Objective To observe the histopathological changes of tumor tissue after intraoperative regional chemotherapy of rectal cancer. Methods After the treatment of intraoperative regional chemotherapy with 5-FU (15 mg/kg)， the histopathological changes of tumor tissue were detected. Results Slight changes with cancer cells in all the cases accepted intraoperative regional chemotherapy were found under light microscope such as karyopyknosis, nuclear swelling, coagulation and necrosis of cytoplasm, hydropsia of intercellular substance, invasion of inflammatory cells, and 9/15 cases with slight inflammation of vessels were observed; While those changes were found in individual cells of the cases without regional chemotherapy. The more enlarged intercellular space of cancer cell was observed under electron microscope in the case with regional chemotherapy. Conclusion The intraoperative regional chemotherapy of rectal tumor can change the histopathological appearance of tumor tissue, that is significant in preventing cancer cells diffusing during operation and relapsing after operation.
Citation：
DU Jiang,WANG Chongshu,WEI Shoujiang,KOU Hongyan,YANG Hua. Pathological and Clinical Effects of Intraoperative Regional Chemotherapy of Rectal Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2008, 15(12): 926-928. doi:
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- 1. 陈 亮， 张思河， 张 青, 等. 大肠癌靶向治疗临床试验的研究进展 [Ｊ]. 中国肿瘤生物治疗杂志, 2006； 13(3)∶230.
- 2. Zalcberg JR, Siderov J, Simes J. On behalf the Australasian gastrointestinal trials group, the role of 5-Fluorouracil does in the adjavant therapy of colorectal cancer [Ｊ]. Ann Oncol, 1996； 7(1)∶41.
- 3. 孙世良, 温海燕, 张连阳, 等主编. 现代大肠癌诊断与治疗 [M]. 重庆: 重庆出版社, 2004∶393.
- 4. 杜 江, 王崇树, 张才全， 等. 直肠癌术中区域化疗和肠腔化疗血液和盆腔液及组织5-Fu浓度比较 [Ｊ]. 第四军医大学学报, 2007； 28(24)∶2278.
- 5. Ragnhammar P, Hafstrm L, Nygren P, et al. A systematic overview of chemotherapy effects in colorectal cancer [Ｊ]. Acta Oncol， 2001; 40(2-3)∶282.
- 6. 黄志强, 林言箴, 祝学光, 等主编. 腹部外科学理论与实践 [M]. 第1版. 北京： 科学出版社, 2003∶333.
- 7. Ohno S, Sumiyoshi Y, Mori M, et al. Hyperthermia for rectal cancer [Ｊ]. Surgery， 2002; 131(1 Suppl)∶S121.
- 8. 王崇树, 吴功柱, 方学胜, 等. 直肠癌温热化疗治疗直肠癌疗效研究 [Ｊ]. 肿瘤防治研究, 1997； 24(3)∶166.
- 9. 顾 晋, 马朝来, 叶颖江, 等. 结肠、直肠癌术前区域动脉灌注化疗的临床病理观察 [Ｊ]. 中华外科杂志, 1999； 37(6)∶333.
- 10. 李 莉, 张珈敏, 胡远扬, 等. 温度及药物诱导肿瘤细胞凋亡的实验观察 [Ｊ]. 高等学校化学学报, 2002； 23(7)∶1379.
- 11. 杨 波, 蒲永东, 蒋成来, 等. 胃癌区域动脉置泵化疗及外周静脉化疗前后T淋巴细胞亚群及免疫球蛋白的变化 [Ｊ]. 中国普外基础与临床杂志, 2004; 11(2)∶110.
- 12. 张成武, 邹寿椿, 裘华森, 等. 术前区域性动脉灌注化疗对进展期胃癌预后的影响 [Ｊ]. 中国普外基础与临床杂志, 2003; 10(5)∶480.
- 13. 李国立, 刘福坤, 陈忠豪, 等. 胃癌术前选择性动脉化疗对组织和细胞结构的影响 [Ｊ]. 中华外科杂志, 1997； 35(5)∶259.
