Efficacy and Safety of Sulindac on Colorectal Polyps: A Systematic_West China Medical Journal

Authors：

LIU Ruming ^1,2 , WU Bin ^1,2 ,  TANG Yao ¹

Department of Pharmacy, West China Hospital; 2. West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

TANG Yao, Email: lrm5218@yahoo.cn

Keywords：

结直肠息肉; 舒林酸; 有效性; 不良反应; 系统评价

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【摘要】　目的　评价舒林酸治疗结直肠息肉的有效性和安全性。　方法　计算机检索PubMed、Cochrane Iibrary、Embase、SCI、CNKI、万方、维普、CBM数据库。按Cochrane系统评价的方法评价纳入研究质量，并进行Meta分析。　结果　共纳入7个随机对照试验（RCT），共235例患者。Meta分析结果显示舒林酸治疗腺瘤性息肉病（FAP）在有效率、息肉消失率方面与安慰剂比较，差异无统计学意义（P gt;0.05）；治疗散发性结肠腺瘤性息肉病（SCAP）在有效率、息肉消失率、腺瘤直径变化方面与安慰剂比较，差异有统计学意义（P lt;0.05）；舒林酸的不良反应多为消化道症状，与安慰剂比较差异有统计学意义（P lt;0.05）。　结论　系统评价结果显示舒林酸对于家族性FAP的疗效尚不确切，而对SCAP有一定的疗效。
【关键词】结直肠息肉；舒林酸；有效性；不良反应；系统评价
【Abstract】　Objective　 To assess the efficacy and safety of sulindac on colorectal polyps.　Methods　 The literatures were searched from several databases including PubMed,Cochrane Iibrary,SCI,CNKI,Wanfang,VIP,and CBM. The quality of the researches was evaluated according to Cochrane systematic reviews, and the Meta analysis was performed.　Results　 Seven RCT were enrolled with a total of 235 patients. Meta analysis showed that there was no significant difference in the effective rate and polyps disappearance rate of FAP between the two groups (P gt;0.05). There were significant differences in the effective rate, polyps disappearance rate and size of adenomas between the two groups (P lt;0.05); the most common adverse event was the symptoms of digestive tract which differed much from that in the placebo group (P lt;0.05).　Conclusion　 The therapeutic effect of sulindac on FAP is not sure, but it is effective on SCAP.

Citation： LIU Ruming,WU Bin,TANG Yao. Efficacy and Safety of Sulindac on Colorectal Polyps: A Systematic. West China Medical Journal, 2011, 26(1): 81-84. doi: Copy

1.	吴在德, 吴肇汉. 外科学[M]. 6版. 北京: 人民卫生出版社, 2006: 510-515.
2.	Baron JA. Epidemiology of non-steroidal anti-inflammatory drugs and cancer [J]. Prog Exp Tumor Re, 2003, 37(1): 1-24.
3.	Cerdan FJ, Torresmelero J, Martinez S, et al. Treatment of familiar adenomatous polyposis-coli with sulindac[J]. Revista Espanola De Enfermedades Digestivas, 1995, 87(8): 574-576.
4.	Cruzcorrea M, Hylind LM, Romans KE, et al. Long-term treatment with sulindac in familial adenomatous polyposis: a prospective cohort study[J]. Gastroenterology, 2002, 122(3): 641-645.
5.	Hixson LJ, Earnest DL, Fennerty MB, et al. NSAID effect on sporadic colon polyps[J]. Am J Gastroenterol, 1993, 88(10): 1652-1656.
6.	Niv Y, Fraser GM. Adenocarcinoma in the rectal segment in familial polyposis coli is not prevented by sulindac therapy[J]. Gastroenterology, 1994, 107(3): 854-857.
7.	Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version 5. 0. 1 [updated September 2008]. The Cochrane Collaboration, 2008.
8.	Giardiello FM, Hamilton SR, Krush AJ, et al. Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis[J]. N Engl J Med, 1993, 328(18): 1313-1316.
9.	Nugent KP, Farmer KC, Spigelman AD, et al. Randomized controlled trial of the effect of sulindac on duodenal and rectal polyposis and cell proliferation in patients with familial adenomatous polyposis[J]. Br J Surg, 1993, 80(12): 1618-1619.
10.	Giardiello FM, Yang VW, Hylind LM, et al. Primary chemoprevention of familial adenomatous polyposis with sulindac[J]. N Engl J Med, 2002, 346(14): 1054-1059.
11.	Ladenheim J, Garcia G, Titzer D, et al. Effect of sulindac on sporadic colonic polyps[J]. Gastroenterology, 1995, 108(4): 1083-1087.
12.	钱跃清, 吕愈敏, 叶嗣懋. 舒林酸治疗散发性结直肠腺瘤的临床研究[J]. 中华消化杂志, 2001, 21(12): 710-712.
13.	贾道全, 武卫国, 罗成福, 等. 舒林酸与内镜下高频电切治疗结直肠腺瘤的转归分析[J]. 中华消化内镜杂志, 2003, 20(2): 125-126.
14.	陈和平, 韩盛玺, 徐刚, 等. 舒林酸治疗散发性结肠腺瘤性息肉的机制研究[J]. 中国医刊, 2008, 43(9): 51-53.

1. 　吴在德, 吴肇汉. 外科学[M]. 6版. 北京: 人民卫生出版社, 2006: 510-515.
2. 　Baron JA. Epidemiology of non-steroidal anti-inflammatory drugs and cancer [J]. Prog Exp Tumor Re, 2003, 37(1): 1-24.
3. 　Cerdan FJ, Torresmelero J, Martinez S, et al. Treatment of familiar adenomatous polyposis-coli with sulindac[J]. Revista Espanola De Enfermedades Digestivas, 1995, 87(8): 574-576.
4. 　Cruzcorrea M, Hylind LM, Romans KE, et al. Long-term treatment with sulindac in familial adenomatous polyposis: a prospective cohort study[J]. Gastroenterology, 2002, 122(3): 641-645.
5. 　Hixson LJ, Earnest DL, Fennerty MB, et al. NSAID effect on sporadic colon polyps[J]. Am J Gastroenterol, 1993, 88(10): 1652-1656.
6. 　Niv Y, Fraser GM. Adenocarcinoma in the rectal segment in familial polyposis coli is not prevented by sulindac therapy[J]. Gastroenterology, 1994, 107(3): 854-857.
7. 　Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version 5. 0. 1 [updated September 2008]. The Cochrane Collaboration, 2008.
8. 　Giardiello FM, Hamilton SR, Krush AJ, et al. Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis[J]. N Engl J Med, 1993, 328(18): 1313-1316.
9. 　Nugent KP, Farmer KC, Spigelman AD, et al. Randomized controlled trial of the effect of sulindac on duodenal and rectal polyposis and cell proliferation in patients with familial adenomatous polyposis[J]. Br J Surg, 1993, 80(12): 1618-1619.
10. 　Giardiello FM, Yang VW, Hylind LM, et al. Primary chemoprevention of familial adenomatous polyposis with sulindac[J]. N Engl J Med, 2002, 346(14): 1054-1059.
11. 　Ladenheim J, Garcia G, Titzer D, et al. Effect of sulindac on sporadic colonic polyps[J]. Gastroenterology, 1995, 108(4): 1083-1087.
12. 　钱跃清, 吕愈敏, 叶嗣懋. 舒林酸治疗散发性结直肠腺瘤的临床研究[J]. 中华消化杂志, 2001, 21(12): 710-712.
13. 　贾道全, 武卫国, 罗成福, 等. 舒林酸与内镜下高频电切治疗结直肠腺瘤的转归分析[J]. 中华消化内镜杂志, 2003, 20(2): 125-126.
14. 　陈和平, 韩盛玺, 徐刚, 等. 舒林酸治疗散发性结肠腺瘤性息肉的机制研究[J]. 中国医刊, 2008, 43(9): 51-53.

West China Medical Journal

Efficacy and Safety of Sulindac on Colorectal Polyps: A Systematic

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