Influence on Quality of Life after Proximal Gastrectomy and Total Gastrectomy for Adenocarcinoma of Esophago-gastric Junction_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

HEN Chaoyong , YANG Hongxin ,  ZHANG Bo , CHEN Haining , CHEN Zhixin , CHEN Jiaping

Department of Gastrointestinal Surgery， West China Hospital， Sichuan University， Chengdu 610041， Sichuan Province， China;

Corresponding author：

ZHANG Bo, Email: hxwcwk@126.com

Keywords：

Quality of life; Adenocarcinoma of esophagogastric junction; Total gastrectomy; Proximal gastr-ectomy

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Abstract Full text Figures/Tables Video References Cited by

Objective 　To investigate the differences of postoperative quality of life （QOL） between proximal gas-
trectomy （PG） and total gastrectomy （TG） in patients with adenocarcinoma of esophagogastric junction （AEG）.
Methods 　Eighty five patients with AEG （Siewert type Ⅱ or Ⅲ） who were underwent PG or TG surgery between Jan. 2011 and
Mar. 2012 at West China Hospital of Sichuan University were enrolled， to measure the QOL by using the Chinese
version of quality of life questionnaire core-30 （QLQ-C30） and the site-specific module for gastric cancer （QLQ-STO22）
which were drawed up by the European Organization for Research and Treatment of Cancer （EORTC） in 12 months after
operation.
Results 　There were no any difference of clinicopathological features between patients in 2 groups （P＞0.05），
such as age， gender， and so on. The scores of eating restriction， diarrhea， and dyspnea in PG group were lower than those of TG group （P＜0.05）， but scores of reflux and taste change were higher （P＜0.05）， no other significant differ-
ence was found between the patients of 2 groups （P＞0.05）.
Conclusion 　Both of PG＋gastric tube reconstruction and TG＋Roux-en-Y anastomosis in treatment of patients with Siewert type Ⅱ or Ⅲ AEG may lead to complications， but patients who underwent former surgery have better situation in eating restriction， diarrhea， and dyspnea， and patients who underwent later surgery have better situation in reflux and taste change.

Citation： HEN Chaoyong,YANG Hongxin,ZHANG Bo,CHEN Haining,CHEN Zhixin,CHEN Jiaping. Influence on Quality of Life after Proximal Gastrectomy and Total Gastrectomy for Adenocarcinoma of Esophago-gastric Junction. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2013, 20(12): 1381-1385. doi: Copy

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2.	Hasegawa S， Yoshikawa T. Adenocarcinoma of the esophagogastric junction：incidence， characteristics， and treatment strategies[J]. Gastric Cancer， 2010， 13(2)：63-73.
3.	Shiraishi N， Hirose P， Morimoto A， et al. Gastric tube reconstru-ction prevented esophageal reflux after proximal gastrectomy[J]. Gastric Cancer， 1998， 1(1)：78-79.
4.	Chen XF， Zhang B， Chen ZX， et al. Gastric tube reconstruction reduces postoperative gastroesophageal reflux in adenocarcinoma of esophagogastric junction[J]. Dig Dis Sci， 2012， 57(3)：738-745.
5.	Matsui H， Igarashi N， Itano O， et al. Laparoscopic function-preserving surgery for early gastric cancer in the upper third of the stomach：vagus-sparing proximal gastrectomy with side-to-side esophagogastric-tube anastomosis[J]. Tokai J Exp Clin Med， 2007， 32(4)：109-114.
6.	Shiraishi N， Adachi Y， Kitano S， et al. Clinical outcome of proximal versus total gastrectomy for proximal gastric cancer[J].World J Surg， 2002， 26(9)：1150-1154.
7.	Wen L， Chen XZ， Wu B， et al. Total vs. proximal gastrectomy for proximal gastric cancer：a systematic review and meta-analysis[J]. Hepatogastroenterology， 2012， 59(114)：633-640.
8.	Barbour AP， Lagergren P， Hughes R， et al. Health-related qualityof life among patients with adenocarcinoma of the gastro-esophageal treated by gastrectomy or esophagectomy[J]. British J Surg， 2008， 95(1)：80-84.
9.	Washington K. 7th edition of the AJCC cancer staging manual：stomach[J]. Ann Surg Oncol， 2010， 17(12)：3077-3079.
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11.	Harrison LE， Karpeh MS， Brennan MF. Total gastrectomy is not necessary for proximal gastric cancer[J]. Surgery， 1998， 123(2)：127-130.
12.	An JY， Youn HG， Choi MG， et al. The difficult choice between total and proximal gastrectomy in proximal early gastric cancer[J].Am J Surg， 2008， 196(4)：587-591.
13.	Kaptein AA， Morita S， Sakamoto J. Quality of life in gastric cancer[J]. World J Gastroenterol， 2005， 11(21)：3189-3196.
14.	Takiguchi S， Yamamoto K， Hirao M， et al. A comparison of postoperative quality of life and dysfunction after Billroth Ⅰ and Roux-en-Y reconstruction following distal gastrectomy for gastric cancer：results from a multi-institutional RCT[J]. Gastric Cancer，2012， 15(2)：198-205.
15.	Park SH， Cho MS， Kim YS， et al. Self-reported health-related quality of life predicts survival for patients with advanced gastric cancer treated with first-line chemotherapy[J]. Qual Life Res， 2008， 17(2)：207-214.
16.	李文英，曹淑红，张晓峰，等. 胃癌术后患者生活质量研究[J]. 现代预防医学， 2011， 38(21)：4441-4443， 4446.
17.	Aaronson NK， Ahmedzai S， Bergman B， et al. The European organization for research and treatment of cancer QLQ-C30：a quality-of-life instrument for use in international clinical trials in oncology[J]. J Natl Cancer Inst， 1993， 85(5)：365-376.
18.	Blazeby JM， Conroy T， Bottomley A， et al. Clinical and psycho-metric validation of a questionnaire module， the EORTC QLQ-STO22， to assess quality of life in patients with gastric cancer[J].Eur J Cancer， 2004， 40(15)：2260-2268.
19.	姜宝法，徐涛，刘春晓，等. 胃癌患者生活质量问卷(QLQ-STO22)中文版的制定[J]. 中国心理卫生杂志， 2005， 19(5)：310-312.
20.	Zhao H， Kanda K. Translation and validation of the standard Chinese version of the EORTC QLQ-C30[J]. Qual Life Res， 2000， 9(2)：129-137.
21.	Collard JM， Romagnoli R. Roux-en-Y jejunal loop and bile reflux[J]. Am J Surg， 2000， 179(4)：298-303.
22.	陈秀峰，陈海宁，张波，等. Ⅱ、Ⅲ型食管胃结合部腺癌的临床分析[J]. 四川大学学报：医学版， 2012， 43(2)：289-292.
23.	代斌，潘琳，杨晨，等. 食管胃结合部腺癌病人行近端胃与全胃切除术后生活质量比较[J]. 中国实用外科杂志， 2011， 31(2)：147-149.
24.	Bae JM， Kim S， Kim YW， et al. Health-related quality of life among disease-free stomach cancer survivors in Korea[J]. Qual Life Res， 2006， 15(10)：1587-1596.
25.	Wu CW， Chiou JM， Ko FS， et al. Quality of life after curativegastrectomy for gastric cancer in a randomised controlled trial[J].Br J Cancer， 2008， 98(1)：54-59.

1. Siewert JR， Stein HJ， Feith M. Adenocarcinoma of the esophago-gastric junction[J]. Scand J Surg， 2006， 95(4)：260-269.
2. Hasegawa S， Yoshikawa T. Adenocarcinoma of the esophagogastric junction：incidence， characteristics， and treatment strategies[J]. Gastric Cancer， 2010， 13(2)：63-73.
3. Shiraishi N， Hirose P， Morimoto A， et al. Gastric tube reconstru-ction prevented esophageal reflux after proximal gastrectomy[J]. Gastric Cancer， 1998， 1(1)：78-79.
4. Chen XF， Zhang B， Chen ZX， et al. Gastric tube reconstruction reduces postoperative gastroesophageal reflux in adenocarcinoma of esophagogastric junction[J]. Dig Dis Sci， 2012， 57(3)：738-745.
5. Matsui H， Igarashi N， Itano O， et al. Laparoscopic function-preserving surgery for early gastric cancer in the upper third of the stomach：vagus-sparing proximal gastrectomy with side-to-side esophagogastric-tube anastomosis[J]. Tokai J Exp Clin Med， 2007， 32(4)：109-114.
6. Shiraishi N， Adachi Y， Kitano S， et al. Clinical outcome of proximal versus total gastrectomy for proximal gastric cancer[J].World J Surg， 2002， 26(9)：1150-1154.
7. Wen L， Chen XZ， Wu B， et al. Total vs. proximal gastrectomy for proximal gastric cancer：a systematic review and meta-analysis[J]. Hepatogastroenterology， 2012， 59(114)：633-640.
8. Barbour AP， Lagergren P， Hughes R， et al. Health-related qualityof life among patients with adenocarcinoma of the gastro-esophageal treated by gastrectomy or esophagectomy[J]. British J Surg， 2008， 95(1)：80-84.
9. Washington K. 7th edition of the AJCC cancer staging manual：stomach[J]. Ann Surg Oncol， 2010， 17(12)：3077-3079.
10. Deans C， Yeo MS， Soe MY， et al. Cancer of the gastric cardia is rising in incidence in an Asian population and is associated with adverse outcome[J]. World J Surg， 2011， 35(3)：617-624.
11. Harrison LE， Karpeh MS， Brennan MF. Total gastrectomy is not necessary for proximal gastric cancer[J]. Surgery， 1998， 123(2)：127-130.
12. An JY， Youn HG， Choi MG， et al. The difficult choice between total and proximal gastrectomy in proximal early gastric cancer[J].Am J Surg， 2008， 196(4)：587-591.
13. Kaptein AA， Morita S， Sakamoto J. Quality of life in gastric cancer[J]. World J Gastroenterol， 2005， 11(21)：3189-3196.
14. Takiguchi S， Yamamoto K， Hirao M， et al. A comparison of postoperative quality of life and dysfunction after Billroth Ⅰ and Roux-en-Y reconstruction following distal gastrectomy for gastric cancer：results from a multi-institutional RCT[J]. Gastric Cancer，2012， 15(2)：198-205.
15. Park SH， Cho MS， Kim YS， et al. Self-reported health-related quality of life predicts survival for patients with advanced gastric cancer treated with first-line chemotherapy[J]. Qual Life Res， 2008， 17(2)：207-214.
16. 李文英，曹淑红，张晓峰，等. 胃癌术后患者生活质量研究[J]. 现代预防医学， 2011， 38(21)：4441-4443， 4446.
17. Aaronson NK， Ahmedzai S， Bergman B， et al. The European organization for research and treatment of cancer QLQ-C30：a quality-of-life instrument for use in international clinical trials in oncology[J]. J Natl Cancer Inst， 1993， 85(5)：365-376.
18. Blazeby JM， Conroy T， Bottomley A， et al. Clinical and psycho-metric validation of a questionnaire module， the EORTC QLQ-STO22， to assess quality of life in patients with gastric cancer[J].Eur J Cancer， 2004， 40(15)：2260-2268.
19. 姜宝法，徐涛，刘春晓，等. 胃癌患者生活质量问卷(QLQ-STO22)中文版的制定[J]. 中国心理卫生杂志， 2005， 19(5)：310-312.
20. Zhao H， Kanda K. Translation and validation of the standard Chinese version of the EORTC QLQ-C30[J]. Qual Life Res， 2000， 9(2)：129-137.
21. Collard JM， Romagnoli R. Roux-en-Y jejunal loop and bile reflux[J]. Am J Surg， 2000， 179(4)：298-303.
22. 陈秀峰，陈海宁，张波，等. Ⅱ、Ⅲ型食管胃结合部腺癌的临床分析[J]. 四川大学学报：医学版， 2012， 43(2)：289-292.
23. 代斌，潘琳，杨晨，等. 食管胃结合部腺癌病人行近端胃与全胃切除术后生活质量比较[J]. 中国实用外科杂志， 2011， 31(2)：147-149.
24. Bae JM， Kim S， Kim YW， et al. Health-related quality of life among disease-free stomach cancer survivors in Korea[J]. Qual Life Res， 2006， 15(10)：1587-1596.
25. Wu CW， Chiou JM， Ko FS， et al. Quality of life after curativegastrectomy for gastric cancer in a randomised controlled trial[J].Br J Cancer， 2008， 98(1)：54-59.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Influence on Quality of Life after Proximal Gastrectomy and Total Gastrectomy for Adenocarcinoma of Esophago-gastric Junction

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