinetics. Int Rev Neurobiol, 2008, 83: 227-240.
16. Pennell PB. Antiepileptic drug pharmacokinetics during pregnancy and lactation. Neurology, 2003, 61(6 Suppl 2): S35-42.

Journal of Epilepsy

癫痫女性孕期奥卡西平血药浓度的动态变化：个案报道

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content